Mutagenetix > Incidental Mutation

Incidental Mutation 'R1750:Syne2'

193442

Institutional Source

Beutler Lab

Gene Symbol

Syne2

Ensembl Gene

ENSMUSG00000063450

Gene Name

spectrin repeat containing, nuclear envelope 2

Synonyms

Nesp2g, diminished cone electroretinogram, Cpfl8, dice, 6820443O06Rik, nesprin-2, syne-2, D12Ertd777e

MMRRC Submission

039782-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.268) question?

Stock #

R1750 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

75865092-76157702 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 76099579 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Serine at position 5335 (C5335S)

Ref Sequence

ENSEMBL: ENSMUSP00000119120 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000044217] [ENSMUST00000085280] [ENSMUST00000143031]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000044217
AA Change: C5334S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000047697
Gene: ENSMUSG00000063450
AA Change: C5334S

Domain	Start	End	E-Value	Type
CH	33	134	7.97e-19	SMART
low complexity region	151	175	N/A	INTRINSIC
CH	185	283	1.34e-20	SMART
low complexity region	494	505	N/A	INTRINSIC
coiled coil region	541	572	N/A	INTRINSIC
low complexity region	665	674	N/A	INTRINSIC
coiled coil region	844	869	N/A	INTRINSIC
coiled coil region	936	969	N/A	INTRINSIC
coiled coil region	1006	1032	N/A	INTRINSIC
SPEC	1427	1525	4.96e0	SMART
SPEC	1528	1632	2.48e-1	SMART
coiled coil region	1660	1699	N/A	INTRINSIC
SPEC	2034	2131	1.83e0	SMART
coiled coil region	2173	2194	N/A	INTRINSIC
low complexity region	2295	2307	N/A	INTRINSIC
coiled coil region	2316	2348	N/A	INTRINSIC
SPEC	2720	2820	1.44e-5	SMART
coiled coil region	2905	2934	N/A	INTRINSIC
coiled coil region	2962	2989	N/A	INTRINSIC
coiled coil region	3108	3136	N/A	INTRINSIC
low complexity region	3333	3350	N/A	INTRINSIC
low complexity region	3514	3523	N/A	INTRINSIC
low complexity region	3666	3676	N/A	INTRINSIC
coiled coil region	3678	3708	N/A	INTRINSIC
coiled coil region	3761	3788	N/A	INTRINSIC
coiled coil region	3846	3903	N/A	INTRINSIC
coiled coil region	4015	4067	N/A	INTRINSIC
low complexity region	4102	4115	N/A	INTRINSIC
coiled coil region	4483	4511	N/A	INTRINSIC
low complexity region	4557	4569	N/A	INTRINSIC
coiled coil region	4655	4688	N/A	INTRINSIC
low complexity region	4749	4763	N/A	INTRINSIC
SPEC	4827	4926	5.25e-1	SMART
SPEC	4933	5038	2.64e-4	SMART
SPEC	5048	5152	1.47e-2	SMART
SPEC	5159	5259	4.29e0	SMART
SPEC	5263	5371	4.47e0	SMART
low complexity region	5373	5393	N/A	INTRINSIC
SPEC	5583	5681	5.7e-1	SMART
Blast:SPEC	5690	5793	2e-53	BLAST
SPEC	5800	5900	2.11e0	SMART
SPEC	5907	6005	6.91e-8	SMART
SPEC	6012	6119	4.45e-11	SMART
SPEC	6126	6228	6.39e-12	SMART
SPEC	6235	6335	7.75e-11	SMART
SPEC	6539	6642	5.53e-7	SMART
SPEC	6649	6753	5.12e-2	SMART
KASH	6817	6874	8.17e-34	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000085280
AA Change: C595S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000082383
Gene: ENSMUSG00000063450
AA Change: C595S

Domain	Start	End	E-Value	Type
low complexity region	10	24	N/A	INTRINSIC
SPEC	88	187	5.25e-1	SMART
SPEC	194	299	2.64e-4	SMART
SPEC	309	413	1.47e-2	SMART
SPEC	420	520	4.29e0	SMART
SPEC	524	632	4.47e0	SMART
low complexity region	634	654	N/A	INTRINSIC
SPEC	844	942	5.7e-1	SMART
Blast:SPEC	951	1054	2e-53	BLAST
SPEC	1061	1161	2.11e0	SMART
SPEC	1168	1266	6.91e-8	SMART
SPEC	1273	1380	4.45e-11	SMART
SPEC	1387	1489	6.39e-12	SMART
SPEC	1496	1596	7.75e-11	SMART
SPEC	1823	1926	5.53e-7	SMART
SPEC	1933	2037	5.12e-2	SMART
KASH	2095	2152	8.17e-34	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000139204
AA Change: C109S

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000118921
Gene: ENSMUSG00000063450
AA Change: C109S

Domain	Start	End	E-Value	Type
SPEC	39	147	4.47e0	SMART
low complexity region	149	169	N/A	INTRINSIC
SPEC	359	457	5.7e-1	SMART
Blast:SPEC	466	569	3e-53	BLAST
SPEC	576	676	2.11e0	SMART
SPEC	683	781	6.91e-8	SMART
SPEC	788	895	4.45e-11	SMART
SPEC	902	1004	6.39e-12	SMART
SPEC	1011	1111	7.75e-11	SMART
SPEC	1315	1418	5.53e-7	SMART
SPEC	1425	1529	5.12e-2	SMART
KASH	1587	1644	8.17e-34	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000143031
AA Change: C5335S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000119120
Gene: ENSMUSG00000063450
AA Change: C5335S

Domain	Start	End	E-Value	Type
CH	33	134	7.97e-19	SMART
low complexity region	151	175	N/A	INTRINSIC
CH	185	283	1.34e-20	SMART
low complexity region	494	505	N/A	INTRINSIC
coiled coil region	541	572	N/A	INTRINSIC
coiled coil region	845	870	N/A	INTRINSIC
coiled coil region	937	970	N/A	INTRINSIC
coiled coil region	1007	1033	N/A	INTRINSIC
SPEC	1428	1526	4.96e0	SMART
SPEC	1529	1633	2.48e-1	SMART
coiled coil region	1661	1700	N/A	INTRINSIC
SPEC	2035	2132	1.83e0	SMART
coiled coil region	2174	2195	N/A	INTRINSIC
low complexity region	2296	2308	N/A	INTRINSIC
coiled coil region	2317	2349	N/A	INTRINSIC
SPEC	2721	2821	1.44e-5	SMART
coiled coil region	2906	2935	N/A	INTRINSIC
coiled coil region	2963	2990	N/A	INTRINSIC
coiled coil region	3109	3137	N/A	INTRINSIC
low complexity region	3334	3351	N/A	INTRINSIC
low complexity region	3515	3524	N/A	INTRINSIC
low complexity region	3667	3677	N/A	INTRINSIC
coiled coil region	3679	3709	N/A	INTRINSIC
coiled coil region	3762	3789	N/A	INTRINSIC
coiled coil region	3847	3904	N/A	INTRINSIC
coiled coil region	4016	4068	N/A	INTRINSIC
low complexity region	4103	4116	N/A	INTRINSIC
coiled coil region	4484	4512	N/A	INTRINSIC
low complexity region	4558	4570	N/A	INTRINSIC
coiled coil region	4656	4689	N/A	INTRINSIC
low complexity region	4750	4764	N/A	INTRINSIC
SPEC	4828	4927	5.25e-1	SMART
SPEC	4934	5039	2.64e-4	SMART
SPEC	5049	5153	1.47e-2	SMART
SPEC	5160	5260	4.29e0	SMART
SPEC	5264	5372	4.47e0	SMART
low complexity region	5374	5394	N/A	INTRINSIC
SPEC	5584	5682	5.7e-1	SMART
Blast:SPEC	5691	5794	2e-53	BLAST
SPEC	5801	5901	2.11e0	SMART
SPEC	5908	6006	6.91e-8	SMART
SPEC	6013	6120	4.45e-11	SMART
SPEC	6127	6229	6.39e-12	SMART
SPEC	6236	6336	7.75e-11	SMART
SPEC	6540	6643	5.53e-7	SMART
SPEC	6650	6754	5.12e-2	SMART
KASH	6813	6870	8.17e-34	SMART

