Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01689:Vmn2r66'

104054

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r66

Ensembl Gene

ENSMUSG00000094950

Gene Name

vomeronasal 2, receptor 66

Synonyms

F830104D24Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.079) question?

Stock #

IGL01689

Quality Score

Status

Chromosome

Chromosomal Location

84643853-84661228 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 84657033 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 124 (N124S)

Ref Sequence

ENSEMBL: ENSMUSP00000122645 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000124773]

AlphaFold

A0A3B2W842

Predicted Effect

probably damaging
Transcript: ENSMUST00000124773
AA Change: N124S

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000122645
Gene: ENSMUSG00000094950
AA Change: N124S

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	463	5e-31	PFAM
Pfam:NCD3G	507	559	6e-21	PFAM
Pfam:7tm_3	589	827	3.8e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 18 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aox4	A	G	1: 58,284,320 (GRCm39)		probably benign	Het
Arhgap10	A	G	8: 78,137,763 (GRCm39)		probably benign	Het
Armc9	T	C	1: 86,202,140 (GRCm39)	V766A	probably benign	Het
Asxl2	A	T	12: 3,546,425 (GRCm39)	Q403L	probably benign	Het
Cd244a	G	A	1: 171,410,462 (GRCm39)		probably benign	Het
Cdc34b	A	G	11: 94,633,345 (GRCm39)	K182E	probably benign	Het
Csnk1d	A	T	11: 120,862,393 (GRCm39)	F295L	probably benign	Het
Gm11541	A	G	11: 94,595,020 (GRCm39)	V16A	unknown	Het
Kdr	T	C	5: 76,097,500 (GRCm39)	D1252G	probably benign	Het
Kif14	A	G	1: 136,447,380 (GRCm39)	D1395G	probably damaging	Het
Lars1	T	A	18: 42,350,014 (GRCm39)	Q930L	probably benign	Het
Lypd5	A	G	7: 24,052,054 (GRCm39)		probably benign	Het
Or2w1b	G	A	13: 21,300,243 (GRCm39)	C127Y	probably damaging	Het
Paics	T	C	5: 77,109,138 (GRCm39)		probably null	Het
Pcnt	A	G	10: 76,247,487 (GRCm39)	V1015A	probably damaging	Het
Thada	C	T	17: 84,754,116 (GRCm39)	S285N	possibly damaging	Het
Tlr1	T	C	5: 65,083,122 (GRCm39)	D485G	probably damaging	Het
Zfyve26	T	C	12: 79,330,827 (GRCm39)	D464G	possibly damaging	Het

