Incidental Mutation 'R8008:Fpr3'
ID616766
Institutional Source Beutler Lab
Gene Symbol Fpr3
Ensembl Gene ENSMUSG00000079700
Gene Nameformyl peptide receptor 3
SynonymsLXA4-R, Fpr-rs1, Lxa4r, Fprl1
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R8008 (G1)
Quality Score225.009
Status Not validated
Chromosome17
Chromosomal Location17887852-17971677 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 17971453 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 329 (S329P)
Ref Sequence ENSEMBL: ENSMUSP00000093316 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054871] [ENSMUST00000115565]
Predicted Effect probably benign
Transcript: ENSMUST00000054871
AA Change: S329P

PolyPhen 2 Score 0.034 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000093316
Gene: ENSMUSG00000079700
AA Change: S329P

DomainStartEndE-ValueType
Pfam:7tm_1 43 302 2.2e-43 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000115565
AA Change: S329P

PolyPhen 2 Score 0.034 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000111227
Gene: ENSMUSG00000079700
AA Change: S329P

DomainStartEndE-ValueType
Pfam:7tm_1 43 302 1.5e-36 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700001C19Rik T A 17: 47,436,736 E28V probably damaging Het
2210408I21Rik A T 13: 77,281,115 I774F probably benign Het
Alpi A G 1: 87,098,662 S536P unknown Het
Ankar A G 1: 72,666,484 V789A possibly damaging Het
Atp5b C A 10: 128,083,408 Q28K unknown Het
Brpf1 T C 6: 113,319,089 V781A probably benign Het
Cd177 G A 7: 24,752,349 S414L not run Het
Clca3b T A 3: 144,844,609 T192S probably benign Het
Coro2a A T 4: 46,551,349 S119T probably damaging Het
Cpped1 T C 16: 11,828,396 N164S probably damaging Het
Crybg2 T A 4: 134,091,104 N1390K probably damaging Het
Epn2 C T 11: 61,546,666 A27T probably damaging Het
Esp34 T C 17: 38,559,599 F128S possibly damaging Het
Evpl T A 11: 116,230,472 N410Y probably null Het
Fam71d T A 12: 78,715,043 D160E probably benign Het
Flnb A G 14: 7,892,155 Y608C probably damaging Het
Frem2 T A 3: 53,652,910 N1392I probably damaging Het
Gm35339 G A 15: 76,360,632 E1125K Het
Gpi1 G T 7: 34,218,301 N249K probably damaging Het
Gpr87 T C 3: 59,180,045 N13S probably benign Het
Gys2 T C 6: 142,454,517 T323A probably damaging Het
Iqgap3 T C 3: 88,109,463 I1084T probably damaging Het
Lrfn4 C G 19: 4,613,537 G323A probably benign Het
Lrrc4c A T 2: 97,630,249 S407C possibly damaging Het
Map3k20 A T 2: 72,438,269 Q540L probably benign Het
Myom1 T C 17: 71,100,062 V1158A probably benign Het
Ncor2 T C 5: 125,067,919 D378G unknown Het
Nhsl1 T A 10: 18,408,438 D42E probably damaging Het
Nr0b2 C A 4: 133,556,028 A192E probably benign Het
Nt5c1b A G 12: 10,375,000 D182G possibly damaging Het
Olfr104-ps T C 17: 37,362,374 S86P probably damaging Het
Olfr1220 A T 2: 89,097,715 C71S probably benign Het
Olfr1475 T C 19: 13,479,806 T131A probably benign Het
Olfr178 T C 16: 58,889,888 T111A probably benign Het
Olfr874 A T 9: 37,746,793 I220F probably damaging Het
Pepd A G 7: 35,021,701 N250S probably benign Het
Plscr4 C T 9: 92,490,790 R322* probably null Het
Pmp22 C T 11: 63,158,407 R159C probably damaging Het
Pou3f1 C T 4: 124,658,971 A422V unknown Het
Rab11fip3 A G 17: 26,067,982 L399P probably damaging Het
Rragc A G 4: 123,935,547 D352G probably damaging Het
Ryr2 A G 13: 11,657,094 V3420A probably benign Het
Sez6 T A 11: 77,973,256 Y521* probably null Het
Smc4 T C 3: 69,007,312 V86A probably damaging Het
Stap2 T A 17: 55,997,790 M331L probably benign Het
Syt8 G A 7: 142,438,522 R89H probably benign Het
Tcof1 G C 18: 60,829,051 A702G possibly damaging Het
Trim21 G T 7: 102,559,976 T280K probably benign Het
Trim36 C A 18: 46,172,489 V476F probably benign Het
Troap G T 15: 99,075,630 R56L probably benign Het
Ttn A T 2: 76,836,786 I11492K unknown Het
Tuft1 T C 3: 94,614,133 T390A probably damaging Het
Ucp1 T C 8: 83,294,011 I150T probably benign Het
Usp17lb A T 7: 104,841,274 C149S possibly damaging Het
Vmn1r159 A T 7: 22,843,240 N122K possibly damaging Het
Vmn1r237 T C 17: 21,314,194 C60R probably damaging Het
Wdr12 A T 1: 60,089,335 Y85* probably null Het
Wdr3 T C 3: 100,154,936 D221G probably benign Het
Zan T C 5: 137,405,362 E3974G unknown Het
Other mutations in Fpr3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01067:Fpr3 APN 17 17970566 missense probably benign 0.17
IGL01520:Fpr3 APN 17 17971063 missense possibly damaging 0.69
IGL02166:Fpr3 APN 17 17970464 utr 5 prime probably benign
IGL02380:Fpr3 APN 17 17970992 missense probably benign 0.00
IGL02587:Fpr3 APN 17 17970691 missense probably benign 0.12
R1521:Fpr3 UTSW 17 17971015 missense probably damaging 1.00
R1533:Fpr3 UTSW 17 17970660 nonsense probably null
R1913:Fpr3 UTSW 17 17971408 missense probably damaging 0.96
R2099:Fpr3 UTSW 17 17971181 missense probably damaging 1.00
R2140:Fpr3 UTSW 17 17970617 missense probably damaging 1.00
R2206:Fpr3 UTSW 17 17970646 missense probably damaging 1.00
R2219:Fpr3 UTSW 17 17971382 missense possibly damaging 0.93
R2224:Fpr3 UTSW 17 17971193 missense probably damaging 1.00
R2244:Fpr3 UTSW 17 17971187 missense probably benign 0.03
R2994:Fpr3 UTSW 17 17970868 nonsense probably null
R5364:Fpr3 UTSW 17 17970544 missense probably benign 0.00
R6179:Fpr3 UTSW 17 17970657 nonsense probably null
R6781:Fpr3 UTSW 17 17970716 missense probably benign 0.09
R6909:Fpr3 UTSW 17 17971167 missense probably benign 0.00
R7565:Fpr3 UTSW 17 17970965 missense probably damaging 1.00
X0021:Fpr3 UTSW 17 17971238 missense probably benign 0.06
Z1176:Fpr3 UTSW 17 17970993 missense possibly damaging 0.55
Predicted Primers PCR Primer
(F):5'- GTCTGGCTCAAAGAGATGCAG -3'
(R):5'- TCTGAATATTCTAGGCCCCTTTGAC -3'

Sequencing Primer
(F):5'- TCTGGCTCAAAGAGATGCAGTTTAG -3'
(R):5'- ATTCGGGGGACAGAGAAGTACTTTTC -3'
Posted On2020-01-23