Incidental Mutation 'R9323:Lancl1'
ID 706294
Institutional Source Beutler Lab
Gene Symbol Lancl1
Ensembl Gene ENSMUSG00000026000
Gene Name LanC (bacterial lantibiotic synthetase component C)-like 1
Synonyms p40, Gpr69a, LanC-like protein 1
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.114) question?
Stock # R9323 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 67039676-67078031 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) T to A at 67077794 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000122752 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027149] [ENSMUST00000113979] [ENSMUST00000119559] [ENSMUST00000149996]
AlphaFold O89112
Predicted Effect probably benign
Transcript: ENSMUST00000027149
SMART Domains Protein: ENSMUSP00000027149
Gene: ENSMUSG00000026000

DomainStartEndE-ValueType
LANC_like 55 399 7.17e-144 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000113979
SMART Domains Protein: ENSMUSP00000109612
Gene: ENSMUSG00000026000

DomainStartEndE-ValueType
LANC_like 55 399 7.17e-144 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000119559
SMART Domains Protein: ENSMUSP00000113080
Gene: ENSMUSG00000026000

DomainStartEndE-ValueType
LANC_like 55 399 7.17e-144 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000149996
SMART Domains Protein: ENSMUSP00000122752
Gene: ENSMUSG00000026000

DomainStartEndE-ValueType
Pfam:LANC_like 55 173 2.3e-29 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
PHENOTYPE: Mice homozygous for a null mutation display postnatal neurodegeneration with increased oxidative stress and mitochondrial impairment. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abat G A 16: 8,420,235 (GRCm39) W178* probably null Het
Alx1 G A 10: 102,858,124 (GRCm39) R192* probably null Het
Apom A G 17: 35,350,633 (GRCm39) C23R probably damaging Het
Asap2 A G 12: 21,162,148 (GRCm39) N35S probably benign Het
Atf6 A T 1: 170,682,682 (GRCm39) Y43* probably null Het
Atosa C T 9: 74,883,415 (GRCm39) probably benign Het
Bag4 T C 8: 26,261,361 (GRCm39) S127G possibly damaging Het
Bag4 G T 8: 26,275,180 (GRCm39) S7* probably null Het
Ccdc88b A G 19: 6,826,475 (GRCm39) L1080P probably damaging Het
Cdcp3 T A 7: 130,828,401 (GRCm39) N285K probably damaging Het
Cdkl2 A T 5: 92,168,107 (GRCm39) D362E probably benign Het
Cep170 A G 1: 176,586,068 (GRCm39) S575P probably benign Het
Col4a2 C T 8: 11,493,413 (GRCm39) P1374L possibly damaging Het
Cpt2 T C 4: 107,761,556 (GRCm39) H617R probably benign Het
Cyp2d22 A G 15: 82,258,207 (GRCm39) S138P probably damaging Het
Cyp2j11 T C 4: 96,195,619 (GRCm39) D359G probably benign Het
Ddb2 T C 2: 91,042,337 (GRCm39) S419G possibly damaging Het
Dmrtc2 A T 7: 24,572,341 (GRCm39) I121F probably benign Het
Dus1l C T 11: 120,684,724 (GRCm39) R149H probably damaging Het
Fam90a1a T A 8: 22,453,640 (GRCm39) Y332N probably benign Het
Fbxo47 A T 11: 97,770,254 (GRCm39) V46D probably benign Het
Grep1 A G 17: 23,937,387 (GRCm39) S54P unknown Het
Grpel1 T A 5: 36,628,007 (GRCm39) V96E possibly damaging Het
Ifi207 A T 1: 173,555,143 (GRCm39) N853K probably damaging Het
Igkv4-80 C T 6: 68,993,751 (GRCm39) A47T probably damaging Het
Il1a T A 2: 129,149,826 (GRCm39) I25F probably benign Het
Ireb2 T A 9: 54,811,523 (GRCm39) probably null Het
Itpr1 A G 6: 108,328,979 (GRCm39) Y131C probably damaging Het
Kmt2a T C 9: 44,731,261 (GRCm39) probably benign Het
Lpl G A 8: 69,340,196 (GRCm39) V64M possibly damaging Het
Marchf10 T C 11: 105,280,581 (GRCm39) H568R probably damaging Het
