Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01776:Armc8'

153873

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Armc8

Ensembl Gene

ENSMUSG00000032468

Gene Name

armadillo repeat containing 8

Synonyms

1200015K23Rik, HSPC056, Gid5

Accession Numbers

Genbank: NM_028768; MGI: 1921375

Is this an essential gene?

Possibly essential (E-score: 0.583) question?

Stock #

IGL01776

Quality Score

Status

Chromosome

Chromosomal Location

99478372-99568899 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

A to G at 99526883 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000140426 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000035043] [ENSMUST00000185524] [ENSMUST00000186049]

Predicted Effect

probably benign
Transcript: ENSMUST00000035043

SMART Domains

Protein: ENSMUSP00000035043
Gene: ENSMUSG00000032468

Domain	Start	End	E-Value	Type
ARM	50	92	1.75e0	SMART
ARM	94	134	5.34e0	SMART
ARM	177	217	2.04e1	SMART
ARM	372	413	3.58e1	SMART
Blast:ARM	414	455	7e-17	BLAST
ARM	457	497	3.81e-1	SMART
ARM	500	540	5.43e1	SMART
Blast:ARM	542	585	1e-20	BLAST
Blast:ARM	633	673	1e-16	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000185524

SMART Domains

Protein: ENSMUSP00000139973
Gene: ENSMUSG00000032468

Domain	Start	End	E-Value	Type
ARM	50	92	1.75e0	SMART
ARM	94	134	5.34e0	SMART
Blast:ARM	138	176	1e-5	BLAST
ARM	177	217	2.04e1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000186049

SMART Domains

Protein: ENSMUSP00000140426
Gene: ENSMUSG00000032468

Domain	Start	End	E-Value	Type
ARM	8	50	8.5e-3	SMART
ARM	52	92	2.6e-2	SMART
Blast:ARM	96	134	7e-6	BLAST
ARM	135	175	9.8e-2	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

All alleles(6) : Targeted, other(2) Gene trapped(4)

Other mutations in this stock

Total: 23 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankrd17	G	A	5: 90,283,364	Q854*	probably null	Het
Chrna7	A	G	7: 63,099,519	V405A	probably benign	Het
Col8a2	C	A	4: 126,309,805		probably benign	Het
Dcn	A	G	10: 97,495,076	I91V	possibly damaging	Het
Dock7	T	A	4: 98,940,941	R2069S	possibly damaging	Het
Gm7247	A	G	14: 51,521,899	S112G	possibly damaging	Het
Hmcn1	T	G	1: 150,672,038	T2721P	possibly damaging	Het
Hsd3b3	T	C	3: 98,743,847	T96A	probably benign	Het
Ifi207	G	A	1: 173,725,044	L936F	probably damaging	Het
Kcp	G	A	6: 29,497,908	P477S	probably damaging	Het
Mei1	T	C	15: 82,095,932		probably null	Het
Mgmt	T	A	7: 137,121,564	L121*	probably null	Het
Mrps35	G	A	6: 147,070,716	V286I	probably benign	Het
Naxd	T	C	8: 11,505,525		probably null	Het
Pam	A	G	1: 97,885,600		probably null	Het
Plcxd1	G	A	5: 110,101,380		probably benign	Het
Rasgrp1	A	G	2: 117,286,840		probably null	Het
Spag9	C	T	11: 94,116,727		probably benign	Het
Spire2	T	C	8: 123,359,392	S288P	probably damaging	Het
Stk11ip	T	C	1: 75,527,821	V322A	probably benign	Het
Syt17	A	C	7: 118,409,953	L343R	probably damaging	Het
Tap1	G	A	17: 34,193,128	V436I	possibly damaging	Het
Virma	C	T	4: 11,527,792	R1228C	probably damaging	Het

