Incidental Mutation 'R7491:Trip11'
| ID |
580785 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trip11
|
| Ensembl Gene |
ENSMUSG00000021188 |
| Gene Name |
thyroid hormone receptor interactor 11 |
| Synonyms |
3110031G15Rik, TRIP230, 2610511G22Rik, GMAP-210, 6030460N08Rik |
| MMRRC Submission |
045565-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7491 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
12 |
| Chromosomal Location |
101800304-101879463 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 101851694 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Arginine
at position 790
(K790R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000021605
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021605]
[ENSMUST00000176728]
[ENSMUST00000177183]
[ENSMUST00000177536]
|
| AlphaFold |
E9Q512 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000021605
AA Change: K790R
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000021605
Gene: ENSMUSG00000021188
AA Change: K790R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
26 |
N/A |
INTRINSIC |
|
coiled coil region
|
54 |
130 |
N/A |
INTRINSIC |
|
coiled coil region
|
167 |
194 |
N/A |
INTRINSIC |
|
coiled coil region
|
218 |
702 |
N/A |
INTRINSIC |
|
coiled coil region
|
754 |
990 |
N/A |
INTRINSIC |
|
coiled coil region
|
1022 |
1051 |
N/A |
INTRINSIC |
|
coiled coil region
|
1196 |
1261 |
N/A |
INTRINSIC |
|
low complexity region
|
1310 |
1322 |
N/A |
INTRINSIC |
|
coiled coil region
|
1336 |
1481 |
N/A |
INTRINSIC |
|
coiled coil region
|
1547 |
1657 |
N/A |
INTRINSIC |
|
coiled coil region
|
1681 |
1771 |
N/A |
INTRINSIC |
|
low complexity region
|
1934 |
1945 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176728
|
| SMART Domains |
Protein: ENSMUSP00000134992
Gene: ENSMUSG00000021188
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
26 |
N/A |
INTRINSIC |
|
Pfam:Orthopox_A5L
|
48 |
282 |
6.5e-9 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000177183
AA Change: K505R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000134976
Gene: ENSMUSG00000021188
AA Change: K505R
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
33 |
158 |
N/A |
INTRINSIC |
|
coiled coil region
|
179 |
417 |
N/A |
INTRINSIC |
|
coiled coil region
|
469 |
705 |
N/A |
INTRINSIC |
|
coiled coil region
|
737 |
766 |
N/A |
INTRINSIC |
|
coiled coil region
|
911 |
976 |
N/A |
INTRINSIC |
|
low complexity region
|
1025 |
1037 |
N/A |
INTRINSIC |
|
coiled coil region
|
1051 |
1196 |
N/A |
INTRINSIC |
|
coiled coil region
|
1262 |
1372 |
N/A |
INTRINSIC |
|
coiled coil region
|
1396 |
1486 |
N/A |
INTRINSIC |
|
low complexity region
|
1649 |
1660 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177480
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177536
|
| SMART Domains |
Protein: ENSMUSP00000135669
Gene: ENSMUSG00000021188
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
26 |
N/A |
INTRINSIC |
|
coiled coil region
|
53 |
129 |
N/A |
INTRINSIC |
|
coiled coil region
|
166 |
193 |
N/A |
INTRINSIC |
|
coiled coil region
|
217 |
517 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010]
PHENOTYPE: Mice homozygous for a null allele exhibit neonatal lethality associated with small size, lung hypoplasia, omphalocele, and ventricular septal defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(12) : Gene trapped(11) Chemically induced(1)
|
| Other mutations in this stock |
Total: 90 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933409G03Rik |
G |
T |
2: 68,445,099 (GRCm39) |
|
probably null |
Het |
| 5730522E02Rik |
A |
T |
11: 25,719,014 (GRCm39) |
V44E |
unknown |
Het |
| Adcy9 |
A |
G |
16: 4,236,673 (GRCm39) |
L246S |
possibly damaging |
Het |
| Adk |
C |
T |
14: 21,284,997 (GRCm39) |
H123Y |
probably damaging |
Het |
| Adra1b |
T |
A |
11: 43,726,794 (GRCm39) |
D41V |
probably benign |
Het |
| Ankib1 |
T |
G |
5: 3,751,911 (GRCm39) |
K710Q |
probably damaging |
Het |
| Aoc2 |
T |
A |
11: 101,219,203 (GRCm39) |
V542D |
probably benign |
Het |
| Arhgef28 |
T |
C |
13: 98,081,194 (GRCm39) |
N1221S |
probably benign |
Het |