Mib1 G A 18: 10,775,685 (GRCm39) V546M probably damaging Het
Mss51 A T 14: 20,534,939 (GRCm39) I277N probably benign Het
Mybpc1 A G 10: 88,360,829 (GRCm39) probably null Het
Myct1 A C 10: 5,554,195 (GRCm39) I21L probably benign Het
Myo5c C A 9: 75,153,531 (GRCm39) A139E probably damaging Het
Nlrp4e C G 7: 23,020,755 (GRCm39) A414G probably benign Het
Npy2r A T 3: 82,447,728 (GRCm39) I349N possibly damaging Het
Nrap T C 19: 56,378,255 (GRCm39) I19V probably benign Het
Or10g7 T C 9: 39,905,360 (GRCm39) S85P possibly damaging Het
Or14j2 A C 17: 37,886,135 (GRCm39) Y60D probably damaging Het
Or52n20 T C 7: 104,320,220 (GRCm39) F104L possibly damaging Het
Or5p6 C T 7: 107,631,230 (GRCm39) V107I probably benign Het
Or6c3b A T 10: 129,527,829 (GRCm39) V27D probably benign Het
Or8d23 T C 9: 38,841,818 (GRCm39) V117A probably benign Het
Pde6b A T 5: 108,551,298 (GRCm39) N194I probably damaging Het
Polg TCTGGATGA TCTGGATGACTGGATGA 7: 79,114,779 (GRCm39) probably null Het
Polg GA GACTGGAGCA 7: 79,114,786 (GRCm39) probably null Het
Ptpn9 T C 9: 56,934,701 (GRCm39) M155T possibly damaging Het
Ret A G 6: 118,158,975 (GRCm39) Y146H probably benign Het
Sdf2l1 T C 16: 16,949,498 (GRCm39) H116R probably damaging Het
Shld2 A G 14: 33,981,596 (GRCm39) V514A probably damaging Het
Slc37a1 T C 17: 31,552,643 (GRCm39) I316T probably damaging Het
Slc4a11 A C 2: 130,528,830 (GRCm39) L473R possibly damaging Het
Smg7 A G 1: 152,731,753 (GRCm39) M344T probably benign Het
Smg9 T C 7: 24,114,465 (GRCm39) L268P probably damaging Het
Tiparp C T 3: 65,439,272 (GRCm39) T196I probably benign Het
Trappc12 A G 12: 28,742,491 (GRCm39) probably null Het
Trappc9 A T 15: 72,565,431 (GRCm39) N953K probably benign Het
Trpa1 A G 1: 14,968,564 (GRCm39) V428A probably benign Het
Utp20 T C 10: 88,583,170 (GRCm39) R2728G probably damaging Het
Zfp612 A G 8: 110,815,372 (GRCm39) E193G probably benign Het
Other mutations in Lancl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00852:Lancl1 APN 1 67,043,996 (GRCm39) missense probably damaging 1.00
IGL01727:Lancl1 APN 1 67,060,101 (GRCm39) missense probably damaging 1.00
IGL01800:Lancl1 APN 1 67,060,029 (GRCm39) missense probably benign 0.08
IGL03036:Lancl1 APN 1 67,046,074 (GRCm39) missense probably damaging 1.00
IGL03329:Lancl1 APN 1 67,060,209 (GRCm39) missense probably damaging 1.00
R0535:Lancl1 UTSW 1 67,049,065 (GRCm39) unclassified probably benign
R0731:Lancl1 UTSW 1 67,049,069 (GRCm39) critical splice donor site probably null
R3798:Lancl1 UTSW 1 67,073,303 (GRCm39) missense probably damaging 1.00
R4405:Lancl1 UTSW 1 67,060,015 (GRCm39) critical splice donor site probably null
R4933:Lancl1 UTSW 1 67,060,193 (GRCm39) missense probably benign 0.08
R4980:Lancl1 UTSW 1 67,043,968 (GRCm39) missense probably benign 0.17
R5193:Lancl1 UTSW 1 67,060,173 (GRCm39) missense probably benign 0.02
R6643:Lancl1 UTSW 1 67,043,542 (GRCm39) missense probably benign 0.07
R7235:Lancl1 UTSW 1 67,077,694 (GRCm39) missense probably benign 0.00
R7250:Lancl1 UTSW 1 67,048,458 (GRCm39) missense possibly damaging 0.54
R8854:Lancl1 UTSW 1 67,073,358 (GRCm39) missense possibly damaging 0.86
R9105:Lancl1 UTSW 1 67,043,962 (GRCm39) missense possibly damaging 0.74
R9487:Lancl1 UTSW 1 67,073,381 (GRCm39) missense probably benign 0.29
Predicted Primers PCR Primer
(F):5'- ATCATCTAGGCAGAAGTGATGTC -3'
(R):5'- GGTTCCATCATCTCCGTGTG -3'

Sequencing Primer
(F):5'- CAGAAGTGATGTCCTTCGGAGC -3'
(R):5'- GTGTGCTCCCCACTCGTG -3'
Posted On 2022-04-18