Incidental Mutation 'R1648:Gpr155'
ID 265927
Institutional Source Beutler Lab
Gene Symbol Gpr155
Ensembl Gene ENSMUSG00000041762
Gene Name G protein-coupled receptor 155
Synonyms DEPDC3, 1110017O10Rik, PGR22, F730029F15Rik
MMRRC Submission 039684-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1648 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 73171850-73216842 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 73194508 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000076463] [ENSMUST00000112043] [ENSMUST00000112043] [ENSMUST00000112044] [ENSMUST00000112044]
AlphaFold A2AWR3
Predicted Effect noncoding transcript
Transcript: ENSMUST00000048504
SMART Domains Protein: ENSMUSP00000037772
Gene: ENSMUSG00000041762

DomainStartEndE-ValueType
Pfam:Mem_trans 40 205 1.9e-16 PFAM
Pfam:Mem_trans 187 360 4.9e-12 PFAM
transmembrane domain 380 402 N/A INTRINSIC
transmembrane domain 415 432 N/A INTRINSIC
transmembrane domain 442 464 N/A INTRINSIC
transmembrane domain 477 499 N/A INTRINSIC
transmembrane domain 519 538 N/A INTRINSIC
transmembrane domain 657 679 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000076463
SMART Domains Protein: ENSMUSP00000075788
Gene: ENSMUSG00000041762

DomainStartEndE-ValueType
Pfam:Mem_trans 40 205 3.3e-15 PFAM
transmembrane domain 209 231 N/A INTRINSIC
transmembrane domain 241 260 N/A INTRINSIC
transmembrane domain 272 291 N/A INTRINSIC
transmembrane domain 311 330 N/A INTRINSIC
transmembrane domain 343 365 N/A INTRINSIC
transmembrane domain 380 402 N/A INTRINSIC
transmembrane domain 415 432 N/A INTRINSIC
transmembrane domain 442 464 N/A INTRINSIC
transmembrane domain 477 499 N/A INTRINSIC
transmembrane domain 519 538 N/A INTRINSIC
transmembrane domain 657 679 N/A INTRINSIC
transmembrane domain 689 711 N/A INTRINSIC
DEP 759 833 8.28e-12 SMART
Predicted Effect probably null
Transcript: ENSMUST00000112043
SMART Domains Protein: ENSMUSP00000107674
Gene: ENSMUSG00000041762

DomainStartEndE-ValueType
Pfam:Mem_trans 40 205 3.3e-15 PFAM
transmembrane domain 209 231 N/A INTRINSIC
transmembrane domain 241 260 N/A INTRINSIC
transmembrane domain 272 291 N/A INTRINSIC
transmembrane domain 311 330 N/A INTRINSIC
transmembrane domain 343 365 N/A INTRINSIC
transmembrane domain 380 402 N/A INTRINSIC
transmembrane domain 415 432 N/A INTRINSIC
transmembrane domain 442 464 N/A INTRINSIC
transmembrane domain 477 499 N/A INTRINSIC
transmembrane domain 519 538 N/A INTRINSIC
transmembrane domain 657 679 N/A INTRINSIC
transmembrane domain 689 711 N/A INTRINSIC
DEP 759 833 8.28e-12 SMART
Predicted Effect probably null
Transcript: ENSMUST00000112043
SMART Domains Protein: ENSMUSP00000107674
Gene: ENSMUSG00000041762

DomainStartEndE-ValueType
Pfam:Mem_trans 40 205 3.3e-15 PFAM
transmembrane domain 209 231 N/A INTRINSIC
transmembrane domain 241 260 N/A INTRINSIC
transmembrane domain 272 291 N/A INTRINSIC
transmembrane domain 311 330 N/A INTRINSIC
transmembrane domain 343 365 N/A INTRINSIC
transmembrane domain 380 402 N/A INTRINSIC
transmembrane domain 415 432 N/A INTRINSIC
transmembrane domain 442 464 N/A INTRINSIC
transmembrane domain 477 499 N/A INTRINSIC
transmembrane domain 519 538 N/A INTRINSIC
transmembrane domain 657 679 N/A INTRINSIC
transmembrane domain 689 711 N/A INTRINSIC
DEP 759 833 8.28e-12 SMART
Predicted Effect probably null
Transcript: ENSMUST00000112044
SMART Domains Protein: ENSMUSP00000107675
Gene: ENSMUSG00000041762