Other mutations in Vmn2r66

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00321:Vmn2r66	APN	7	84,656,299 (GRCm39)	missense	probably benign
IGL01562:Vmn2r66	APN	7	84,656,495 (GRCm39)	missense	probably benign	0.03
IGL02237:Vmn2r66	APN	7	84,643,908 (GRCm39)	missense	probably benign
IGL02415:Vmn2r66	APN	7	84,656,020 (GRCm39)	missense	probably damaging	0.97
IGL02439:Vmn2r66	APN	7	84,654,455 (GRCm39)	splice site	probably benign
IGL02545:Vmn2r66	APN	7	84,655,798 (GRCm39)	missense	possibly damaging	0.50
IGL02708:Vmn2r66	APN	7	84,655,796 (GRCm39)	missense	probably benign	0.00
IGL02794:Vmn2r66	APN	7	84,644,623 (GRCm39)	missense	probably benign	0.00
IGL02885:Vmn2r66	APN	7	84,644,723 (GRCm39)	missense	probably benign	0.00
IGL02975:Vmn2r66	APN	7	84,656,182 (GRCm39)	missense	probably damaging	0.98
IGL03027:Vmn2r66	APN	7	84,644,777 (GRCm39)	splice site	probably benign
IGL03081:Vmn2r66	APN	7	84,657,138 (GRCm39)	missense	probably benign
PIT4131001:Vmn2r66	UTSW	7	84,644,301 (GRCm39)	missense	probably damaging	1.00
R0098:Vmn2r66	UTSW	7	84,654,965 (GRCm39)	missense	probably damaging	1.00
R0504:Vmn2r66	UTSW	7	84,656,023 (GRCm39)	missense	probably damaging	0.99
R0557:Vmn2r66	UTSW	7	84,643,972 (GRCm39)	missense	probably damaging	1.00
R0617:Vmn2r66	UTSW	7	84,644,484 (GRCm39)	missense	probably benign	0.02
R0883:Vmn2r66	UTSW	7	84,657,070 (GRCm39)	missense	probably benign
R1159:Vmn2r66	UTSW	7	84,644,613 (GRCm39)	missense	probably benign	0.44
R1168:Vmn2r66	UTSW	7	84,656,062 (GRCm39)	missense	possibly damaging	0.46
R1172:Vmn2r66	UTSW	7	84,654,799 (GRCm39)	missense	probably benign	0.04
R1175:Vmn2r66	UTSW	7	84,654,799 (GRCm39)	missense	probably benign	0.04
R1538:Vmn2r66	UTSW	7	84,644,166 (GRCm39)	missense	possibly damaging	0.84
R1658:Vmn2r66	UTSW	7	84,656,955 (GRCm39)	missense	probably benign	0.07
R1937:Vmn2r66	UTSW	7	84,644,344 (GRCm39)	missense	probably damaging	0.99
R1989:Vmn2r66	UTSW	7	84,661,201 (GRCm39)	missense	probably benign	0.01
R2698:Vmn2r66	UTSW	7	84,644,607 (GRCm39)	missense	probably damaging	1.00
R2890:Vmn2r66	UTSW	7	84,661,027 (GRCm39)	splice site	probably null
R3686:Vmn2r66	UTSW	7	84,644,397 (GRCm39)	missense	probably damaging	0.96
R4152:Vmn2r66	UTSW	7	84,654,800 (GRCm39)	missense	probably benign	0.08
R4500:Vmn2r66	UTSW	7	84,657,162 (GRCm39)	missense	probably damaging	1.00
R4618:Vmn2r66	UTSW	7	84,644,296 (GRCm39)	missense	possibly damaging	0.62
R4656:Vmn2r66	UTSW	7	84,661,204 (GRCm39)	missense	possibly damaging	0.87
R4668:Vmn2r66	UTSW	7	84,643,905 (GRCm39)	missense	probably damaging	1.00
R4942:Vmn2r66	UTSW	7	84,656,980 (GRCm39)	missense	probably damaging	1.00
R5163:Vmn2r66	UTSW	7	84,656,017 (GRCm39)	missense	probably benign	0.01
R5223:Vmn2r66	UTSW	7	84,657,093 (GRCm39)	missense	probably benign
R5377:Vmn2r66	UTSW	7	84,656,026 (GRCm39)	missense	probably damaging	0.99
R5512:Vmn2r66	UTSW	7	84,657,149 (GRCm39)	missense	probably damaging	1.00
R5611:Vmn2r66	UTSW	7	84,654,951 (GRCm39)	nonsense	probably null
R5749:Vmn2r66	UTSW	7	84,655,979 (GRCm39)	nonsense	probably null
R6131:Vmn2r66	UTSW	7	84,644,224 (GRCm39)	missense	probably damaging	1.00
R6183:Vmn2r66	UTSW	7	84,644,766 (GRCm39)	missense	possibly damaging	0.81
R6509:Vmn2r66	UTSW	7	84,656,054 (GRCm39)	missense	probably benign	0.12
R6930:Vmn2r66	UTSW	7	84,661,216 (GRCm39)	missense	possibly damaging	0.80
R6992:Vmn2r66	UTSW	7	84,654,436 (GRCm39)	missense	possibly damaging	0.90
R7015:Vmn2r66	UTSW	7	84,644,766 (GRCm39)	missense	possibly damaging	0.81
R7302:Vmn2r66	UTSW	7	84,654,423 (GRCm39)	missense	probably benign	0.00
R7516:Vmn2r66	UTSW	7	84,661,176 (GRCm39)	missense	possibly damaging	0.51
R7763:Vmn2r66	UTSW	7	84,654,909 (GRCm39)	missense	probably benign	0.01
R7814:Vmn2r66	UTSW	7	84,656,472 (GRCm39)	missense	probably benign	0.02
R8077:Vmn2r66	UTSW	7	84,656,093 (GRCm39)	missense	probably benign
R8307:Vmn2r66	UTSW	7	84,656,270 (GRCm39)	missense	probably benign
R8315:Vmn2r66	UTSW	7	84,643,932 (GRCm39)	missense	possibly damaging	0.90
R8490:Vmn2r66	UTSW	7	84,654,794 (GRCm39)	critical splice donor site	probably null
R8511:Vmn2r66	UTSW	7	84,656,026 (GRCm39)	missense	probably damaging	0.99
R8781:Vmn2r66	UTSW	7	84,644,355 (GRCm39)	nonsense	probably null
R8812:Vmn2r66	UTSW	7	84,654,893 (GRCm39)	missense	probably damaging	0.99
R9203:Vmn2r66	UTSW	7	84,654,950 (GRCm39)	missense	probably benign	0.01
R9277:Vmn2r66	UTSW	7	84,661,164 (GRCm39)	missense	probably benign	0.00

Posted On

2014-01-21