Other mutations in Armc8

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00232:Armc8	APN	9	99505734	critical splice acceptor site	probably null
IGL00951:Armc8	APN	9	99505704	missense	probably benign	0.00
IGL02215:Armc8	APN	9	99483978	missense	possibly damaging	0.92
IGL02244:Armc8	APN	9	99483174	missense	probably benign	0.10
IGL02610:Armc8	APN	9	99527069	splice site	probably benign
IGL02612:Armc8	APN	9	99527069	splice site	probably benign
IGL02615:Armc8	APN	9	99527069	splice site	probably benign
IGL02619:Armc8	APN	9	99527069	splice site	probably benign
IGL02621:Armc8	APN	9	99527069	splice site	probably benign
IGL02622:Armc8	APN	9	99527069	splice site	probably benign
IGL02623:Armc8	APN	9	99527069	splice site	probably benign
IGL02624:Armc8	APN	9	99527069	splice site	probably benign
Scrambler	UTSW	9	99496149	critical splice donor site	probably null
D4043:Armc8	UTSW	9	99483976	missense	probably benign	0.13
R0321:Armc8	UTSW	9	99533177	missense	probably damaging	0.99
R0498:Armc8	UTSW	9	99497292	missense	probably damaging	1.00
R0646:Armc8	UTSW	9	99505688	missense	probably damaging	1.00
R0658:Armc8	UTSW	9	99536158	splice site	probably benign
R1061:Armc8	UTSW	9	99537731	missense	probably damaging	1.00
R1406:Armc8	UTSW	9	99523248	missense	probably benign	0.37
R1406:Armc8	UTSW	9	99523248	missense	probably benign	0.37
R1429:Armc8	UTSW	9	99536207	missense	possibly damaging	0.67
R1432:Armc8	UTSW	9	99523132	splice site	probably benign
R1538:Armc8	UTSW	9	99505290	missense	probably damaging	0.96
R1606:Armc8	UTSW	9	99537729	missense	probably damaging	0.98
R1817:Armc8	UTSW	9	99536259	missense	possibly damaging	0.67
R1866:Armc8	UTSW	9	99536280	missense	probably benign
R2015:Armc8	UTSW	9	99483105	nonsense	probably null
R2143:Armc8	UTSW	9	99505308	missense	probably damaging	0.99
R2251:Armc8	UTSW	9	99502600	critical splice acceptor site	probably null
R2842:Armc8	UTSW	9	99505681	missense	probably benign
R3010:Armc8	UTSW	9	99487913	missense	probably benign	0.06
R3709:Armc8	UTSW	9	99520497	missense	probably damaging	1.00
R4440:Armc8	UTSW	9	99484034	missense	probably benign	0.37
R4865:Armc8	UTSW	9	99526889	critical splice donor site	probably null
R5492:Armc8	UTSW	9	99527131	nonsense	probably null
R5606:Armc8	UTSW	9	99536262	missense	probably benign	0.23
R5639:Armc8	UTSW	9	99496149	critical splice donor site	probably null
R5693:Armc8	UTSW	9	99496149	critical splice donor site	probably null
R5694:Armc8	UTSW	9	99496149	critical splice donor site	probably null
R5698:Armc8	UTSW	9	99535820	missense	probably benign	0.12
R5700:Armc8	UTSW	9	99496149	critical splice donor site	probably null
R5701:Armc8	UTSW	9	99496149	critical splice donor site	probably null
R5735:Armc8	UTSW	9	99497394	critical splice acceptor site	probably null
R6314:Armc8	UTSW	9	99535884	missense	probably benign	0.28
R7034:Armc8	UTSW	9	99483965	critical splice donor site	probably null
R7036:Armc8	UTSW	9	99483965	critical splice donor site	probably null
R7393:Armc8	UTSW	9	99483999	missense	possibly damaging	0.47
R7395:Armc8	UTSW	9	99533132	missense	probably damaging	0.99
R7937:Armc8	UTSW	9	99536219	missense	probably damaging	0.98
R8130:Armc8	UTSW	9	99551547	missense	probably benign	0.02
R8373:Armc8	UTSW	9	99527099	missense	probably benign	0.02
Z1177:Armc8	UTSW	9	99497386	missense	probably damaging	0.99

Posted On

2014-02-04