Incidental Mutation 'R8155:Morf4l1'
ID 633271
Institutional Source Beutler Lab
Gene Symbol Morf4l1
Ensembl Gene ENSMUSG00000062270
Gene Name mortality factor 4 like 1
Synonyms TEG-189, Tex189, MORFRG15, MRG15
MMRRC Submission 067581-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R8155 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 89973718-89996827 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 89977225 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 232 (I232T)
Ref Sequence ENSEMBL: ENSMUSP00000082346 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085248] [ENSMUST00000169860] [ENSMUST00000190345] [ENSMUST00000191189] [ENSMUST00000191353]
AlphaFold P60762
Predicted Effect probably damaging
Transcript: ENSMUST00000085248
AA Change: I232T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000082346
Gene: ENSMUSG00000062270
AA Change: I232T

DomainStartEndE-ValueType
Pfam:Tudor-knot 11 53 8.9e-11 PFAM
Blast:CHROMO 83 117 4e-6 BLAST
Pfam:MRG 174 348 3.5e-57 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000169860
AA Change: I193T

PolyPhen 2 Score 0.957 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000132020
Gene: ENSMUSG00000062270
AA Change: I193T

DomainStartEndE-ValueType
CHROMO 10 78 1.8e-9 SMART
Pfam:MRG 127 311 2.8e-59 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000190345
Predicted Effect possibly damaging
Transcript: ENSMUST00000191189
AA Change: I166T

PolyPhen 2 Score 0.759 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000140118
Gene: ENSMUSG00000062270
AA Change: I166T

DomainStartEndE-ValueType
CHROMO 10 78 1.1e-11 SMART
Pfam:MRG 100 284 1.1e-56 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000191353
SMART Domains Protein: ENSMUSP00000140023
Gene: ENSMUSG00000062270