Coding Region Coverage

1x: 97.4%
3x: 96.9%
10x: 95.2%
20x: 91.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
PHENOTYPE: Homozygotes for one knock-out allele show normal myonuclear positioning of both synaptic and non-synaptic nuclei in skeletal muscle cells. Homozygotes for another knock-out allele exhibit a thickened epidermis and altered nuclear envelope architecture inprimary dermal fibroblasts and keratinocytes. Mice homozygous for a spontaneous mutation exhibit early retinal defects in photoreceptors, secondary Neurons, and muller glia. [provided by MGI curators]

Allele List at MGI

All alleles(5) : Targeted, knock-out(2) Gene trapped(3)

Other mutations in this stock

Total: 113 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933402N03Rik	G	T	7: 130,747,859 (GRCm39)	N44K	probably benign	Het
Acd	C	A	8: 106,425,524 (GRCm39)	A270S	possibly damaging	Het
Acnat1	G	A	4: 49,451,042 (GRCm39)	T23I	probably benign	Het
Adam26a	T	G	8: 44,023,226 (GRCm39)	E88A	possibly damaging	Het
Adgrb1	G	A	15: 74,413,676 (GRCm39)	V589M	probably benign	Het
Agbl2	T	A	2: 90,646,720 (GRCm39)		probably benign	Het
Aif1	G	A	17: 35,391,127 (GRCm39)	P44L	probably benign	Het
Amh	AGCGCCTTGG	AG	10: 80,641,419 (GRCm39)		probably null	Het
Asap2	T	C	12: 21,253,999 (GRCm39)	L170P	probably damaging	Het
Btg2	T	C	1: 134,006,769 (GRCm39)	D8G	probably benign	Het
Cacna1g	A	T	11: 94,334,118 (GRCm39)	V841E	probably damaging	Het
Cacna2d1	C	T	5: 16,469,286 (GRCm39)	P230L	probably benign	Het
Cacna2d2	A	T	9: 107,401,843 (GRCm39)	D766V	probably damaging	Het
Carns1	A	G	19: 4,223,156 (GRCm39)	W23R	possibly damaging	Het
Cdk11b	T	A	4: 155,713,137 (GRCm39)		probably null	Het
Chrna3	T	C	9: 54,923,341 (GRCm39)	S156G	probably damaging	Het
Cmya5	A	T	13: 93,232,171 (GRCm39)	N972K	probably benign	Het
Cpne7	C	A	8: 123,861,263 (GRCm39)	P541T	probably damaging	Het
Cracd	A	G	5: 77,005,522 (GRCm39)	I628V	unknown	Het
Csmd1	A	T	8: 15,967,303 (GRCm39)	L3187I	probably damaging	Het
Dbt	A	G	3: 116,339,943 (GRCm39)	I404V	probably benign	Het
Dgki	A	T	6: 36,893,369 (GRCm39)	I819K	probably damaging	Het
Dip2b	T	A	15: 100,076,347 (GRCm39)	S782T	probably benign	Het
Dlc1	A	T	8: 37,325,244 (GRCm39)		probably null	Het
Dnajc13	A	T	9: 104,098,676 (GRCm39)	V459E	probably damaging	Het
Enam	A	G	5: 88,651,086 (GRCm39)	E790G	probably damaging	Het
Epb41l4a	G	C	18: 33,961,261 (GRCm39)	Y424*	probably null	Het
Extl1	A	G	4: 134,089,999 (GRCm39)	S370P	probably benign	Het
Fan1	T	C	7: 64,022,761 (GRCm39)	Y164C	probably benign	Het
Fbxw15	G	A	9: 109,387,314 (GRCm39)	S227F	probably damaging	Het
Fbxw25	A	T	9: 109,479,141 (GRCm39)	I370N	probably benign	Het
Fcgbp	T	A	7: 27,792,868 (GRCm39)	Y957*	probably null	Het
Gkap1	C	A	13: 58,384,857 (GRCm39)	E77*	probably null	Het
Gkn1	A	T	6: 87,326,105 (GRCm39)	N28K	unknown	Het
Gls2	A	G	10: 128,037,194 (GRCm39)	E245G	probably damaging	Het
Glyat	G	A	19: 12,623,679 (GRCm39)	V32I	probably benign	Het
Gm2431	A	T	7: 141,811,762 (GRCm39)	C47*	probably null	Het
Gm5431	T	C	11: 48,785,658 (GRCm39)	D239G	probably benign	Het
Ift70a1	C	T	2: 75,810,599 (GRCm39)	V495I	probably benign	Het
Inpp5d	T	C	1: 87,626,803 (GRCm39)	F540L	probably damaging	Het
Kcna1	A	C	6: 126,619,771 (GRCm39)	I183S	probably benign	Het
Kpna2	G	T	11: 106,882,271 (GRCm39)	L212I	probably damaging	Het
Krt36	C	G	11: 99,994,884 (GRCm39)	R229S	probably benign	Het
Krt78	G	A	15: 101,854,812 (GRCm39)	H1000Y	probably benign	Het
Krt90	A	G	15: 101,461,800 (GRCm39)		probably benign	Het
Ldlrad4	C	A	18: 68,239,758 (GRCm39)	F59L	probably benign	Het
Lrrc3b	T	C	14: 15,358,601 (GRCm38)	N2D	probably benign	Het
Madd	T	C	2: 90,998,236 (GRCm39)	D239G	probably damaging	Het
Mapk8ip3	C	T	17: 25,133,433 (GRCm39)	G332S	probably null	Het
Mastl	A	T	2: 23,036,093 (GRCm39)	L141*	probably null	Het
Mdh1b	T	C	1: 63,758,681 (GRCm39)	N304D	probably benign	Het
