Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03135:Lrrc41'

410475

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lrrc41

Ensembl Gene

ENSMUSG00000028703

Gene Name

leucine rich repeat containing 41

Synonyms

MUF1, D630045E04Rik, D730026A16Rik

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.430) question?

Stock #

IGL03135

Quality Score

Status

Chromosome

Chromosomal Location

115932466-115954240 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 115945728 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Serine at position 148 (R148S)

Ref Sequence

ENSEMBL: ENSMUSP00000030471 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030471]

AlphaFold

Q8K1C9

Predicted Effect

probably benign
Transcript: ENSMUST00000030471
AA Change: R148S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000030471
Gene: ENSMUSG00000028703
AA Change: R148S

Domain	Start	End	E-Value	Type
low complexity region	30	45	N/A	INTRINSIC
low complexity region	280	291	N/A	INTRINSIC
low complexity region	314	325	N/A	INTRINSIC
low complexity region	352	382	N/A	INTRINSIC
low complexity region	417	429	N/A	INTRINSIC
SCOP:d1yrga_	449	742	4e-12	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000133799

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134983

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138952

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Apmap	A	C	2: 150,429,035 (GRCm39)	M196R	possibly damaging	Het
Arhgap27	T	A	11: 103,229,891 (GRCm39)		probably null	Het
Arl8b	A	C	6: 108,795,506 (GRCm39)	N148T	probably benign	Het
Baz1a	A	G	12: 54,976,375 (GRCm39)	F434L	probably damaging	Het
Birc2	A	G	9: 7,849,722 (GRCm39)		probably benign	Het
Brwd1	C	A	16: 95,822,458 (GRCm39)	R1249I	probably damaging	Het
Cab39l	T	C	14: 59,757,100 (GRCm39)	F161L	probably benign	Het
Ccr8	A	T	9: 119,923,689 (GRCm39)	D268V	possibly damaging	Het
Col25a1	A	T	3: 130,323,332 (GRCm39)		probably benign	Het
Cpn1	A	G	19: 43,974,693 (GRCm39)	L12P	possibly damaging	Het
Dnah6	A	G	6: 73,121,987 (GRCm39)	I1360T	probably benign	Het
Dnajb8	A	G	6: 88,200,013 (GRCm39)	E183G	probably damaging	Het
Dpp8	T	A	9: 64,960,322 (GRCm39)		probably null	Het
Fsd1	C	A	17: 56,297,416 (GRCm39)		probably null	Het
Grina	T	A	15: 76,132,162 (GRCm39)	F28I	possibly damaging	Het
H2-M3	G	A	17: 37,583,324 (GRCm39)	D262N	possibly damaging	Het
Hdgfl3	G	A	7: 81,543,587 (GRCm39)	T188M	probably damaging	Het
Kif18b	A	G	11: 102,805,086 (GRCm39)	I353T	probably damaging	Het
Lrrc8e	T	A	8: 4,285,776 (GRCm39)	L667Q	probably damaging	Het
Lrrk1	A	G	7: 65,912,638 (GRCm39)	F1641L	probably benign	Het
Naaladl1	A	T	19: 6,162,386 (GRCm39)	T443S	probably benign	Het
Naga	C	A	15: 82,214,942 (GRCm39)	V339F	probably damaging	Het
Nedd4l	A	G	18: 65,338,741 (GRCm39)	K702E	probably damaging	Het
Nwd2	T	A	5: 63,963,338 (GRCm39)	L974H	probably damaging	Het
Parp14	A	G	16: 35,678,381 (GRCm39)	M529T	probably damaging	Het
Parp8	A	G	13: 117,047,478 (GRCm39)	V198A	probably benign	Het
Pcdhb19	A	T	18: 37,631,588 (GRCm39)	H461L	probably benign	Het
Ppp6r1	T	C	7: 4,645,159 (GRCm39)	D236G	possibly damaging	Het
Psg21	T	C	7: 18,388,843 (GRCm39)	D83G	probably benign	Het
Ptpru	A	G	4: 131,546,111 (GRCm39)	C308R	probably damaging	Het
Ralgds	T	A	2: 28,439,100 (GRCm39)	S696T	probably damaging	Het
Rttn	T	A	18: 89,033,274 (GRCm39)	L695Q	probably damaging	Het
Scel	A	T	14: 103,823,950 (GRCm39)	I393F	probably benign	Het
Serpina3j	T	A	12: 104,281,166 (GRCm39)	I113N	probably damaging	Het
Slc4a3	C	A	1: 75,524,579 (GRCm39)		probably benign	Het
Slc6a11	A	T	6: 114,171,570 (GRCm39)		probably null	Het
Slc8a3	C	T	12: 81,249,023 (GRCm39)	V802M	probably damaging	Het
Smarcal1	T	A	1: 72,655,660 (GRCm39)		probably null	Het
Tmprss11c	A	G	5: 86,385,509 (GRCm39)	V308A	probably damaging	Het
Trim10	A	G	17: 37,185,113 (GRCm39)	R279G	possibly damaging	Het
Trim30a	A	G	7: 104,060,348 (GRCm39)	V476A	probably damaging	Het
Trio	T	C	15: 27,832,097 (GRCm39)		probably benign	Het
Urgcp	G	A	11: 5,666,091 (GRCm39)	T749I	possibly damaging	Het
Vmn2r60	A	G	7: 41,786,018 (GRCm39)	I274V	probably benign	Het
Vps11	A	G	9: 44,267,653 (GRCm39)	F40L	probably benign	Het
Ywhab	A	G	2: 163,857,195 (GRCm39)	I157V	probably benign	Het
Zfp638	G	A	6: 83,919,857 (GRCm39)	R485H	probably damaging	Het
Zfp944	A	G	17: 22,558,737 (GRCm39)	I170T	probably benign	Het

