Incidental Mutation 'R0116:Mgam'
| ID |
20791 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mgam
|
| Ensembl Gene |
ENSMUSG00000068587 |
| Gene Name |
maltase-glucoamylase |
| Synonyms |
6030407P20Rik |
| MMRRC Submission |
038402-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.237)
|
| Stock # |
R0116 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
(trace)
|
| Chromosome |
6 |
| Chromosomal Location |
40605765-40746057 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 40635921 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Asparagine
at position 359
(Y359N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000143946
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000071535]
[ENSMUST00000201148]
[ENSMUST00000202636]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000071535
AA Change: Y359N
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000071466
Gene: ENSMUSG00000068587
AA Change: Y359N
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
12 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
47 |
59 |
N/A |
INTRINSIC |
|
PD
|
63 |
111 |
1.81e-8 |
SMART |
|
Pfam:NtCtMGAM_N
|
124 |
233 |
6.2e-36 |
PFAM |
|
Pfam:Glyco_hydro_31
|
323 |
795 |
3.4e-145 |
PFAM |
|
PD
|
924 |
977 |
4.52e-9 |
SMART |
|
Pfam:NtCtMGAM_N
|
988 |
1101 |
1.5e-30 |
PFAM |
|
Blast:ANK
|
1141 |
1171 |
1e-7 |
BLAST |
|
Pfam:Glyco_hydro_31
|
1189 |
1691 |
2e-139 |
PFAM |
|
low complexity region
|
1776 |
1791 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000201148
AA Change: Y359N
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000143946
Gene: ENSMUSG00000068587
AA Change: Y359N
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
12 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
47 |
59 |
N/A |
INTRINSIC |
|
PD
|
63 |
111 |
1.81e-8 |
SMART |
|
Pfam:NtCtMGAM_N
|
124 |
233 |
6.2e-36 |
PFAM |
|
Pfam:Glyco_hydro_31
|
323 |
795 |
3.4e-145 |
PFAM |
|
PD
|
924 |
977 |
4.52e-9 |
SMART |
|
Pfam:NtCtMGAM_N
|
988 |
1101 |
1.5e-30 |
PFAM |
|
Blast:ANK
|
1141 |
1171 |
1e-7 |
BLAST |
|
Pfam:Glyco_hydro_31
|
1189 |
1691 |
2e-139 |
PFAM |
|
low complexity region
|
1776 |
1791 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000202636
|
| SMART Domains |
Protein: ENSMUSP00000144652
Gene: ENSMUSG00000068587
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
10 |
22 |
N/A |
INTRINSIC |
|
Pfam:Trefoil
|
28 |
70 |
3.6e-12 |
PFAM |
|
Pfam:NtCtMGAM_N
|
87 |
196 |
1.4e-36 |
PFAM |
|
| Meta Mutation Damage Score |
0.5432 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.7%
- 20x: 94.2%
|
| Validation Efficiency |
94% (95/101) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes maltase-glucoamylase, which is a brush border membrane enzyme that plays a role in the final steps of digestion of starch. The protein has two catalytic sites identical to those of sucrase-isomaltase, but the proteins are only 59% homologous. Both are members of glycosyl hydrolase family 31, which has a variety of substrate specificities. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele display abnormalities in starch digestion and prandial glucose homeostasis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 95 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4931406C07Rik |
A |
T |
9: 15,202,066 (GRCm39) |
V152E |
probably damaging |
Het |
| Abca5 |
T |
G |
11: 110,167,331 (GRCm39) |
E1495A |
probably damaging |
Het |
| Abcc12 |
G |
A |
8: 87,261,627 (GRCm39) |
