Incidental Mutation 'R8311:Tmem37'
ID 641359
Institutional Source Beutler Lab
Gene Symbol Tmem37
Ensembl Gene ENSMUSG00000050777
Gene Name transmembrane protein 37
Synonyms Pr1
MMRRC Submission 067796-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8311 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 119995106-120001799 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 119995982 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 32 (V32M)
Ref Sequence ENSEMBL: ENSMUSP00000050862 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056089] [ENSMUST00000072886] [ENSMUST00000189037]
AlphaFold Q9JJV3
Predicted Effect possibly damaging
Transcript: ENSMUST00000056089
AA Change: V32M

PolyPhen 2 Score 0.573 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000050862
Gene: ENSMUSG00000050777
AA Change: V32M

DomainStartEndE-ValueType
Pfam:TMEM37 7 189 4.1e-97 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000072886
SMART Domains Protein: ENSMUSP00000072660
Gene: ENSMUSG00000026387

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
low complexity region 36 53 N/A INTRINSIC
HormR 76 146 5.18e-21 SMART
Pfam:7tm_2 153 398 3.8e-88 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000189037
SMART Domains Protein: ENSMUSP00000139932
Gene: ENSMUSG00000026387

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
low complexity region 36 53 N/A INTRINSIC
HormR 61 131 2.59e-21 SMART
Pfam:7tm_2 138 383 1.9e-89 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 100% (53/53)
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik A G 12: 71,184,815 (GRCm39) probably benign Het
4930407I10Rik T C 15: 81,947,440 (GRCm39) W446R possibly damaging Het
Aldh1l2 T A 10: 83,326,479 (GRCm39) E912D probably damaging Het
Apol9a T C 15: 77,289,220 (GRCm39) D49G possibly damaging Het
Bnc2 A T 4: 84,194,582 (GRCm39) D847E possibly damaging Het
Ccdc91 A G 6: 147,437,114 (GRCm39) N100S possibly damaging Het
Copb2 G T 9: 98,450,072 (GRCm39) K10N possibly damaging Het
Cyp4a14 A G 4: 115,348,275 (GRCm39) S401P probably damaging Het
Cyp4f15 A T 17: 32,916,914 (GRCm39) Q277L probably benign Het
Dmxl2 A T 9: 54,354,217 (GRCm39) S410T probably benign Het
Dnah9 T C 11: 65,880,644 (GRCm39) N2651S probably benign Het
Efhb A G 17: 53,720,489 (GRCm39) probably null Het
Eif4ebp1 T A 8: 27,765,124 (GRCm39) F113L probably damaging Het
Emilin2 C G 17: 71,562,141 (GRCm39) D954H probably damaging Het
Eng A G 2: 32,569,005 (GRCm39) T511A probably benign Het
Eps8l1 A G 7: 4,474,817 (GRCm39) D266G probably damaging Het
Fam120a T C 13: 49,087,433 (GRCm39) H309R possibly damaging Het
Gga3 A T 11: 115,477,834 (GRCm39) S585T probably benign Het
Gm12117 T C 11: 33,226,126 (GRCm39) Q70R probably damaging Het
Gpr158 A G 2: 21,373,701 (GRCm39) H212R probably benign Het
Hmgb1 A G 5: 148,987,427 (GRCm39) F41L possibly damaging Het
Iqcm T A 8: 76,480,118 (GRCm39) probably benign Het
Itgav T A 2: 83,596,121 (GRCm39) I214N probably damaging Het
Kcna1 T A 6: 126,619,255 (GRCm39) H355L probably benign Het
Lrrc37a C T 11: 103,394,247 (GRCm39) V393I probably benign Het
Mak16 T C 8: 31,658,697 (GRCm39) D4G probably damaging Het
Metap2 C T 10: 93,697,384 (GRCm39) R432H possibly damaging Het
Nlrc4 G A 17: 74,753,540 (GRCm39) T281M probably damaging Het
Ntrk1 T A 3: 87,688,870 (GRCm39) Q561L probably damaging Het
Or10ak7 A C 4: 118,791,347 (GRCm39) S231A probably damaging Het
Or10w3 A G 19: 13,704,035 (GRCm39) T137A possibly damaging Het
Pira1 T C 7: 3,739,482 (GRCm39) D462G probably benign Het
Polr2a T C 11: 69,628,282 (GRCm39) I1304V probably null Het
Ppp4r2 T C 6: 100,843,343 (GRCm39) S354P probably benign Het
Ptchd3 A G 11: 121,727,299 (GRCm39) H391R possibly damaging Het
Rchy1 T C 5: 92,099,762 (GRCm39) D192G probably damaging Het
Rmdn1 T C 4: 19,575,329 (GRCm39) probably null Het
Rp1 T A 1: 4,418,572 (GRCm39) I847L probably benign Het
Rtn1 T C 12: 72,350,838 (GRCm39) E457G probably damaging Het
Serpind1 G A 16: 17,160,730 (GRCm39) S420N possibly damaging Het
Sirpa T C 2: 129,458,143 (GRCm39) V253A probably damaging Het
Snapc4 A T 2: 26,268,546 (GRCm39) F38L probably benign Het
Spata31g1 T C 4: 42,973,169 (GRCm39) V834A probably benign Het
Srcap T C 7: 127,156,969 (GRCm39) F2321S probably damaging Het
Stat4 A T 1: 52,142,075 (GRCm39) I641F probably damaging Het
Tmem216 A T 19: 10,529,191 (GRCm39) F65Y probably benign Het
Tmprss11c T G 5: 86,383,412 (GRCm39) Q338P probably damaging Het
Tonsl C T 15: 76,517,463 (GRCm39) S752N probably benign Het
Vmn1r26 T C 6: 57,985,518 (GRCm39) K224E probably benign Het
Vps13b T A 15: 35,887,100 (GRCm39) V3229D probably benign Het
Vwa5b2 C T 16: 20,409,972 (GRCm39) R21W probably damaging Het
Wdr37 T C 13: 8,903,609 (GRCm39) R165G unknown Het
Yars2 T C 16: 16,125,147 (GRCm39) F388L probably benign Het
Ykt6 T A 11: 5,912,366 (GRCm39) D106E probably benign Het
Zc3h12a A C 4: 125,020,788 (GRCm39) S18R possibly damaging Het
Other mutations in Tmem37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02573:Tmem37 APN 1 119,995,719 (GRCm39) missense probably damaging 0.99
R1864:Tmem37 UTSW 1 119,995,952 (GRCm39) missense probably damaging 1.00
R1865:Tmem37 UTSW 1 119,995,952 (GRCm39) missense probably damaging 1.00
R4632:Tmem37 UTSW 1 119,995,979 (GRCm39) missense probably damaging 1.00
R4715:Tmem37 UTSW 1 119,995,935 (GRCm39) missense probably damaging 1.00
U24488:Tmem37 UTSW 1 119,995,684 (GRCm39) missense probably benign 0.00
Z1177:Tmem37 UTSW 1 119,995,758 (GRCm39) missense probably benign 0.15
Predicted Primers PCR Primer
(F):5'- CATCTCCAAGCCGAAGATGG -3'
(R):5'- TCCATGGTATCAGAGCAGAAAGC -3'

Sequencing Primer
(F):5'- GAAGATGGCAGCCACCACTG -3'
(R):5'- GCAGAAAGCAGGGCTGG -3'
Posted On 2020-07-28