Incidental Mutation 'R1668:Mroh5'
ID 187401
Institutional Source Beutler Lab
Gene Symbol Mroh5
Ensembl Gene ENSMUSG00000072487
Gene Name maestro heat-like repeat family member 5
Synonyms Gm628, LOC268816
MMRRC Submission 039704-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R1668 (G1)
Quality Score 225
Status Not validated
Chromosome 15
Chromosomal Location 73658785-73711520 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 73659754 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 359 (N359S)
Ref Sequence ENSEMBL: ENSMUSP00000071366 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071419] [ENSMUST00000110021] [ENSMUST00000151999]
AlphaFold A0A571BEG0
Predicted Effect probably benign
Transcript: ENSMUST00000071419
AA Change: N359S

PolyPhen 2 Score 0.427 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000071366
Gene: ENSMUSG00000072487
AA Change: N359S

DomainStartEndE-ValueType
low complexity region 173 184 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000110021
AA Change: N362S

PolyPhen 2 Score 0.377 (Sensitivity: 0.90; Specificity: 0.89)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126186
Predicted Effect probably benign
Transcript: ENSMUST00000151999
AA Change: N527S

PolyPhen 2 Score 0.377 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000118236
Gene: ENSMUSG00000072487
AA Change: N527S

DomainStartEndE-ValueType
low complexity region 5 16 N/A INTRINSIC
SCOP:d1gw5a_ 294 635 1e-2 SMART
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adra2c T C 5: 35,437,641 (GRCm39) S138P probably damaging Het
Appl1 A C 14: 26,645,811 (GRCm39) S666R probably damaging Het
Arhgap45 A G 10: 79,864,584 (GRCm39) S879G possibly damaging Het
Calcoco2 T C 11: 95,993,563 (GRCm39) M140V probably benign Het
Cap2 C A 13: 46,768,799 (GRCm39) H147N probably damaging Het
Chd9 A T 8: 91,767,814 (GRCm39) H2437L probably damaging Het
Col5a3 A G 9: 20,682,392 (GRCm39) I1684T unknown Het
Comp A T 8: 70,831,607 (GRCm39) probably null Het
Cyp2c50 A T 19: 40,079,499 (GRCm39) M198L probably benign Het
Dnaaf2 A G 12: 69,243,465 (GRCm39) V532A probably benign Het
Dnah10 A T 5: 124,842,626 (GRCm39) Q1358L probably benign Het
Dop1b T A 16: 93,562,404 (GRCm39) S832T probably damaging Het
Dus3l T G 17: 57,073,912 (GRCm39) F162C possibly damaging Het
Epb41l4a A G 18: 34,054,962 (GRCm39) L42P probably damaging Het
Ercc5 T A 1: 44,206,193 (GRCm39) S369T probably benign Het
Fbxl2 C T 9: 113,818,214 (GRCm39) V211M probably benign Het
Fermt3 A G 19: 6,996,060 (GRCm39) V45A probably damaging Het
Frs3 C A 17: 48,014,147 (GRCm39) P280Q possibly damaging Het
Fxn A G 19: 24,239,377 (GRCm39) Y172H probably damaging Het
Gabpa T C 16: 84,643,069 (GRCm39) V122A probably damaging Het
Gsta4 A G 9: 78,111,570 (GRCm39) T66A probably benign Het
Hsdl2 C T 4: 59,612,697 (GRCm39) T296M probably damaging Het
Kank4 T C 4: 98,667,133 (GRCm39) N438S probably damaging Het
Krt24 A G 11: 99,175,444 (GRCm39) I197T probably benign Het
Lct T C 1: 128,215,459 (GRCm39) probably null Het