S668F |
probably benign |
Het |
| Adgrl4 |
A |
T |
3: 151,223,247 (GRCm39) |
T608S |
probably benign |
Het |
| Angel2 |
G |
A |
1: 190,673,187 (GRCm39) |
D255N |
probably benign |
Het |
| Apob |
T |
A |
12: 8,039,113 (GRCm39) |
|
probably benign |
Het |
| Arfgef2 |
A |
T |
2: 166,715,603 (GRCm39) |
R1349S |
probably damaging |
Het |
| Atp2b2 |
C |
T |
6: 113,770,656 (GRCm39) |
V418I |
probably damaging |
Het |
| Birc6 |
C |
A |
17: 74,930,741 (GRCm39) |
|
probably benign |
Het |
| Capn13 |
T |
A |
17: 73,658,519 (GRCm39) |
Y183F |
probably damaging |
Het |
| Cngb1 |
A |
G |
8: 95,987,266 (GRCm39) |
S352P |
probably damaging |
Het |
| Col6a3 |
A |
G |
1: 90,741,273 (GRCm39) |
S720P |
probably damaging |
Het |
| Cpa4 |
C |
T |
6: 30,579,657 (GRCm39) |
R155W |
probably damaging |
Het |
| Dapk1 |
A |
G |
13: 60,908,914 (GRCm39) |
I1176V |
probably benign |
Het |
| Dnah17 |
T |
C |
11: 117,949,132 (GRCm39) |
E2959G |
probably benign |
Het |
| Dnah7b |
T |
A |
1: 46,252,520 (GRCm39) |
I1734N |
possibly damaging |
Het |
| Dnajb7 |
A |
G |
15: 81,291,555 (GRCm39) |
Y261H |
probably benign |
Het |
| Dock2 |
T |
C |
11: 34,579,392 (GRCm39) |
|
probably benign |
Het |
| Dyrk3 |
A |
T |
1: 131,057,576 (GRCm39) |
V199E |
probably damaging |
Het |
| F2r |
G |
T |
13: 95,740,994 (GRCm39) |
C180* |
probably null |
Het |
| F5 |
A |
G |
1: 164,012,483 (GRCm39) |
S466G |
probably benign |
Het |
| Fbn2 |
A |
T |
18: 58,235,445 (GRCm39) |
C677* |
probably null |
Het |
| Fbxo41 |
A |
G |
6: 85,454,890 (GRCm39) |
S673P |
probably damaging |
Het |
| Fhad1 |
G |
T |
4: 141,667,406 (GRCm39) |
H639N |
probably benign |
Het |
| Fmnl3 |
G |
C |
15: 99,220,619 (GRCm39) |
|
probably benign |
Het |
| Foxa2 |
A |
G |
2: 147,885,481 (GRCm39) |
S270P |
probably damaging |
Het |
| Fxyd7 |
C |
T |
7: 30,746,793 (GRCm39) |
|
probably null |
Het |
| Gm5225 |
A |
G |
17: 24,243,032 (GRCm39) |
D67G |
probably benign |
Het |
| Grik3 |
G |
A |
4: 125,564,349 (GRCm39) |
E444K |
probably benign |
Het |
| Gsdma2 |
A |
G |
11: 98,540,009 (GRCm39) |
K44E |
probably damaging |
Het |
| Haus1 |
T |
A |
18: 77,849,770 (GRCm39) |
K130* |
probably null |
Het |
| Heg1 |
A |
G |
16: 33,556,028 (GRCm39) |
|
probably benign |
Het |
| Hormad2 |
A |
G |
11: 4,362,206 (GRCm39) |
|
probably benign |
Het |
| Hsd17b3 |
G |
A |
13: 64,206,403 (GRCm39) |
R300C |
possibly damaging |
Het |
| Irf5 |
T |
C |
6: 29,536,108 (GRCm39) |
F374S |
probably damaging |
Het |
| Itch |
A |
G |
2: 155,059,903 (GRCm39) |
|
probably benign |
Het |
| Jade2 |
A |
T |
11: 51,722,136 (GRCm39) |
L139Q |
probably damaging |
Het |
| Kif5c |
G |
A |
2: 49,642,251 (GRCm39) |
|
probably benign |
Het |
| Lama1 |
T |
C |
17: 68,083,918 (GRCm39) |
Y1387H |
probably benign |
Het |
| Larp4b |
A |
G |
13: 9,220,724 (GRCm39) |
R658G |
probably damaging |
Het |
| Mcph1 |
C |
T |
8: 18,838,264 (GRCm39) |
L729F |
probably benign |
Het |
| Me1 |
A |
T |
9: 86,536,720 (GRCm39) |
N118K |
probably benign |
Het |
| Med13 |
A |
G |
11: 86,210,723 (GRCm39) |
L473S |
probably damaging |
Het |
| Morc2b |
A |
G |
17: 33,356,015 (GRCm39) |
S586P |
probably damaging |
Het |
| Mthfr |
A |
G |
4: 148,135,980 (GRCm39) |
D310G |
probably benign |
Het |
| Mtmr7 |
A |
T |
8: 41,034,447 (GRCm39) |
|
probably benign |
Het |
| Mtus1 |
A |
G |
8: 41,451,514 (GRCm39) |
|
probably benign |
Het |
| Mus81 |
G |
T |
19: 5,536,552 (GRCm39) |
A138D |
probably damaging |
Het |
| Myom2 |
A |
