Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01518:Tmem132b'

89386

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem132b

Ensembl Gene

ENSMUSG00000070498

Gene Name

transmembrane protein 132B

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.092) question?

Stock #

IGL01518

Quality Score

Status

Chromosome

Chromosomal Location

125609449-125869647 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 125855855 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Methionine at position 529 (T529M)

Ref Sequence

ENSEMBL: ENSMUSP00000031446 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000031446]

AlphaFold

F7BAB2

Predicted Effect

probably damaging
Transcript: ENSMUST00000031446
AA Change: T529M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000031446
Gene: ENSMUSG00000070498
AA Change: T529M

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:TMEM132D_N	44	173	2.9e-53	PFAM
Pfam:TMEM132	432	774	5.9e-145	PFAM
Pfam:TMEM132D_C	870	953	1.3e-36	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930447F04Rik	A	C	X: 65,347,660 (GRCm39)	V16G	unknown	Het
4933427I04Rik	A	T	4: 123,754,494 (GRCm39)	E136V	probably benign	Het
Aadac	A	G	3: 59,943,320 (GRCm39)	D75G	probably damaging	Het
Arfgap1	T	A	2: 180,614,518 (GRCm39)	S125T	probably benign	Het
Atxn2	G	T	5: 121,949,042 (GRCm39)	A813S	probably damaging	Het
Cadps	C	A	14: 12,522,352 (GRCm38)	S604I	probably damaging	Het
Ces1a	G	T	8: 93,771,726 (GRCm39)	P24T	probably damaging	Het
Col4a4	T	A	1: 82,433,480 (GRCm39)	M1488L	unknown	Het
Fndc3c1	T	C	X: 105,475,029 (GRCm39)	N941S	probably damaging	Het
Fryl	T	C	5: 73,244,305 (GRCm39)	Y1172C	possibly damaging	Het
Gm1527	T	C	3: 28,949,737 (GRCm39)		probably benign	Het
Hsf2	T	C	10: 57,388,230 (GRCm39)	L458P	probably damaging	Het
Il2	T	C	3: 37,177,156 (GRCm39)	T127A	possibly damaging	Het
Inpp5e	A	G	2: 26,287,946 (GRCm39)	Y617H	probably damaging	Het
Isoc2b	G	A	7: 4,853,763 (GRCm39)	S137F	probably damaging	Het
Map2	C	T	1: 66,464,490 (GRCm39)	P241S	probably damaging	Het
Mfsd6	C	A	1: 52,748,481 (GRCm39)	R128L	probably damaging	Het
Mrnip	A	G	11: 50,088,462 (GRCm39)	T153A	probably damaging	Het
Or4x6	A	G	2: 89,949,315 (GRCm39)	F209S	possibly damaging	Het
Or8d1	A	T	9: 38,767,095 (GRCm39)	M246L	probably benign	Het
Pi4ka	T	C	16: 17,098,599 (GRCm39)	N2022S	probably benign	Het
Scrt2	C	A	2: 151,935,560 (GRCm39)	R238S	probably damaging	Het
St3gal6	T	A	16: 58,305,138 (GRCm39)	D108V	probably benign	Het
Trappc11	T	C	8: 47,954,904 (GRCm39)		probably null	Het
Tspyl1	T	A	10: 34,159,195 (GRCm39)	S307T	possibly damaging	Het
Ush2a	A	G	1: 188,131,982 (GRCm39)	S735G	probably benign	Het
Wnk2	T	C	13: 49,221,668 (GRCm39)	M1186V	possibly damaging	Het