| BC028528 |
CTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTT |
CTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTT |
3: 95,795,448 (GRCm39) |
|
probably benign |
Het |
| BC028528 |
CACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGT |
CACTGGTTCTGTGGTTACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGT |
3: 95,795,450 (GRCm39) |
|
probably benign |
Het |
| Bmal1 |
T |
C |
7: 112,898,631 (GRCm39) |
V353A |
probably benign |
Het |
| Cacna1a |
C |
A |
8: 85,285,922 (GRCm39) |
R856S |
possibly damaging |
Het |
| Cacna1c |
T |
C |
6: 118,590,304 (GRCm39) |
M1559V |
|
Het |
| Cdh10 |
G |
C |
15: 19,013,445 (GRCm39) |
E682Q |
probably damaging |
Het |
| Celsr1 |
T |
C |
15: 85,916,719 (GRCm39) |
D418G |
possibly damaging |
Het |
| Cfap44 |
T |
C |
16: 44,291,111 (GRCm39) |
L1537P |
probably damaging |
Het |
| Clca3a2 |
A |
G |
3: 144,519,340 (GRCm39) |
S279P |
probably damaging |
Het |
| Col2a1 |
C |
T |
15: 97,874,040 (GRCm39) |
V1449I |
not run |
Het |
| Cpt2 |
A |
G |
4: 107,764,339 (GRCm39) |
F475S |
probably damaging |
Het |
| Cpxm1 |
T |
C |
2: 130,235,487 (GRCm39) |
T502A |
probably benign |
Het |
| Creb3l2 |
G |
T |
6: 37,356,794 (GRCm39) |
T91N |
probably benign |
Het |
| D630045J12Rik |
A |
T |
6: 38,119,601 (GRCm39) |
S1714T |
possibly damaging |
Het |
| Dennd1c |
C |
A |
17: 57,379,379 (GRCm39) |
V246F |
probably damaging |
Het |
| Dse |
A |
G |
10: 34,028,561 (GRCm39) |
V843A |
probably benign |
Het |
| Ern2 |
C |
A |
7: 121,769,756 (GRCm39) |
W810L |
probably damaging |
Het |
| Fer1l6 |
G |
A |
15: 58,472,281 (GRCm39) |
D906N |
probably damaging |
Het |
| Fry |
A |
G |
5: 150,389,791 (GRCm39) |
E140G |
|
Het |
| Galnt7 |
A |
G |
8: 58,005,552 (GRCm39) |
V227A |
probably damaging |
Het |
| Gas2l3 |
A |
G |
10: 89,249,763 (GRCm39) |
S452P |
probably benign |
Het |
| Gm40460 |
ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG |
ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG |
7: 141,794,450 (GRCm39) |
|
probably benign |
Het |
| Gm826 |
A |
T |
2: 160,153,942 (GRCm39) |
S34T |
unknown |
Het |
| Gzmk |
A |
T |
13: 113,308,535 (GRCm39) |
I222N |
probably benign |
Het |
| Hivep3 |
A |
T |
4: 119,956,027 (GRCm39) |
T1448S |
probably benign |
Het |
| Hk1 |
T |
C |
10: 62,131,524 (GRCm39) |
D278G |
probably damaging |
Het |
| Ipo7 |
C |
A |
7: 109,638,401 (GRCm39) |
Q223K |
possibly damaging |
Het |
| Itga9 |
T |
A |
9: 118,598,179 (GRCm39) |
I571N |
probably damaging |
Het |
| Itgb6 |
T |
C |
2: 60,450,720 (GRCm39) |
Y573C |
probably damaging |
Het |
| Kmt2c |
T |
A |
5: 25,489,562 (GRCm39) |
H4459L |
probably damaging |
Het |
| Limch1 |
T |
G |
5: 67,211,580 (GRCm39) |
S894R |
probably damaging |
Het |
| Lrit2 |
A |
T |
14: 36,790,867 (GRCm39) |
Q182L |
possibly damaging |
Het |
| Mlph |
A |
T |
1: 90,867,100 (GRCm39) |
H374L |
possibly damaging |
Het |
| Mmrn2 |
A |
G |
14: 34,121,374 (GRCm39) |
H748R |
probably damaging |
Het |
| Mrpl58 |
T |
C |
11: 115,301,092 (GRCm39) |
V134A |
possibly damaging |
Het |
| Nae1 |
A |
T |
8: 105,244,871 (GRCm39) |
D353E |
probably benign |
Het |
| Naip5 |
A |
C |
13: 100,353,579 (GRCm39) |
F1227V |
probably benign |
Het |
| Nln |
A |
T |
13: 104,205,831 (GRCm39) |
F108I |
probably damaging |
Het |
| Nop16 |
C |
T |
13: 54,736,417 (GRCm39) |
V94I |
probably benign |
Het |
| Nt5c1b |
A |
T |
12: 10,424,903 (GRCm39) |
T150S |
probably benign |
Het |
| Or10d4b |
T |
G |
9: 39,535,268 (GRCm39) |
I281S |
possibly damaging |
Het |
| Pcdha4 |
T |
C |
18: 37,087,689 (GRCm39) |
V624A |
probably damaging |
Het |
| Pcdhga8 |
T |
C |
18: 37,860,483 (GRCm39) |
I513T |
probably benign |
Het |
| Prc1 |
A |
T |
7: 79,959,239 (GRCm39) |
|
probably null |
Het |
| Prpf4 |
T |
A |
4: 62,336,113 (GRCm39) |
F280Y |
probably damaging |
Het |
| Ptprd |
T |
C |
4: 76,051,392 (GRCm39) |
E43G |
probably benign |
Het |
| Pum1 |
T |
A |
4: 130,446,485 (GRCm39) |
D181E |
probably benign |
Het |
| Rab7 |
A |
G |
6: 87,990,624 (GRCm39) |
S17P |
probably damaging |
Het |
| Rgs1 |
T |
C |
1: 144,121,134 (GRCm39) |
Y179C |
probably damaging |
Het |
| Rrm1 |
T |
C |
7: 102,103,764 (GRCm39) |