DomainStartEndE-ValueType
Pfam:Mem_trans 40 205 3.3e-15 PFAM
Pfam:Mem_trans 187 360 8.3e-11 PFAM
transmembrane domain 382 404 N/A INTRINSIC
transmembrane domain 414 436 N/A INTRINSIC
transmembrane domain 449 471 N/A INTRINSIC
transmembrane domain 491 510 N/A INTRINSIC
transmembrane domain 629 651 N/A INTRINSIC
transmembrane domain 661 683 N/A INTRINSIC
DEP 731 805 8.28e-12 SMART
Predicted Effect probably null
Transcript: ENSMUST00000112044
SMART Domains Protein: ENSMUSP00000107675
Gene: ENSMUSG00000041762

DomainStartEndE-ValueType
Pfam:Mem_trans 40 205 3.3e-15 PFAM
Pfam:Mem_trans 187 360 8.3e-11 PFAM
transmembrane domain 382 404 N/A INTRINSIC
transmembrane domain 414 436 N/A INTRINSIC
transmembrane domain 449 471 N/A INTRINSIC
transmembrane domain 491 510 N/A INTRINSIC
transmembrane domain 629 651 N/A INTRINSIC
transmembrane domain 661 683 N/A INTRINSIC
DEP 731 805 8.28e-12 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129184
Predicted Effect probably null
Transcript: ENSMUST00000131430
SMART Domains Protein: ENSMUSP00000114294
Gene: ENSMUSG00000041762

