Incidental Mutation 'R7503:Vmn2r97'
| ID |
581643 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r97
|
| Ensembl Gene |
ENSMUSG00000091491 |
| Gene Name |
vomeronasal 2, receptor 97 |
| Synonyms |
EG627367 |
| MMRRC Submission |
045576-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.071)
|
| Stock # |
R7503 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
19134584-19168333 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 19148470 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 122
(T122A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129313
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168710]
[ENSMUST00000232219]
|
| AlphaFold |
K7N6Z2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168710
AA Change: T122A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000129313
Gene: ENSMUSG00000091491
AA Change: T122A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
442 |
2.9e-36 |
PFAM |
|
Pfam:NCD3G
|
513 |
566 |
4.9e-21 |
PFAM |
|
Pfam:7tm_3
|
599 |
834 |
1.7e-52 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232219
AA Change: T122A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.8%
|
| Validation Efficiency |
100% (63/63) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 62 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A230072I06Rik |
G |
A |
8: 12,329,554 (GRCm39) |
G3D |
unknown |
Het |
| Aif1 |
A |
T |
17: 35,390,549 (GRCm39) |
I67N |
probably damaging |
Het |
| Akap11 |
T |
C |
14: 78,749,441 (GRCm39) |
D982G |
|
Het |
| Anpep |
A |
G |
7: 79,476,385 (GRCm39) |
L827P |
probably damaging |
Het |
| Arhgef5 |
A |
T |
6: 43,250,933 (GRCm39) |
K561N |
probably benign |
Het |
| Arsj |
T |
C |
3: 126,158,493 (GRCm39) |
F24S |
probably benign |
Het |
| Bard1 |
T |
C |
1: 71,069,995 (GRCm39) |
D661G |
probably damaging |
Het |
| Cc2d2b |
A |
G |
19: 40,783,056 (GRCm39) |
I618V |
unknown |
Het |
| Cfap251 |
G |
T |
5: 123,435,521 (GRCm39) |
E994* |
probably null |
Het |
| Cfap54 |
T |
A |
10: 92,723,298 (GRCm39) |
|
probably null |
Het |
| Cfhr2 |
T |
A |
1: 139,758,952 (GRCm39) |
I33F |
probably damaging |
Het |
| Dsc1 |
G |
A |
18: 20,218,922 (GRCm39) |
H827Y |
probably damaging |
Het |
| Eif3i |
C |
T |
4: 129,494,207 (GRCm39) |
D31N |
probably damaging |
Het |
| Eno1b |
A |
T |
18: 48,179,878 (GRCm39) |
T19S |
probably damaging |
Het |
| Eva1a |
G |
A |
6: 82,048,210 (GRCm39) |
W29* |
probably null |
Het |
| Evc |
T |
C |
5: 37,458,111 (GRCm39) |
K803R |
unknown |
Het |
| F5 |
T |
A |
1: 164,019,779 (GRCm39) |
N751K |
probably damaging |
Het |
| Fam120a |
A |
T |
13: 49,102,723 (GRCm39) |
N177K |
probably benign |
Het |
| Farp2 |
T |
G |
1: 93,495,219 (GRCm39) |
I164R |
probably benign |
Het |
| Gm20379 |
C |
T |
13: 92,442,565 (GRCm39) |
P26L |
|
Het |
| Hmgcs2 |
T |
C |
3: 98,209,940 (GRCm39) |
S433P |
probably damaging |
Het |
| Inava |
T |
C |
1: 136,143,675 (GRCm39) |
D587G |
possibly damaging |
Het |
| Ints2 |
T |
C |
11: 86,122,881 (GRCm39) |
T633A |
probably benign |
Het |
| Invs |
C |
T |
4: 48,396,347 (GRCm39) |
T340M |
probably damaging |
Het |
| Mef2c |
A |
C |
13: 83,810,623 (GRCm39) |
D391A |
possibly damaging |
Het |
| Msh4 |
A |
C |
3: 153,573,387 (GRCm39) |
