Mutagenetix > Incidental Mutation

Incidental Mutation 'R7156:Or10g6'

557317

Institutional Source

Beutler Lab

Gene Symbol

Or10g6

Ensembl Gene

ENSMUSG00000046678

Gene Name

olfactory receptor family 10 subfamily G member 6

Synonyms

MOR223-8, GA_x6K02T2PVTD-33720892-33721824, Olfr981

MMRRC Submission

045257-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.165) question?

Stock #

R7156 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

39933691-39934623 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 39934526 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 279 (I279T)

Ref Sequence

ENSEMBL: ENSMUSP00000149436 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000059859] [ENSMUST00000215956]

AlphaFold

Q8VEU2

Predicted Effect

probably benign
Transcript: ENSMUST00000059859
AA Change: I279T

PolyPhen 2 Score 0.230 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000057952
Gene: ENSMUSG00000046678
AA Change: I279T

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	304	1.4e-54	PFAM
Pfam:7tm_1	41	288	8.8e-21	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000215956
AA Change: I279T

PolyPhen 2 Score 0.230 (Sensitivity: 0.91; Specificity: 0.88)

Meta Mutation Damage Score

0.0857

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 98.9%

Validation Efficiency

100% (81/81)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 79 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930433I11Rik	T	C	7: 40,643,282 (GRCm39)	I317T	possibly damaging	Het
Acsl5	G	A	19: 55,257,260 (GRCm39)		probably null	Het
Ahrr	G	A	13: 74,378,035 (GRCm39)	T136I	probably damaging	Het
AI597479	G	A	1: 43,150,261 (GRCm39)	D124N	probably damaging	Het
Arap2	G	T	5: 62,761,914 (GRCm39)	A1604D	probably damaging	Het
Bcl6	G	A	16: 23,784,976 (GRCm39)	R675*	probably null	Het
Cadps2	T	C	6: 23,688,955 (GRCm39)	N118S	probably benign	Het
Caskin1	T	A	17: 24,719,657 (GRCm39)		probably null	Het
Cc2d1a	C	T	8: 84,862,389 (GRCm39)	V684M	possibly damaging	Het
Ccdc91	T	C	6: 147,435,676 (GRCm39)	S87P	possibly damaging	Het
Cdr2l	A	G	11: 115,281,792 (GRCm39)	Q99R	probably benign	Het
Celsr3	T	C	9: 108,715,203 (GRCm39)	L2066P	possibly damaging	Het
Cep95	A	C	11: 106,700,050 (GRCm39)	L313F	possibly damaging	Het
Chst10	G	A	1: 38,913,088 (GRCm39)	T63M	probably damaging	Het
Clrn2	G	A	5: 45,611,258 (GRCm39)	G36R	probably damaging	Het
Cnn2	T	G	10: 79,830,349 (GRCm39)	Y273*	probably null	Het
Crtap	T	C	9: 114,207,164 (GRCm39)	T365A	probably benign	Het
D630045J12Rik	T	C	6: 38,171,964 (GRCm39)	T735A	possibly damaging	Het
Disp2	C	T	2: 118,622,292 (GRCm39)	A1008V	probably damaging	Het
Dmrt3	A	G	19: 25,588,317 (GRCm39)	D52G	probably damaging	Het
Dmrta1	T	G	4: 89,576,700 (GRCm39)	L52R	probably damaging	Het
Dmrta2	A	G	4: 109,839,185 (GRCm39)	T311A	probably damaging	Het
Dnm1	T	A	2: 32,230,479 (GRCm39)	N112Y	probably damaging	Het
Dysf	T	C	6: 84,064,858 (GRCm39)		probably null	Het
Ep400	A	G	5: 110,833,229 (GRCm39)	F2034L	unknown	Het
F12	G	A	13: 55,566,310 (GRCm39)	A494V	probably damaging	Het
Fbp2	A	T	13: 62,989,675 (GRCm39)	F210L	probably benign	Het
