Mutagenetix > Incidental Mutation

Incidental Mutation 'R7630:Vmn2r-ps117'

589612

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r-ps117

Ensembl Gene

ENSMUSG00000093531

Gene Name

vomeronasal 2, receptor, pseudogene 117

Synonyms

EG665303

MMRRC Submission

045691-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.168) question?

Stock #

R7630 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

19042822-19059004 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 19044909 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 442 (D442G)

Ref Sequence

ENSEMBL: ENSMUSP00000156026 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000176899]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000176899
AA Change: D442G

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.1%

Validation Efficiency

93% (40/43)

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A530084C06Rik	G	T	13: 31,742,978 (GRCm39)	R92S	unknown	Het
Agbl1	A	T	7: 76,535,904 (GRCm39)	I1019F	unknown	Het
Arhgap15	A	G	2: 43,670,648 (GRCm39)	T11A	probably benign	Het
Armh1	C	A	4: 117,070,938 (GRCm39)	A396S	probably benign	Het
Atg2b	T	C	12: 105,613,213 (GRCm39)		probably null	Het
Aup1	C	A	6: 83,031,904 (GRCm39)	D50E	unknown	Het
Ccl25	A	G	8: 4,403,955 (GRCm39)	Y49C	probably damaging	Het
Cnga3	A	G	1: 37,297,127 (GRCm39)	D148G	probably damaging	Het
Cpeb3	A	T	19: 37,031,693 (GRCm39)	F570I	probably damaging	Het
Cyp3a16	T	A	5: 145,373,120 (GRCm39)		probably null	Het
Eif2d	C	T	1: 131,082,103 (GRCm39)	T65M	probably benign	Het
Fryl	T	C	5: 73,267,588 (GRCm39)	I426V	possibly damaging	Het
Hgf	T	C	5: 16,803,248 (GRCm39)	S387P	probably benign	Het
Hyal6	T	C	6: 24,734,583 (GRCm39)	V172A	probably damaging	Het
Il10ra	T	C	9: 45,167,369 (GRCm39)	D396G	probably damaging	Het
Kif26a	A	G	12: 112,142,131 (GRCm39)	D795G	probably damaging	Het
Lrrc8c	T	A	5: 105,755,568 (GRCm39)	S448T	probably damaging	Het
Myl10	G	C	5: 136,726,825 (GRCm39)	V70L	probably benign	Het
Notch2	A	G	3: 98,044,824 (GRCm39)	D1582G	possibly damaging	Het
Or14c42-ps1	T	C	7: 86,211,680 (GRCm39)	S247P	probably damaging	Het
Or1l4b	A	C	2: 37,036,371 (GRCm39)	D49A	probably damaging	Het
Osmr	T	C	15: 6,846,452 (GRCm39)	I741V	possibly damaging	Het
Plec	C	T	15: 76,074,816 (GRCm39)		probably null	Het
Prkag3	A	G	1: 74,783,894 (GRCm39)	F330L	probably damaging	Het
Prkn	A	G	17: 11,456,455 (GRCm39)	E93G	probably benign	Het
Rexo4	A	T	2: 26,850,622 (GRCm39)	F247I	probably damaging	Het
Rph3a	T	C	5: 121,081,113 (GRCm39)	D628G	probably damaging	Het
Rsf1	GGCG	GGCGACGGCCGCG	7: 97,229,113 (GRCm39)		probably benign	Het
Rxylt1	T	C	10: 121,931,865 (GRCm39)	I103V	possibly damaging	Het
Scnn1g	T	C	7: 121,359,704 (GRCm39)	S396P	probably damaging	Het
Slc1a5	G	A	7: 16,529,732 (GRCm39)	V384M	probably damaging	Het
Sltm	C	G	9: 70,493,955 (GRCm39)	P802R	possibly damaging	Het
Smc4	CTA	CTATA	3: 68,925,400 (GRCm39)		probably benign	Het
Synpo2	A	G	3: 122,873,681 (GRCm39)	V1154A	probably damaging	Het
Tanc2	T	C	11: 105,667,734 (GRCm39)	V105A	probably benign	Het
Tapbp	T	C	17: 34,139,318 (GRCm39)	S105P	probably benign	Het
Tmem79	T	C	3: 88,240,768 (GRCm39)	E60G	possibly damaging	Het
Txnrd2	A	G	16: 18,257,140 (GRCm39)	D152G	possibly damaging	Het
Vcl	T	A	14: 21,033,470 (GRCm39)	L142*	probably null	Het
Vmn2r58	T	C	7: 41,513,611 (GRCm39)	Y344C	probably damaging	Het
Xpo6	A	T	7: 125,739,561 (GRCm39)		probably null	Het

Other mutations in Vmn2r-ps117

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R6903:Vmn2r-ps117	UTSW	17	19,058,552 (GRCm39)	missense	possibly damaging	0.94
R6912:Vmn2r-ps117	UTSW	17	19,047,464 (GRCm39)	missense	probably damaging	1.00
R6934:Vmn2r-ps117	UTSW	17	19,044,967 (GRCm39)	nonsense	probably null
R6953:Vmn2r-ps117	UTSW	17	19,045,095 (GRCm39)	missense	probably benign
R6974:Vmn2r-ps117	UTSW	17	19,058,495 (GRCm39)	missense	probably benign	0.15
R7373:Vmn2r-ps117	UTSW	17	19,044,948 (GRCm39)	missense	probably benign
R7776:Vmn2r-ps117	UTSW	17	19,043,934 (GRCm39)	missense	probably damaging	0.96
R8060:Vmn2r-ps117	UTSW	17	19,058,124 (GRCm39)	missense	possibly damaging	0.85
R8126:Vmn2r-ps117	UTSW	17	19,042,814 (GRCm39)	missense	probably benign	0.00
R8751:Vmn2r-ps117	UTSW	17	19,044,021 (GRCm39)	missense	probably benign
R8986:Vmn2r-ps117	UTSW	17	19,044,943 (GRCm39)	nonsense	probably null
R9324:Vmn2r-ps117	UTSW	17	19,042,911 (GRCm39)	missense	probably benign	0.20
R9417:Vmn2r-ps117	UTSW	17	19,044,037 (GRCm39)	nonsense	probably null
R9607:Vmn2r-ps117	UTSW	17	19,043,940 (GRCm39)	missense	probably benign	0.03
Z1177:Vmn2r-ps117	UTSW	17	19,058,338 (GRCm39)	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- TGGACACTGTAGCTCTTACATATTC -3'
(R):5'- GGCCATTGTATCATCTGTTCAG -3'

Sequencing Primer
(F):5'- TGCTTACTTGAACTTGGTTCTAAG -3'
(R):5'- GATAAAGACAACTGTTGACCCTG -3'

Posted On

2019-10-24