S756A |
probably damaging |
Het |
| Mylk3 |
T |
C |
8: 86,080,218 (GRCm39) |
T490A |
probably benign |
Het |
| Myo1b |
A |
T |
1: 51,815,761 (GRCm39) |
|
probably null |
Het |
| Nsmce1 |
A |
G |
7: 125,071,106 (GRCm39) |
S107P |
probably benign |
Het |
| Or52a24 |
T |
A |
7: 103,381,474 (GRCm39) |
S114T |
probably damaging |
Het |
| Or5d43 |
T |
C |
2: 88,105,039 (GRCm39) |
Y118C |
probably damaging |
Het |
| Pcdhb21 |
G |
A |
18: 37,648,028 (GRCm39) |
D386N |
probably benign |
Het |
| Pcdhb22 |
T |
G |
18: 37,652,155 (GRCm39) |
L208V |
probably benign |
Het |
| Pigu |
C |
T |
2: 155,173,064 (GRCm39) |
|
probably null |
Het |
| Plcz1 |
T |
A |
6: 139,936,474 (GRCm39) |
E585V |
probably damaging |
Het |
| Pnpla7 |
C |
A |
2: 24,873,544 (GRCm39) |
C183* |
probably null |
Het |
| Pomgnt1 |
T |
C |
4: 116,009,949 (GRCm39) |
V133A |
possibly damaging |
Het |
| Prl3d3 |
A |
G |
13: 27,345,096 (GRCm39) |
Y156C |
probably benign |
Het |
| Prpf39 |
A |
G |
12: 65,100,167 (GRCm39) |
D280G |
probably benign |
Het |
| Recql5 |
C |
A |
11: 115,785,881 (GRCm39) |
A631S |
probably benign |
Het |
| Runx3 |
C |
A |
4: 134,882,679 (GRCm39) |
N138K |
probably damaging |
Het |
| Scaper |
T |
C |
9: 55,715,038 (GRCm39) |
D750G |
probably damaging |
Het |
| Slc16a3 |
T |
C |
11: 120,847,853 (GRCm39) |
L347P |
probably damaging |
Het |
| Slc25a1 |
G |
T |
16: 17,744,303 (GRCm39) |
Y209* |
probably null |
Het |
| Smad2 |
A |
G |
18: 76,419,956 (GRCm39) |
S88G |
probably benign |
Het |
| Sorcs1 |
A |
G |
19: 50,141,490 (GRCm39) |
C1125R |
probably benign |
Het |
| Spata21 |
T |
A |
4: 140,822,614 (GRCm39) |
I140N |
probably benign |
Het |
| Speer3 |
A |
T |
5: 13,843,348 (GRCm39) |
D85V |
probably benign |
Het |
| Spopfm1 |
A |
T |
3: 94,173,780 (GRCm39) |
M259L |
probably benign |
Het |
| Stra6 |
A |
G |
9: 58,058,528 (GRCm39) |
N463S |
possibly damaging |
Het |
| Tmem14a |
T |
G |
1: 21,299,623 (GRCm39) |
|
probably null |
Het |
| Tsc1 |
T |
A |
2: 28,577,088 (GRCm39) |
L1130Q |
possibly damaging |
Het |
| Ttn |
T |
C |
2: 76,611,401 (GRCm39) |
D17377G |
possibly damaging |
Het |
| Utf1 |
A |
G |
7: 139,524,046 (GRCm39) |
D87G |
probably damaging |
Het |
| Vmn2r6 |
G |
A |
3: 64,447,372 (GRCm39) |
Q565* |
probably null |
Het |
| Vmn2r63 |
A |
T |
7: 42,583,014 (GRCm39) |
M67K |
probably benign |
Het |
| Vmn2r90 |
T |
C |
17: 17,933,510 (GRCm39) |
Y357H |
not run |
Het |
| Wdhd1 |
T |
C |
14: 47,488,248 (GRCm39) |
E753G |
probably benign |
Het |
| Wdr11 |
A |
G |
7: 129,204,834 (GRCm39) |
N213S |
probably benign |
Het |
| Xdh |
A |
C |
17: 74,233,205 (GRCm39) |
D207E |
probably damaging |
Het |
| Zfp281 |
T |
A |
1: 136,554,678 (GRCm39) |
I552N |
possibly damaging |
Het |
| Zzef1 |
T |
A |
11: 72,716,893 (GRCm39) |
I361K |
probably damaging |
Het |
|
| Other mutations in Vmn2r97 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00897:Vmn2r97
|
APN |
17 |
19,167,921 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL00962:Vmn2r97
|
APN |
17 |
19,149,490 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01704:Vmn2r97
|
APN |
17 |
19,168,073 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01888:Vmn2r97
|
APN |
17 |
19,149,286 (GRCm39) |
nonsense |