Fbxo31	T	A	8: 122,281,060 (GRCm39)	Q362L	possibly damaging	Het
Fkbp4	C	T	6: 128,412,787 (GRCm39)	A95T	probably benign	Het
Frmd6	T	G	12: 70,923,983 (GRCm39)	C80W	probably damaging	Het
Fsip2	A	G	2: 82,813,085 (GRCm39)	I3135V	probably benign	Het
Garre1	G	T	7: 33,945,133 (GRCm39)	N582K	possibly damaging	Het
Guca2b	T	A	4: 119,514,887 (GRCm39)	E34V	probably damaging	Het
Hdlbp	G	A	1: 93,341,637 (GRCm39)	T974I	probably damaging	Het
Hsdl2	T	A	4: 59,617,653 (GRCm39)	M460K	possibly damaging	Het
Ift172	C	T	5: 31,429,419 (GRCm39)	V581M	probably damaging	Het
Ift74	A	G	4: 94,549,189 (GRCm39)	K313R	possibly damaging	Het
Ints4	T	A	7: 97,184,493 (GRCm39)		probably null	Het
Iqca1l	C	T	5: 24,757,648 (GRCm39)	E150K	probably benign	Het
Kif21b	A	C	1: 136,075,562 (GRCm39)	T230P	probably damaging	Het
Kit	A	T	5: 75,776,034 (GRCm39)	Y272F	probably benign	Het
Krt77	G	A	15: 101,773,931 (GRCm39)	T241M	probably benign	Het
Lce1j	T	A	3: 92,696,491 (GRCm39)	S96C	unknown	Het
Marveld3	T	A	8: 110,674,820 (GRCm39)	D332V	probably damaging	Het
Matr3	G	T	18: 35,705,974 (GRCm39)	V300F	probably damaging	Het
Mical1	T	A	10: 41,361,253 (GRCm39)		probably null	Het
Mslnl	T	A	17: 25,962,184 (GRCm39)	V194E	probably benign	Het
Mug1	C	A	6: 121,857,864 (GRCm39)	T1119K	probably damaging	Het
Mug1	C	T	6: 121,861,302 (GRCm39)	P1308S	probably damaging	Het
Neb	C	A	2: 52,195,295 (GRCm39)		probably null	Het
Neo1	T	A	9: 58,810,206 (GRCm39)	T1082S	probably damaging	Het
Nkx6-2	C	T	7: 139,162,045 (GRCm39)		probably null	Het
Or8k27	T	A	2: 86,275,652 (GRCm39)	I225L	probably damaging	Het
Orc1	A	T	4: 108,452,656 (GRCm39)	E177V	probably benign	Het
Parp1	G	A	1: 180,426,629 (GRCm39)	V924I	possibly damaging	Het
Pax2	A	T	19: 44,777,298 (GRCm39)	I165F	probably benign	Het
Pnma2	C	T	14: 67,153,980 (GRCm39)	P135S	probably benign	Het
Ranbp17	A	G	11: 33,247,420 (GRCm39)	I718T	probably damaging	Het
Rbm25	T	A	12: 83,710,965 (GRCm39)	D359E	unknown	Het
Rgs3	T	C	4: 62,535,363 (GRCm39)	L194P	probably damaging	Het
Serpinb6b	A	G	13: 33,155,598 (GRCm39)	I104V	probably benign	Het
Smg9	A	G	7: 24,120,286 (GRCm39)	D420G	probably benign	Het
Smpd1	C	T	7: 105,203,693 (GRCm39)		probably benign	Het
Snx17	T	A	5: 31,354,692 (GRCm39)	M318K	probably damaging	Het
Spata31e5	A	T	1: 28,815,848 (GRCm39)	M728K	possibly damaging	Het
Stard10	G	A	7: 100,995,258 (GRCm39)	D337N	probably damaging	Het
Tex14	A	G	11: 87,375,545 (GRCm39)	T103A	probably damaging	Het
Tle1	A	G	4: 72,088,953 (GRCm39)	S97P	probably benign	Het
Tnfrsf8	T	A	4: 145,041,654 (GRCm39)	M1L	unknown	Het
Traf3ip2	T	C	10: 39,502,173 (GRCm39)	L107P	possibly damaging	Het
Trpc7	A	T	13: 56,937,579 (GRCm39)	S626T	possibly damaging	Het
Ubl7	T	A	9: 57,837,039 (GRCm39)	I350N	probably damaging	Het
Ubr3	T	A	2: 69,851,967 (GRCm39)	I1878N	probably damaging	Het
Usp24	G	T	4: 106,245,116 (GRCm39)		probably null	Het
Vcan	A	T	13: 89,837,229 (GRCm39)	S2772T	possibly damaging	Het
Vmn2r79	T	C	7: 86,686,851 (GRCm39)	V744A	probably damaging	Het
Wbp2nl	T	C	15: 82,189,903 (GRCm39)	S32P	probably damaging	Het
Wwc1	A	G	11: 35,788,201 (GRCm39)		probably null	Het
Zfp629	C	T	7: 127,211,463 (GRCm39)	W115*	probably null	Het

