Incidental Mutation 'R1888:Fndc1'
ID |
211934 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Fndc1
|
Ensembl Gene |
ENSMUSG00000071984 |
Gene Name |
fibronectin type III domain containing 1 |
Synonyms |
1110027O12Rik |
MMRRC Submission |
039909-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.073)
|
Stock # |
R1888 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
17 |
Chromosomal Location |
7957401-8046134 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 7990621 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Glutamic Acid to Glycine
at position 1025
(E1025G)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000095036
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000097425]
|
AlphaFold |
A0A6I8MWX0 |
Predicted Effect |
unknown
Transcript: ENSMUST00000097425
AA Change: E1025G
|
SMART Domains |
Protein: ENSMUSP00000095036 Gene: ENSMUSG00000071984 AA Change: E1025G
Domain | Start | End | E-Value | Type |
Blast:FN3
|
1 |
50 |
6e-25 |
BLAST |
FN3
|
54 |
137 |
7.82e-4 |
SMART |
FN3
|
156 |
240 |
1.48e-4 |
SMART |
FN3
|
256 |
340 |
3.67e-9 |
SMART |
low complexity region
|
377 |
388 |
N/A |
INTRINSIC |
low complexity region
|
579 |
601 |
N/A |
INTRINSIC |
low complexity region
|
646 |
676 |
N/A |
INTRINSIC |
low complexity region
|
766 |
777 |
N/A |
INTRINSIC |
low complexity region
|
868 |
884 |
N/A |
INTRINSIC |
low complexity region
|
1021 |
1027 |
N/A |
INTRINSIC |
low complexity region
|
1036 |
1050 |
N/A |
INTRINSIC |
low complexity region
|
1076 |
1090 |
N/A |
INTRINSIC |
Blast:FN3
|
1227 |
1276 |
2e-18 |
BLAST |
low complexity region
|
1277 |
1354 |
N/A |
INTRINSIC |
low complexity region
|
1395 |
1403 |
N/A |
INTRINSIC |
low complexity region
|
1407 |
1423 |
N/A |
INTRINSIC |
FN3
|
1494 |
1577 |
4.32e-6 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000114579
|
Meta Mutation Damage Score |
0.0687 |
Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.4%
- 20x: 92.9%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 87 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4930447C04Rik |
A |
G |
12: 72,960,030 (GRCm39) |
M80T |
unknown |
Het |
4930578I06Rik |
A |
G |
14: 64,223,632 (GRCm39) |
L48P |
probably damaging |
Het |
Abcc9 |
A |
G |
6: 142,625,040 (GRCm39) |
S452P |
probably benign |
Het |
Adgrb2 |
T |
C |
4: 129,907,419 (GRCm39) |
F977S |
probably damaging |
Het |
Adgrf5 |
T |
G |
17: 43,737,896 (GRCm39) |
|
probably null |
Het |
Adgrl4 |
A |
G |
3: 151,144,914 (GRCm39) |
N21S |
probably benign |
Het |
Adss2 |
A |
T |
1: 177,612,517 (GRCm39) |
Y77* |
probably null |
Het |
Ahnak |
A |
T |
19: 8,984,452 (GRCm39) |
D1912V |
probably damaging |
Het |
Ahnak2 |
A |
G |
12: 112,740,325 (GRCm39) |
M1249T |
possibly damaging |
Het |
Akap6 |
A |
T |
12: 53,188,958 (GRCm39) |
D2124V |
possibly damaging |