probably null |
|
|
IGL02429:Vmn2r97
|
APN |
17 |
19,150,596 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02742:Vmn2r97
|
APN |
17 |
19,149,432 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02934:Vmn2r97
|
APN |
17 |
19,149,947 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02978:Vmn2r97
|
APN |
17 |
19,168,298 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03230:Vmn2r97
|
APN |
17 |
19,149,668 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL03241:Vmn2r97
|
APN |
17 |
19,148,438 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL03050:Vmn2r97
|
UTSW |
17 |
19,167,900 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
PIT4469001:Vmn2r97
|
UTSW |
17 |
19,149,878 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0482:Vmn2r97
|
UTSW |
17 |
19,167,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0514:Vmn2r97
|
UTSW |
17 |
19,134,734 (GRCm39) |
missense |
probably benign |
0.25 |
|
R0944:Vmn2r97
|
UTSW |
17 |
19,167,665 (GRCm39) |
missense |
probably benign |
0.13 |
|
R1061:Vmn2r97
|
UTSW |
17 |
19,148,440 (GRCm39) |
nonsense |
probably null |
|
|
R1546:Vmn2r97
|
UTSW |
17 |
19,168,110 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1725:Vmn2r97
|
UTSW |
17 |
19,149,397 (GRCm39) |
missense |
probably benign |
0.43 |
|
R1860:Vmn2r97
|
UTSW |
17 |
19,167,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1938:Vmn2r97
|
UTSW |
17 |
19,149,593 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1944:Vmn2r97
|
UTSW |
17 |
19,160,500 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2027:Vmn2r97
|
UTSW |
17 |
19,149,944 (GRCm39) |
missense |
unknown |
|
|
R2106:Vmn2r97
|
UTSW |
17 |
19,168,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2151:Vmn2r97
|
UTSW |
17 |
19,167,584 (GRCm39) |
nonsense |
probably null |
|
|
R2153:Vmn2r97
|
UTSW |
17 |
19,167,584 (GRCm39) |
nonsense |
probably null |
|
|
R2154:Vmn2r97
|
UTSW |
17 |
19,167,584 (GRCm39) |
nonsense |
probably null |
|
|
R2516:Vmn2r97
|
UTSW |
17 |
19,167,814 (GRCm39) |
missense |
probably benign |
|
|
R3739:Vmn2r97
|
UTSW |
17 |
19,148,413 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3744:Vmn2r97
|
UTSW |
17 |
19,149,890 (GRCm39) |
missense |
probably benign |
|
|
R3885:Vmn2r97
|
UTSW |
17 |
19,148,596 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3899:Vmn2r97
|
UTSW |
17 |
19,167,873 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4115:Vmn2r97
|
UTSW |
17 |
19,148,332 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4247:Vmn2r97
|
UTSW |
17 |
19,167,542 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4287:Vmn2r97
|
UTSW |
17 |
19,168,337 (GRCm39) |
intron |
probably benign |
|
|
R4439:Vmn2r97
|
UTSW |
17 |
19,150,616 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4523:Vmn2r97
|
UTSW |
17 |
19,149,333 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4783:Vmn2r97
|
UTSW |
17 |
19,149,550 (GRCm39) |
missense |
probably benign |
|
|
R4948:Vmn2r97
|
UTSW |
17 |
19,167,561 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4981:Vmn2r97
|
UTSW |
17 |
19,160,436 (GRCm39) |
nonsense |
probably null |
|
|
R5029:Vmn2r97
|
UTSW |
17 |
19,168,173 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5200:Vmn2r97
