Mutagenetix > Incidental Mutation

Incidental Mutation 'R1629:Vmn2r98'

172699

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r98

Ensembl Gene

ENSMUSG00000096717

Gene Name

vomeronasal 2, receptor 98

Synonyms

EG224552

MMRRC Submission

039666-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.096) question?

Stock #

R1629 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

19273755-19301573 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 19287645 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 493 (S493P)

Ref Sequence

ENSEMBL: ENSMUSP00000131261 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170424]

AlphaFold

E9PZ56

Predicted Effect

possibly damaging
Transcript: ENSMUST00000170424
AA Change: S493P

PolyPhen 2 Score 0.939 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000131261
Gene: ENSMUSG00000096717
AA Change: S493P

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	460	2.6e-35	PFAM
Pfam:NCD3G	509	562	7.4e-22	PFAM
Pfam:7tm_3	594	830	1.4e-52	PFAM
low complexity region	844	856	N/A	INTRINSIC

Coding Region Coverage

1x: 99.1%
3x: 98.2%
10x: 95.9%
20x: 91.5%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts19	A	C	18: 59,087,691 (GRCm39)	I574L	probably damaging	Het
Alkbh2	C	T	5: 114,262,287 (GRCm39)	E148K	probably damaging	Het
BC005624	T	C	2: 30,864,020 (GRCm39)	E191G	probably damaging	Het
Cbx2	A	G	11: 118,919,806 (GRCm39)	D457G	probably damaging	Het
Ccdc110	A	G	8: 46,395,164 (GRCm39)	K352E	probably benign	Het
Cdk14	A	T	5: 5,153,807 (GRCm39)	H183Q	probably benign	Het
Cfap58	A	G	19: 47,929,778 (GRCm39)	T80A	probably benign	Het
Cftr	C	T	6: 18,226,105 (GRCm39)	T351I	probably damaging	Het
Col27a1	A	G	4: 63,248,100 (GRCm39)		probably benign	Het
Cp	T	A	3: 20,020,614 (GRCm39)		probably null	Het
Cpne8	A	T	15: 90,456,175 (GRCm39)	V196E	probably benign	Het
Dmxl1	T	G	18: 49,992,353 (GRCm39)		probably null	Het
Dnm2	T	A	9: 21,415,754 (GRCm39)	L642Q	probably damaging	Het
Dock2	G	T	11: 34,212,480 (GRCm39)		probably null	Het
Dock9	A	G	14: 121,780,986 (GRCm39)	F2091L	possibly damaging	Het
Eaf2	A	G	16: 36,645,063 (GRCm39)	V53A	probably damaging	Het
Fbl	G	T	7: 27,874,212 (GRCm39)		probably benign	Het
Fbn2	T	C	18: 58,159,610 (GRCm39)	D2373G	probably damaging	Het
Gbp2b	A	G	3: 142,316,735 (GRCm39)	Y462C	possibly damaging	Het
Il1rl2	T	A	1: 40,396,020 (GRCm39)	F348I	probably benign	Het
Khdc1a	T	A	1: 21,421,121 (GRCm39)	I102N	possibly damaging	Het
Klhl11	T	C	11: 100,355,012 (GRCm39)	T270A	probably benign	Het
Lama1	T	C	17: 68,112,423 (GRCm39)	S2288P	probably benign	Het
Lrfn4	T	C	19: 4,663,523 (GRCm39)	E337G	possibly damaging	Het
Macf1	C	A	4: 123,402,208 (GRCm39)	E549*	probably null	Het
Mmp3	G	T	9: 7,447,641 (GRCm39)	V209F	probably benign	Het
Mslnl	G	A	17: 25,961,908 (GRCm39)	V128M	probably damaging	Het
Myh9	G	A	15: 77,648,601 (GRCm39)	R1725W	probably damaging	Het
Nbea	A	T	3: 55,910,312 (GRCm39)	D1294E	possibly damaging	Het
Nrcam	G	A	12: 44,610,769 (GRCm39)	A496T	probably benign	Het
Nufip2	A	G	11: 77,583,834 (GRCm39)	T583A	probably benign	Het
Or5m3b	A	G	2: 85,871,766 (GRCm39)	T36A	probably damaging	Het
Ppig	C	A	2: 69,566,217 (GRCm39)	T128K	probably damaging	Het
Ppp2r2a	A	T	14: 67,257,208 (GRCm39)	C341S	possibly damaging	Het
Ptpre	A	T	7: 135,271,528 (GRCm39)	D374V	probably damaging	Het
Ranbp3l	A	C	15: 9,065,068 (GRCm39)	Q485P	probably damaging	Het
Rapgef6	TG	TGG	11: 54,437,223 (GRCm39)		probably null	Het
Slc1a7	A	G	4: 107,865,340 (GRCm39)	Y276C	probably damaging	Het
Smarcad1	A	G	6: 65,044,091 (GRCm39)	D221G	probably benign	Het
Smn1	C	A	13: 100,264,404 (GRCm39)	T45N	probably damaging	Het
Son	T	C	16: 91,454,510 (GRCm39)	S1086P	probably damaging	Het
Ssmem1	T	A	6: 30,512,491 (GRCm39)	Y45N	possibly damaging	Het
Tasor2	T	C	13: 3,624,121 (GRCm39)	H1943R	possibly damaging	Het
Tmem184c	A	C	8: 78,329,551 (GRCm39)	F170V	possibly damaging	Het
Tmem184c	A	T	8: 78,332,791 (GRCm39)		probably null	Het
Vmn1r59	C	T	7: 5,457,466 (GRCm39)	C98Y	probably damaging	Het
Vmn2r23	T	A	6: 123,690,386 (GRCm39)	S421T	probably benign	Het