Mfsd4b3-ps	G	T	10: 39,823,929 (GRCm39)	N110K	probably benign	Het
Mtus2	T	C	5: 148,214,443 (GRCm39)	S1035P	probably damaging	Het
Muc21	T	A	17: 35,931,940 (GRCm39)		probably benign	Het
Myh11	T	C	16: 14,033,654 (GRCm39)	E1080G	probably damaging	Het
Myh11	T	A	16: 14,018,622 (GRCm39)	D1908V	probably damaging	Het
Mypn	A	C	10: 62,971,976 (GRCm39)	M688R	probably benign	Het
Nat8l	G	T	5: 34,158,130 (GRCm39)	C180F	probably damaging	Het
Nip7	T	A	8: 107,784,018 (GRCm39)	L86Q	probably damaging	Het
Nisch	C	T	14: 30,896,839 (GRCm39)		probably benign	Het
Nop2	A	G	6: 125,114,601 (GRCm39)	I283V	probably benign	Het
Oas1h	T	A	5: 121,009,840 (GRCm39)		probably null	Het
Or10ag56	T	C	2: 87,139,196 (GRCm39)	V41A	probably benign	Het
Or2g25	A	C	17: 37,970,564 (GRCm39)	I220S	probably damaging	Het
Or4c101	C	A	2: 88,390,402 (GRCm39)	D185E	possibly damaging	Het
Or4c104	T	C	2: 88,586,117 (GRCm39)	R301G	probably benign	Het
Or56b1b	A	T	7: 108,164,564 (GRCm39)	L146*	probably null	Het
Or5w17	T	A	2: 87,583,530 (GRCm39)	D269V	probably damaging	Het
Or8b42	T	A	9: 38,341,986 (GRCm39)	M136K	probably damaging	Het
P4hb	A	G	11: 120,453,546 (GRCm39)	V373A	probably damaging	Het
Pappa2	C	A	1: 158,590,720 (GRCm39)	E1645*	probably null	Het
Pcdh10	G	T	3: 45,336,316 (GRCm39)	E877*	probably null	Het
Pcdhb17	A	G	18: 37,620,070 (GRCm39)	H620R	possibly damaging	Het
Pcdhb17	C	T	18: 37,618,764 (GRCm39)	R185C	probably damaging	Het
Pdcl3	T	A	1: 39,034,946 (GRCm39)	F168I	probably damaging	Het
Pde4a	T	A	9: 21,114,528 (GRCm39)	I365N	probably damaging	Het
Pdzd2	A	G	15: 12,385,950 (GRCm39)	V940A	probably damaging	Het
Picalm	T	A	7: 89,840,390 (GRCm39)	S399T	possibly damaging	Het
Pigk	A	T	3: 152,450,101 (GRCm39)	I249F	probably damaging	Het
Plxnb1	C	A	9: 108,940,836 (GRCm39)	H1570Q	probably benign	Het
Plxnc1	A	G	10: 94,635,359 (GRCm39)	Y1321H	probably damaging	Het
Ppm1g	G	A	5: 31,363,560 (GRCm39)	S114F	probably damaging	Het
Rassf4	A	G	6: 116,617,228 (GRCm39)	M259T	probably damaging	Het
Rbm47	T	C	5: 66,176,653 (GRCm39)	K557E	possibly damaging	Het
Rhobtb1	A	G	10: 69,115,236 (GRCm39)	K21R	probably damaging	Het
Selenoi	T	C	5: 30,462,771 (GRCm39)	F212S	probably benign	Het
Shc3	T	G	13: 51,603,328 (GRCm39)	Y259S	probably damaging	Het
Skic3	T	A	13: 76,288,720 (GRCm39)	L951Q	possibly damaging	Het
Slc11a2	T	C	15: 100,299,168 (GRCm39)	N134S	probably damaging	Het
Slc9a7	A	T	X: 20,028,717 (GRCm39)	M368K	probably damaging	Het
Slx4ip	T	A	2: 136,888,669 (GRCm39)	C117S	probably damaging	Het
Spata31d1d	T	A	13: 59,876,509 (GRCm39)	Q342L	probably benign	Het
Spink13	T	A	18: 62,740,820 (GRCm39)	Y93F	probably damaging	Het
St6galnac5	A	T	3: 152,551,958 (GRCm39)	I203N	possibly damaging	Het
Tagap	T	A	17: 8,148,742 (GRCm39)	D173E	probably benign	Het
Tekt3	A	C	11: 62,960,867 (GRCm39)	Y12S	probably damaging	Het
Tmem81	T	A	1: 132,435,321 (GRCm39)	N42K	probably damaging	Het
Tnc	A	G	4: 63,890,972 (GRCm39)	W1728R	probably damaging	Het
Ttc33	C	T	15: 5,241,579 (GRCm39)	R135*	probably null	Het
Unc5c	A	G	3: 141,533,278 (GRCm39)	D842G	possibly damaging	Het
Usp43	A	T	11: 67,770,779 (GRCm39)	H618Q	probably damaging	Het
Vmn2r50	T	G	7: 9,786,915 (GRCm39)	N64T	possibly damaging	Het
Vmn2r53	T	C	7: 12,315,632 (GRCm39)	Y729C	probably damaging	Het
Vmn2r59	T	A	7: 41,695,251 (GRCm39)	H387L	possibly damaging	Het
Vstm2a	G	T	11: 16,213,166 (GRCm39)	V184F	possibly damaging	Het
Wdr53	T	G	16: 32,070,935 (GRCm39)	N93K	probably damaging	Het
Wdr95	A	G	5: 149,505,351 (GRCm39)		probably null	Het
Xpot	A	T	10: 121,438,932 (GRCm39)		probably null	Het
Xrcc5	C	T	1: 72,364,246 (GRCm39)	Q233*	probably null	Het
Zbtb18	T	A	1: 177,275,077 (GRCm39)	C137S	possibly damaging	Het
Zfp58	C	A	13: 67,639,598 (GRCm39)	G298*	probably null	Het
Zfp963	A	G	8: 70,196,100 (GRCm39)	S118P	possibly damaging	Het
Zmynd15	A	T	11: 70,353,393 (GRCm39)	Q336L	probably benign	Het