Het |
Bbs12 |
C |
A |
3: 37,374,712 (GRCm39) |
L387I |
probably damaging |
Het |
Ciita |
T |
C |
16: 10,328,948 (GRCm39) |
Y411H |
probably damaging |
Het |
Ckb |
TCCACCACCA |
TCCACCA |
12: 111,636,079 (GRCm39) |
|
probably benign |
Het |
Clec9a |
G |
A |
6: 129,387,249 (GRCm39) |
V35I |
probably benign |
Het |
Cntn5 |
T |
A |
9: 9,984,082 (GRCm39) |
Q382L |
possibly damaging |
Het |
Cracdl |
T |
C |
1: 37,663,364 (GRCm39) |
K845E |
possibly damaging |
Het |
Dock2 |
A |
T |
11: 34,598,169 (GRCm39) |
I334N |
probably damaging |
Het |
Dock9 |
G |
T |
14: 121,862,617 (GRCm39) |
T833K |
probably benign |
Het |
Drd2 |
G |
A |
9: 49,313,442 (GRCm39) |
V204I |
probably benign |
Het |
Fam120a |
A |
T |
13: 49,039,342 (GRCm39) |
I938N |
possibly damaging |
Het |
Fsip2 |
G |
A |
2: 82,774,504 (GRCm39) |
D64N |
probably benign |
Het |
Gm14496 |
T |
A |
2: 181,641,989 (GRCm39) |
C553* |
probably null |
Het |
Gm6020 |
C |
T |
19: 61,172,391 (GRCm39) |
H22Y |
possibly damaging |
Het |
Hexa |
A |
G |
9: 59,464,586 (GRCm39) |
T159A |
probably benign |
Het |
Hmcn1 |
C |
G |
1: 150,695,251 (GRCm39) |
A218P |
possibly damaging |
Het |
Hpgds |
A |
G |
6: 65,115,217 (GRCm39) |
F22S |
probably damaging |
Het |
Il5ra |
T |
A |
6: 106,708,874 (GRCm39) |
N289Y |
probably damaging |
Het |
Irf2 |
A |
T |
8: 47,260,388 (GRCm39) |
R107* |
probably null |
Het |
Kcnk6 |
T |
C |
7: 28,925,075 (GRCm39) |
I180M |
probably benign |
Het |
Krtap5-3 |
G |
A |
7: 141,755,979 (GRCm39) |
|
probably benign |
Het |
Lrig1 |
C |
T |
6: 94,631,859 (GRCm39) |
A114T |
probably benign |
Het |
Lrrc37a |
A |
G |
11: 103,389,587 (GRCm39) |
V1946A |
probably benign |
Het |
Lrrc8b |
T |
C |
5: 105,629,217 (GRCm39) |
V521A |
probably benign |
Het |
Macf1 |
T |
G |
4: 123,348,835 (GRCm39) |
I2154L |
possibly damaging |
Het |
Macf1 |
C |
A |
4: 123,368,505 (GRCm39) |
E2085D |
probably benign |
Het |
Maml1 |
C |
T |
11: 50,157,468 (GRCm39) |
A236T |
probably benign |
Het |
Mdc1 |
C |
A |
17: 36,165,117 (GRCm39) |
T1481K |
probably benign |
Het |
Mecp2 |
C |
T |
X: 73,080,781 (GRCm39) |
A79T |
probably damaging |
Het |
Mfap3l |
T |
C |
8: 61,124,424 (GRCm39) |
V222A |
possibly damaging |
Het |
Mis18bp1 |
A |
G |
12: 65,196,102 (GRCm39) |
I554T |
probably benign |
Het |
Mpped2 |
T |
C |
2: 106,529,790 (GRCm39) |
I13T |
probably benign |
Het |
Mthfd1l |
C |
A |
10: 4,056,528 (GRCm39) |
T948K |
probably damaging |
Het |
Mtus1 |
C |
T |
8: 41,537,362 (GRCm39) |
S118N |
probably damaging |
Het |
Mtx3 |
A |
G |
13: 92,984,191 (GRCm39) |
E156G |
probably benign |
Het |
Mybbp1a |
C |
T |
11: 72,336,863 (GRCm39) |
T565I |
probably benign |
Het |
Myh2 |
G |
A |
11: 67,071,676 (GRCm39) |
V498M |
probably damaging |
Het |
Myo15b |
G |
A |
11: 115,777,899 (GRCm39) |
G1049S |
probably damaging |
Het |