Other mutations in Vmn2r98

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00897:Vmn2r98	APN	17	19,286,007 (GRCm39)	splice site	probably benign
IGL01296:Vmn2r98	APN	17	19,285,447 (GRCm39)	missense	probably damaging	1.00
IGL01363:Vmn2r98	APN	17	19,286,020 (GRCm39)	missense	probably benign	0.01
IGL01618:Vmn2r98	APN	17	19,285,521 (GRCm39)	missense	possibly damaging	0.93
IGL01746:Vmn2r98	APN	17	19,286,713 (GRCm39)	missense	probably damaging	1.00
IGL01747:Vmn2r98	APN	17	19,286,702 (GRCm39)	missense	probably damaging	1.00
IGL01770:Vmn2r98	APN	17	19,286,702 (GRCm39)	missense	probably damaging	1.00
IGL01868:Vmn2r98	APN	17	19,286,548 (GRCm39)	missense	probably benign
IGL02123:Vmn2r98	APN	17	19,300,941 (GRCm39)	missense	probably damaging	1.00
IGL02323:Vmn2r98	APN	17	19,286,113 (GRCm39)	missense	probably damaging	0.99
IGL02543:Vmn2r98	APN	17	19,286,083 (GRCm39)	missense	probably benign
IGL02650:Vmn2r98	APN	17	19,301,223 (GRCm39)	missense	probably benign	0.00
IGL02676:Vmn2r98	APN	17	19,285,521 (GRCm39)	missense	probably benign	0.00
IGL02803:Vmn2r98	APN	17	19,286,275 (GRCm39)	missense	probably benign
IGL02807:Vmn2r98	APN	17	19,301,283 (GRCm39)	missense	probably damaging	1.00
IGL03307:Vmn2r98	APN	17	19,286,242 (GRCm39)	missense	possibly damaging	0.62
IGL03396:Vmn2r98	APN	17	19,290,107 (GRCm39)	missense	possibly damaging	0.92
PIT4131001:Vmn2r98	UTSW	17	19,301,223 (GRCm39)	missense	probably benign	0.00
R0122:Vmn2r98	UTSW	17	19,286,662 (GRCm39)	missense	probably benign	0.06
R0329:Vmn2r98	UTSW	17	19,286,609 (GRCm39)	missense	probably benign	0.21
R0330:Vmn2r98	UTSW	17	19,286,609 (GRCm39)	missense	probably benign	0.21
R0368:Vmn2r98	UTSW	17	19,286,089 (GRCm39)	nonsense	probably null
R0545:Vmn2r98	UTSW	17	19,273,875 (GRCm39)	missense	probably benign	0.15
R0635:Vmn2r98	UTSW	17	19,300,759 (GRCm39)	missense	probably benign	0.00
R0689:Vmn2r98	UTSW	17	19,300,782 (GRCm39)	missense	possibly damaging	0.83
R1035:Vmn2r98	UTSW	17	19,301,011 (GRCm39)	missense	possibly damaging	0.90
R1243:Vmn2r98	UTSW	17	19,286,210 (GRCm39)	missense	possibly damaging	0.52
R1421:Vmn2r98	UTSW	17	19,285,440 (GRCm39)	missense	probably damaging	1.00
R1643:Vmn2r98	UTSW	17	19,301,170 (GRCm39)	missense	probably damaging	1.00
R1795:Vmn2r98	UTSW	17	19,286,702 (GRCm39)	missense	probably damaging	1.00
R1958:Vmn2r98	UTSW	17	19,286,680 (GRCm39)	missense	possibly damaging	0.70
R1962:Vmn2r98	UTSW	17	19,285,595 (GRCm39)	nonsense	probably null
R2165:Vmn2r98	UTSW	17	19,301,553 (GRCm39)	missense	unknown
R2238:Vmn2r98	UTSW	17	19,286,213 (GRCm39)	missense	probably damaging	1.00
R2252:Vmn2r98	UTSW	17	19,300,698 (GRCm39)	missense	probably benign	0.00
R2323:Vmn2r98	UTSW	17	19,286,081 (GRCm39)	missense	probably benign	0.18
R2887:Vmn2r98	UTSW	17	19,301,439 (GRCm39)	missense	possibly damaging	0.83
R2909:Vmn2r98	UTSW	17	19,287,664 (GRCm39)	missense	probably damaging	1.00
R3001:Vmn2r98	UTSW	17	19,286,125 (GRCm39)	missense	probably benign	0.01
R3002:Vmn2r98	UTSW	17	19,286,125 (GRCm39)	missense	probably benign	0.01
