Incidental Mutation 'R7876:Morf4l1'
ID 608445
Institutional Source Beutler Lab
Gene Symbol Morf4l1
Ensembl Gene ENSMUSG00000062270
Gene Name mortality factor 4 like 1
Synonyms TEG-189, Tex189, MORFRG15, MRG15
MMRRC Submission 045928-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R7876 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 89973718-89996827 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 89975859 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 311 (A311V)
Ref Sequence ENSEMBL: ENSMUSP00000082346 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085248] [ENSMUST00000169860] [ENSMUST00000190345] [ENSMUST00000191189] [ENSMUST00000191353]
AlphaFold P60762
Predicted Effect possibly damaging
Transcript: ENSMUST00000085248
AA Change: A311V

PolyPhen 2 Score 0.647 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000082346
Gene: ENSMUSG00000062270
AA Change: A311V

DomainStartEndE-ValueType
Pfam:Tudor-knot 11 53 8.9e-11 PFAM
Blast:CHROMO 83 117 4e-6 BLAST
Pfam:MRG 174 348 3.5e-57 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000169860
AA Change: A272V

PolyPhen 2 Score 0.220 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000132020
Gene: ENSMUSG00000062270
AA Change: A272V

DomainStartEndE-ValueType
CHROMO 10 78 1.8e-9 SMART
Pfam:MRG 127 311 2.8e-59 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000190345
Predicted Effect probably benign
Transcript: ENSMUST00000191189
AA Change: A245V

PolyPhen 2 Score 0.084 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000140118
Gene: ENSMUSG00000062270
AA Change: A245V

DomainStartEndE-ValueType
CHROMO 10 78 1.1e-11 SMART
Pfam:MRG 100 284 1.1e-56 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000191353
SMART Domains Protein: ENSMUSP00000140023
Gene: ENSMUSG00000062270