T |
8: 15,167,633 (GRCm39) |
I1073F |
probably damaging |
Het |
| Nhsl1 |
A |
T |
10: 18,400,990 (GRCm39) |
K739* |
probably null |
Het |
| Nlrp4d |
T |
A |
7: 10,108,818 (GRCm39) |
K762N |
probably benign |
Het |
| Nrap |
T |
C |
19: 56,343,978 (GRCm39) |
Y724C |
probably damaging |
Het |
| Ogn |
A |
T |
13: 49,774,514 (GRCm39) |
Y219F |
possibly damaging |
Het |
| Or6c212 |
T |
A |
10: 129,558,846 (GRCm39) |
D189V |
probably damaging |
Het |
| Or8b56 |
T |
C |
9: 38,739,860 (GRCm39) |
L291P |
probably damaging |
Het |
| Or8g30 |
A |
T |
9: 39,230,160 (GRCm39) |
I250N |
probably damaging |
Het |
| Padi2 |
T |
C |
4: 140,653,550 (GRCm39) |
V180A |
probably benign |
Het |
| Papss2 |
C |
T |
19: 32,615,768 (GRCm39) |
R167* |
probably null |
Het |
| Pcbp2 |
T |
C |
15: 102,382,670 (GRCm39) |
|
probably benign |
Het |
| Per1 |
T |
A |
11: 68,992,706 (GRCm39) |
|
probably benign |
Het |
| Pik3ca |
T |
C |
3: 32,514,094 (GRCm39) |
I860T |
probably damaging |
Het |
| Pkdrej |
G |
A |
15: 85,701,746 (GRCm39) |
Q1397* |
probably null |
Het |
| Plce1 |
T |
C |
19: 38,710,265 (GRCm39) |
V1133A |
probably benign |
Het |
| Pnma8a |
T |
G |
7: 16,694,625 (GRCm39) |
V160G |
probably damaging |
Het |
| Prss12 |
T |
C |
3: 123,276,423 (GRCm39) |
C351R |
probably damaging |
Het |
| Qprt |
A |
T |
7: 126,708,269 (GRCm39) |
L54Q |
probably damaging |
Het |
| Raf1 |
C |
T |
6: 115,603,344 (GRCm39) |
S165N |
probably damaging |
Het |
| Rere |
A |
G |
4: 150,701,433 (GRCm39) |
N1271S |
probably benign |
Het |
| Rnasel |
T |
A |
1: 153,630,258 (GRCm39) |
L258H |
probably damaging |
Het |
| Ryr2 |
T |
C |
13: 11,724,807 (GRCm39) |
D2502G |
probably damaging |
Het |
| Ryr3 |
G |
A |
2: 112,633,510 (GRCm39) |
S2081L |
probably damaging |
Het |
| Sc5d |
G |
T |
9: 42,171,155 (GRCm39) |
Y11* |
probably null |
Het |
| Slc25a29 |
A |
C |
12: 108,793,017 (GRCm39) |
L187R |
possibly damaging |
Het |
| Slc2a7 |
G |
A |
4: 150,252,721 (GRCm39) |
V454M |
probably benign |
Het |
| Slco1b2 |
A |
T |
6: 141,615,114 (GRCm39) |
T340S |
probably benign |
Het |
| Smarcc1 |
A |
G |
9: 109,976,172 (GRCm39) |
N153S |
possibly damaging |
Het |
| Snx1 |
C |
A |
9: 65,995,821 (GRCm39) |
E516* |
probably null |
Het |
| Sptlc2 |
T |
C |
12: 87,403,454 (GRCm39) |
D115G |
probably benign |
Het |
| Stard9 |
A |
G |
2: 120,464,736 (GRCm39) |
N67S |
probably damaging |
Het |
| Styxl2 |
A |
C |
1: 165,927,270 (GRCm39) |
S781A |
probably benign |
Het |
| Swap70 |
G |
A |
7: 109,872,489 (GRCm39) |
R368H |
probably benign |
Het |
| Tcaf3 |
T |
C |
6: 42,568,284 (GRCm39) |
K691E |
probably benign |
Het |
| Tmco4 |
T |
C |
4: 138,781,231 (GRCm39) |
F465S |
probably damaging |
Het |
| Tmem245 |
A |
G |
4: 56,926,213 (GRCm39) |
S290P |
probably benign |
Het |
| Top2a |
T |
C |
11: 98,894,416 (GRCm39) |
T972A |
probably benign |
Het |
| Tpr |
T |
A |
1: 150,285,898 (GRCm39) |
S527R |
probably damaging |
Het |
| Traf2 |
T |
C |
2: 25,409,621 (GRCm39) |
D443G |
probably damaging |
Het |
| Trim40 |
A |
T |
17: 37,194,039 (GRCm39) |
|
probably null |
Het |
| Trim42 |
A |
T |
9: 97,245,456 (GRCm39) |
I448N |
possibly damaging |
Het |
| Ttll9 |
G |
A |
2: 152,825,054 (GRCm39) |
V78M |
probably damaging |
Het |
| Vav1 |
C |
T |
17: 57,603,039 (GRCm39) |
L88F |
probably damaging |
Het |
| Vps13b |
A |
G |
15: 35,423,301 (GRCm39) |
D207G |
probably damaging |
Het |
| Wdsub1 |
A |
G |
2: 59,707,009 (GRCm39) |
|
probably null |
Het |
| Zfp799 |