Other mutations in Tmem132b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01397:Tmem132b	APN	5	125,775,792 (GRCm39)	missense	probably benign
IGL02542:Tmem132b	APN	5	125,699,558 (GRCm39)	missense	probably damaging	1.00
IGL02652:Tmem132b	APN	5	125,864,639 (GRCm39)	missense	probably damaging	1.00
IGL02671:Tmem132b	APN	5	125,855,791 (GRCm39)	missense	probably damaging	0.97
IGL02951:Tmem132b	APN	5	125,864,611 (GRCm39)	missense	probably damaging	0.99
R0456:Tmem132b	UTSW	5	125,864,788 (GRCm39)	missense	probably damaging	0.99
R0462:Tmem132b	UTSW	5	125,862,990 (GRCm39)	missense	probably damaging	1.00
R0724:Tmem132b	UTSW	5	125,860,485 (GRCm39)	missense	possibly damaging	0.95
R1137:Tmem132b	UTSW	5	125,860,606 (GRCm39)	missense	possibly damaging	0.94
R1168:Tmem132b	UTSW	5	125,864,083 (GRCm39)	missense	probably damaging	0.99
R1418:Tmem132b	UTSW	5	125,715,313 (GRCm39)	missense	probably benign	0.01
R1689:Tmem132b	UTSW	5	125,864,678 (GRCm39)	missense	possibly damaging	0.95
R1744:Tmem132b	UTSW	5	125,855,908 (GRCm39)	critical splice donor site	probably null
R1835:Tmem132b	UTSW	5	125,862,963 (GRCm39)	missense	probably damaging	1.00
R2016:Tmem132b	UTSW	5	125,700,080 (GRCm39)	missense	probably benign
R2033:Tmem132b	UTSW	5	125,826,353 (GRCm39)	missense	probably damaging	0.98
R2097:Tmem132b	UTSW	5	125,715,272 (GRCm39)	missense	probably damaging	0.99
R2114:Tmem132b	UTSW	5	125,699,615 (GRCm39)	missense	probably damaging	1.00
R2116:Tmem132b	UTSW	5	125,699,615 (GRCm39)	missense	probably damaging	1.00
R2117:Tmem132b	UTSW	5	125,699,615 (GRCm39)	missense	probably damaging	1.00
R2870:Tmem132b	UTSW	5	125,715,332 (GRCm39)	missense	probably benign
R2870:Tmem132b	UTSW	5	125,715,332 (GRCm39)	missense	probably benign
R3807:Tmem132b	UTSW	5	125,864,644 (GRCm39)	missense	probably damaging	1.00
R4825:Tmem132b	UTSW	5	125,860,497 (GRCm39)	missense	probably benign
R5149:Tmem132b	UTSW	5	125,699,989 (GRCm39)	missense	probably damaging	0.99
R5484:Tmem132b	UTSW	5	125,864,797 (GRCm39)	missense	probably damaging	1.00
R5623:Tmem132b	UTSW	5	125,700,416 (GRCm39)	missense	probably damaging	0.99
R5624:Tmem132b	UTSW	5	125,699,710 (GRCm39)	missense	probably benign	0.04
R5775:Tmem132b	UTSW	5	125,715,394 (GRCm39)	critical splice donor site	probably null
R7012:Tmem132b	UTSW	5	125,775,654 (GRCm39)	missense	probably damaging	1.00
R7142:Tmem132b	UTSW	5	125,699,737 (GRCm39)	missense	probably damaging	1.00
R7308:Tmem132b	UTSW	5	125,864,710 (GRCm39)	missense	possibly damaging	0.88
R7414:Tmem132b	UTSW	5	125,864,555 (GRCm39)	missense	probably damaging	1.00
R7452:Tmem132b	UTSW	5	125,715,332 (GRCm39)	missense	probably benign
R7650:Tmem132b	UTSW	5	125,864,074 (GRCm39)	missense	probably benign	0.04
R8111:Tmem132b	UTSW	5	125,699,857 (GRCm39)	missense	probably benign	0.00
R8326:Tmem132b	UTSW	5	125,864,618 (GRCm39)	missense	probably damaging	1.00
R8525:Tmem132b	UTSW	5	125,715,380 (GRCm39)	missense	probably benign	0.01
R8900:Tmem132b	UTSW	5	125,855,884 (GRCm39)	missense	probably damaging	0.96
R9147:Tmem132b	UTSW	5	125,864,167 (GRCm39)	missense	probably damaging	1.00
R9148:Tmem132b	UTSW	5	125,864,167 (GRCm39)	missense	probably damaging	1.00
R9179:Tmem132b	UTSW	5	125,700,115 (GRCm39)	missense	probably benign	0.02
R9215:Tmem132b	UTSW	5	125,864,180 (GRCm39)	missense	probably damaging	0.99
R9231:Tmem132b	UTSW	5	125,860,531 (GRCm39)	missense	probably damaging	1.00
R9284:Tmem132b	UTSW	5	125,864,711 (GRCm39)	missense	possibly damaging	0.67
R9311:Tmem132b	UTSW	5	125,863,029 (GRCm39)	missense	possibly damaging	0.56
R9436:Tmem132b	UTSW	5	125,775,633 (GRCm39)	missense	possibly damaging	0.53
R9484:Tmem132b	UTSW	5	125,860,420 (GRCm39)	missense	probably damaging	0.98
R9775:Tmem132b	UTSW	5	125,864,566 (GRCm39)	missense	probably benign	0.07
Z1176:Tmem132b	UTSW	5	125,864,950 (GRCm39)	missense	possibly damaging	0.51

Posted On

2013-12-03