C238R |
probably damaging |
Het |
| Rusc2 |
T |
A |
4: 43,426,528 (GRCm39) |
L1484Q |
probably damaging |
Het |
| Sall3 |
C |
T |
18: 81,015,920 (GRCm39) |
M669I |
probably benign |
Het |
| Saxo1 |
A |
C |
4: 86,363,644 (GRCm39) |
F280V |
probably benign |
Het |
| Scn2a |
T |
C |
2: 65,532,352 (GRCm39) |
S655P |
probably damaging |
Het |
| Senp6 |
G |
T |
9: 80,031,010 (GRCm39) |
E571* |
probably null |
Het |
| Sin3b |
C |
G |
8: 73,473,069 (GRCm39) |
T463S |
probably damaging |
Het |
| Sirt7 |
C |
A |
11: 120,509,837 (GRCm39) |
R349L |
probably benign |
Het |
| Skor1 |
T |
C |
9: 63,053,730 (GRCm39) |
T80A |
probably damaging |
Het |
| Slc12a9 |
C |
A |
5: 137,321,082 (GRCm39) |
A478S |
probably damaging |
Het |
| Slc25a23 |
T |
A |
17: 57,359,822 (GRCm39) |
R310* |
probably null |
Het |
| Slco6c1 |
A |
T |
1: 97,055,579 (GRCm39) |
H107Q |
probably benign |
Het |
| Slit2 |
A |
G |
5: 48,377,336 (GRCm39) |
E455G |
probably benign |
Het |
| Smo |
G |
C |
6: 29,736,119 (GRCm39) |
G37A |
probably damaging |
Het |
| St6galnac1 |
T |
C |
11: 116,660,010 (GRCm39) |
K101R |
probably benign |
Het |
| Stat1 |
C |
A |
1: 52,191,530 (GRCm39) |
N628K |
probably benign |
Het |
| Syn2 |
A |
T |
6: 115,231,615 (GRCm39) |
Y302F |
probably benign |
Het |
| Tapt1 |
T |
G |
5: 44,345,978 (GRCm39) |
Q324P |
probably damaging |
Het |
| Tgoln1 |
C |
T |
6: 72,593,403 (GRCm39) |
A26T |
unknown |
Het |
| Timm13 |
T |
A |
10: 80,736,378 (GRCm39) |
T43S |
probably benign |
Het |
| Tnfrsf19 |
G |
A |
14: 61,242,654 (GRCm39) |
P77S |
possibly damaging |
Het |
| Trem3 |
T |
G |
17: 48,564,969 (GRCm39) |
F157V |
probably benign |
Het |
| Trgv3 |
T |
A |
13: 19,427,016 (GRCm39) |
M1K |
probably null |
Het |
| Trim33 |
T |
A |
3: 103,233,464 (GRCm39) |
S420T |
probably benign |
Het |
| Trnt1 |
A |
G |
6: 106,755,865 (GRCm39) |
T307A |
probably benign |
Het |
| Tshz1 |
T |
C |
18: 84,033,766 (GRCm39) |
Y214C |
probably damaging |
Het |
| Vmn2r105 |
T |
A |
17: 20,448,827 (GRCm39) |
T117S |
probably benign |
Het |
| Vmn2r45 |
A |
G |
7: 8,484,342 (GRCm39) |
Y488H |
probably benign |
Het |
| Vwa8 |
A |
T |
14: 79,320,254 (GRCm39) |
K1088N |
probably benign |
Het |
| Wdr35 |
T |
C |
12: 9,036,000 (GRCm39) |
V257A |
probably benign |
Het |
| Zfp189 |
T |
A |
4: 49,521,569 (GRCm39) |
S3T |
probably benign |
Het |
| Zscan22 |
G |
A |
7: 12,640,833 (GRCm39) |
C359Y |
probably damaging |
Het |
| Zscan4-ps2 |
A |
T |
7: 11,251,812 (GRCm39) |
R283* |
probably null |
Het |
|
| Other mutations in Trip11 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00430:Trip11
|
APN |
12 |
101,852,406 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL00484:Trip11
|
APN |
12 |
101,851,570 (GRCm39) |
nonsense |
probably null |
|
|
IGL00972:Trip11
|
APN |
12 |
101,860,596 (GRCm39) |
missense |
probably null |
1.00 |
|
IGL01476:Trip11
|
APN |
12 |
101,865,170 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01591:Trip11
|
APN |
12 |
101,849,604 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01667:Trip11
|
APN |
12 |
101,845,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01764:Trip11
|
APN |
12 |
101,850,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01789:Trip11
|
APN |
12 |
101,838,090 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01814:Trip11
|
APN |
12 |
101,850,747 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01898:Trip11
|
APN |
12 |
101,851,935 (GRCm39) |
missense |
probably benign |
|
|
IGL01924:Trip11
|
APN |
12 |
101,853,143 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02020:Trip11
|
APN |
12 |
101,850,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02475:Trip11
|
APN |
12 |
101,861,942 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02544:Trip11
|
APN |
12 |
101,859,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02678:Trip11
|
APN |
12 |
101,849,649 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02714:Trip11
|
APN |
12 |
101,850,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02718:Trip11
|
APN |
12 |
101,852,284 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL02904:Trip11
|
APN |