|
UTSW |
17 |
19,148,615 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5541:Vmn2r97
|
UTSW |
17 |
19,148,617 (GRCm39) |
nonsense |
probably null |
|
|
R5637:Vmn2r97
|
UTSW |
17 |
19,167,628 (GRCm39) |
nonsense |
probably null |
|
|
R5765:Vmn2r97
|
UTSW |
17 |
19,167,442 (GRCm39) |
nonsense |
probably null |
|
|
R5885:Vmn2r97
|
UTSW |
17 |
19,168,035 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R6272:Vmn2r97
|
UTSW |
17 |
19,167,861 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R6553:Vmn2r97
|
UTSW |
17 |
19,150,566 (GRCm39) |
nonsense |
probably null |
|
|
R6818:Vmn2r97
|
UTSW |
17 |
19,168,193 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6880:Vmn2r97
|
UTSW |
17 |
19,134,770 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7012:Vmn2r97
|
UTSW |
17 |
19,167,756 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7023:Vmn2r97
|
UTSW |
17 |
19,134,663 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7044:Vmn2r97
|
UTSW |
17 |
19,134,629 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7191:Vmn2r97
|
UTSW |
17 |
19,150,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7862:Vmn2r97
|
UTSW |
17 |
19,167,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7876:Vmn2r97
|
UTSW |
17 |
19,149,326 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7890:Vmn2r97
|
UTSW |
17 |
19,149,802 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7936:Vmn2r97
|
UTSW |
17 |
19,150,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7978:Vmn2r97
|
UTSW |
17 |
19,167,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8405:Vmn2r97
|
UTSW |
17 |
19,134,802 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8755:Vmn2r97
|
UTSW |
17 |
19,168,104 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8790:Vmn2r97
|
UTSW |
17 |
19,160,472 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8850:Vmn2r97
|
UTSW |
17 |
19,149,607 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9060:Vmn2r97
|
UTSW |
17 |
19,134,585 (GRCm39) |
start codon destroyed |
probably null |
0.94 |
|
R9079:Vmn2r97
|
UTSW |
17 |
19,149,640 (GRCm39) |
missense |
probably benign |
|
|
R9252:Vmn2r97
|
UTSW |
17 |
19,167,849 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9278:Vmn2r97
|
UTSW |
17 |
19,134,762 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9342:Vmn2r97
|
UTSW |
17 |
19,149,368 (GRCm39) |
missense |
probably benign |
|
|
R9422:Vmn2r97
|
UTSW |
17 |
19,149,333 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9496:Vmn2r97
|
UTSW |
17 |
19,149,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9571:Vmn2r97
|
UTSW |
17 |
19,149,919 (GRCm39) |
missense |
probably benign |
|
|
R9601:Vmn2r97
|
UTSW |
17 |
19,134,770 (GRCm39) |
missense |
probably benign |
|
|
R9672:Vmn2r97
|
UTSW |
17 |
19,149,442 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9773:Vmn2r97
|
UTSW |
17 |
19,168,221 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9795:Vmn2r97
|
UTSW |
17 |
19,167,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGTAAAGGAGCCTGCTTAAACC -3'
(R):5'- ACATGAACTAAGAGAACTGACTCTC -3'
Sequencing Primer
(F):5'- AGGAGCCTGCTTAAACCTAATG -3'
(R):5'- GACTCTCAGTTCCCACAATCC -3'
|
| Posted On |
2019-10-17 |
Incidental Mutation