Other mutations in Syne2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00329:Syne2	APN	12	76,078,474 (GRCm39)	unclassified	probably benign
IGL00595:Syne2	APN	12	75,972,420 (GRCm39)	missense	possibly damaging	0.76
IGL00672:Syne2	APN	12	76,110,958 (GRCm39)	missense	probably damaging	1.00
IGL00781:Syne2	APN	12	76,070,836 (GRCm39)	missense	probably benign	0.00
IGL00823:Syne2	APN	12	76,036,016 (GRCm39)	missense	probably damaging	0.98
IGL01014:Syne2	APN	12	75,952,051 (GRCm39)	missense	probably damaging	0.99
IGL01074:Syne2	APN	12	76,078,361 (GRCm39)	nonsense	probably null
IGL01074:Syne2	APN	12	76,033,785 (GRCm39)	missense	probably benign	0.00
IGL01324:Syne2	APN	12	76,090,526 (GRCm39)	missense	probably damaging	1.00
IGL01325:Syne2	APN	12	75,973,288 (GRCm39)	missense	probably benign	0.01
IGL01331:Syne2	APN	12	75,976,027 (GRCm39)	splice site	probably benign
IGL01338:Syne2	APN	12	76,107,000 (GRCm39)	missense	possibly damaging	0.55
IGL01373:Syne2	APN	12	76,033,881 (GRCm39)	missense	probably damaging	1.00
IGL01446:Syne2	APN	12	76,088,149 (GRCm39)	missense	probably damaging	1.00
IGL01556:Syne2	APN	12	76,134,589 (GRCm39)	missense	probably damaging	1.00
IGL01585:Syne2	APN	12	75,995,834 (GRCm39)	critical splice acceptor site	probably null
IGL01629:Syne2	APN	12	76,051,377 (GRCm39)	missense	possibly damaging	0.49
IGL01686:Syne2	APN	12	75,956,110 (GRCm39)	missense	probably benign
IGL01935:Syne2	APN	12	75,972,087 (GRCm39)	missense	probably damaging	1.00
IGL01941:Syne2	APN	12	76,013,994 (GRCm39)	missense	probably benign	0.01
IGL01956:Syne2	APN	12	76,144,748 (GRCm39)	missense	probably damaging	1.00
IGL01967:Syne2	APN	12	75,988,077 (GRCm39)	missense	probably damaging	1.00
IGL01990:Syne2	APN	12	76,101,707 (GRCm39)	missense	probably damaging	1.00
IGL02000:Syne2	APN	12	76,062,419 (GRCm39)	missense	probably damaging	0.99
IGL02063:Syne2	APN	12	76,098,874 (GRCm39)	missense	probably damaging	0.96
IGL02069:Syne2	APN	12	75,974,186 (GRCm39)	missense	probably benign	0.13
IGL02120:Syne2	APN	12	75,993,480 (GRCm39)	missense	probably damaging	1.00
IGL02222:Syne2	APN	12	75,999,617 (GRCm39)	missense	probably damaging	0.96
IGL02223:Syne2	APN	12	76,155,079 (GRCm39)	missense	probably benign	0.00
IGL02321:Syne2	APN	12	75,965,773 (GRCm39)	missense	possibly damaging	0.58
IGL02488:Syne2	APN	12	76,012,512 (GRCm39)	missense	probably benign	0.24
IGL02491:Syne2	APN	12	76,118,953 (GRCm39)	missense	probably benign	0.10
IGL02525:Syne2	APN	12	76,147,777 (GRCm39)	missense	probably damaging	0.99
IGL02578:Syne2	APN	12	76,069,053 (GRCm39)	missense	possibly damaging	0.76
IGL02615:Syne2	APN	12	76,143,768 (GRCm39)	missense	probably damaging	1.00
IGL02702:Syne2	APN	12	76,144,698 (GRCm39)	missense	probably damaging	1.00
IGL02726:Syne2	APN	12	76,062,356 (GRCm39)	missense	probably damaging	0.99
IGL02795:Syne2	APN	12	76,013,323 (GRCm39)	missense	probably damaging	0.99
IGL02803:Syne2	APN	12	76,078,320 (GRCm39)	missense	probably damaging	1.00
IGL02814:Syne2	APN	12	75,992,150 (GRCm39)	missense	possibly damaging	0.64
IGL03013:Syne2	APN	12	75,976,111 (GRCm39)	missense	probably benign	0.00
IGL03131:Syne2	APN	12	76,104,264 (GRCm39)	missense	probably damaging	1.00
IGL03152:Syne2	APN	12	76,012,486 (GRCm39)	missense	probably benign	0.12
IGL03216:Syne2	APN	12	75,989,735 (GRCm39)	splice site	probably benign
IGL03228:Syne2	APN	12	76,026,686 (GRCm39)	missense	probably benign	0.01
IGL03259:Syne2	APN	12	76,035,853 (GRCm39)	missense	probably benign	0.05
IGL03374:Syne2	APN	12	76,121,360 (GRCm39)	missense	possibly damaging	0.66
IGL03375:Syne2	APN	12	75,972,209 (GRCm39)	missense	possibly damaging	0.57
3-1:Syne2	UTSW	12	75,977,406 (GRCm39)	missense	probably benign	0.02
B5639:Syne2	UTSW	12	75,976,564 (GRCm39)	missense	probably benign
K3955:Syne2	UTSW	12	75,977,439 (GRCm39)	missense	probably damaging	1.00
P0026:Syne2	UTSW	12	75,926,994 (GRCm39)	splice site	probably benign
PIT4514001:Syne2	UTSW	12	76,151,789 (GRCm39)	missense	probably damaging	0.99
R0089:Syne2	UTSW	12	76,010,650 (GRCm39)	missense	probably damaging	1.00
R0110:Syne2	UTSW	12	76,144,734 (GRCm39)	nonsense	probably null
R0113:Syne2	UTSW	12	76,080,496 (GRCm39)	missense	probably damaging	1.00
R0113:Syne2	UTSW	12	75,977,352 (GRCm39)	missense	probably damaging	1.00
R0141:Syne2	UTSW	12	75,988,072 (GRCm39)	missense	probably damaging	1.00
R0211:Syne2	UTSW	12	76,144,731 (GRCm39)	missense	probably damaging	1.00
R0219:Syne2	UTSW	12	76,088,778 (GRCm39)	missense	probably damaging	1.00
R0242:Syne2	UTSW	12	76,144,808 (GRCm39)	missense	probably damaging	1.00
R0242:Syne2	UTSW	12	76,144,808 (GRCm39)	missense	probably damaging	1.00
R0279:Syne2	UTSW	12	76,142,387 (GRCm39)	missense	probably damaging	1.00
R0319:Syne2	UTSW	12	76,110,936 (GRCm39)	missense	probably damaging	0.99
R0325:Syne2	UTSW	12	76,009,415 (GRCm39)	missense	probably benign	0.00
R0329:Syne2	UTSW	12	76,013,727 (GRCm39)	missense	probably benign
R0330:Syne2	UTSW	12	76,013,727 (GRCm39)	missense	probably benign
R0361:Syne2	UTSW	12	75,965,384 (GRCm39)	missense	probably benign	0.22
R0363:Syne2	UTSW	12	76,118,981 (GRCm39)	missense	probably damaging	0.98
