Mutagenetix > Incidental Mutation

Incidental Mutation 'R9596:Or2ag13'

723278

Institutional Source

Beutler Lab

Gene Symbol

Or2ag13

Ensembl Gene

ENSMUSG00000108948

Gene Name

olfactory receptor family 2 subfamily AG member 13

Synonyms

Olfr695, GA_x6K02T2PBJ9-9092181-9091234, MOR283-6

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.121) question?

Stock #

R9596 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

106312939-106315552 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 106313412 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Asparagine at position 159 (Y159N)

Ref Sequence

ENSEMBL: ENSMUSP00000149773 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000216868]

AlphaFold

Q8VFM3

Predicted Effect

probably benign
Transcript: ENSMUST00000216868
AA Change: Y159N

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.1%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aamp	G	T	1: 74,320,262 (GRCm39)	Q355K	probably benign	Het
Acte1	G	T	7: 143,434,902 (GRCm39)		probably null	Het
AI661453	T	C	17: 47,780,411 (GRCm39)	S188P	unknown	Het
Atp10a	A	G	7: 58,477,553 (GRCm39)	S1251G	probably damaging	Het
Ccr10	A	G	11: 101,065,018 (GRCm39)	F171L	probably benign	Het
Clec10a	A	T	11: 70,059,973 (GRCm39)	D65V	probably damaging	Het
Clybl	A	T	14: 122,548,768 (GRCm39)	I57L	probably benign	Het
Col5a1	G	T	2: 27,819,551 (GRCm39)	E218*	probably null	Het
Diaph1	G	A	18: 38,024,111 (GRCm39)	P576S	unknown	Het
Dsg1c	T	A	18: 20,416,361 (GRCm39)	I754N	probably benign	Het
Fam47e	G	C	5: 92,726,395 (GRCm39)	R111P	probably benign	Het
Fastkd3	G	A	13: 68,735,806 (GRCm39)	V519M	probably damaging	Het
Fhod3	T	A	18: 25,193,392 (GRCm39)	Y634*	probably null	Het
Frem3	G	A	8: 81,341,951 (GRCm39)	V1415I	probably benign	Het
Herc2	G	A	7: 55,834,595 (GRCm39)	S3191N		Het
Kif19a	A	T	11: 114,676,752 (GRCm39)	E527V	probably benign	Het
Lmbr1	C	A	5: 29,440,105 (GRCm39)	G420*	probably null	Het
Map3k9	A	G	12: 81,777,404 (GRCm39)	S526P	probably damaging	Het
Mink1	T	A	11: 70,497,915 (GRCm39)	L506Q	possibly damaging	Het
Mroh9	T	C	1: 162,893,576 (GRCm39)	I200V	probably damaging	Het
Mrps14	T	C	1: 160,027,122 (GRCm39)	V110A	possibly damaging	Het
Mta1	A	G	12: 113,090,470 (GRCm39)	Q209R	probably damaging	Het
Mtss2	G	A	8: 111,458,689 (GRCm39)	S195N		Het
Nlgn1	T	A	3: 25,488,587 (GRCm39)	I583F	probably damaging	Het
Ntng1	T	C	3: 110,042,956 (GRCm39)		probably benign	Het
Or10w1	A	G	19: 13,632,002 (GRCm39)	S70G	probably damaging	Het
Or1p1c	C	T	11: 74,160,289 (GRCm39)	H25Y	probably benign	Het
Or5ac25	A	G	16: 59,181,942 (GRCm39)	I213T	possibly damaging	Het
Or6c65	A	G	10: 129,603,988 (GRCm39)	T208A	probably damaging	Het
Pcdha12	A	T	18: 37,154,302 (GRCm39)	L340F	probably benign	Het
Pdk4	T	A	6: 5,491,842 (GRCm39)	M173L	probably benign	Het
Pds5a	A	G	5: 65,772,830 (GRCm39)	S1258P	probably benign	Het
Plcd1	A	T	9: 118,917,183 (GRCm39)	L22Q	probably benign	Het
Prag1	A	G	8: 36,570,113 (GRCm39)	D232G	probably damaging	Het
Rest	C	T	5: 77,423,141 (GRCm39)	T315M	probably damaging	Het
Scrn2	G	A	11: 96,923,907 (GRCm39)	V264M	probably damaging	Het
Sipa1l3	C	A	7: 29,031,691 (GRCm39)	V1513F	probably benign	Het
Skic3	T	C	13: 76,330,968 (GRCm39)	V1466A	possibly damaging	Het
Slc44a1	T	A	4: 53,544,553 (GRCm39)	N421K	probably benign	Het
Smc6	G	T	12: 11,345,045 (GRCm39)	R662I	probably damaging	Het
Spata31e5	C	A	1: 28,815,688 (GRCm39)	M781I	probably benign	Het
Srcap	T	A	7: 127,131,036 (GRCm39)	W751R	probably damaging	Het
Sv2b	A	G	7: 74,767,462 (GRCm39)	F645L	probably damaging	Het
Sycp2	A	G	2: 177,990,212 (GRCm39)		probably null	Het
Syne4	A	G	7: 30,014,504 (GRCm39)	T41A	probably benign	Het
Tns3	G	A	11: 8,401,142 (GRCm39)	T1052M	possibly damaging	Het
Trap1	A	T	16: 3,871,374 (GRCm39)	I381N	probably damaging	Het
Tshz1	A	G	18: 84,031,904 (GRCm39)	S835P	possibly damaging	Het
Ube3b	T	A	5: 114,527,171 (GRCm39)	W130R	probably damaging	Het
Ubr5	G	A	15: 37,986,213 (GRCm39)	T2207I		Het
Vmn1r43	G	A	6: 89,846,877 (GRCm39)	T203M	probably damaging	Het
Vmn2r11	T	G	5: 109,201,563 (GRCm39)	I314L	possibly damaging	Het
Vmn2r15	T	A	5: 109,440,791 (GRCm39)	I356L	probably benign	Het
Vmn2r31	G	T	7: 7,397,292 (GRCm39)	T322N	probably benign	Het
Vmn2r8	A	T	5: 108,947,196 (GRCm39)	F519I	possibly damaging	Het
Wdr35	T	C	12: 9,036,092 (GRCm39)	F288L	probably benign	Het
Xab2	A	T	8: 3,663,018 (GRCm39)	V521D	probably damaging	Het
Zfp639	T	C	3: 32,574,269 (GRCm39)	F298S	probably damaging	Het
Zfp786	G	A	6: 47,797,406 (GRCm39)	R511*	probably null	Het
Zfp936	T	A	7: 42,839,834 (GRCm39)	C434S	probably damaging	Het
Zranb1	T	C	7: 132,552,146 (GRCm39)	F266L	probably benign	Het