DomainStartEndE-ValueType
Pfam:Tudor-knot 11 53 3.1e-8 PFAM
Blast:CHROMO 82 116 2e-6 BLAST
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.5%
  • 20x: 98.9%
Validation Efficiency 100% (62/62)
MGI Phenotype PHENOTYPE: Homozygous null mice display perinatal lethality, cardiac hypertrophy, reduced alveolar space, decreased cell proliferation, congestion of the liver, lung, and spleen, skin edema, and thin skin. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 G A 1: 71,330,497 (GRCm39) T1386I probably damaging Het
Abcb6 A T 1: 75,151,413 (GRCm39) V504E probably damaging Het
Abtb3 G A 10: 85,476,473 (GRCm39) probably null Het
Adprhl1 C T 8: 13,271,764 (GRCm39) A1665T probably damaging Het
Arhgap32 T A 9: 32,093,196 (GRCm39) L183H probably damaging Het
Arhgef12 A G 9: 42,953,958 (GRCm39) L24S probably damaging Het
B3gnt4 C T 5: 123,649,426 (GRCm39) H264Y possibly damaging Het
Cfi A G 3: 129,648,739 (GRCm39) T208A probably benign Het
Chd4 T A 6: 125,082,287 (GRCm39) F605Y probably benign Het
Cimap1d A T 10: 79,481,466 (GRCm39) V21E probably benign Het
Clip1 A G 5: 123,751,699 (GRCm39) L694P Het
Crybb3 A T 5: 113,225,466 (GRCm39) D135E probably damaging Het
Ddx60 T A 8: 62,470,205 (GRCm39) S1398T possibly damaging Het
Dusp5 T A 19: 53,529,537 (GRCm39) Y313* probably null Het
Eloa A G 4: 135,734,438 (GRCm39) V689A probably benign Het
Ep300 T A 15: 81,505,269 (GRCm39) Y630N unknown Het
Galnt5 A T 2: 57,889,427 (GRCm39) K342N probably benign Het
Gm4841 A G 18: 60,403,409 (GRCm39) V228A probably damaging Het
Gna14 A T 19: 16,576,338 (GRCm39) D115V probably benign Het
Gpx5 T C 13: 21,472,917 (GRCm39) D139G probably damaging Het
Hmcn1 G T 1: 150,480,705 (GRCm39) N4490K probably damaging Het
Hsp90aa1 T C 12: 110,661,828 (GRCm39) S63G unknown Het
Itpkb T C 1: 180,159,913 (GRCm39) I13T possibly damaging Het
Itprid2 T C 2: 79,475,177 (GRCm39) S379P probably benign Het
Lamb2 C T 9: 108,357,845 (GRCm39) R123W probably damaging Het
Ldha A G 7: 46,503,508 (GRCm39) H300R probably damaging Het
Lrp2 A G 2: 69,313,342 (GRCm39) L2463P possibly damaging Het
Mtg1 A G 7: 139,724,622 (GRCm39) H166R probably benign Het
Or14a260 A G 7: 85,985,386 (GRCm39) S73P probably damaging Het
Or2ad1 A G 13: 21,327,062 (GRCm39) L55P probably damaging Het
Or52r1 C T 7: 102,536,452 (GRCm39) D303N probably benign Het
Or5d46 A G 2: 88,170,296 (GRCm39) N129S probably damaging Het
Or6d12 T A 6: 116,492,813 (GRCm39) V25E probably benign Het
Or7g32 A T 9: 19,389,453 (GRCm39) V31D probably benign Het
Papss2 A G 19: 32,618,742 (GRCm39) T267A probably benign Het
Park7 G A 4: 150,991,547 (GRCm39) R48C possibly damaging Het
Pecr A G 1: 72,309,443 (GRCm39) V199A probably damaging Het
Pla2g10 G A 16: 13,543,048 (GRCm39) R80W probably damaging Het
Plek2 G A 12: 78,943,066 (GRCm39) R77* probably null Het
Psg23 A G 7: 18,346,179 (GRCm39) L172P probably damaging Het
Psg25 A C 7: 18,260,445 (GRCm39) F151C probably benign Het
Ptpn3 G T 4: 57,232,336 (GRCm39) H433Q probably benign Het
Rasal3 A G 17: 32,616,381 (GRCm39) V294A possibly damaging Het
Rnf6 T C 5: 146,147,815 (GRCm39) D401G probably damaging Het
Rsf1 GCG GCGACG 7: 97,229,114 (GRCm39) probably benign Het
Sema3d T C 5: 12,498,148 (GRCm39) probably null Het
Serpinb1c A T 13: 33,081,038 (GRCm39) L15Q probably damaging Het
Slfn3 T A 11: 83,103,611 (GRCm39) Y161N probably damaging Het
Spns2 T C 11: 72,347,394 (GRCm39) M404V possibly damaging Het
Stk39 T A 2: 68,097,410 (GRCm39) I479L probably damaging Het
Tbx15 C A 3: 99,259,886 (GRCm39) Q586K possibly damaging Het
Thap11 C T 8: 106,582,854 (GRCm39) R288* probably null Het
Tm7sf2 T A 19: 6,114,125 (GRCm39) D236V probably damaging Het
Tmem214 T C 5: 31,029,136 (GRCm39) S192P possibly damaging Het
Tnfaip3 A G 10: 18,880,439 (GRCm39) S543P possibly damaging Het
Traf3ip3 A G 1: 192,860,524 (GRCm39) L466P probably damaging Het
Tspan18 C T 2: 93,040,357 (GRCm39) probably null Het
Vmn1r229 T A 17: 21,035,472 (GRCm39) L239Q probably damaging Het
Vsig2 T C 9: 37,455,329 (GRCm39) V293A possibly damaging Het
Wdfy4 A T 14: 32,884,776 (GRCm39) V42D Het
Wnk2 G A 13: 49,192,577 (GRCm39) P2055S unknown Het
Zfp953 C A 13: 67,491,535 (GRCm39) C139F probably damaging Het
Other mutations in Morf4l1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02145:Morf4l1 APN 9 89,975,848 (GRCm39) missense probably benign 0.16
IGL03309:Morf4l1 APN 9 89,985,798 (GRCm39) missense probably benign
R0848:Morf4l1 UTSW 9 89,982,502 (GRCm39) missense probably benign 0.24
R0893:Morf4l1 UTSW 9 89,984,403 (GRCm39) missense probably damaging 1.00
R1155:Morf4l1 UTSW 9 89,976,557 (GRCm39) missense probably benign 0.11
R1765:Morf4l1 UTSW 9 89,984,401 (GRCm39) missense possibly damaging 0.60
R1972:Morf4l1 UTSW 9 89,977,267 (GRCm39) unclassified probably benign
R3805:Morf4l1 UTSW 9 89,977,196 (GRCm39) missense probably benign 0.10
R3806:Morf4l1 UTSW 9 89,977,196 (GRCm39) missense probably benign 0.10
R3894:Morf4l1 UTSW 9 89,976,501 (GRCm39) missense possibly damaging 0.90
R3895:Morf4l1 UTSW 9 89,976,501 (GRCm39) missense possibly damaging 0.90
R5460:Morf4l1 UTSW 9 89,977,183 (GRCm39) missense probably benign 0.10
R6884:Morf4l1 UTSW 9 89,976,532 (GRCm39) missense probably damaging 1.00
R7088:Morf4l1 UTSW 9 89,979,433 (GRCm39) missense possibly damaging 0.59
R7869:Morf4l1 UTSW 9 89,975,844 (GRCm39) missense probably damaging 1.00
R7876:Morf4l1 UTSW 9 89,975,859 (GRCm39) missense possibly damaging 0.65
R8223:Morf4l1 UTSW 9 89,979,475 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- AATAGTAGAAATTTTGGGCTATGGG -3'
(R):5'- TTGACAAATGACAGATGCAGTG -3'

Sequencing Primer
(F):5'- GTCCTGAAACTTACTCTGTAGACCAG -3'
(R):5'- CAGATGCAGTGGGAATGGTG -3'
Posted On 2020-06-30