A |
G |
17: 33,040,009 (GRCm39) |
W85R |
possibly damaging |
Het |
| Zfp839 |
A |
T |
12: 110,825,203 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Mgam |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01024:Mgam
|
APN |
6 |
40,619,944 (GRCm39) |
missense |
probably benign |
|
|
IGL01065:Mgam
|
APN |
6 |
40,639,644 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01402:Mgam
|
APN |
6 |
40,621,879 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01404:Mgam
|
APN |
6 |
40,621,879 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01413:Mgam
|
APN |
6 |
40,638,211 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01546:Mgam
|
APN |
6 |
40,631,627 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01596:Mgam
|
APN |
6 |
40,635,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02133:Mgam
|
APN |
6 |
40,620,010 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02734:Mgam
|
APN |
6 |
40,639,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB002:Mgam
|
UTSW |
6 |
40,735,985 (GRCm39) |
missense |
probably damaging |
0.99 |
|
BB012:Mgam
|
UTSW |
6 |
40,735,985 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0012:Mgam
|
UTSW |
6 |
40,742,190 (GRCm39) |
splice site |
probably null |
|
|
R0310:Mgam
|
UTSW |
6 |
40,737,969 (GRCm39) |
splice site |
probably benign |
|
|
R0452:Mgam
|
UTSW |
6 |
40,736,024 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0497:Mgam
|
UTSW |
6 |
40,641,826 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0699:Mgam
|
UTSW |
6 |
40,619,953 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R0738:Mgam
|
UTSW |
6 |
40,731,869 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1033:Mgam
|
UTSW |
6 |
40,657,558 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1403:Mgam
|
UTSW |
6 |
40,643,815 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1403:Mgam
|
UTSW |
6 |
40,643,815 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1430:Mgam
|
UTSW |
6 |
40,733,305 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1432:Mgam
|
UTSW |
6 |
40,733,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1443:Mgam
|
UTSW |
6 |
40,736,714 (GRCm39) |
nonsense |
probably null |
|
|
R1470:Mgam
|
UTSW |
6 |
40,736,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1470:Mgam
|
UTSW |
6 |
40,736,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1519:Mgam
|
UTSW |
6 |
40,638,617 (GRCm39) |
missense |
probably benign |
0.45 |
|
R1654:Mgam
|
UTSW |
6 |
40,734,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1667:Mgam
|
UTSW |
6 |
40,653,978 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R1730:Mgam
|
UTSW |
6 |
40,641,794 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1781:Mgam
|
UTSW |
6 |
40,646,797 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1783:Mgam
|
UTSW |
6 |
40,641,794 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1829:Mgam
|
UTSW |
6 |
40,643,826 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1833:Mgam
|
UTSW |
6 |
40,631,652 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1872:Mgam
|
UTSW |
6 |
40,638,234 (GRCm39) |
nonsense |
probably null |
|
|
R1912:Mgam
|
UTSW |
6 |
40,741,119 (GRCm39) |
nonsense |
probably null |
|
|
R1977:Mgam
|
UTSW |
6 |
40,641,814 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2048:Mgam
|
UTSW |
6 |
40,633,363 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R2086:Mgam
|
UTSW |
6 |
40,737,962 (GRCm39) |
splice site |
