Mutagenetix > Incidental Mutations

Incidental Mutation 'R0113:Gm5155'

20580

Institutional Source

Beutler Lab

Gene Symbol

Gm5155

Ensembl Gene

ENSMUSG00000078793

Gene Name

predicted gene 5155

Synonyms

MMRRC Submission

038399-MU

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0113 (G1)

Quality Score

225

Status

Validated (trace)

Chromosome

Chromosomal Location

17871768-17919024 bp(+) (GRCm38)

Type of Mutation

exon

DNA Base Change (assembly)

G to A at 17908948 bp

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000072381

SMART Domains

Protein: ENSMUSP00000072218
Gene: ENSMUSG00000078793

Domain	Start	End	E-Value	Type
IG	40	141	2.27e-2	SMART
IG_like	160	261	2.73e1	SMART
IG_like	277	378	6.69e0	SMART
IG_like	397	498	4.07e1	SMART
IG_like	514	615	6.52e0	SMART
IG_like	634	735	1.05e1	SMART
IG	753	853	1.28e-1	SMART
IGc2	869	933	3.82e-9	SMART

Meta Mutation Damage Score

0.1275

Coding Region Coverage

1x: 99.2%
3x: 98.1%
10x: 95.2%
20x: 87.5%

Validation Efficiency

99% (70/71)

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3930402G23Rik	A	G	8: 10,926,126		noncoding transcript	Het
4930432K21Rik	C	T	8: 84,167,242	T311I	probably damaging	Het
Abca13	A	T	11: 9,292,114	I1326F	possibly damaging	Het
Arnt2	G	A	7: 84,347,530	R63C	probably damaging	Het
Aspscr1	C	G	11: 120,688,925	Q97E	probably damaging	Het
Atad2	A	G	15: 58,120,934		probably benign	Het
Atcay	A	T	10: 81,214,720		probably null	Het
C4b	T	A	17: 34,741,240	Y279F	probably damaging	Het
Cav1	A	T	6: 17,308,049	S67C	possibly damaging	Het
Celf2	A	C	2: 6,624,714	H113Q	probably damaging	Het
Cep170	A	C	1: 176,758,455	N590K	probably damaging	Het
Ces1f	A	T	8: 93,279,699	M1K	probably null	Het
Chrna1	C	A	2: 73,566,836	D370Y	possibly damaging	Het
Csmd1	C	A	8: 15,984,849	G2441C	probably damaging	Het
D630003M21Rik	C	T	2: 158,196,575	D984N	possibly damaging	Het
Dhrs1	T	C	14: 55,739,939	T241A	probably benign	Het
Edar	A	C	10: 58,629,449	C31G	probably damaging	Het
Eps8	A	G	6: 137,537,684	S24P	possibly damaging	Het
Fam149a	T	C	8: 45,341,024	E669G	probably damaging	Het
Fcrla	A	T	1: 170,922,299	M1K	probably null	Het
G3bp1	T	A	11: 55,495,426	V237E	probably benign	Het
Galnt5	A	G	2: 57,998,877	E163G	probably benign	Het
Gpr87	T	C	3: 59,179,511	D192G	possibly damaging	Het
Ino80	G	A	2: 119,382,960	R1249C	probably damaging	Het
Ints1	T	C	5: 139,765,213	T810A		Het
Kalrn	A	G	16: 34,049,936		probably benign	Het
Kcnk6	T	C	7: 29,232,209	D92G	probably damaging	Het
Marf1	C	T	16: 14,142,534	A549T	probably damaging	Het
Mfsd13a	C	T	19: 46,366,504	T40I	probably benign	Het
Mfsd6	A	T	1: 52,709,189	N172K	probably damaging	Het
Mtcl1	G	T	17: 66,354,242	Q1225K	possibly damaging	Het
Nav2	C	T	7: 49,535,953	T948M	probably damaging	Het
Nfic	T	C	10: 81,420,585	K104E	probably damaging	Het
Nupl1	G	A	14: 60,251,291		probably benign	Het
Nwd2	A	T	5: 63,807,898	K1608N	probably damaging	Het
Olfr148	T	A	9: 39,614,002	I145K	probably benign	Het
Olfr50	G	A	2: 36,793,994	G253R	probably damaging	Het
Olfr50	G	T	2: 36,793,995	G253V	probably damaging	Het
Phf21b	T	C	15: 84,804,767	D186G	probably damaging	Het
Poli	C	T	18: 70,528,758	C57Y	probably damaging	Het
Ppp1r16a	C	T	15: 76,690,799		probably benign	Het
Psg23	T	C	7: 18,612,002	Y256C	probably benign	Het
Satb1	C	A	17: 51,782,698	E374*	probably null	Het
Scn4a	C	T	11: 106,345,436	E333K	probably benign	Het
Sec14l2	C	T	11: 4,103,661		probably benign	Het
Slain1	T	C	14: 103,685,825		probably benign	Het
Snapc1	C	T	12: 73,975,032	R81C	probably damaging	Het
Syne2	T	C	12: 75,930,578	S1266P	probably damaging	Het
Syne2	A	G	12: 76,033,722	E4810G	probably damaging	Het
Tbck	T	C	3: 132,743,080	I618T	probably damaging	Het
Tmem132d	A	T	5: 127,784,593	N821K	probably benign	Het
Trim28	T	A	7: 13,028,701	V381E	probably damaging	Het
Ttc1	T	C	11: 43,745,288	S43G	probably benign	Het
Ube2u	A	G	4: 100,481,655	E39G	possibly damaging	Het
Urb2	T	C	8: 124,030,926	V1124A	probably benign	Het
Usp13	A	G	3: 32,817,876		probably benign	Het
Vmn1r216	A	T	13: 23,099,461	S105C	probably damaging	Het
Yipf2	T	C	9: 21,590,116	T23A	probably damaging	Het
Zfp521	G	A	18: 13,845,091	T755M	probably damaging	Het
Zfp619	T	A	7: 39,537,759	M1071K	probably benign	Het
Zfp942	A	T	17: 21,929,085	C188S	probably benign	Het