DomainStartEndE-ValueType
Pfam:Tudor-knot 11 53 3.1e-8 PFAM
Blast:CHROMO 82 116 2e-6 BLAST
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (56/56)
MGI Phenotype PHENOTYPE: Homozygous null mice display perinatal lethality, cardiac hypertrophy, reduced alveolar space, decreased cell proliferation, congestion of the liver, lung, and spleen, skin edema, and thin skin. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acvr2a A G 2: 48,760,439 (GRCm39) K65R probably benign Het
Adprhl1 T C 8: 13,273,509 (GRCm39) D1083G probably benign Het
Aox1 C T 1: 58,101,330 (GRCm39) Q434* probably null Het
Atp13a5 T A 16: 29,140,566 (GRCm39) N330I possibly damaging Het
Brd8 A G 18: 34,739,740 (GRCm39) F678L probably benign Het
C1ra G A 6: 124,494,684 (GRCm39) E316K probably benign Het
C87436 T A 6: 86,423,411 (GRCm39) probably null Het
Cacna1h A T 17: 25,594,225 (GRCm39) I2311K probably benign Het
Ccng2 C G 5: 93,421,202 (GRCm39) S237R probably benign Het
Cux1 T C 5: 136,392,161 (GRCm39) T187A probably benign Het
Dip2b A G 15: 100,088,922 (GRCm39) I1031V probably benign Het
Efna5 T C 17: 62,957,929 (GRCm39) N109S possibly damaging Het
Fat2 A T 11: 55,202,046 (GRCm39) S343T probably benign Het
Fubp1 T C 3: 151,937,928 (GRCm39) Y654H unknown Het
Gbe1 G A 16: 70,238,059 (GRCm39) V282I probably benign Het
Grik1 T C 16: 87,720,121 (GRCm39) K719E Het
Grm6 A T 11: 50,750,457 (GRCm39) Y540F probably damaging Het
Hmcn1 C T 1: 150,620,722 (GRCm39) V1163I probably benign Het
Igkv4-53 T A 6: 69,625,987 (GRCm39) Q60L possibly damaging Het
Igkv4-59 A T 6: 69,415,337 (GRCm39) S73T probably damaging Het
Il1a A C 2: 129,142,762 (GRCm39) W228G probably damaging Het
Klk13 A G 7: 43,370,403 (GRCm39) D22G probably benign Het
Kntc1 T A 5: 123,913,850 (GRCm39) C602S probably damaging Het
Kras T C 6: 145,170,848 (GRCm39) K176E probably benign Het
Krtap5-4 G A 7: 141,857,585 (GRCm39) C85Y unknown Het
Map3k13 A G 16: 21,741,069 (GRCm39) T799A probably benign Het
Mfhas1 T C 8: 36,056,697 (GRCm39) Y391H probably damaging Het
Ms4a8a T A 19: 11,056,848 (GRCm39) Q78L probably damaging Het
Muc5ac G C 7: 141,363,040 (GRCm39) G2117A unknown Het
Nav3 T C 10: 109,689,359 (GRCm39) N306S probably benign Het
Ncapd3 T C 9: 26,956,519 (GRCm39) probably null Het
Nrg2 T A 18: 36,330,140 (GRCm39) Y25F unknown Het
Nup153 C T 13: 46,835,084 (GRCm39) S1407N probably benign Het
Or2c1 T A 16: 3,656,658 (GRCm39) probably null Het
Or4c99 A G 2: 88,329,999 (GRCm39) Y190C probably damaging Het
Or5b123 A G 19: 13,596,628 (GRCm39) Y34C probably damaging Het
Pcf11 A C 7: 92,310,534 (GRCm39) S485A probably damaging Het
Pde8a A G 7: 80,973,819 (GRCm39) D592G probably damaging Het
Perm1 G A 4: 156,302,046 (GRCm39) G197R probably damaging Het
Pigo A T 4: 43,020,671 (GRCm39) M757K probably benign Het
Pls1 G A 9: 95,667,558 (GRCm39) Q117* probably null Het
Plscr2 T C 9: 92,169,781 (GRCm39) V77A probably benign Het
Polm T C 11: 5,781,695 (GRCm39) E267G probably benign Het
Pomgnt1 A T 4: 116,015,106 (GRCm39) K519M probably damaging Het
Ralyl G A 3: 14,104,850 (GRCm39) probably null Het
Rhbdd3 C T 11: 5,055,832 (GRCm39) T338I possibly damaging Het
Rnf31 T C 14: 55,830,534 (GRCm39) probably null Het
Slc51a A T 16: 32,297,601 (GRCm39) S99T probably benign Het
Sorbs1 A T 19: 40,285,032 (GRCm39) L700H probably damaging Het
Tdrd7 G A 4: 46,025,684 (GRCm39) V835I probably benign Het
Tmcc3 T C 10: 94,414,397 (GRCm39) V64A probably benign Het
Tmprss5 A G 9: 49,020,391 (GRCm39) S140G probably benign Het
Tspan11 G T 6: 127,900,629 (GRCm39) V67F possibly damaging Het
Usp42 T C 5: 143,707,426 (GRCm39) T252A probably damaging Het
Vmn2r97 A T 17: 19,149,326 (GRCm39) E238V probably damaging Het
Wdpcp T A 11: 21,661,486 (GRCm39) W253R probably benign Het
Zdhhc23 A T 16: 43,789,663 (GRCm39) V375E probably damaging Het
Zkscan5 A C 5: 145,157,676 (GRCm39) H726P probably damaging Het
Zmym1 A T 4: 126,941,496 (GRCm39) M964K probably damaging Het
Other mutations in Morf4l1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02145:Morf4l1 APN 9 89,975,848 (GRCm39) missense probably benign 0.16
IGL03309:Morf4l1 APN 9 89,985,798 (GRCm39) missense probably benign
R0848:Morf4l1 UTSW 9 89,982,502 (GRCm39) missense probably benign 0.24
R0893:Morf4l1 UTSW 9 89,984,403 (GRCm39) missense probably damaging 1.00
R1155:Morf4l1 UTSW 9 89,976,557 (GRCm39) missense probably benign 0.11
R1765:Morf4l1 UTSW 9 89,984,401 (GRCm39) missense possibly damaging 0.60
R1972:Morf4l1 UTSW 9 89,977,267 (GRCm39) unclassified probably benign
R3805:Morf4l1 UTSW 9 89,977,196 (GRCm39) missense probably benign 0.10
R3806:Morf4l1 UTSW 9 89,977,196 (GRCm39) missense probably benign 0.10
R3894:Morf4l1 UTSW 9 89,976,501 (GRCm39) missense possibly damaging 0.90
R3895:Morf4l1 UTSW 9 89,976,501 (GRCm39) missense possibly damaging 0.90
R5460:Morf4l1 UTSW 9 89,977,183 (GRCm39) missense probably benign 0.10
R6884:Morf4l1 UTSW 9 89,976,532 (GRCm39) missense probably damaging 1.00
R7088:Morf4l1 UTSW 9 89,979,433 (GRCm39) missense possibly damaging 0.59
R7869:Morf4l1 UTSW 9 89,975,844 (GRCm39) missense probably damaging 1.00
R8155:Morf4l1 UTSW 9 89,977,225 (GRCm39) missense probably damaging 1.00
R8223:Morf4l1 UTSW 9 89,979,475 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- GCTTGAGATTTAGTCACTCCATTC -3'
(R):5'- AGTTGGTGAACCCCAGTCTG -3'

Sequencing Primer
(F):5'- AGCACTTACATGTTTACTCTTCATC -3'
(R):5'- TGAACCCCAGTCTGGTGTGAG -3'
Posted On 2019-12-20