R0367:Syne2	UTSW	12	75,926,951 (GRCm39)	missense	probably damaging	1.00
R0371:Syne2	UTSW	12	75,980,619 (GRCm39)	missense	probably damaging	1.00
R0374:Syne2	UTSW	12	75,968,000 (GRCm39)	nonsense	probably null
R0388:Syne2	UTSW	12	76,033,749 (GRCm39)	missense	probably benign	0.41
R0411:Syne2	UTSW	12	76,106,358 (GRCm39)	splice site	probably null
R0432:Syne2	UTSW	12	75,995,838 (GRCm39)	missense	probably damaging	0.99
R0469:Syne2	UTSW	12	75,900,923 (GRCm39)	critical splice donor site	probably null
R0492:Syne2	UTSW	12	76,028,837 (GRCm39)	critical splice donor site	probably null
R0496:Syne2	UTSW	12	76,085,714 (GRCm39)	missense	possibly damaging	0.80
R0504:Syne2	UTSW	12	76,080,365 (GRCm39)	splice site	probably benign
R0505:Syne2	UTSW	12	76,146,238 (GRCm39)	missense	probably damaging	1.00
R0510:Syne2	UTSW	12	75,900,923 (GRCm39)	critical splice donor site	probably null
R0518:Syne2	UTSW	12	76,155,636 (GRCm39)	critical splice acceptor site	probably null
R0539:Syne2	UTSW	12	76,070,895 (GRCm39)	missense	possibly damaging	0.69
R0552:Syne2	UTSW	12	75,977,778 (GRCm39)	missense	probably benign	0.00
R0557:Syne2	UTSW	12	75,976,075 (GRCm39)	missense	probably benign	0.04
R0567:Syne2	UTSW	12	75,937,004 (GRCm39)	missense	probably damaging	0.98
R0599:Syne2	UTSW	12	76,144,734 (GRCm39)	nonsense	probably null
R0602:Syne2	UTSW	12	76,144,734 (GRCm39)	nonsense	probably null
R0608:Syne2	UTSW	12	76,010,587 (GRCm39)	missense	probably damaging	1.00
R0614:Syne2	UTSW	12	75,959,127 (GRCm39)	splice site	probably null
R0636:Syne2	UTSW	12	75,977,757 (GRCm39)	missense	possibly damaging	0.75
R0647:Syne2	UTSW	12	75,934,977 (GRCm39)	missense	probably benign
R0654:Syne2	UTSW	12	76,144,734 (GRCm39)	nonsense	probably null
R0658:Syne2	UTSW	12	76,141,110 (GRCm39)	missense	probably damaging	1.00
R0666:Syne2	UTSW	12	75,969,787 (GRCm39)	missense	probably damaging	0.99
R0707:Syne2	UTSW	12	76,028,837 (GRCm39)	critical splice donor site	probably null
R0714:Syne2	UTSW	12	76,144,734 (GRCm39)	nonsense	probably null
R0841:Syne2	UTSW	12	76,121,209 (GRCm39)	splice site	probably benign
R0848:Syne2	UTSW	12	76,144,734 (GRCm39)	nonsense	probably null
R0848:Syne2	UTSW	12	76,144,733 (GRCm39)	frame shift	probably null
R1077:Syne2	UTSW	12	76,088,809 (GRCm39)	missense	possibly damaging	0.94
R1103:Syne2	UTSW	12	76,156,609 (GRCm39)	missense	probably benign	0.00
R1144:Syne2	UTSW	12	76,013,298 (GRCm39)	missense	probably benign	0.04
R1194:Syne2	UTSW	12	75,981,287 (GRCm39)	missense	probably damaging	1.00
R1247:Syne2	UTSW	12	76,014,264 (GRCm39)	missense	probably benign	0.39
R1276:Syne2	UTSW	12	75,987,963 (GRCm39)	critical splice acceptor site	probably null
R1343:Syne2	UTSW	12	76,080,417 (GRCm39)	missense	probably damaging	1.00
R1442:Syne2	UTSW	12	75,993,489 (GRCm39)	missense	probably damaging	1.00
R1448:Syne2	UTSW	12	76,098,952 (GRCm39)	missense	possibly damaging	0.56
R1448:Syne2	UTSW	12	76,067,099 (GRCm39)	splice site	probably null
R1522:Syne2	UTSW	12	76,150,557 (GRCm39)	missense	probably damaging	0.98
R1528:Syne2	UTSW	12	76,012,874 (GRCm39)	missense	probably benign	0.00
R1636:Syne2	UTSW	12	76,051,506 (GRCm39)	missense	probably benign	0.01
R1637:Syne2	UTSW	12	76,042,776 (GRCm39)	missense	probably damaging	1.00
R1650:Syne2	UTSW	12	75,951,033 (GRCm39)	nonsense	probably null
R1654:Syne2	UTSW	12	76,147,868 (GRCm39)	missense	possibly damaging	0.56
R1714:Syne2	UTSW	12	76,101,713 (GRCm39)	missense	probably benign	0.26
R1772:Syne2	UTSW	12	75,985,503 (GRCm39)	missense	probably benign	0.19
R1797:Syne2	UTSW	12	76,010,557 (GRCm39)	missense	probably benign	0.00
R1830:Syne2	UTSW	12	76,156,636 (GRCm39)	missense	probably damaging	1.00
R1837:Syne2	UTSW	12	76,014,434 (GRCm39)	missense	probably damaging	0.99
R1908:Syne2	UTSW	12	76,141,053 (GRCm39)	critical splice acceptor site	probably null
R1913:Syne2	UTSW	12	75,946,020 (GRCm39)	missense	possibly damaging	0.60
R1944:Syne2	UTSW	12	76,121,318 (GRCm39)	missense	probably damaging	1.00
R1950:Syne2	UTSW	12	75,999,644 (GRCm39)	missense	probably benign
R1958:Syne2	UTSW	12	76,016,319 (GRCm39)	missense	probably benign	0.11
R2018:Syne2	UTSW	12	76,121,353 (GRCm39)	missense	probably damaging	1.00
R2037:Syne2	UTSW	12	76,072,343 (GRCm39)	missense	probably benign	0.04
R2067:Syne2	UTSW	12	75,935,116 (GRCm39)	critical splice donor site	probably null
R2073:Syne2	UTSW	12	76,062,353 (GRCm39)	missense	possibly damaging	0.54
R2099:Syne2	UTSW	12	76,026,747 (GRCm39)	missense	probably benign	0.06
R2102:Syne2	UTSW	12	76,074,853 (GRCm39)	missense	probably benign	0.01
R2134:Syne2	UTSW	12	75,999,560 (GRCm39)	missense	probably damaging	0.99
R2135:Syne2	UTSW	12	75,999,560 (GRCm39)	missense	probably damaging	0.99
R2157:Syne2	UTSW	12	76,141,230 (GRCm39)	missense	probably damaging	1.00
R2173:Syne2	UTSW	12	76,147,763 (GRCm39)	splice site	probably benign
R2248:Syne2	UTSW	12	76,143,678 (GRCm39)	missense	probably damaging	1.00
R2276:Syne2	UTSW	12	75,974,240 (GRCm39)	missense	possibly damaging	0.87
R2277:Syne2	UTSW	12	75,974,240 (GRCm39)	missense	possibly damaging	0.87
R2278:Syne2	UTSW	12	75,974,240 (GRCm39)	missense	possibly damaging	0.87