DomainStartEndE-ValueType
transmembrane domain 98 120 N/A INTRINSIC
transmembrane domain 130 152 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000184503
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150705
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 95.9%
  • 20x: 91.4%
Validation Efficiency 95% (73/77)
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik A G 3: 137,775,181 (GRCm39) N1457D probably benign Het
Adgb A G 10: 10,271,115 (GRCm39) F817L probably damaging Het
Akap6 A T 12: 53,188,789 (GRCm39) K2068* probably null Het
Alms1 T C 6: 85,655,384 (GRCm39) L3310P probably damaging Het
Ankrd27 T A 7: 35,303,278 (GRCm39) D219E probably benign Het
Atp10a T C 7: 58,434,575 (GRCm39) V283A probably damaging Het
Atp11a C T 8: 12,897,495 (GRCm39) S270L probably damaging Het
Casp3 T C 8: 47,091,109 (GRCm39) S254P probably benign Het
Cep104 G A 4: 154,063,553 (GRCm39) probably null Het
Cep170b C T 12: 112,702,806 (GRCm39) T423I probably damaging Het
Cfap58 A G 19: 47,943,844 (GRCm39) E348G probably benign Het
Chd6 A G 2: 160,883,978 (GRCm39) L89S probably damaging Het
Cyp2a22 T C 7: 26,631,793 (GRCm39) S488G probably damaging Het
D130040H23Rik C A 8: 69,755,633 (GRCm39) H363Q probably benign Het
Dcaf7 T A 11: 105,942,628 (GRCm39) F192I probably damaging Het
Ddx20 T C 3: 105,586,504 (GRCm39) I614V probably benign Het
Ehbp1 G A 11: 22,046,000 (GRCm39) T558I probably damaging Het
Eif2ak3 T A 6: 70,860,615 (GRCm39) V397D possibly damaging Het
Eif2b5 T C 16: 20,321,335 (GRCm39) V296A possibly damaging Het
Esr1 A G 10: 4,951,260 (GRCm39) E546G possibly damaging Het
Fras1 T A 5: 96,874,472 (GRCm39) probably null Het
G930045G22Rik T C 6: 50,823,698 (GRCm39) noncoding transcript Het
Gemin5 A T 11: 58,038,805 (GRCm39) L568* probably null Het
Gm22697+Rbm27 AGGTCCAGGCCCAGGCCCTGGTCCTGGCCCTGGCCCTGGTCCCGGCCCAGGCCC AGGTCCCGGCCCAGGCCC 18: 42,434,948 (GRCm39) probably benign Het
Has1 A G 17: 18,070,247 (GRCm39) Y225H probably damaging Het
Hk3 A G 13: 55,162,274 (GRCm39) F110S probably damaging Het
Iars1 A G 13: 49,876,478 (GRCm39) K848E possibly damaging Het
Kif17 A G 4: 137,997,206 (GRCm39) Y43C probably damaging Het
Kif20b A T 19: 34,914,190 (GRCm39) T355S possibly damaging Het
Kif21a T C 15: 90,878,570 (GRCm39) T237A probably damaging Het
Klc1 T C 12: 111,743,321 (GRCm39) L216P probably damaging Het
Krt7 A C 15: 101,310,448 (GRCm39) S32R probably damaging Het
Lama3 A G 18: 12,665,256 (GRCm39) D2330G possibly damaging Het
Limch1 T A 5: 67,156,599 (GRCm39) S511R probably damaging Het
Luzp2 T A 7: 54,914,018 (GRCm39) probably null Het
Macc1 T C 12: 119,410,156 (GRCm39) M308T probably benign Het
Mroh9 T G 1: 162,873,625 (GRCm39) E510A probably damaging Het
Myo1h G T 5: 114,474,336 (GRCm39) L458F probably damaging Het
Neto1 A T 18: 86,518,179 (GRCm39) Y528F probably damaging Het
Nlrp9b T A 7: 19,760,469 (GRCm39) C187S possibly damaging Het
Nup160 T C 2: 90,540,432 (GRCm39) Y854H probably damaging Het
Odc1 T C 12: 17,598,538 (GRCm39) probably benign Het
Or10a3n A G 7: 108,492,972 (GRCm39) I214T probably damaging Het
Or51a10 A G 7: 103,699,376 (GRCm39) Y62H probably damaging Het
Or5an10 T A 19: 12,276,023 (GRCm39) I158L probably benign Het
Plcb2 A T 2: 118,554,261 (GRCm39) M64K possibly damaging Het
Plcxd3 A T 15: 4,405,291 (GRCm39) I33F probably benign Het
Postn A G 3: 54,283,522 (GRCm39) T534A probably damaging Het
Prkd2 T A 7: 16,591,732 (GRCm39) F588I possibly damaging Het
Prrg4 C A 2: 104,663,088 (GRCm39) A173S probably benign Het
Rinl C T 7: 28,497,057 (GRCm39) A519V probably damaging Het
Rpgrip1l A C 8: 91,979,517 (GRCm39) V975G probably damaging Het
Rps6ka4 C A 19: 6,816,730 (GRCm39) V118L probably benign Het
Rtkn T C 6: 83,112,975 (GRCm39) S16P probably damaging Het
Sbspon C A 1: 15,953,983 (GRCm39) R99L probably damaging Het
Sdf4 G A 4: 156,083,886 (GRCm39) A119T probably damaging Het
Sgpp1 T A 12: 75,762,990 (GRCm39) H397L possibly damaging Het
Shc2 T A 10: 79,461,945 (GRCm39) M367L probably benign Het
Slc26a5 T A 5: 22,018,974 (GRCm39) K590* probably null Het
Slc39a12 T C 2: 14,456,803 (GRCm39) V597A probably benign Het
Smcp A T 3: 92,491,788 (GRCm39) C20S unknown Het
