Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00326:Gpat2'

7043

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpat2

Ensembl Gene

ENSMUSG00000046338

Gene Name

glycerol-3-phosphate acyltransferase 2, mitochondrial

Synonyms

A530057A03Rik, Gpat2

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00326

Quality Score

Status

Chromosome

Chromosomal Location

127267119-127278012 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 127274316 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 353 (T353A)

Ref Sequence

ENSEMBL: ENSMUSP00000049619 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000028848] [ENSMUST00000062211]

AlphaFold

Q14DK4

Predicted Effect

probably benign
Transcript: ENSMUST00000028848

SMART Domains

Protein: ENSMUSP00000028848
Gene: ENSMUSG00000027371

Domain	Start	End	E-Value	Type
low complexity region	47	53	N/A	INTRINSIC
Pfam:FAA_hydrolase	107	313	3.1e-75	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000062211
AA Change: T353A

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)

SMART Domains

Protein: ENSMUSP00000049619
Gene: ENSMUSG00000046338
AA Change: T353A

Domain	Start	End	E-Value	Type
PlsC	199	333	1.45e-11	SMART
Blast:PlsC	347	387	7e-13	BLAST
low complexity region	431	468	N/A	INTRINSIC
low complexity region	515	528	N/A	INTRINSIC
low complexity region	593	613	N/A	INTRINSIC
low complexity region	664	675	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000123327

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000137366

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000146757

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933430I17Rik	G	T	4: 62,461,981 (GRCm39)		probably null	Het
9230109A22Rik	G	T	15: 25,139,201 (GRCm39)		noncoding transcript	Het
Acd	A	T	8: 106,425,086 (GRCm39)	Y378N	probably damaging	Het
Adcy9	A	G	16: 4,112,560 (GRCm39)	V709A	probably benign	Het
Axl	A	T	7: 25,485,324 (GRCm39)	L168H	probably benign	Het
Barhl2	C	T	5: 106,603,365 (GRCm39)	A265T	possibly damaging	Het
Drd3	G	A	16: 43,582,684 (GRCm39)	R59H	probably benign	Het
Erlec1	T	C	11: 30,898,510 (GRCm39)	N180S	possibly damaging	Het
Fnip2	G	T	3: 79,388,828 (GRCm39)	S634R	probably benign	Het
Focad	A	T	4: 88,275,711 (GRCm39)	T1107S	unknown	Het
Galnt11	T	C	5: 25,453,829 (GRCm39)		probably benign	Het
Gigyf1	C	T	5: 137,517,210 (GRCm39)		probably benign	Het
H2bc3	G	T	13: 23,931,111 (GRCm39)	V112L	possibly damaging	Het
Hip1	A	G	5: 135,478,676 (GRCm39)	F178L	probably damaging	Het
Igkv6-13	A	T	6: 70,434,645 (GRCm39)	S67T	probably damaging	Het
Iqch	T	C	9: 63,387,936 (GRCm39)	T824A	probably damaging	Het
Kansl1	A	G	11: 104,315,292 (GRCm39)	S249P	probably damaging	Het
Large1	C	T	8: 73,858,611 (GRCm39)	A86T	probably benign	Het
Lysmd3	C	T	13: 81,813,363 (GRCm39)	A77V	probably damaging	Het
Npr3	T	A	15: 11,895,780 (GRCm39)	S289C	probably damaging	Het
Or52n2	A	T	7: 104,542,179 (GRCm39)	S219T	probably damaging	Het
Or5p57	A	G	7: 107,665,495 (GRCm39)	V140A	probably benign	Het
Pear1	C	T	3: 87,659,423 (GRCm39)	V804I	possibly damaging	Het
Rgs11	T	A	17: 26,426,371 (GRCm39)	I230N	probably damaging	Het
Slc13a3	A	T	2: 165,315,017 (GRCm39)	L22Q	possibly damaging	Het
Slc5a9	A	G	4: 111,755,766 (GRCm39)	V44A	probably damaging	Het
Ttc12	G	T	9: 49,382,506 (GRCm39)		probably null	Het
Vmn2r2	A	G	3: 64,041,319 (GRCm39)		probably benign	Het
Zc3h18	T	C	8: 123,113,591 (GRCm39)		probably benign	Het
Zfp354a	G	A	11: 50,960,190 (GRCm39)	E132K	probably benign	Het