R2279:Syne2	UTSW	12	75,974,240 (GRCm39)	missense	possibly damaging	0.87
R2483:Syne2	UTSW	12	76,142,311 (GRCm39)	missense	probably damaging	1.00
R2877:Syne2	UTSW	12	76,047,605 (GRCm39)	missense	probably benign	0.00
R2884:Syne2	UTSW	12	76,010,533 (GRCm39)	missense	probably benign	0.00
R3119:Syne2	UTSW	12	75,956,058 (GRCm39)	missense	probably benign	0.01
R3499:Syne2	UTSW	12	76,101,752 (GRCm39)	splice site	probably null
R3827:Syne2	UTSW	12	76,033,805 (GRCm39)	missense	probably benign	0.02
R3847:Syne2	UTSW	12	76,095,396 (GRCm39)	missense	probably damaging	1.00
R3849:Syne2	UTSW	12	76,092,839 (GRCm39)	nonsense	probably null
R3850:Syne2	UTSW	12	76,095,396 (GRCm39)	missense	probably damaging	1.00
R3859:Syne2	UTSW	12	75,976,558 (GRCm39)	missense	possibly damaging	0.55
R3861:Syne2	UTSW	12	76,013,253 (GRCm39)	missense	probably damaging	0.98
R4078:Syne2	UTSW	12	76,082,398 (GRCm39)	missense	probably damaging	1.00
R4116:Syne2	UTSW	12	75,977,853 (GRCm39)	missense	probably damaging	1.00
R4326:Syne2	UTSW	12	75,999,516 (GRCm39)	missense	probably damaging	1.00
R4335:Syne2	UTSW	12	76,074,866 (GRCm39)	missense	probably damaging	1.00
R4410:Syne2	UTSW	12	76,141,167 (GRCm39)	missense	probably damaging	1.00
R4412:Syne2	UTSW	12	76,152,834 (GRCm39)	missense	probably benign	0.01
R4444:Syne2	UTSW	12	76,069,804 (GRCm39)	missense	probably damaging	1.00
R4595:Syne2	UTSW	12	76,013,845 (GRCm39)	missense	possibly damaging	0.88
R4604:Syne2	UTSW	12	76,014,484 (GRCm39)	missense	probably damaging	0.99
R4606:Syne2	UTSW	12	76,036,027 (GRCm39)	missense	probably damaging	1.00
R4651:Syne2	UTSW	12	76,036,013 (GRCm39)	missense	probably damaging	0.99
R4656:Syne2	UTSW	12	76,078,147 (GRCm39)	missense	probably damaging	1.00
R4675:Syne2	UTSW	12	75,996,075 (GRCm39)	missense	probably damaging	1.00
R4790:Syne2	UTSW	12	76,067,165 (GRCm39)	missense	probably benign	0.19
R4791:Syne2	UTSW	12	75,956,018 (GRCm39)	missense	possibly damaging	0.96
R4799:Syne2	UTSW	12	75,945,941 (GRCm39)	missense	probably benign	0.04
R4836:Syne2	UTSW	12	76,026,593 (GRCm39)	missense	probably damaging	1.00
R4880:Syne2	UTSW	12	76,026,593 (GRCm39)	missense	probably damaging	1.00
R4881:Syne2	UTSW	12	76,026,593 (GRCm39)	missense	probably damaging	1.00
R4899:Syne2	UTSW	12	75,900,875 (GRCm39)	missense	probably benign	0.03
R4934:Syne2	UTSW	12	75,946,046 (GRCm39)	missense	probably benign	0.14
R4981:Syne2	UTSW	12	75,987,993 (GRCm39)	missense	probably damaging	0.98
R4996:Syne2	UTSW	12	75,990,724 (GRCm39)	missense	possibly damaging	0.87
R5056:Syne2	UTSW	12	75,955,905 (GRCm39)	unclassified	probably benign
R5066:Syne2	UTSW	12	76,013,325 (GRCm39)	missense	probably benign	0.05
R5095:Syne2	UTSW	12	75,999,600 (GRCm39)	missense	probably damaging	0.99
R5151:Syne2	UTSW	12	76,090,484 (GRCm39)	missense	probably benign	0.06
R5193:Syne2	UTSW	12	76,141,194 (GRCm39)	missense	probably damaging	1.00
R5267:Syne2	UTSW	12	75,985,515 (GRCm39)	missense	possibly damaging	0.74
R5288:Syne2	UTSW	12	76,146,112 (GRCm39)	missense	possibly damaging	0.94
R5402:Syne2	UTSW	12	76,106,213 (GRCm39)	missense	probably damaging	0.98
R5434:Syne2	UTSW	12	76,018,649 (GRCm39)	missense	probably damaging	1.00
R5441:Syne2	UTSW	12	76,035,917 (GRCm39)	missense	possibly damaging	0.75
R5488:Syne2	UTSW	12	75,934,946 (GRCm39)	missense	probably benign	0.13
R5497:Syne2	UTSW	12	75,927,163 (GRCm39)	missense	probably benign	0.19
R5506:Syne2	UTSW	12	75,985,495 (GRCm39)	missense	probably benign	0.01
R5509:Syne2	UTSW	12	75,968,018 (GRCm39)	missense	probably damaging	1.00
R5518:Syne2	UTSW	12	75,991,944 (GRCm39)	missense	possibly damaging	0.88
R5561:Syne2	UTSW	12	76,141,232 (GRCm39)	nonsense	probably null
R5581:Syne2	UTSW	12	75,991,859 (GRCm39)	missense	probably benign	0.01
R5625:Syne2	UTSW	12	76,141,886 (GRCm39)	missense	probably benign	0.06
R5642:Syne2	UTSW	12	75,965,306 (GRCm39)	missense	probably damaging	1.00
R5665:Syne2	UTSW	12	76,154,991 (GRCm39)	critical splice donor site	probably null
R5666:Syne2	UTSW	12	75,997,733 (GRCm39)	missense	probably benign	0.16
R5670:Syne2	UTSW	12	75,997,733 (GRCm39)	missense	probably benign	0.16
R5691:Syne2	UTSW	12	76,074,630 (GRCm39)	frame shift	probably null
R5696:Syne2	UTSW	12	76,040,919 (GRCm39)	missense	probably benign	0.00
R5720:Syne2	UTSW	12	76,014,441 (GRCm39)	missense	probably benign	0.03
R5739:Syne2	UTSW	12	76,044,239 (GRCm39)	missense	possibly damaging	0.53
R5840:Syne2	UTSW	12	75,927,065 (GRCm39)	splice site	probably null
R5846:Syne2	UTSW	12	76,074,898 (GRCm39)	missense	probably benign	0.01
R5850:Syne2	UTSW	12	76,144,749 (GRCm39)	missense	probably damaging	1.00
R5889:Syne2	UTSW	12	76,119,026 (GRCm39)	nonsense	probably null
R5912:Syne2	UTSW	12	75,955,721 (GRCm39)	critical splice donor site	probably null
R5931:Syne2	UTSW	12	76,055,639 (GRCm39)	missense	probably benign	0.37
R5985:Syne2	UTSW	12	76,012,933 (GRCm39)	missense	probably damaging	0.96
R5988:Syne2	UTSW	12	75,976,191 (GRCm39)	critical splice donor site	probably null
R5990:Syne2	UTSW	12	76,070,918 (GRCm39)	missense	probably benign	0.10
R6038:Syne2	UTSW	12	75,925,158 (GRCm39)	nonsense	probably null
R6038:Syne2	UTSW	12	75,925,158 (GRCm39)	nonsense	probably null