Other mutations in Gm5155

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00480:Gm5155	APN	7	17910697	missense	probably benign	0.32
IGL01085:Gm5155	APN	7	17915691	missense	possibly damaging	0.71
IGL01135:Gm5155	APN	7	17902471	exon	noncoding transcript
IGL01291:Gm5155	APN	7	17905116	exon	noncoding transcript
IGL02252:Gm5155	APN	7	17910532	missense	possibly damaging	0.93
IGL03243:Gm5155	APN	7	17918649	exon	noncoding transcript
R0833:Gm5155	UTSW	7	17904981	missense	possibly damaging	0.95
R0836:Gm5155	UTSW	7	17904981	missense	possibly damaging	0.95
R1462:Gm5155	UTSW	7	17915591	exon	noncoding transcript
R1473:Gm5155	UTSW	7	17905091	exon	noncoding transcript
R1817:Gm5155	UTSW	7	17873330	exon	noncoding transcript
R1905:Gm5155	UTSW	7	17873552	exon	noncoding transcript
R2362:Gm5155	UTSW	7	17902473	exon	noncoding transcript
R3721:Gm5155	UTSW	7	17902738	missense	probably benign	0.41
R4305:Gm5155	UTSW	7	17905193	missense	probably benign	0.19
R4567:Gm5155	UTSW	7	17908966	missense	probably damaging	0.97
R4587:Gm5155	UTSW	7	17886224	missense	possibly damaging	0.47
R4691:Gm5155	UTSW	7	17908966	missense	possibly damaging	0.93
R4989:Gm5155	UTSW	7	17905218	splice site	probably null
R5023:Gm5155	UTSW	7	17902706	missense	probably damaging	1.00
R5024:Gm5155	UTSW	7	17910682	missense	probably benign	0.06
R5274:Gm5155	UTSW	7	17915717	splice site	probably null
R5279:Gm5155	UTSW	7	17873289	splice site	noncoding transcript
R5304:Gm5155	UTSW	7	17902692	missense	probably benign	0.06
R5312:Gm5155	UTSW	7	17909142	missense	probably damaging	1.00
R5899:Gm5155	UTSW	7	17917444	missense	possibly damaging	0.92

Predicted Primers

PCR Primer
(F):5'- GTTGACACCCAAGTAGAGAGCACC -3'
(R):5'- TGACAATCCTGTGAGTCTGAGCCC -3'

Sequencing Primer
(F):5'- GGAAGATACTTCCTCCACAGTTAGG -3'
(R):5'- GAGAACCACTTACTGTCCAGC -3'

Posted On

2013-04-11