12 |
101,853,097 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03012:Trip11
|
APN |
12 |
101,850,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03191:Trip11
|
APN |
12 |
101,865,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03327:Trip11
|
APN |
12 |
101,849,677 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL03337:Trip11
|
APN |
12 |
101,851,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
NA:Trip11
|
UTSW |
12 |
101,860,580 (GRCm39) |
splice site |
probably null |
|
|
R0027:Trip11
|
UTSW |
12 |
101,851,428 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0028:Trip11
|
UTSW |
12 |
101,851,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0238:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0238:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0239:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0239:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0505:Trip11
|
UTSW |
12 |
101,851,931 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0556:Trip11
|
UTSW |
12 |
101,850,777 (GRCm39) |
nonsense |
probably null |
|
|
R0573:Trip11
|
UTSW |
12 |
101,853,119 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0626:Trip11
|
UTSW |
12 |
101,852,235 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R1519:Trip11
|
UTSW |
12 |
101,852,419 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1530:Trip11
|
UTSW |
12 |
101,879,026 (GRCm39) |
missense |
unknown |
|
|
R1647:Trip11
|
UTSW |
12 |
101,850,651 (GRCm39) |
nonsense |
probably null |
|
|
R1648:Trip11
|
UTSW |
12 |
101,850,651 (GRCm39) |
nonsense |
probably null |
|
|
R1856:Trip11
|
UTSW |
12 |
101,849,592 (GRCm39) |
nonsense |
probably null |
|
|
R2013:Trip11
|
UTSW |
12 |
101,803,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2017:Trip11
|
UTSW |
12 |
101,851,619 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2206:Trip11
|
UTSW |
12 |
101,839,701 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2207:Trip11
|
UTSW |
12 |
101,839,701 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2304:Trip11
|
UTSW |
12 |
101,865,236 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R2328:Trip11
|
UTSW |
12 |
101,845,086 (GRCm39) |
makesense |
probably null |
|
|
R2513:Trip11
|
UTSW |
12 |
101,803,986 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3499:Trip11
|
UTSW |
12 |
101,859,953 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4105:Trip11
|
UTSW |
12 |
101,860,581 (GRCm39) |
nonsense |
probably null |
|
|
R4124:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4126:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4128:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4175:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4176:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4181:Trip11
|
UTSW |
12 |
101,860,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4296:Trip11
|
UTSW |
12 |
101,852,127 (GRCm39) |
nonsense |
probably null |
|
|
R4302:Trip11
|
UTSW |
12 |
101,860,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4306:Trip11
|
UTSW |
12 |
101,853,198 (GRCm39) |
missense |
probably benign |
|
|
R4342:Trip11
|
UTSW |
12 |
101,850,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4576:Trip11
|
UTSW |
12 |
101,852,499 (GRCm39) |
nonsense |
probably null |
|
|
R4586:Trip11
|
UTSW |
12 |
101,849,600 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4634:Trip11
|
UTSW |
12 |
101,803,875 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4696:Trip11
|
UTSW |
12 |
101,851,549 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4792:Trip11
|
UTSW |
12 |
101,851,705 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4903:Trip11
|
UTSW |
12 |
101,853,065 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5001:Trip11
|
UTSW |
12 |
101,851,169 (GRCm39) |
nonsense |
probably null |
|
|
R5017:Trip11
|
UTSW |
12 |
101,812,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5227:Trip11
|
UTSW |
12 |
101,851,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5231:Trip11
|
UTSW |
12 |
101,851,860 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5539:Trip11
|
UTSW |