Myo1b |
T |
A |
1: 51,799,562 (GRCm39) |
|
probably null |
Het |
Ndufa2 |
T |
A |
18: 36,877,573 (GRCm39) |
|
probably benign |
Het |
Nipal2 |
T |
C |
15: 34,625,167 (GRCm39) |
I129M |
possibly damaging |
Het |
Nt5dc3 |
A |
G |
10: 86,669,926 (GRCm39) |
N507S |
possibly damaging |
Het |
Or4b12 |
A |
G |
2: 90,095,913 (GRCm39) |
L287P |
probably damaging |
Het |
Or8b12b |
T |
A |
9: 37,684,163 (GRCm39) |
D69E |
possibly damaging |
Het |
Pcdhb17 |
G |
A |
18: 37,620,438 (GRCm39) |
|
probably null |
Het |
Pcyt2 |
A |
G |
11: 120,508,677 (GRCm39) |
M1T |
probably null |
Het |
Pla2g2d |
T |
C |
4: 138,503,126 (GRCm39) |
M1T |
probably null |
Het |
Plekhg6 |
T |
C |
6: 125,340,306 (GRCm39) |
T685A |
probably damaging |
Het |
Pramel19 |
T |
A |
4: 101,798,335 (GRCm39) |
V102E |
probably damaging |
Het |
Pwwp4a |
G |
T |
X: 72,171,261 (GRCm39) |
G218C |
probably damaging |
Het |
Pxk |
T |
C |
14: 8,151,540 (GRCm38) |
S452P |
probably damaging |
Het |
Rab42 |
A |
T |
4: 132,030,529 (GRCm39) |
D40E |
probably benign |
Het |
Rapgef6 |
A |
C |
11: 54,551,654 (GRCm39) |
T836P |
probably damaging |
Het |
Serpina3a |
A |
G |
12: 104,082,362 (GRCm39) |
D45G |
probably benign |
Het |
Sntb1 |
T |
A |
15: 55,612,745 (GRCm39) |
R278* |
probably null |
Het |
Spice1 |
T |
G |
16: 44,185,989 (GRCm39) |
S111A |
probably damaging |
Het |
Stk40 |
T |
A |
4: 126,019,538 (GRCm39) |
L90Q |
probably damaging |
Het |
Syk |
A |
G |
13: 52,794,826 (GRCm39) |
Y520C |
probably damaging |
Het |
Syngr2 |
G |
A |
11: 117,704,224 (GRCm39) |
V170M |
possibly damaging |
Het |
Tcf12 |
A |
T |
9: 71,765,816 (GRCm39) |
D541E |
possibly damaging |
Het |
Tedc2 |
T |
A |
17: 24,435,291 (GRCm39) |
E366V |
probably damaging |
Het |
Tedc2 |
C |
A |
17: 24,435,292 (GRCm39) |
E366* |
probably null |
Het |
Tlr4 |
T |
C |
4: 66,759,409 (GRCm39) |
V734A |
probably damaging |
Het |
Tmem132a |
T |
C |
19: 10,840,863 (GRCm39) |
E389G |
probably damaging |
Het |
Tmem150b |
A |
G |
7: 4,712,044 (GRCm39) |
I112T |
probably benign |
Het |
Tril |
A |
G |
6: 53,796,577 (GRCm39) |
L215P |
probably damaging |
Het |
Trim24 |
G |
T |
6: 37,934,013 (GRCm39) |
R652L |
probably damaging |
Het |
Ttn |
G |
A |
2: 76,623,151 (GRCm39) |
P15429S |
probably damaging |
Het |
Ttn |
T |
A |
2: 76,706,302 (GRCm39) |
|
probably benign |
Het |
Tubgcp2 |
A |
G |
7: 139,579,183 (GRCm39) |
V701A |
probably damaging |
Het |
Tubgcp2 |
A |
G |
7: 139,586,069 (GRCm39) |
F407L |
probably damaging |
Het |
Vmn1r30 |
A |
C |
6: 58,412,475 (GRCm39) |
L119R |
possibly damaging |
Het |
Washc5 |
A |
C |
15: 59,231,174 (GRCm39) |
L363R |
probably damaging |
Het |
Zan |
T |
C |
5: 137,387,590 (GRCm39) |
T4874A |
unknown |
Het |
Zfp420 |
A |
T |
7: 29,573,933 (GRCm39) |
H51L |
probably damaging |
Het |
Zfp512b |
C |
A |
2: 181,230,235 (GRCm39) |