Other mutations in Lrrc41

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01309:Lrrc41	APN	4	115,953,663 (GRCm39)	missense	probably damaging	0.97
IGL01358:Lrrc41	APN	4	115,932,784 (GRCm39)	missense	probably benign	0.16
IGL01734:Lrrc41	APN	4	115,950,331 (GRCm39)	critical splice donor site	probably null
IGL01986:Lrrc41	APN	4	115,946,519 (GRCm39)	missense	probably benign	0.27
IGL02159:Lrrc41	APN	4	115,945,683 (GRCm39)	missense	probably benign	0.03
IGL02892:Lrrc41	APN	4	115,946,032 (GRCm39)	missense	possibly damaging	0.68
R1478:Lrrc41	UTSW	4	115,952,405 (GRCm39)	nonsense	probably null
R1765:Lrrc41	UTSW	4	115,946,248 (GRCm39)	missense	possibly damaging	0.94
R2233:Lrrc41	UTSW	4	115,953,582 (GRCm39)	missense	possibly damaging	0.66
R4080:Lrrc41	UTSW	4	115,937,743 (GRCm39)	splice site	probably null
R4677:Lrrc41	UTSW	4	115,952,332 (GRCm39)	missense	probably benign
R4833:Lrrc41	UTSW	4	115,950,374 (GRCm39)	unclassified	probably benign
R4877:Lrrc41	UTSW	4	115,936,602 (GRCm39)	missense	probably damaging	0.99
R4926:Lrrc41	UTSW	4	115,946,521 (GRCm39)	missense	possibly damaging	0.46
R6459:Lrrc41	UTSW	4	115,945,977 (GRCm39)	missense	possibly damaging	0.95
R6817:Lrrc41	UTSW	4	115,946,502 (GRCm39)	missense	possibly damaging	0.66
R6834:Lrrc41	UTSW	4	115,953,726 (GRCm39)	missense	possibly damaging	0.46
R7479:Lrrc41	UTSW	4	115,946,238 (GRCm39)	missense	probably damaging	0.96
R7512:Lrrc41	UTSW	4	115,950,191 (GRCm39)	missense	possibly damaging	0.66
R7593:Lrrc41	UTSW	4	115,950,141 (GRCm39)	missense	possibly damaging	0.94
R8006:Lrrc41	UTSW	4	115,952,085 (GRCm39)	missense	possibly damaging	0.79
R8810:Lrrc41	UTSW	4	115,932,488 (GRCm39)	unclassified	probably benign
R9134:Lrrc41	UTSW	4	115,945,782 (GRCm39)	missense	possibly damaging	0.89
R9495:Lrrc41	UTSW	4	115,932,806 (GRCm39)	critical splice donor site	probably null

Posted On

2016-08-02