Mutagenetix > Incidental Mutation

Incidental Mutation 'R7135:Wdr11'

553001

Institutional Source

Beutler Lab

Gene Symbol

Wdr11

Ensembl Gene

ENSMUSG00000042055

Gene Name

WD repeat domain 11

Synonyms

Wdr11, Brwd2, 2900055P10Rik

MMRRC Submission

045247-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.245) question?

Stock #

R7135 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

129193587-129237462 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 129229830 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 872 (S872P)

Ref Sequence

ENSEMBL: ENSMUSP00000081567 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000084519]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000084519
AA Change: S872P

PolyPhen 2 Score 0.764 (Sensitivity: 0.85; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000081567
Gene: ENSMUSG00000042055
AA Change: S872P

Domain	Start	End	E-Value	Type
WD40	50	99	2e-1	SMART
WD40	102	145	2.84e2	SMART
low complexity region	189	200	N/A	INTRINSIC
low complexity region	213	227	N/A	INTRINSIC
low complexity region	454	465	N/A	INTRINSIC
WD40	552	595	4.42e1	SMART
WD40	696	735	1.66e0	SMART
WD40	737	777	1.43e1	SMART
WD40	780	821	1.38e1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000136560

Predicted Effect

probably benign
Transcript: ENSMUST00000148752

Meta Mutation Damage Score

0.0757

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.1%

Validation Efficiency

100% (83/83)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 86 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aars2	T	A	17: 45,819,887 (GRCm39)	Y221*	probably null	Het
AC166344.1	T	A	14: 43,158,245 (GRCm39)	F97I		Het
Ankmy2	T	C	12: 36,246,311 (GRCm39)	S412P	probably benign	Het
Ap1s3	T	C	1: 79,586,919 (GRCm39)	T144A	probably benign	Het
Armh2	T	C	13: 24,925,489 (GRCm39)	S78P	probably benign	Het
Asb3	T	A	11: 30,948,501 (GRCm39)	L59*	probably null	Het
Asxl3	G	T	18: 22,650,758 (GRCm39)	G916*	probably null	Het
Asxl3	G	C	18: 22,650,759 (GRCm39)	G916A	probably damaging	Het
Birc2	A	C	9: 7,818,762 (GRCm39)	F610V	probably damaging	Het
Camk4	G	A	18: 33,240,996 (GRCm39)		probably null	Het
Ccdc162	A	G	10: 41,549,855 (GRCm39)	S343P	probably benign	Het
Ccnk	T	A	12: 108,152,734 (GRCm39)	L17Q	probably damaging	Het
Cd59b	G	A	2: 103,914,792 (GRCm39)	W63*	probably null	Het
Chrm3	C	T	13: 9,927,837 (GRCm39)	V400I	probably benign	Het
Crb1	C	A	1: 139,171,105 (GRCm39)	V762F	probably damaging	Het
Cspp1	C	T	1: 10,159,161 (GRCm39)	T529I	possibly damaging	Het
Cttnbp2	A	G	6: 18,448,446 (GRCm39)	I71T	possibly damaging	Het
Cyb561	C	A	11: 105,826,393 (GRCm39)	G90V	probably damaging	Het
Cyld	T	A	8: 89,471,520 (GRCm39)	D804E	possibly damaging	Het
Ddx31	G	A	2: 28,738,318 (GRCm39)	V160I	probably benign	Het
Dgkg	T	C	16: 22,319,132 (GRCm39)	D643G	probably damaging	Het
Dnah12	G	A	14: 26,500,869 (GRCm39)		probably null	Het
Dnah12	T	G	14: 26,523,370 (GRCm39)	I1953S	probably damaging	Het
Dnah7b	T	C	1: 46,178,870 (GRCm39)	W848R	probably damaging	Het
Dnah7c	C	T	1: 46,572,368 (GRCm39)	T947M	probably damaging	Het
Dnmt3c	C	A	2: 153,556,872 (GRCm39)		probably null	Het
Dsp	A	T	13: 38,363,049 (GRCm39)	Y443F	probably damaging	Het
Espl1	T	A	15: 102,227,959 (GRCm39)	C1603*	probably null	Het
Faiml	G	T	9: 99,116,496 (GRCm39)	R65S	probably benign	Het
Gfpt2	T	C	11: 49,695,782 (GRCm39)	I4T	probably damaging	Het