12 |
101,851,386 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5754:Trip11
|
UTSW |
12 |
101,851,924 (GRCm39) |
nonsense |
probably null |
|
|
R5755:Trip11
|
UTSW |
12 |
101,851,924 (GRCm39) |
nonsense |
probably null |
|
|
R5890:Trip11
|
UTSW |
12 |
101,852,231 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5910:Trip11
|
UTSW |
12 |
101,849,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6083:Trip11
|
UTSW |
12 |
101,856,001 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6208:Trip11
|
UTSW |
12 |
101,865,154 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6216:Trip11
|
UTSW |
12 |
101,856,859 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6315:Trip11
|
UTSW |
12 |
101,851,837 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6413:Trip11
|
UTSW |
12 |
101,851,790 (GRCm39) |
missense |
probably benign |
0.12 |
|
R6590:Trip11
|
UTSW |
12 |
101,851,710 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6690:Trip11
|
UTSW |
12 |
101,851,710 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6914:Trip11
|
UTSW |
12 |
101,812,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6938:Trip11
|
UTSW |
12 |
101,803,886 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7015:Trip11
|
UTSW |
12 |
101,859,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7023:Trip11
|
UTSW |
12 |
101,852,126 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7133:Trip11
|
UTSW |
12 |
101,850,329 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7271:Trip11
|
UTSW |
12 |
101,850,611 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7424:Trip11
|
UTSW |
12 |
101,851,457 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7431:Trip11
|
UTSW |
12 |
101,850,278 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R7472:Trip11
|
UTSW |
12 |
101,851,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7752:Trip11
|
UTSW |
12 |
101,853,233 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7763:Trip11
|
UTSW |
12 |
101,811,114 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7779:Trip11
|
UTSW |
12 |
101,849,796 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7844:Trip11
|
UTSW |
12 |
101,844,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8055:Trip11
|
UTSW |
12 |
101,803,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8076:Trip11
|
UTSW |
12 |
101,849,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8288:Trip11
|
UTSW |
12 |
101,860,643 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8294:Trip11
|
UTSW |
12 |
101,811,160 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8318:Trip11
|
UTSW |
12 |
101,879,063 (GRCm39) |
missense |
unknown |
|
|
R8690:Trip11
|
UTSW |
12 |
101,839,656 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R8879:Trip11
|
UTSW |
12 |
101,828,857 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8964:Trip11
|
UTSW |
12 |
101,811,315 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9005:Trip11
|
UTSW |
12 |
101,845,131 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9013:Trip11
|
UTSW |
12 |
101,851,377 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9020:Trip11
|
UTSW |
12 |
101,850,770 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9041:Trip11
|
UTSW |
12 |
101,845,127 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9234:Trip11
|
UTSW |
12 |
101,811,990 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9447:Trip11
|
UTSW |
12 |
101,850,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9631:Trip11
|
UTSW |
12 |
101,859,807 (GRCm39) |
missense |
probably benign |
|
|
R9641:Trip11
|
UTSW |
12 |
101,859,957 (GRCm39) |
nonsense |
probably null |
|
|
R9691:Trip11
|
UTSW |
12 |
101,850,123 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9751:Trip11
|
UTSW |
12 |
101,850,765 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
X0020:Trip11
|
UTSW |
12 |
101,852,172 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCCAGCTCCTCTTGCAAGTG -3'
(R):5'- GGAAGTACGAGCAAACTGTCC -3'
Sequencing Primer
(F):5'- TCATGGATCCAAGACTTCTATCC -3'
(R):5'- GTACGAGCAAACTGTCCAGGAAC -3'
|
| Posted On |
2019-10-17 |
Incidental Mutation