Lsmem1 GTACATACATACATACATACATACATACA GTACATACATACATACATACATACATACATACA 12: 40,235,260 (GRCm39) probably null Het
Mc4r A G 18: 66,992,480 (GRCm39) L211P probably damaging Het
Mfsd4b5 T C 10: 39,849,687 (GRCm39) T111A probably damaging Het
Mgat5b T A 11: 116,874,474 (GRCm39) N635K probably benign Het
Mms19 A T 19: 41,940,995 (GRCm39) M443K possibly damaging Het
Morc2a G A 11: 3,625,885 (GRCm39) V162M probably benign Het
Mroh9 T C 1: 162,852,161 (GRCm39) I843V possibly damaging Het
Nbeal2 T C 9: 110,467,961 (GRCm39) D436G probably damaging Het
Nbr1 A G 11: 101,460,592 (GRCm39) D502G probably benign Het
Ngfr C T 11: 95,478,371 (GRCm39) G5D probably damaging Het
Nlrc4 G A 17: 74,752,901 (GRCm39) T494M probably damaging Het
Notch3 T A 17: 32,377,563 (GRCm39) H171L probably damaging Het
Nsmaf A G 4: 6,398,880 (GRCm39) L795P probably damaging Het
Nup210 T C 6: 91,005,787 (GRCm39) T616A possibly damaging Het
Or10d5 C A 9: 39,861,465 (GRCm39) V201L possibly damaging Het
Or1j18 T A 2: 36,625,204 (GRCm39) Y290* probably null Het
Or5ak25 T A 2: 85,269,220 (GRCm39) Y94F probably benign Het
Or5b113 A C 19: 13,342,234 (GRCm39) M81L probably benign Het
Osbpl5 T C 7: 143,262,776 (GRCm39) H192R probably damaging Het
Parp2 G A 14: 51,058,313 (GRCm39) R486Q probably benign Het
Pcgf6 G A 19: 47,028,544 (GRCm39) A286V probably damaging Het
Pla2r1 T C 2: 60,258,990 (GRCm39) T1133A probably damaging Het
Plekha2 T C 8: 25,562,070 (GRCm39) N48S probably damaging Het
Pole T G 5: 110,445,235 (GRCm39) S461A probably damaging Het
Ppfibp2 T C 7: 107,329,099 (GRCm39) L536P probably damaging Het
Prkcz G T 4: 155,374,208 (GRCm39) F69L probably damaging Het
Prkd1 G A 12: 50,441,709 (GRCm39) H277Y probably damaging Het
Rab23 A T 1: 33,773,935 (GRCm39) K132* probably null Het
Rbck1 T A 2: 152,158,819 (GRCm39) S488C probably damaging Het
Rbl1 T C 2: 157,001,654 (GRCm39) Y878C probably damaging Het
Rpn2 C T 2: 157,136,075 (GRCm39) T161M possibly damaging Het
Rufy4 G A 1: 74,186,837 (GRCm39) V542I probably benign Het
Serpinb3d A G 1: 107,008,481 (GRCm39) V128A probably benign Het
Smarca2 A G 19: 26,624,434 (GRCm39) I365V possibly damaging Het
Spata31f1a G T 4: 42,848,424 (GRCm39) T1244K probably damaging Het
Sptb A G 12: 76,667,943 (GRCm39) V718A probably benign Het
Susd4 A G 1: 182,686,128 (GRCm39) H226R probably benign Het
Tmem151b T C 17: 45,856,831 (GRCm39) Y203C probably damaging Het
Tmppe T C 9: 114,233,968 (GRCm39) V89A possibly damaging Het
Trappc6b A T 12: 59,094,907 (GRCm39) probably null Het
Ube4b A T 4: 149,445,751 (GRCm39) M433K probably benign Het
Vmn1r202 A T 13: 22,685,540 (GRCm39) D292E possibly damaging Het
Vmn1r22 A G 6: 57,877,704 (GRCm39) M91T probably benign Het
Vmn1r43 T C 6: 89,846,683 (GRCm39) I268V probably benign Het
Vmn1r49 T A 6: 90,049,764 (GRCm39) R79S probably benign Het
Vmn2r14 T A 5: 109,366,913 (GRCm39) K436* probably null Het
Wdr72 A G 9: 74,117,444 (GRCm39) S719G probably damaging Het
Zfp526 T C 7: 24,924,967 (GRCm39) F409L probably benign Het
Zfp804b A C 5: 6,821,323 (GRCm39) L580R possibly damaging Het
Zfp977 T C 7: 42,230,070 (GRCm39) T152A probably benign Het