Other mutations in Or2ag13

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01010:Or2ag13	APN	7	106,473,460 (GRCm39)	utr 5 prime	probably benign
IGL02143:Or2ag13	APN	7	106,473,180 (GRCm39)	missense	probably benign	0.02
R0492:Or2ag13	UTSW	7	106,473,084 (GRCm39)	missense	probably damaging	1.00
R1816:Or2ag13	UTSW	7	106,472,695 (GRCm39)	nonsense	probably null
R1834:Or2ag13	UTSW	7	106,473,348 (GRCm39)	missense	probably damaging	1.00
R2011:Or2ag13	UTSW	7	106,472,634 (GRCm39)	missense	probably benign	0.03
R3434:Or2ag13	UTSW	7	106,472,976 (GRCm39)	missense	probably benign	0.01
R3842:Or2ag13	UTSW	7	106,473,302 (GRCm39)	missense	probably benign	0.07
R4405:Or2ag13	UTSW	7	106,472,580 (GRCm39)	missense	probably damaging	1.00
R4742:Or2ag13	UTSW	7	106,472,635 (GRCm39)	missense	probably damaging	0.99
R4815:Or2ag13	UTSW	7	106,473,444 (GRCm39)	missense	probably benign
R4851:Or2ag13	UTSW	7	106,473,221 (GRCm39)	missense	probably damaging	1.00
R4856:Or2ag13	UTSW	7	106,473,177 (GRCm39)	missense	probably damaging	1.00
R5663:Or2ag13	UTSW	7	106,472,877 (GRCm39)	missense	probably benign	0.43
R5783:Or2ag13	UTSW	7	106,472,541 (GRCm39)	missense	probably damaging	0.97
R6552:Or2ag13	UTSW	7	106,313,850 (GRCm39)	small deletion	probably benign
R6640:Or2ag13	UTSW	7	106,313,247 (GRCm39)	missense	probably damaging	1.00
R6798:Or2ag13	UTSW	7	106,313,402 (GRCm39)	missense	probably damaging	1.00
R7365:Or2ag13	UTSW	7	106,313,171 (GRCm39)	missense	probably benign	0.03
R7496:Or2ag13	UTSW	7	106,313,435 (GRCm39)	missense	probably benign	0.23
R7923:Or2ag13	UTSW	7	106,313,649 (GRCm39)	nonsense	probably null
R9012:Or2ag13	UTSW	7	106,313,115 (GRCm39)	missense	probably benign	0.10
R9572:Or2ag13	UTSW	7	106,313,546 (GRCm39)	missense	probably damaging	1.00
R9756:Or2ag13	UTSW	7	106,313,002 (GRCm39)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- TGCCAACCACAGTCAGATGG -3'
(R):5'- CTGGCACTGACACTTGGTAG -3'

Sequencing Primer
(F):5'- CTCATTTGAGGGCATATGGAGCAC -3'
(R):5'- ACTTGGTAGTGCAGAGGACCTC -3'

Posted On

2022-08-09