Other mutations in Gpat2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00479:Gpat2	APN	2	127,276,381 (GRCm39)	missense	probably damaging	0.99
IGL01393:Gpat2	APN	2	127,274,571 (GRCm39)	missense	probably damaging	1.00
IGL01759:Gpat2	APN	2	127,272,816 (GRCm39)	missense	possibly damaging	0.94
IGL01764:Gpat2	APN	2	127,269,456 (GRCm39)	missense	probably benign	0.18
IGL02631:Gpat2	APN	2	127,276,152 (GRCm39)	splice site	probably benign
IGL02657:Gpat2	APN	2	127,269,251 (GRCm39)	missense	probably benign	0.04
IGL02813:Gpat2	APN	2	127,276,375 (GRCm39)	missense	possibly damaging	0.90
IGL02873:Gpat2	APN	2	127,273,675 (GRCm39)	missense	probably benign	0.00
IGL02993:Gpat2	APN	2	127,269,486 (GRCm39)	missense	probably damaging	1.00
Hygroscopic	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
PIT4494001:Gpat2	UTSW	2	127,275,800 (GRCm39)	missense	probably benign	0.00
R0078:Gpat2	UTSW	2	127,270,169 (GRCm39)	missense	probably damaging	1.00
R0230:Gpat2	UTSW	2	127,277,765 (GRCm39)	missense	possibly damaging	0.95
R1619:Gpat2	UTSW	2	127,270,637 (GRCm39)	missense	probably benign	0.00
R1851:Gpat2	UTSW	2	127,276,739 (GRCm39)	missense	possibly damaging	0.77
R1939:Gpat2	UTSW	2	127,277,879 (GRCm39)	makesense	probably null
R2143:Gpat2	UTSW	2	127,275,682 (GRCm39)	missense	probably damaging	1.00
R2165:Gpat2	UTSW	2	127,270,211 (GRCm39)	missense	probably damaging	0.97
R2518:Gpat2	UTSW	2	127,270,211 (GRCm39)	missense	probably damaging	0.97
R3410:Gpat2	UTSW	2	127,270,211 (GRCm39)	missense	probably damaging	0.97
R3411:Gpat2	UTSW	2	127,270,211 (GRCm39)	missense	probably damaging	0.97
R3898:Gpat2	UTSW	2	127,277,018 (GRCm39)	missense	probably damaging	1.00
R4080:Gpat2	UTSW	2	127,275,542 (GRCm39)	missense	probably damaging	0.99
R4725:Gpat2	UTSW	2	127,273,902 (GRCm39)	missense	possibly damaging	0.83
R4841:Gpat2	UTSW	2	127,275,887 (GRCm39)	missense	probably benign	0.10
R5354:Gpat2	UTSW	2	127,270,643 (GRCm39)	missense	probably damaging	1.00
R5941:Gpat2	UTSW	2	127,270,195 (GRCm39)	missense	possibly damaging	0.53
R6362:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6374:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6375:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6377:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6380:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6381:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6382:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6383:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6384:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6393:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6565:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6594:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6595:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6649:Gpat2	UTSW	2	127,274,355 (GRCm39)	missense	possibly damaging	0.81
R6665:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6666:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6667:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6668:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6669:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R7031:Gpat2	UTSW	2	127,277,395 (GRCm39)	missense	probably damaging	0.99
R7096:Gpat2	UTSW	2	127,270,209 (GRCm39)	missense	probably benign	0.02
R7307:Gpat2	UTSW	2	127,276,810 (GRCm39)	missense	probably damaging	1.00
R7313:Gpat2	UTSW	2	127,270,215 (GRCm39)	missense	probably damaging	0.99
R7365:Gpat2	UTSW	2	127,268,901 (GRCm39)	splice site	probably null
R8111:Gpat2	UTSW	2	127,275,777 (GRCm39)	missense	probably damaging	1.00
R8113:Gpat2	UTSW	2	127,273,267 (GRCm39)	missense	possibly damaging	0.52
R8729:Gpat2	UTSW	2	127,275,739 (GRCm39)	missense	probably damaging	0.99
R9010:Gpat2	UTSW	2	127,277,146 (GRCm39)	missense	probably benign	0.28
R9146:Gpat2	UTSW	2	127,273,206 (GRCm39)	missense	possibly damaging	0.58
Z1176:Gpat2	UTSW	2	127,275,728 (GRCm39)	missense	probably damaging	1.00
Z1176:Gpat2	UTSW	2	127,272,802 (GRCm39)	missense	probably benign

Posted On

2012-04-20