probably null |
|
|
R2138:Mgam
|
UTSW |
6 |
40,733,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2224:Mgam
|
UTSW |
6 |
40,741,208 (GRCm39) |
splice site |
probably null |
|
|
R2408:Mgam
|
UTSW |
6 |
40,663,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2508:Mgam
|
UTSW |
6 |
40,736,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2842:Mgam
|
UTSW |
6 |
40,638,279 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2847:Mgam
|
UTSW |
6 |
40,629,649 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R2848:Mgam
|
UTSW |
6 |
40,629,649 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R2965:Mgam
|
UTSW |
6 |
40,745,154 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R2966:Mgam
|
UTSW |
6 |
40,745,154 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R3035:Mgam
|
UTSW |
6 |
40,640,464 (GRCm39) |
missense |
probably benign |
|
|
R3895:Mgam
|
UTSW |
6 |
40,736,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4027:Mgam
|
UTSW |
6 |
40,731,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4030:Mgam
|
UTSW |
6 |
40,731,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4302:Mgam
|
UTSW |
6 |
40,740,019 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4707:Mgam
|
UTSW |
6 |
40,691,566 (GRCm39) |
splice site |
probably null |
|
|
R4826:Mgam
|
UTSW |
6 |
40,657,582 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R4898:Mgam
|
UTSW |
6 |
40,619,988 (GRCm39) |
missense |
probably benign |
|
|
R5438:Mgam
|
UTSW |
6 |
40,661,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5492:Mgam
|
UTSW |
6 |
40,733,297 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5770:Mgam
|
UTSW |
6 |
40,646,738 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5839:Mgam
|
UTSW |
6 |
40,716,998 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5845:Mgam
|
UTSW |
6 |
40,652,257 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R5847:Mgam
|
UTSW |
6 |
40,660,989 (GRCm39) |
missense |
probably benign |
0.42 |
|
R5891:Mgam
|
UTSW |
6 |
40,721,282 (GRCm39) |
missense |
probably benign |
|
|
R6158:Mgam
|
UTSW |
6 |
40,734,648 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6193:Mgam
|
UTSW |
6 |
40,724,854 (GRCm39) |
nonsense |
probably null |
|
|
R6423:Mgam
|
UTSW |
6 |
40,653,979 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6706:Mgam
|
UTSW |
6 |
40,721,720 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6813:Mgam
|
UTSW |
6 |
40,727,099 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6863:Mgam
|
UTSW |
6 |
40,705,943 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6906:Mgam
|
UTSW |
6 |
40,724,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7091:Mgam
|
UTSW |
6 |
40,745,210 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7099:Mgam
|
UTSW |
6 |
40,638,650 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7282:Mgam
|
UTSW |
6 |
40,740,045 (GRCm39) |
missense |
probably benign |
|
|
R7282:Mgam
|
UTSW |
6 |
40,633,446 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7354:Mgam
|
UTSW |
6 |
40,721,732 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7374:Mgam
|
UTSW |
6 |
40,734,373 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7399:Mgam
|
UTSW |
6 |
40,643,788 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7406:Mgam
|
UTSW |
6 |
40,640,459 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7446:Mgam
|
UTSW |
6 |
40,723,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7466:Mgam
|
UTSW |
6 |