R6132:Syne2	UTSW	12	75,991,921 (GRCm39)	missense	probably benign	0.14
R6136:Syne2	UTSW	12	75,952,099 (GRCm39)	missense	probably benign	0.24
R6229:Syne2	UTSW	12	75,967,994 (GRCm39)	missense	probably benign	0.00
R6252:Syne2	UTSW	12	76,016,210 (GRCm39)	missense	probably benign	0.39
R6271:Syne2	UTSW	12	75,937,155 (GRCm39)	missense	probably damaging	1.00
R6320:Syne2	UTSW	12	76,108,424 (GRCm39)	missense	probably damaging	0.96
R6339:Syne2	UTSW	12	76,035,927 (GRCm39)	missense	probably benign	0.34
R6380:Syne2	UTSW	12	76,151,754 (GRCm39)	missense	probably damaging	0.98
R6394:Syne2	UTSW	12	76,037,269 (GRCm39)	missense	probably benign	0.09
R6419:Syne2	UTSW	12	76,143,740 (GRCm39)	missense	probably damaging	1.00
R6426:Syne2	UTSW	12	75,969,857 (GRCm39)	missense	probably null	0.97
R6434:Syne2	UTSW	12	76,088,230 (GRCm39)	missense	probably damaging	0.99
R6437:Syne2	UTSW	12	76,037,188 (GRCm39)	missense	possibly damaging	0.87
R6466:Syne2	UTSW	12	75,990,675 (GRCm39)	missense	probably damaging	0.97
R6501:Syne2	UTSW	12	76,074,621 (GRCm39)	splice site	probably null
R6552:Syne2	UTSW	12	75,937,015 (GRCm39)	missense	possibly damaging	0.89
R6744:Syne2	UTSW	12	76,121,221 (GRCm39)	missense	probably damaging	1.00
R6810:Syne2	UTSW	12	75,989,659 (GRCm39)	missense	probably benign	0.00
R6831:Syne2	UTSW	12	76,013,568 (GRCm39)	missense	probably benign	0.39
R6861:Syne2	UTSW	12	75,956,040 (GRCm39)	missense	probably damaging	1.00
R6875:Syne2	UTSW	12	76,082,404 (GRCm39)	missense	probably damaging	0.99
R6892:Syne2	UTSW	12	76,009,302 (GRCm39)	missense	probably damaging	0.98
R6899:Syne2	UTSW	12	76,142,503 (GRCm39)	splice site	probably null
R6906:Syne2	UTSW	12	76,042,760 (GRCm39)	missense	possibly damaging	0.93
R6909:Syne2	UTSW	12	76,110,969 (GRCm39)	missense	probably benign	0.04
R6925:Syne2	UTSW	12	75,900,906 (GRCm39)	missense	possibly damaging	0.58
R6949:Syne2	UTSW	12	76,012,771 (GRCm39)	missense	probably benign	0.00
R6952:Syne2	UTSW	12	75,974,205 (GRCm39)	missense	possibly damaging	0.76
R6996:Syne2	UTSW	12	76,074,786 (GRCm39)	missense	probably damaging	0.99
R7080:Syne2	UTSW	12	76,099,501 (GRCm39)	missense	probably benign	0.00
R7083:Syne2	UTSW	12	75,990,662 (GRCm39)	missense	probably damaging	1.00
R7090:Syne2	UTSW	12	75,989,125 (GRCm39)	missense	probably benign
R7144:Syne2	UTSW	12	76,052,152 (GRCm39)	missense	probably benign	0.03
R7154:Syne2	UTSW	12	76,106,231 (GRCm39)	missense	possibly damaging	0.63
R7177:Syne2	UTSW	12	76,018,654 (GRCm39)	nonsense	probably null
R7190:Syne2	UTSW	12	76,113,361 (GRCm39)	missense	probably benign	0.01
R7206:Syne2	UTSW	12	76,051,531 (GRCm39)	missense	probably benign	0.02
R7208:Syne2	UTSW	12	76,078,172 (GRCm39)	splice site	probably null
R7230:Syne2	UTSW	12	75,980,674 (GRCm39)	missense	probably benign	0.12
R7260:Syne2	UTSW	12	75,991,853 (GRCm39)	missense	probably damaging	1.00
R7272:Syne2	UTSW	12	76,095,417 (GRCm39)	missense	probably benign	0.00
R7296:Syne2	UTSW	12	76,149,810 (GRCm39)	missense	probably benign	0.00
R7322:Syne2	UTSW	12	76,030,798 (GRCm39)	missense	probably damaging	1.00
R7329:Syne2	UTSW	12	76,013,758 (GRCm39)	missense	probably benign	0.01
R7332:Syne2	UTSW	12	76,014,529 (GRCm39)	critical splice donor site	probably null
R7381:Syne2	UTSW	12	75,973,263 (GRCm39)	missense	probably benign	0.11
R7401:Syne2	UTSW	12	76,014,155 (GRCm39)	missense	probably damaging	0.98
R7403:Syne2	UTSW	12	75,962,020 (GRCm39)	missense	not run
R7429:Syne2	UTSW	12	76,087,184 (GRCm39)	nonsense	probably null
R7429:Syne2	UTSW	12	75,980,770 (GRCm39)	missense	probably damaging	1.00
R7430:Syne2	UTSW	12	76,087,184 (GRCm39)	nonsense	probably null
R7430:Syne2	UTSW	12	75,980,770 (GRCm39)	missense	probably damaging	1.00
R7438:Syne2	UTSW	12	76,062,337 (GRCm39)	missense	probably benign	0.04
R7447:Syne2	UTSW	12	76,074,853 (GRCm39)	missense	probably benign	0.01
R7466:Syne2	UTSW	12	76,092,960 (GRCm39)	missense	possibly damaging	0.92
R7493:Syne2	UTSW	12	76,012,654 (GRCm39)	missense	probably benign	0.00
R7502:Syne2	UTSW	12	76,141,100 (GRCm39)	missense	probably damaging	1.00
R7543:Syne2	UTSW	12	75,953,616 (GRCm39)	missense	possibly damaging	0.93
R7569:Syne2	UTSW	12	75,974,164 (GRCm39)	missense	probably benign	0.00
R7599:Syne2	UTSW	12	76,013,145 (GRCm39)	missense	probably benign	0.04
R7618:Syne2	UTSW	12	75,992,108 (GRCm39)	missense	probably benign	0.01
R7639:Syne2	UTSW	12	75,981,273 (GRCm39)	missense	probably damaging	1.00
R7698:Syne2	UTSW	12	75,995,838 (GRCm39)	missense	probably damaging	0.99
R7702:Syne2	UTSW	12	76,037,161 (GRCm39)	missense	probably benign	0.16
R7737:Syne2	UTSW	12	75,989,622 (GRCm39)	missense	probably damaging	1.00
R7742:Syne2	UTSW	12	76,106,209 (GRCm39)	missense	probably benign	0.02
R7753:Syne2	UTSW	12	76,085,697 (GRCm39)	missense	probably benign	0.43
R7755:Syne2	UTSW	12	76,044,181 (GRCm39)	missense	probably benign	0.19
R7757:Syne2	UTSW	12	76,108,553 (GRCm39)	missense	possibly damaging	0.87
R7790:Syne2	UTSW	12	75,975,877 (GRCm39)	splice site	probably null
R7808:Syne2	UTSW	12	76,030,501 (GRCm39)	splice site	probably null
R7809:Syne2	UTSW	12	76,014,230 (GRCm39)	missense	probably benign	0.00
