Incidental Mutation 'R0882:Or51a5'
ID 80639
Institutional Source Beutler Lab
Gene Symbol Or51a5
Ensembl Gene ENSMUSG00000066268
Gene Name olfactory receptor family 51 subfamily A member 5
Synonyms MOR8-7, MOR8-2, GA_x6K02T2PBJ9-5836380-5835439, Olfr586
MMRRC Submission 039049-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.207) question?
Stock # R0882 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 102771036-102771989 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 102771782 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Alanine at position 66 (S66A)
Ref Sequence ENSEMBL: ENSMUSP00000149226 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084811] [ENSMUST00000211075] [ENSMUST00000213281] [ENSMUST00000215304]
AlphaFold Q8VH13
Predicted Effect probably benign
Transcript: ENSMUST00000084811
AA Change: S70A

PolyPhen 2 Score 0.091 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000081872
Gene: ENSMUSG00000066268
AA Change: S70A

DomainStartEndE-ValueType
Pfam:7tm_4 37 315 6.1e-111 PFAM
Pfam:7TM_GPCR_Srsx 41 312 1.6e-11 PFAM
Pfam:7tm_1 47 297 1.7e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000211075
AA Change: S66A

PolyPhen 2 Score 0.091 (Sensitivity: 0.93; Specificity: 0.85)
Predicted Effect probably benign
Transcript: ENSMUST00000213281
AA Change: S66A

PolyPhen 2 Score 0.091 (Sensitivity: 0.93; Specificity: 0.85)
Predicted Effect probably benign
Transcript: ENSMUST00000215304
AA Change: S66A