Gm10376	T	A	14: 42,867,950 (GRCm39)	M179L	probably benign	Het
Gm4302	T	A	10: 100,177,589 (GRCm39)	M291K	unknown	Het
Gnb1l	T	A	16: 18,363,918 (GRCm39)	D154E	probably benign	Het
Igkv10-94	T	C	6: 68,681,727 (GRCm39)	R38G	possibly damaging	Het
Inmt	A	T	6: 55,148,013 (GRCm39)	Y205*	probably null	Het
Krba1	A	G	6: 48,393,233 (GRCm39)	Q1049R	probably benign	Het
Lpxn	T	A	19: 12,810,683 (GRCm39)	C376S	probably damaging	Het
Lrrc52	T	A	1: 167,294,019 (GRCm39)	I89F	probably damaging	Het
Map9	A	T	3: 82,270,765 (GRCm39)	T110S	probably benign	Het
Mccc1	T	C	3: 36,049,967 (GRCm39)	Y75C	probably damaging	Het
Mff	T	A	1: 82,724,812 (GRCm39)	L203*	probably null	Het
Micall1	C	A	15: 78,993,624 (GRCm39)	D47E	unknown	Het
Mink1	T	C	11: 70,494,329 (GRCm39)	F243S	probably damaging	Het
Mlycd	C	T	8: 120,129,216 (GRCm39)	R228W	probably damaging	Het
Msr1	A	T	8: 40,042,465 (GRCm39)	V370E	possibly damaging	Het
Naip6	T	C	13: 100,436,927 (GRCm39)	E532G	probably damaging	Het
Nepn	G	A	10: 52,267,815 (GRCm39)	C27Y	probably damaging	Het
Ninl	T	C	2: 150,797,524 (GRCm39)	H592R	probably benign	Het
Nr4a2	A	G	2: 57,002,261 (GRCm39)	M64T	possibly damaging	Het
Oprm1	A	T	10: 6,780,203 (GRCm39)	I171F	possibly damaging	Het
Or4g16	T	A	2: 111,137,365 (GRCm39)	F272I	probably benign	Het
Or5p60	T	C	7: 107,723,781 (GRCm39)	K230E	probably damaging	Het
Pcbp1	A	T	6: 86,502,488 (GRCm39)	M137K	possibly damaging	Het
Pcf11	A	T	7: 92,306,524 (GRCm39)	S1215T	probably benign	Het
Pdlim5	A	T	3: 142,017,683 (GRCm39)		probably null	Het
Pecam1	T	C	11: 106,579,857 (GRCm39)	I402V	probably damaging	Het
Pex12	T	C	11: 83,188,468 (GRCm39)	T176A	probably benign	Het
Phf3	T	C	1: 30,870,190 (GRCm39)	K286R	possibly damaging	Het
Pik3ap1	T	A	19: 41,320,760 (GRCm39)	D153V	probably damaging	Het
Pkhd1l1	T	A	15: 44,448,374 (GRCm39)		probably null	Het
Plekhn1	A	G	4: 156,307,792 (GRCm39)	V378A	probably benign	Het
Pramel26	A	T	4: 143,537,233 (GRCm39)	L366Q	probably damaging	Het
Ptprm	A	T	17: 67,251,283 (GRCm39)	D531E	possibly damaging	Het
Pum2	A	T	12: 8,778,952 (GRCm39)	Q508L	possibly damaging	Het
Rad54l	A	G	4: 115,963,027 (GRCm39)	S324P	probably damaging	Het
Recql5	C	T	11: 115,821,498 (GRCm39)		probably null	Het
Reln	A	T	5: 22,181,594 (GRCm39)	V1763D	possibly damaging	Het
Rp1	T	C	1: 4,418,391 (GRCm39)	N907S	possibly damaging	Het
Scaf11	T	A	15: 96,318,209 (GRCm39)	N452Y	possibly damaging	Het
Scgb2b3	T	A	7: 31,059,639 (GRCm39)	H45L	possibly damaging	Het
Sim1	A	G	10: 50,772,023 (GRCm39)	T11A	probably damaging	Het
Slc5a12	T	A	2: 110,447,059 (GRCm39)	M189K	possibly damaging	Het
Slco2b1	C	T	7: 99,344,270 (GRCm39)	G10S	probably null	Het
Speer1j	C	T	5: 11,555,198 (GRCm39)	P83S	probably damaging	Het
Stxbp3	A	G	3: 108,708,071 (GRCm39)	L410P	probably damaging	Het
Sugct	T	C	13: 17,476,594 (GRCm39)	N297D	probably benign	Het
Syne1	A	G	10: 5,183,409 (GRCm39)	I4132T	probably benign	Het
Teddm1b	A	T	1: 153,750,912 (GRCm39)	L240F	probably damaging	Het
Tlr5	C	A	1: 182,803,088 (GRCm39)	D797E	possibly damaging	Het
Tmprss13	G	T	9: 45,249,643 (GRCm39)	G327C	probably damaging	Het
Tnrc18	G	T	5: 142,773,572 (GRCm39)	A419D		Het
Ttc28	T	C	5: 111,427,873 (GRCm39)	Y1790H	probably damaging	Het
Vmn1r125	T	G	7: 21,006,327 (GRCm39)	M75R	probably damaging	Het
Vwa3a	T	A	7: 120,372,253 (GRCm39)	D276E	possibly damaging	Het
Wdfy3	C	T	5: 102,063,303 (GRCm39)	V1322M	probably damaging	Het
Zc3h13	T	C	14: 75,559,161 (GRCm39)	S357P	unknown	Het