Tdrd6 A C 17: 43,938,000 (GRCm39) V1016G possibly damaging Het
Tmem132c T A 5: 127,540,120 (GRCm39) probably benign Het
Tmem170b A T 13: 41,759,738 (GRCm39) Q16L probably null Het
Tmem30a A G 9: 79,700,311 (GRCm39) F61S probably damaging Het
Tnfsf13b T C 8: 10,081,534 (GRCm39) M232T probably damaging Het
Trip11 T A 12: 101,850,651 (GRCm39) K853* probably null Het
Tusc3 C A 8: 39,513,721 (GRCm39) S64* probably null Het
Vmn2r111 A T 17: 22,788,042 (GRCm39) D436E probably benign Het
Zfp607a T C 7: 27,578,493 (GRCm39) V521A probably benign Het
Zfp704 A T 3: 9,536,099 (GRCm39) S140R probably damaging Het
Other mutations in Gpr155
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00731:Gpr155 APN 2 73,192,957 (GRCm39) missense probably damaging 1.00
IGL01432:Gpr155 APN 2 73,182,229 (GRCm39) missense possibly damaging 0.51
IGL01528:Gpr155 APN 2 73,192,767 (GRCm39) critical splice donor site probably null
IGL01718:Gpr155 APN 2 73,212,576 (GRCm39) missense probably benign
IGL01733:Gpr155 APN 2 73,183,956 (GRCm39) splice site probably null
IGL03342:Gpr155 APN 2 73,180,022 (GRCm39) missense probably damaging 1.00
PIT1430001:Gpr155 UTSW 2 73,200,482 (GRCm39) missense probably benign 0.08
PIT4810001:Gpr155 UTSW 2 73,178,607 (GRCm39) missense probably benign 0.08
R0226:Gpr155 UTSW 2 73,197,936 (GRCm39) missense probably benign 0.02
R0399:Gpr155 UTSW 2 73,200,346 (GRCm39) missense possibly damaging 0.91
R0445:Gpr155 UTSW 2 73,200,488 (GRCm39) splice site probably benign
R1570:Gpr155 UTSW 2 73,200,382 (GRCm39) missense possibly damaging 0.87
R1598:Gpr155 UTSW 2 73,200,434 (GRCm39) missense probably damaging 0.98
R1647:Gpr155 UTSW 2 73,194,508 (GRCm39) splice site probably null
R1756:Gpr155 UTSW 2 73,197,921 (GRCm39) missense probably benign 0.00
R1760:Gpr155 UTSW 2 73,212,279 (GRCm39) missense probably damaging 1.00
R2033:Gpr155 UTSW 2 73,178,526 (GRCm39) missense probably benign 0.18
R2044:Gpr155 UTSW 2 73,203,977 (GRCm39) missense probably damaging 1.00
R2145:Gpr155 UTSW 2 73,187,002 (GRCm39) missense probably benign 0.01
R2172:Gpr155 UTSW 2 73,212,471 (GRCm39) missense probably benign 0.00
R2274:Gpr155 UTSW 2 73,178,479 (GRCm39) critical splice donor site probably null
R3878:Gpr155 UTSW 2 73,198,736 (GRCm39) nonsense probably null
R3924:Gpr155 UTSW 2 73,200,420 (GRCm39) missense probably damaging 1.00
R4910:Gpr155 UTSW 2 73,197,882 (GRCm39) nonsense probably null
R4950:Gpr155 UTSW 2 73,212,529 (GRCm39) missense probably benign
R5337:Gpr155 UTSW 2 73,178,592 (GRCm39) missense probably benign 0.32
R5830:Gpr155 UTSW 2 73,200,433 (GRCm39) missense possibly damaging 0.93
R5887:Gpr155 UTSW 2 73,174,062 (GRCm39) nonsense probably null
R5929:Gpr155 UTSW 2 73,204,011 (GRCm39) nonsense probably null
R6293:Gpr155 UTSW 2 73,204,341 (GRCm39) missense possibly damaging 0.47
R6553:Gpr155 UTSW 2 73,179,989 (GRCm39) missense probably damaging 1.00
R6585:Gpr155 UTSW 2 73,179,989 (GRCm39) missense probably damaging 1.00
R7003:Gpr155 UTSW 2 73,173,961 (GRCm39) missense probably damaging 0.99
R7353:Gpr155 UTSW 2 73,197,835 (GRCm39) nonsense probably null
R7506:Gpr155 UTSW 2 73,198,683 (GRCm39) missense probably damaging 0.97
R7631:Gpr155 UTSW 2 73,213,291 (GRCm39) intron probably benign
R7753:Gpr155 UTSW 2 73,212,550 (GRCm39) missense probably benign 0.27
R7810:Gpr155 UTSW 2 73,212,296 (GRCm39) missense probably damaging 0.99
R7813:Gpr155 UTSW 2 73,212,329 (GRCm39) nonsense probably null
R7815:Gpr155 UTSW 2 73,192,904 (GRCm39) missense probably benign
R7873:Gpr155 UTSW 2 73,173,934 (GRCm39) missense possibly damaging 0.51
R8506:Gpr155 UTSW 2 73,173,806 (GRCm39) missense probably damaging 0.99
R8680:Gpr155 UTSW 2 73,174,039 (GRCm39) missense probably damaging 0.99
R8856:Gpr155 UTSW 2 73,203,993 (GRCm39) missense probably benign 0.27
R8872:Gpr155 UTSW 2 73,197,936 (GRCm39) missense probably benign 0.02
R9116:Gpr155 UTSW 2 73,204,109 (GRCm39) missense possibly damaging 0.78
R9683:Gpr155 UTSW 2 73,192,780 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AAGGCTGAGTCAATGCTGTCTCCG -3'
(R):5'- ATCGAAACATGCAGGGTCTCTCAC -3'

Sequencing Primer
(F):5'- TTTCCAGTTATCAGAAGCACGC -3'
(R):5'- TCTCTCACAGAGTAAAGTGCTGC -3'
Posted On 2015-02-05