R3003:Vmn2r98	UTSW	17	19,286,125 (GRCm39)	missense	probably benign	0.01
R3788:Vmn2r98	UTSW	17	19,300,887 (GRCm39)	missense	probably benign	0.31
R4570:Vmn2r98	UTSW	17	19,286,354 (GRCm39)	missense	probably benign	0.11
R4706:Vmn2r98	UTSW	17	19,290,007 (GRCm39)	missense	probably damaging	1.00
R4723:Vmn2r98	UTSW	17	19,286,602 (GRCm39)	missense	probably benign	0.01
R5036:Vmn2r98	UTSW	17	19,286,419 (GRCm39)	missense	probably benign	0.00
R5072:Vmn2r98	UTSW	17	19,286,306 (GRCm39)	missense	probably benign	0.07
R5121:Vmn2r98	UTSW	17	19,273,815 (GRCm39)	missense	probably benign	0.13
R5283:Vmn2r98	UTSW	17	19,300,981 (GRCm39)	missense	probably benign	0.05
R5294:Vmn2r98	UTSW	17	19,290,016 (GRCm39)	nonsense	probably null
R5371:Vmn2r98	UTSW	17	19,290,015 (GRCm39)	missense	probably damaging	1.00
R5532:Vmn2r98	UTSW	17	19,287,645 (GRCm39)	missense	possibly damaging	0.94
R5598:Vmn2r98	UTSW	17	19,301,161 (GRCm39)	missense	probably benign	0.37
R5800:Vmn2r98	UTSW	17	19,286,260 (GRCm39)	missense	probably benign	0.17
R6089:Vmn2r98	UTSW	17	19,286,336 (GRCm39)	missense	probably benign	0.29
R6155:Vmn2r98	UTSW	17	19,286,143 (GRCm39)	missense	possibly damaging	0.87
R6853:Vmn2r98	UTSW	17	19,286,063 (GRCm39)	missense	probably benign	0.00
R6920:Vmn2r98	UTSW	17	19,285,510 (GRCm39)	missense	probably damaging	0.98
R7012:Vmn2r98	UTSW	17	19,286,530 (GRCm39)	missense	probably benign	0.06
R7042:Vmn2r98	UTSW	17	19,301,184 (GRCm39)	missense	probably benign
R7068:Vmn2r98	UTSW	17	19,285,575 (GRCm39)	missense	probably benign
R7607:Vmn2r98	UTSW	17	19,287,570 (GRCm39)	missense	possibly damaging	0.95
R7763:Vmn2r98	UTSW	17	19,300,797 (GRCm39)	missense	probably benign	0.00
R7771:Vmn2r98	UTSW	17	19,287,460 (GRCm39)	splice site	probably null
R7915:Vmn2r98	UTSW	17	19,287,493 (GRCm39)	missense	probably benign	0.10
R8028:Vmn2r98	UTSW	17	19,273,912 (GRCm39)	missense	probably benign	0.00
R8205:Vmn2r98	UTSW	17	19,301,425 (GRCm39)	missense	probably damaging	0.99
R8241:Vmn2r98	UTSW	17	19,301,031 (GRCm39)	missense	probably damaging	0.99
R8906:Vmn2r98	UTSW	17	19,286,532 (GRCm39)	missense	probably benign
R8952:Vmn2r98	UTSW	17	19,285,531 (GRCm39)	missense	possibly damaging	0.76
R9147:Vmn2r98	UTSW	17	19,286,383 (GRCm39)	missense	probably benign	0.04
R9148:Vmn2r98	UTSW	17	19,286,383 (GRCm39)	missense	probably benign	0.04
R9187:Vmn2r98	UTSW	17	19,301,481 (GRCm39)	missense	probably damaging	1.00
R9344:Vmn2r98	UTSW	17	19,286,777 (GRCm39)	missense	probably benign	0.14
R9467:Vmn2r98	UTSW	17	19,287,517 (GRCm39)	missense	probably benign	0.01
R9487:Vmn2r98	UTSW	17	19,301,496 (GRCm39)	missense	possibly damaging	0.78
R9753:Vmn2r98	UTSW	17	19,285,665 (GRCm39)	missense	probably benign	0.27
Z1177:Vmn2r98	UTSW	17	19,287,685 (GRCm39)	nonsense	probably null
Z1177:Vmn2r98	UTSW	17	19,285,398 (GRCm39)	critical splice acceptor site	probably null

Predicted Primers

PCR Primer
(F):5'- TCATTTTGGACACTGTTGCTCTGAACAT -3'
(R):5'- CCCCAAAACAGATTTTCCTCCAGTACAT -3'

Sequencing Primer
(F):5'- GCTATTCTGAACAGTCAGGTTTTCAC -3'
(R):5'- TTCCTCCAGTACATTAACACATGAG -3'

Posted On

2014-04-24