Other mutations in Or10g6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01481:Or10g6	APN	9	39,934,574 (GRCm39)	missense	possibly damaging	0.61
IGL02089:Or10g6	APN	9	39,934,066 (GRCm39)	missense	probably damaging	1.00
R0722:Or10g6	UTSW	9	39,934,295 (GRCm39)	missense	probably damaging	1.00
R1117:Or10g6	UTSW	9	39,934,058 (GRCm39)	missense	probably damaging	0.99
R1781:Or10g6	UTSW	9	39,934,541 (GRCm39)	missense	probably damaging	1.00
R1874:Or10g6	UTSW	9	39,934,151 (GRCm39)	missense	possibly damaging	0.86
R1893:Or10g6	UTSW	9	39,934,270 (GRCm39)	missense	possibly damaging	0.64
R1942:Or10g6	UTSW	9	39,934,048 (GRCm39)	missense	probably damaging	1.00
R1942:Or10g6	UTSW	9	39,934,031 (GRCm39)	missense	probably damaging	1.00
R1999:Or10g6	UTSW	9	39,933,985 (GRCm39)	missense	probably benign
R2000:Or10g6	UTSW	9	39,933,985 (GRCm39)	missense	probably benign
R2173:Or10g6	UTSW	9	39,934,550 (GRCm39)	missense	probably damaging	0.97
R2760:Or10g6	UTSW	9	39,933,692 (GRCm39)	start codon destroyed	probably null	0.00
R4300:Or10g6	UTSW	9	39,934,435 (GRCm39)	missense	probably benign	0.02
R4530:Or10g6	UTSW	9	39,934,589 (GRCm39)	missense	probably benign
R4614:Or10g6	UTSW	9	39,934,255 (GRCm39)	missense	probably damaging	1.00
R4661:Or10g6	UTSW	9	39,933,823 (GRCm39)	missense	probably damaging	1.00
R4777:Or10g6	UTSW	9	39,933,994 (GRCm39)	missense	possibly damaging	0.90
R5017:Or10g6	UTSW	9	39,933,672 (GRCm39)	start gained	probably benign
R5065:Or10g6	UTSW	9	39,934,546 (GRCm39)	missense	probably benign	0.44
R5467:Or10g6	UTSW	9	39,933,733 (GRCm39)	missense	probably benign	0.00
R5668:Or10g6	UTSW	9	39,933,964 (GRCm39)	missense	probably damaging	1.00
R5687:Or10g6	UTSW	9	39,933,731 (GRCm39)	missense	probably damaging	1.00
R6432:Or10g6	UTSW	9	39,933,824 (GRCm39)	missense	probably damaging	1.00
R6620:Or10g6	UTSW	9	39,934,225 (GRCm39)	missense	probably damaging	1.00
R6992:Or10g6	UTSW	9	39,933,896 (GRCm39)	nonsense	probably null
R7250:Or10g6	UTSW	9	39,934,050 (GRCm39)	nonsense	probably null
R7273:Or10g6	UTSW	9	39,933,961 (GRCm39)	missense	probably benign	0.04
R8006:Or10g6	UTSW	9	39,933,770 (GRCm39)	missense	probably damaging	1.00
R8701:Or10g6	UTSW	9	39,933,815 (GRCm39)	missense	probably damaging	1.00
R8835:Or10g6	UTSW	9	39,934,171 (GRCm39)	missense	possibly damaging	0.48
R9497:Or10g6	UTSW	9	39,934,616 (GRCm39)	missense	probably benign
R9733:Or10g6	UTSW	9	39,934,171 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TGTAGACATTGGCTTCCTGGC -3'
(R):5'- CCTAGTTACTTGCCACAATGTC -3'

Sequencing Primer
(F):5'- CCTATGGCTACATCGTGGCTG -3'
(R):5'- AGTTACTTGCCACAATGTCTCTCATC -3'

Posted On

2019-06-26