Zyx T A 6: 42,332,966 (GRCm39) V372E possibly damaging Het
Other mutations in Mroh5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00420:Mroh5 APN 15 73,664,638 (GRCm39) splice site probably benign
IGL00466:Mroh5 APN 15 73,664,638 (GRCm39) splice site probably benign
IGL02937:Mroh5 APN 15 73,661,827 (GRCm39) missense probably damaging 1.00
R0102:Mroh5 UTSW 15 73,691,199 (GRCm39) missense probably benign 0.07
R0321:Mroh5 UTSW 15 73,661,892 (GRCm39) missense probably damaging 1.00
R0433:Mroh5 UTSW 15 73,662,657 (GRCm39) missense probably damaging 1.00
R0433:Mroh5 UTSW 15 73,661,877 (GRCm39) missense probably benign 0.01
R0707:Mroh5 UTSW 15 73,662,588 (GRCm39) missense possibly damaging 0.48
R1666:Mroh5 UTSW 15 73,659,754 (GRCm39) missense probably benign 0.43
R2139:Mroh5 UTSW 15 73,661,940 (GRCm39) missense probably damaging 1.00
R2269:Mroh5 UTSW 15 73,664,997 (GRCm39) missense probably benign 0.02
R4078:Mroh5 UTSW 15 73,657,889 (GRCm39) missense possibly damaging 0.79
R4420:Mroh5 UTSW 15 73,654,923 (GRCm39) small deletion probably benign
R4460:Mroh5 UTSW 15 73,663,645 (GRCm39) missense probably damaging 0.97
R4585:Mroh5 UTSW 15 73,661,120 (GRCm39) missense probably benign 0.38
R5285:Mroh5 UTSW 15 73,654,923 (GRCm39) small deletion probably benign
R5287:Mroh5 UTSW 15 73,654,923 (GRCm39) small deletion probably benign
R5437:Mroh5 UTSW 15 73,659,818 (GRCm39) missense probably benign 0.02
R5760:Mroh5 UTSW 15 73,693,356 (GRCm39) missense probably damaging 0.98
R5972:Mroh5 UTSW 15 73,662,568 (GRCm39) critical splice donor site probably null
R6192:Mroh5 UTSW 15 73,662,630 (GRCm39) missense probably damaging 1.00
R6457:Mroh5 UTSW 15 73,662,691 (GRCm39) missense probably damaging 1.00
R6477:Mroh5 UTSW 15 73,662,604 (GRCm39) missense probably damaging 1.00
R6776:Mroh5 UTSW 15 73,661,817 (GRCm39) critical splice donor site probably null
R6979:Mroh5 UTSW 15 73,664,978 (GRCm39) missense probably benign 0.16
R7238:Mroh5 UTSW 15 73,663,278 (GRCm39) critical splice acceptor site probably null
R7406:Mroh5 UTSW 15 73,659,583 (GRCm39) missense probably benign 0.38
R7853:Mroh5 UTSW 15 73,663,189 (GRCm39) missense probably benign 0.00
R7973:Mroh5 UTSW 15 73,664,614 (GRCm39) nonsense probably null
R8215:Mroh5 UTSW 15 73,691,139 (GRCm39) missense probably damaging 0.96
R8251:Mroh5 UTSW 15 73,655,002 (GRCm39) missense probably benign 0.01
R8771:Mroh5 UTSW 15 73,693,203 (GRCm39) missense possibly damaging 0.92
R9032:Mroh5 UTSW 15 73,655,302 (GRCm39) missense probably benign 0.00
R9070:Mroh5 UTSW 15 73,656,688 (GRCm39) missense probably damaging 1.00
R9238:Mroh5 UTSW 15 73,663,586 (GRCm39) missense probably benign 0.05
R9321:Mroh5 UTSW 15 73,661,113 (GRCm39) missense probably benign 0.00
X0024:Mroh5 UTSW 15 73,659,570 (GRCm39) missense probably benign 0.01
Z1088:Mroh5 UTSW 15 73,659,880 (GRCm39) missense possibly damaging 0.85
Predicted Primers PCR Primer
(F):5'- ACAGTGGTGACTTCTTTGCCTATGC -3'
(R):5'- TGAACTCGGCCTTCACAATCCCAG -3'

Sequencing Primer
(F):5'- ACATGGACCTTGTGTCAGC -3'
(R):5'- AATCCCAGGCCCTCAGG -3'
Posted On 2014-05-09