Incidental Mutation 'IGL01649:Mrgpra9'
| ID |
102755 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Mrgpra9
|
| Ensembl Gene |
ENSMUSG00000074111 |
| Gene Name |
MAS-related GPR, member A9 |
| Synonyms |
MrgA9, EG668725 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.049)
|
| Stock # |
IGL01649
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
46884667-46902627 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 46884900 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Valine
at position 256
(L256V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000136396
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000098436]
[ENSMUST00000179005]
|
| AlphaFold |
A0A140T8U8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000098436
AA Change: L255V
PolyPhen 2
Score 0.223 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000096035
Gene: ENSMUSG00000074111
AA Change: L255V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
37 |
48 |
N/A |
INTRINSIC |
|
Pfam:7tm_1
|
56 |
225 |
1.5e-11 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000179005
AA Change: L256V
PolyPhen 2
Score 0.223 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000136396
Gene: ENSMUSG00000074111
AA Change: L256V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
12 |
178 |
3.4e-9 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4931429L15Rik |
A |
G |
9: 46,217,116 (GRCm39) |
S220P |
probably benign |
Het |
| Adam18 |
T |
C |
8: 25,104,912 (GRCm39) |
N634S |
possibly damaging |
Het |
| Arhgef18 |
T |
A |
8: 3,491,211 (GRCm39) |
|
probably benign |
Het |
| Birc6 |
A |
G |
17: 74,911,541 (GRCm39) |
S1518G |
probably benign |
Het |
| Cltc |
A |
G |
11: 86,617,226 (GRCm39) |
V341A |
probably benign |
Het |
| Dlg5 |
A |
G |
14: 24,188,759 (GRCm39) |
V1721A |
probably damaging |
Het |
| Dnah10 |
A |
T |
5: 124,809,553 (GRCm39) |
I274F |
probably damaging |
Het |
| Dock1 |
T |
A |
7: 134,379,139 (GRCm39) |
L622Q |
probably damaging |
Het |
| Dysf |
A |
G |
6: 84,176,821 (GRCm39) |
D1960G |
probably damaging |
Het |
| Fat3 |
T |
C |
9: 16,288,015 (GRCm39) |
T503A |
possibly damaging |
Het |
| Glb1 |
A |
G |
9: 114,253,016 (GRCm39) |
Y73C |
probably damaging |
Het |
| Gm9396 |
G |
T |
3: 129,862,268 (GRCm39) |
|
noncoding transcript |
Het |
| Gml2 |
G |
T |
15: 74,696,070 (GRCm39) |
E155* |
probably null |
Het |
| Ikzf4 |
G |
A |
10: 128,471,689 (GRCm39) |
R323C |
probably damaging |
Het |
| Kiz |
A |
G |
2: 146,731,229 (GRCm39) |
T240A |
probably benign |
Het |
| Lzts3 |
T |
C |
2: 130,477,351 (GRCm39) |
K480E |
probably damaging |
Het |
| Mcm7 |
T |
C |
5: 138,167,698 (GRCm39) |
H105R |
probably damaging |
Het |
| Mpdz |
A |
G |
4: 81,221,870 (GRCm39) |
L1464P |
probably damaging |
Het |
| Mrpl40 |
T |
C |
16: 18,691,329 (GRCm39) |
Q127R |
probably benign |
Het |
| Myom2 |
G |
T |
8: 15,163,755 (GRCm39) |
R1003L |
probably benign |
Het |
| Nav2 |
A |
G |
7: 49,225,477 (GRCm39) |
T1806A |
probably damaging |
Het |
| Or10x4 |
T |
C |
1: 174,218,974 (GRCm39) |
L113P |
probably damaging |
Het |
| Pibf1 |
A |
T |
14: 99,425,199 (GRCm39) |
Y562F |
possibly damaging |
Het |
| Potefam1 |
A |
T |
2: 111,044,921 (GRCm39) |
|
probably benign |
Het |
| Ppm1n |
A |
T |
7: 19,012,122 (GRCm39) |
|
probably benign |
Het |
| Psg17 |
A |
G |
7: 18,550,727 (GRCm39) |
V376A |
possibly damaging |
Het |
| Septin8 |
T |
A |
11: 53,425,855 (GRCm39) |
F143I |
possibly damaging |
Het |
| Sestd1 |
A |
G |
2: 77,029,389 (GRCm39) |
Y330H |
probably damaging |
Het |
| Sntg1 |
C |
T |
1: 8,752,193 (GRCm39) |
|
probably benign |
Het |
| Stpg2 |
C |
A |
3: 139,125,623 (GRCm39) |
P472Q |
probably damaging |
Het |
| Thbs1 |
A |
G |
2: 117,945,463 (GRCm39) |
K314R |
probably benign |
Het |
| Vav3 |
T |
C |
3: 109,470,078 (GRCm39) |
Y508H |
probably benign |
Het |
|
| Other mutations in Mrgpra9 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00095:Mrgpra9
|
APN |
7 |
46,884,839 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL00575:Mrgpra9
|
APN |
7 |
46,885,053 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
IGL03207:Mrgpra9
|
APN |
7 |
46,885,385 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R0388:Mrgpra9
|
UTSW |
7 |
46,902,542 (GRCm39) |
start codon destroyed |
probably null |
0.08 |
|
R0972:Mrgpra9
|
UTSW |
7 |
46,885,203 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1270:Mrgpra9
|
UTSW |
7 |
46,902,531 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1381:Mrgpra9
|
UTSW |
7 |
46,885,050 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R1403:Mrgpra9
|
UTSW |
7 |
46,885,386 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1403:Mrgpra9
|
UTSW |
7 |
46,885,386 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1448:Mrgpra9
|
UTSW |
7 |
46,885,561 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2045:Mrgpra9
|
UTSW |
7 |
46,885,583 (GRCm39) |
missense |
probably benign |
|
|
R2144:Mrgpra9
|
UTSW |
7 |
46,885,211 (GRCm39) |
missense |
probably benign |
0.31 |
|
R2187:Mrgpra9
|
UTSW |
7 |
46,884,797 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2507:Mrgpra9
|
UTSW |
7 |
46,885,242 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R2913:Mrgpra9
|
UTSW |
7 |
46,884,828 (GRCm39) |
missense |
probably benign |
|
|
R3810:Mrgpra9
|
UTSW |
7 |
46,885,527 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4177:Mrgpra9
|
UTSW |
7 |
46,885,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4521:Mrgpra9
|
UTSW |
7 |
46,884,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4781:Mrgpra9
|
UTSW |
7 |
46,884,795 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4926:Mrgpra9
|
UTSW |
7 |
46,884,759 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R6469:Mrgpra9
|
UTSW |
7 |
46,884,854 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6505:Mrgpra9
|
UTSW |
7 |
46,884,884 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6724:Mrgpra9
|
UTSW |
7 |
46,884,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7398:Mrgpra9
|
UTSW |
7 |
46,885,385 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R8737:Mrgpra9
|
UTSW |
7 |
46,885,624 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8824:Mrgpra9
|
UTSW |
7 |
46,885,041 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8881:Mrgpra9
|
UTSW |
7 |
46,885,242 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R9320:Mrgpra9
|
UTSW |
7 |
46,885,392 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Posted On |
2014-01-21 |
Incidental Mutation