PolyPhen 2 Score 0.091 (Sensitivity: 0.93; Specificity: 0.85)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 99.0%
  • 10x: 97.8%
  • 20x: 96.0%
Validation Efficiency 100% (49/49)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdh G A 5: 77,024,130 (GRCm39) T174M probably damaging Het
Adh1 A T 3: 137,992,558 (GRCm39) I225F possibly damaging Het
Agap2 A G 10: 126,923,319 (GRCm39) K691E unknown Het
Alcam T C 16: 52,073,573 (GRCm39) D564G possibly damaging Het
Apbb2 T A 5: 66,557,598 (GRCm39) T289S probably damaging Het
Cacna1c C T 6: 118,589,586 (GRCm39) R1446H probably damaging Het
Cep68 T C 11: 20,189,393 (GRCm39) I540V probably benign Het
Ctla4 T C 1: 60,948,397 (GRCm39) V23A probably benign Het
Dnah7b T A 1: 46,379,292 (GRCm39) D3675E probably benign Het
Fam209 G T 2: 172,314,555 (GRCm39) V15F probably benign Het
Fat3 A G 9: 15,942,664 (GRCm39) V1236A possibly damaging Het
Gabbr2 A G 4: 46,718,904 (GRCm39) I38T probably damaging Het
Gdpd4 T C 7: 97,615,505 (GRCm39) I110T probably damaging Het
Gm4841 C T 18: 60,402,852 (GRCm39) A414T possibly damaging Het
Gtf3c4 A T 2: 28,724,782 (GRCm39) Y176N probably damaging Het
H2bc18 G A 3: 96,177,060 (GRCm39) probably null Het
Igsf9b T C 9: 27,230,612 (GRCm39) Y264H probably damaging Het
Itih4 A T 14: 30,614,231 (GRCm39) N394Y probably damaging Het
Kmt2c T C 5: 25,500,605 (GRCm39) T3815A possibly damaging Het
Lrwd1 T C 5: 136,152,254 (GRCm39) probably null Het
Mc3r A G 2: 172,091,711 (GRCm39) K311R probably benign Het
Myb T C 10: 21,032,259 (GRCm39) T41A possibly damaging Het
Nfix T C 8: 85,454,554 (GRCm39) D201G probably damaging Het
Nos1 T C 5: 118,085,512 (GRCm39) V1280A probably damaging Het
Or8a1b T C 9: 37,623,168 (GRCm39) M136V probably benign Het
Pcdh15 A G 10: 74,178,488 (GRCm39) T582A probably damaging Het
Pcdhb12 C A 18: 37,570,375 (GRCm39) A507E probably damaging Het
Pdia3 G A 2: 121,262,858 (GRCm39) G275S probably damaging Het
Pkp2 C A 16: 16,087,575 (GRCm39) A753E probably damaging Het
Plekha3 G A 2: 76,513,142 (GRCm39) V76I possibly damaging Het
Pnpla6 T C 8: 3,567,081 (GRCm39) L33P probably damaging Het
Pot1b C T 17: 55,973,400 (GRCm39) probably benign Het
Prr5l T C 2: 101,588,886 (GRCm39) E88G possibly damaging Het
Prss57 G A 10: 79,621,699 (GRCm39) H97Y probably damaging Het
Rttn C T 18: 88,991,813 (GRCm39) Q131* probably null Het
Scaf11 G T 15: 96,316,176 (GRCm39) S1129R possibly damaging Het
Slc25a20 T A 9: 108,559,189 (GRCm39) M185K possibly damaging Het
Sorbs3 T A 14: 70,445,021 (GRCm39) E19V probably damaging Het
Srgap2 A T 1: 131,217,253 (GRCm39) C1020S probably benign Het
Thoc2l T C 5: 104,666,875 (GRCm39) S466P probably benign Het
Tmem109 T C 19: 10,849,205 (GRCm39) R217G possibly damaging Het
Trio A T 15: 27,732,980 (GRCm39) I2967N probably damaging Het
Vars2 T C 17: 35,968,191 (GRCm39) E899G probably benign Het
Vmn2r109 A G 17: 20,774,842 (GRCm39) probably benign Het
Vps53 A G 11: 75,973,485 (GRCm39) F170L probably damaging Het
Zc2hc1a G A 3: 7,591,422 (GRCm39) S149N possibly damaging Het
Zfp820 A G 17: 22,042,817 (GRCm39) probably benign Het
Zhx3 A C 2: 160,622,629 (GRCm39) F513V probably damaging Het
Other mutations in Or51a5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02708:Or51a5 APN 7 102,771,027 (GRCm39) utr 3 prime probably benign
R0502:Or51a5 UTSW 7 102,771,643 (GRCm39) missense possibly damaging 0.94
R0503:Or51a5 UTSW 7 102,771,643 (GRCm39) missense possibly damaging 0.94
R0508:Or51a5 UTSW 7 102,771,193 (GRCm39) missense possibly damaging 0.93
R0962:Or51a5 UTSW 7 102,771,217 (GRCm39) missense possibly damaging 0.50
R1112:Or51a5 UTSW 7 102,771,611 (GRCm39) missense probably damaging 1.00
R2226:Or51a5 UTSW 7 102,771,115 (GRCm39) missense probably benign 0.06
R4285:Or51a5 UTSW 7 102,771,867 (GRCm39) nonsense probably null
R5817:Or51a5 UTSW 7 102,771,115 (GRCm39) missense possibly damaging 0.94
R6342:Or51a5 UTSW 7 102,771,563 (GRCm39) missense probably damaging 0.99
R6380:Or51a5 UTSW 7 102,771,136 (GRCm39) missense probably benign 0.02
R6565:Or51a5 UTSW 7 102,771,445 (GRCm39) missense probably damaging 0.99
R7861:Or51a5 UTSW 7 102,771,899 (GRCm39) missense probably benign 0.03
R7921:Or51a5 UTSW 7 102,771,635 (GRCm39) missense probably damaging 0.99
RF020:Or51a5 UTSW 7 102,771,098 (GRCm39) missense probably benign 0.05
Z1177:Or51a5 UTSW 7 102,771,598 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAGCAAGCCCGATTTGAAGGACCC -3'
(R):5'- GGAGCCATCCATCTTGATTCCATGC -3'

Sequencing Primer
(F):5'- ATTTGAAGGACCCTGGCACTG -3'
(R):5'- CATCTTGATTCCATGCATACTGG -3'
Posted On 2013-11-07