R7811:Syne2	UTSW	12	76,030,501 (GRCm39)	splice site	probably null
R7834:Syne2	UTSW	12	76,014,021 (GRCm39)	missense	probably benign	0.00
R7853:Syne2	UTSW	12	76,078,278 (GRCm39)	missense	probably damaging	1.00
R7867:Syne2	UTSW	12	76,030,501 (GRCm39)	splice site	probably null
R7896:Syne2	UTSW	12	76,082,397 (GRCm39)	missense	probably damaging	0.99
R7903:Syne2	UTSW	12	76,110,958 (GRCm39)	missense	probably damaging	1.00
R7944:Syne2	UTSW	12	75,951,079 (GRCm39)	missense	probably damaging	0.98
R7945:Syne2	UTSW	12	75,951,079 (GRCm39)	missense	probably damaging	0.98
R7963:Syne2	UTSW	12	76,067,174 (GRCm39)	missense	probably benign	0.38
R7996:Syne2	UTSW	12	76,051,441 (GRCm39)	missense	probably damaging	1.00
R7998:Syne2	UTSW	12	76,134,632 (GRCm39)	missense	probably damaging	1.00
R8010:Syne2	UTSW	12	75,977,512 (GRCm39)	missense	probably benign	0.39
R8016:Syne2	UTSW	12	75,989,681 (GRCm39)	missense	probably benign	0.19
R8140:Syne2	UTSW	12	75,959,127 (GRCm39)	missense	possibly damaging	0.63
R8141:Syne2	UTSW	12	76,108,442 (GRCm39)	missense	possibly damaging	0.66
R8206:Syne2	UTSW	12	76,062,365 (GRCm39)	missense	probably benign	0.03
R8258:Syne2	UTSW	12	75,996,143 (GRCm39)	missense	possibly damaging	0.95
R8259:Syne2	UTSW	12	75,996,143 (GRCm39)	missense	possibly damaging	0.95
R8320:Syne2	UTSW	12	76,150,604 (GRCm39)	missense	probably damaging	0.99
R8464:Syne2	UTSW	12	76,012,546 (GRCm39)	missense	probably benign	0.39
R8465:Syne2	UTSW	12	75,900,898 (GRCm39)	missense	possibly damaging	0.92
R8486:Syne2	UTSW	12	76,088,881 (GRCm39)	nonsense	probably null
R8488:Syne2	UTSW	12	76,012,546 (GRCm39)	missense	probably benign	0.39
R8511:Syne2	UTSW	12	76,055,647 (GRCm39)	missense	probably benign	0.03
R8540:Syne2	UTSW	12	76,141,148 (GRCm39)	missense	probably damaging	1.00
R8711:Syne2	UTSW	12	76,104,258 (GRCm39)	missense	probably damaging	1.00
R8722:Syne2	UTSW	12	75,972,095 (GRCm39)	missense	probably benign	0.04
R8827:Syne2	UTSW	12	76,095,357 (GRCm39)	missense	probably benign	0.00
R8867:Syne2	UTSW	12	75,989,620 (GRCm39)	missense	probably damaging	1.00
R8878:Syne2	UTSW	12	75,952,067 (GRCm39)	missense	probably benign
R8924:Syne2	UTSW	12	75,943,444 (GRCm39)	missense	probably damaging	0.97
R8966:Syne2	UTSW	12	76,146,197 (GRCm39)	missense	probably damaging	1.00
R9007:Syne2	UTSW	12	76,146,224 (GRCm39)	missense	possibly damaging	0.82
R9019:Syne2	UTSW	12	75,999,618 (GRCm39)	missense	possibly damaging	0.93
R9057:Syne2	UTSW	12	75,937,167 (GRCm39)	missense	probably damaging	1.00
R9067:Syne2	UTSW	12	75,950,994 (GRCm39)	missense	probably damaging	1.00
R9081:Syne2	UTSW	12	76,016,290 (GRCm39)	nonsense	probably null
R9091:Syne2	UTSW	12	75,977,834 (GRCm39)	missense	probably damaging	1.00
R9123:Syne2	UTSW	12	76,040,838 (GRCm39)	missense	probably damaging	1.00
R9147:Syne2	UTSW	12	75,937,158 (GRCm39)	missense	probably damaging	1.00
R9148:Syne2	UTSW	12	75,937,158 (GRCm39)	missense	probably damaging	1.00
R9163:Syne2	UTSW	12	76,009,349 (GRCm39)	missense	possibly damaging	0.88
R9192:Syne2	UTSW	12	76,156,703 (GRCm39)	missense	probably damaging	1.00
R9248:Syne2	UTSW	12	76,154,230 (GRCm39)	intron	probably benign
R9270:Syne2	UTSW	12	75,977,834 (GRCm39)	missense	probably damaging	1.00
R9292:Syne2	UTSW	12	75,997,823 (GRCm39)	missense	probably benign
R9397:Syne2	UTSW	12	76,040,849 (GRCm39)	missense	possibly damaging	0.59
R9454:Syne2	UTSW	12	76,141,844 (GRCm39)	nonsense	probably null
R9454:Syne2	UTSW	12	76,067,275 (GRCm39)	missense	probably damaging	0.99
R9478:Syne2	UTSW	12	76,154,387 (GRCm39)	missense	probably damaging	0.96
R9492:Syne2	UTSW	12	75,995,839 (GRCm39)	missense	possibly damaging	0.77
R9573:Syne2	UTSW	12	75,927,134 (GRCm39)	missense	probably damaging	1.00
R9611:Syne2	UTSW	12	76,080,460 (GRCm39)	missense	probably benign	0.05
R9623:Syne2	UTSW	12	75,986,760 (GRCm39)	missense	probably benign	0.12
R9647:Syne2	UTSW	12	76,151,875 (GRCm39)	missense	possibly damaging	0.55
R9652:Syne2	UTSW	12	76,101,620 (GRCm39)	missense	probably benign	0.00
R9667:Syne2	UTSW	12	75,926,951 (GRCm39)	missense	probably damaging	1.00
R9701:Syne2	UTSW	12	76,037,197 (GRCm39)	missense	probably damaging	1.00
R9794:Syne2	UTSW	12	76,047,617 (GRCm39)	missense	probably benign	0.04
R9802:Syne2	UTSW	12	76,037,197 (GRCm39)	missense	probably damaging	1.00
X0019:Syne2	UTSW	12	76,020,061 (GRCm39)	missense	probably benign	0.41
X0026:Syne2	UTSW	12	76,147,790 (GRCm39)	missense	possibly damaging	0.78
X0061:Syne2	UTSW	12	75,974,285 (GRCm39)	critical splice donor site	probably null
X0066:Syne2	UTSW	12	76,143,701 (GRCm39)	missense	probably damaging	1.00
Z1176:Syne2	UTSW	12	76,087,157 (GRCm39)	missense	possibly damaging	0.48
Z1176:Syne2	UTSW	12	76,014,315 (GRCm39)	missense	probably benign	0.01
Z1177:Syne2	UTSW	12	76,020,197 (GRCm39)	missense	probably damaging	1.00
Z1177:Syne2	UTSW	12	76,144,748 (GRCm39)	missense	probably damaging	1.00
Z1177:Syne2	UTSW	12	76,110,912 (GRCm39)	missense	possibly damaging	0.51

Predicted Primers

PCR Primer
(F):5'- GAGGAAGGAATGTCTTGCCAGTCG -3'
(R):5'- ATGAAGCCATGTCACTGTGAAGGAG -3'

Sequencing Primer
(F):5'- ATTGTCCTGTAAGGTCTGCATC -3'
(R):5'- TCACTGTGAAGGAGGGAGAAG -3'

Posted On

2014-05-23