Other mutations in Wdr11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00834:Wdr11	APN	7	129,194,817 (GRCm39)	splice site	probably null
IGL01121:Wdr11	APN	7	129,229,746 (GRCm39)	missense	probably benign	0.02
IGL01385:Wdr11	APN	7	129,209,637 (GRCm39)	missense	probably benign
IGL01923:Wdr11	APN	7	129,234,046 (GRCm39)	critical splice acceptor site	probably null
IGL02274:Wdr11	APN	7	129,232,896 (GRCm39)	critical splice acceptor site	probably null
IGL02894:Wdr11	APN	7	129,232,890 (GRCm39)	splice site	probably benign
IGL02927:Wdr11	APN	7	129,208,822 (GRCm39)	critical splice donor site	probably null
IGL03008:Wdr11	APN	7	129,208,715 (GRCm39)	unclassified	probably benign
IGL03026:Wdr11	APN	7	129,226,060 (GRCm39)	missense	probably damaging	1.00
IGL03354:Wdr11	APN	7	129,227,026 (GRCm39)	missense	probably benign	0.01
IGL03379:Wdr11	APN	7	129,200,847 (GRCm39)	missense	probably damaging	1.00
beeline	UTSW	7	129,207,437 (GRCm39)	nonsense	probably null
bekummernis	UTSW	7	129,226,451 (GRCm39)	missense	probably damaging	0.97
hort	UTSW	7	129,232,523 (GRCm39)	critical splice donor site	probably null
Knees	UTSW	7	129,236,560 (GRCm39)	missense	probably benign	0.02
Propeller	UTSW	7	129,208,399 (GRCm39)	missense	possibly damaging	0.91
Zuversicht	UTSW	7	129,208,264 (GRCm39)	missense	probably benign	0.13
R0003:Wdr11	UTSW	7	129,200,785 (GRCm39)	missense	probably damaging	1.00
R0928:Wdr11	UTSW	7	129,208,377 (GRCm39)	missense	probably damaging	1.00
R1170:Wdr11	UTSW	7	129,208,831 (GRCm39)	unclassified	probably benign
R1645:Wdr11	UTSW	7	129,215,613 (GRCm39)	missense	probably benign	0.29
R1908:Wdr11	UTSW	7	129,206,954 (GRCm39)	missense	possibly damaging	0.60
R1938:Wdr11	UTSW	7	129,208,331 (GRCm39)	missense	probably benign	0.08
R2122:Wdr11	UTSW	7	129,233,490 (GRCm39)	missense	probably damaging	1.00
R2148:Wdr11	UTSW	7	129,230,807 (GRCm39)	splice site	probably null
R2240:Wdr11	UTSW	7	129,207,418 (GRCm39)	critical splice acceptor site	probably null
R2362:Wdr11	UTSW	7	129,236,560 (GRCm39)	missense	probably benign	0.05
R3774:Wdr11	UTSW	7	129,233,417 (GRCm39)	splice site	probably null
R4297:Wdr11	UTSW	7	129,226,910 (GRCm39)	missense	probably benign	0.18
R4546:Wdr11	UTSW	7	129,230,729 (GRCm39)	missense	probably damaging	1.00
R4787:Wdr11	UTSW	7	129,210,658 (GRCm39)	splice site	probably benign