40,721,723 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7525:Mgam
|
UTSW |
6 |
40,742,954 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7530:Mgam
|
UTSW |
6 |
40,686,152 (GRCm39) |
splice site |
probably null |
|
|
R7570:Mgam
|
UTSW |
6 |
40,723,367 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7669:Mgam
|
UTSW |
6 |
40,635,944 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7679:Mgam
|
UTSW |
6 |
40,619,980 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7746:Mgam
|
UTSW |
6 |
40,645,127 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7859:Mgam
|
UTSW |
6 |
40,717,113 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7925:Mgam
|
UTSW |
6 |
40,735,985 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8206:Mgam
|
UTSW |
6 |
40,657,169 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8244:Mgam
|
UTSW |
6 |
40,727,520 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8309:Mgam
|
UTSW |
6 |
40,722,111 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8472:Mgam
|
UTSW |
6 |
40,671,460 (GRCm39) |
splice site |
probably null |
|
|
R8758:Mgam
|
UTSW |
6 |
40,705,977 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8777:Mgam
|
UTSW |
6 |
40,632,185 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8777-TAIL:Mgam
|
UTSW |
6 |
40,632,185 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8783:Mgam
|
UTSW |
6 |
40,633,423 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8939:Mgam
|
UTSW |
6 |
40,740,137 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8968:Mgam
|
UTSW |
6 |
40,734,745 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8987:Mgam
|
UTSW |
6 |
40,706,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9055:Mgam
|
UTSW |
6 |
40,691,663 (GRCm39) |
intron |
probably benign |
|
|
R9171:Mgam
|
UTSW |
6 |
40,745,146 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R9252:Mgam
|
UTSW |
6 |
40,706,577 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9258:Mgam
|
UTSW |
6 |
40,657,121 (GRCm39) |
missense |
probably benign |
|
|
R9262:Mgam
|
UTSW |
6 |
40,723,422 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9287:Mgam
|
UTSW |
6 |
40,705,905 (GRCm39) |
intron |
probably benign |
|
|
R9521:Mgam
|
UTSW |
6 |
40,722,118 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9589:Mgam
|
UTSW |
6 |
40,727,519 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9658:Mgam
|
UTSW |
6 |
40,721,311 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9784:Mgam
|
UTSW |
6 |
40,736,024 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF011:Mgam
|
UTSW |
6 |
40,734,370 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF020:Mgam
|
UTSW |
6 |
40,662,243 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF023:Mgam
|
UTSW |
6 |
40,657,642 (GRCm39) |
missense |
probably benign |
|
|
X0021:Mgam
|
UTSW |
6 |
40,635,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Mgam
|
UTSW |
6 |
40,619,994 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1176:Mgam
|
UTSW |
6 |
40,706,000 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Mgam
|
UTSW |
6 |
40,654,578 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1177:Mgam
|
UTSW |
6 |
40,717,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAAGATACCCCGAATGTAGCCATACTCT -3'
(R):5'- AGCACCATTTCCCACTGAAAGAAACT -3'
Sequencing Primer
(F):5'- tcagtgattccaagttcaatgtaag -3'
(R):5'- CCCTCCTTGGATTTCAGGAAACT -3'
|
| Posted On |
2013-04-11 |
Incidental Mutation