Incidental Mutation 'IGL01520:Fpr3'
ID90454
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fpr3
Ensembl Gene ENSMUSG00000079700
Gene Nameformyl peptide receptor 3
SynonymsLXA4-R, Fpr-rs1, Lxa4r, Fprl1
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01520
Quality Score
Status
Chromosome17
Chromosomal Location17887852-17971677 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 17971063 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 199 (T199A)
Ref Sequence ENSEMBL: ENSMUSP00000111227 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054871] [ENSMUST00000115565]
Predicted Effect possibly damaging
Transcript: ENSMUST00000054871
AA Change: T199A

PolyPhen 2 Score 0.688 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000093316
Gene: ENSMUSG00000079700
AA Change: T199A

DomainStartEndE-ValueType
Pfam:7tm_1 43 302 2.2e-43 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000115565
AA Change: T199A

PolyPhen 2 Score 0.688 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000111227
Gene: ENSMUSG00000079700
AA Change: T199A

DomainStartEndE-ValueType
Pfam:7tm_1 43 302 1.5e-36 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410089E03Rik C A 15: 8,221,911 T1889K probably damaging Het
4430402I18Rik A T 19: 28,896,132 probably null Het
4932438A13Rik T A 3: 36,973,260 Y2265* probably null Het
Acan T A 7: 79,084,570 H58Q probably damaging Het
Atp6v1c2 A T 12: 17,297,753 L149Q probably damaging Het
Cd40lg A G X: 57,219,788 N132D probably benign Het
Cemip G T 7: 83,948,622 T1060K probably benign Het
Ces1a G T 8: 93,045,098 P24T probably damaging Het
Ces5a A T 8: 93,519,578 S328T probably benign Het
Cfap70 A G 14: 20,420,687 C497R probably benign Het
Cndp2 T C 18: 84,668,607 K430R probably benign Het
Crlf3 T C 11: 80,060,146 D126G probably benign Het
Cxcr1 A T 1: 74,192,275 L196Q probably damaging Het
E330013P04Rik A G 19: 60,161,897 noncoding transcript Het
Erbb2 C T 11: 98,434,009 H810Y probably benign Het
Fam57a T C 11: 76,207,225 probably null Het
Fmn1 C A 2: 113,444,368 probably benign Het
Gcsh A G 8: 116,983,949 probably benign Het
Gm10073 T A 8: 106,573,269 I28F probably benign Het
Gucy1a2 C A 9: 3,759,561 Q456K probably damaging Het
Hgs C A 11: 120,478,348 P317T probably damaging Het
Inmt C A 6: 55,171,228 V139F probably damaging Het
Kcnma1 C A 14: 23,501,143 M460I possibly damaging Het
Map9 A T 3: 82,378,965 N359I probably damaging Het
Mavs T C 2: 131,245,343 S254P probably benign Het
Mcts1 T A X: 38,611,759 probably benign Het
Mecp2 C A X: 74,035,841 R344L possibly damaging Het
Olfr1006 T C 2: 85,674,357 T265A probably benign Het
Olfr1427 A G 19: 12,099,636 M1T probably null Het
Olfr1469 G T 19: 13,410,750 M60I probably damaging Het
Olfr392 T G 11: 73,814,786 T99P probably damaging Het
Olfr957 T C 9: 39,511,046 I225V possibly damaging Het
Olfr969 T G 9: 39,795,378 M1R probably null Het
Rasgrp1 T C 2: 117,288,663 I498V probably damaging Het
Rbbp6 T A 7: 122,985,675 S185T possibly damaging Het
Rd3 A T 1: 191,985,322 H251L possibly damaging Het
Rnf180 T A 13: 105,250,356 D148V probably damaging Het
Rnf43 C A 11: 87,664,716 A34E probably damaging Het
Rslcan18 A G 13: 67,102,108 V21A probably benign Het
Sept9 T C 11: 117,352,643 V128A probably damaging Het
Slc36a1 A G 11: 55,219,656 H103R probably benign Het
Ssh2 A G 11: 77,449,906 D628G probably damaging Het
Tmem119 A G 5: 113,795,485 F85S probably damaging Het
Tpp1 A T 7: 105,747,729 I398N probably benign Het
Ttc3 T C 16: 94,390,207 Y203H probably benign Het
Vars G T 17: 35,013,873 V898L probably benign Het
Vmn1r85 A C 7: 13,085,154 V21G probably damaging Het
Zfp521 T C 18: 13,938,988 H65R possibly damaging Het
Other mutations in Fpr3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01067:Fpr3 APN 17 17970566 missense probably benign 0.17
IGL02166:Fpr3 APN 17 17970464 utr 5 prime probably benign
IGL02380:Fpr3 APN 17 17970992 missense probably benign 0.00
IGL02587:Fpr3 APN 17 17970691 missense probably benign 0.12
R1521:Fpr3 UTSW 17 17971015 missense probably damaging 1.00
R1533:Fpr3 UTSW 17 17970660 nonsense probably null
R1913:Fpr3 UTSW 17 17971408 missense probably damaging 0.96
R2099:Fpr3 UTSW 17 17971181 missense probably damaging 1.00
R2140:Fpr3 UTSW 17 17970617 missense probably damaging 1.00
R2206:Fpr3 UTSW 17 17970646 missense probably damaging 1.00
R2219:Fpr3 UTSW 17 17971382 missense possibly damaging 0.93
R2224:Fpr3 UTSW 17 17971193 missense probably damaging 1.00
R2244:Fpr3 UTSW 17 17971187 missense probably benign 0.03
R2994:Fpr3 UTSW 17 17970868 nonsense probably null
R5364:Fpr3 UTSW 17 17970544 missense probably benign 0.00
R6179:Fpr3 UTSW 17 17970657 nonsense probably null
R6781:Fpr3 UTSW 17 17970716 missense probably benign 0.09
R6909:Fpr3 UTSW 17 17971167 missense probably benign 0.00
R7565:Fpr3 UTSW 17 17970965 missense probably damaging 1.00
R8008:Fpr3 UTSW 17 17971453 missense probably benign 0.03
X0021:Fpr3 UTSW 17 17971238 missense probably benign 0.06
Z1176:Fpr3 UTSW 17 17970993 missense possibly damaging 0.55
Posted On2013-12-09