R4789:Wdr11	UTSW	7	129,220,394 (GRCm39)	nonsense	probably null
R4807:Wdr11	UTSW	7	129,229,746 (GRCm39)	missense	probably benign	0.02
R4855:Wdr11	UTSW	7	129,202,158 (GRCm39)	splice site	probably null
R4898:Wdr11	UTSW	7	129,235,445 (GRCm39)	missense	probably benign
R5022:Wdr11	UTSW	7	129,226,435 (GRCm39)	missense	probably benign	0.10
R5326:Wdr11	UTSW	7	129,226,973 (GRCm39)	missense	probably damaging	1.00
R5398:Wdr11	UTSW	7	129,232,956 (GRCm39)	missense	probably damaging	1.00
R6120:Wdr11	UTSW	7	129,226,515 (GRCm39)	missense	probably damaging	0.99
R6136:Wdr11	UTSW	7	129,220,427 (GRCm39)	missense	possibly damaging	0.86
R6280:Wdr11	UTSW	7	129,200,830 (GRCm39)	nonsense	probably null
R6352:Wdr11	UTSW	7	129,208,399 (GRCm39)	missense	possibly damaging	0.91
R6432:Wdr11	UTSW	7	129,208,242 (GRCm39)	missense	possibly damaging	0.83
R6766:Wdr11	UTSW	7	129,226,036 (GRCm39)	missense	probably benign	0.02
R6911:Wdr11	UTSW	7	129,208,819 (GRCm39)	missense	probably benign	0.28
R7151:Wdr11	UTSW	7	129,208,376 (GRCm39)	missense	probably damaging	1.00
R7463:Wdr11	UTSW	7	129,208,810 (GRCm39)	missense	probably damaging	0.99
R7503:Wdr11	UTSW	7	129,204,834 (GRCm39)	missense	probably benign
R8097:Wdr11	UTSW	7	129,209,611 (GRCm39)	missense	probably damaging	1.00
R8254:Wdr11	UTSW	7	129,236,560 (GRCm39)	missense	probably benign	0.02
R8354:Wdr11	UTSW	7	129,204,723 (GRCm39)	missense	probably damaging	0.99
R8377:Wdr11	UTSW	7	129,208,412 (GRCm39)	missense	possibly damaging	0.56
R8416:Wdr11	UTSW	7	129,232,403 (GRCm39)	missense	possibly damaging	0.62
R8708:Wdr11	UTSW	7	129,200,780 (GRCm39)	missense	probably benign	0.07
R8896:Wdr11	UTSW	7	129,207,437 (GRCm39)	nonsense	probably null
R9092:Wdr11	UTSW	7	129,226,451 (GRCm39)	missense	probably damaging	0.97
R9136:Wdr11	UTSW	7	129,204,816 (GRCm39)	missense
R9315:Wdr11	UTSW	7	129,208,264 (GRCm39)	missense	probably benign	0.13
R9343:Wdr11	UTSW	7	129,232,523 (GRCm39)	critical splice donor site	probably null
R9663:Wdr11	UTSW	7	129,210,647 (GRCm39)	missense	probably damaging	1.00
R9771:Wdr11	UTSW	7	129,206,851 (GRCm39)	missense	probably damaging	1.00
Z1177:Wdr11	UTSW	7	129,209,602 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AGTGATAGCTGAGACGTTGCTG -3'
(R):5'- AGCATCCTATGACCCTGCAG -3'

Sequencing Primer
(F):5'- GCTGAGGCATGAAAGTTCATTTTAC -3'
(R):5'- CCACGGTGGTGCAAACAG -3'

Posted On

2019-05-15