R497L |
probably damaging |
Het |
Zmat4 |
A |
G |
8: 24,505,177 (GRCm39) |
N139S |
probably damaging |
Het |
Zng1 |
A |
T |
19: 24,932,769 (GRCm39) |
V88D |
probably damaging |
Het |
|
Other mutations in Fndc1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00513:Fndc1
|
APN |
17 |
7,984,086 (GRCm39) |
missense |
unknown |
|
IGL00590:Fndc1
|
APN |
17 |
7,983,933 (GRCm39) |
missense |
unknown |
|
IGL00765:Fndc1
|
APN |
17 |
7,991,525 (GRCm39) |
missense |
unknown |
|
IGL00904:Fndc1
|
APN |
17 |
7,975,195 (GRCm39) |
missense |
probably benign |
0.35 |
IGL01153:Fndc1
|
APN |
17 |
7,998,874 (GRCm39) |
critical splice donor site |
probably null |
|
IGL01557:Fndc1
|
APN |
17 |
7,975,221 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02493:Fndc1
|
APN |
17 |
7,994,377 (GRCm39) |
missense |
unknown |
|
IGL02501:Fndc1
|
APN |
17 |
7,984,230 (GRCm39) |
missense |
unknown |
|
IGL02503:Fndc1
|
APN |
17 |
7,990,348 (GRCm39) |
missense |
unknown |
|
IGL02887:Fndc1
|
APN |
17 |
7,992,470 (GRCm39) |
missense |
unknown |
|
IGL03348:Fndc1
|
APN |
17 |
7,991,479 (GRCm39) |
missense |
unknown |
|
pinnacle
|
UTSW |
17 |
7,992,154 (GRCm39) |
missense |
unknown |
|
spire
|
UTSW |
17 |
7,990,312 (GRCm39) |
missense |
unknown |
|
IGL02988:Fndc1
|
UTSW |
17 |
7,972,355 (GRCm39) |
missense |
possibly damaging |
0.95 |
PIT4466001:Fndc1
|
UTSW |
17 |
7,969,206 (GRCm39) |
missense |
probably damaging |
1.00 |
R0336:Fndc1
|
UTSW |
17 |
7,983,939 (GRCm39) |
missense |
unknown |
|
R0403:Fndc1
|
UTSW |
17 |
7,994,420 (GRCm39) |
splice site |
probably null |
|
R0403:Fndc1
|
UTSW |
17 |
7,972,555 (GRCm39) |
missense |
probably damaging |
1.00 |
R0538:Fndc1
|
UTSW |
17 |
8,003,173 (GRCm39) |
splice site |
probably benign |
|
R0646:Fndc1
|
UTSW |
17 |
7,960,505 (GRCm39) |
missense |
possibly damaging |
0.92 |
R1140:Fndc1
|
UTSW |
17 |
7,994,258 (GRCm39) |
missense |
unknown |
|
R1523:Fndc1
|
UTSW |
17 |
7,992,041 (GRCm39) |
missense |
unknown |
|
R1609:Fndc1
|
UTSW |
17 |
7,991,598 (GRCm39) |
missense |
unknown |
|
R1632:Fndc1
|
UTSW |
17 |
7,992,032 (GRCm39) |
missense |
unknown |
|
R1888:Fndc1
|
UTSW |
17 |
7,990,621 (GRCm39) |
missense |
unknown |
|
R2004:Fndc1
|
UTSW |
17 |
8,023,761 (GRCm39) |
missense |
probably damaging |
1.00 |
R2007:Fndc1
|
UTSW |
17 |
7,997,580 (GRCm39) |
unclassified |
probably benign |
|
R2128:Fndc1
|
UTSW |
17 |
7,997,497 (GRCm39) |
unclassified |
probably benign |
|
R2187:Fndc1
|
UTSW |
17 |
7,960,604 (GRCm39) |
missense |
probably damaging |
1.00 |
R2251:Fndc1
|
UTSW |
17 |
7,972,439 (GRCm39) |
missense |
probably damaging |
1.00 |
R2322:Fndc1
|
UTSW |
17 |
8,007,847 (GRCm39) |
missense |
probably damaging |
0.98 |
R2425:Fndc1
|
UTSW |
17 |
8,023,850 (GRCm39) |
missense |
probably damaging |
1.00 |
R2921:Fndc1
|
UTSW |
17 |
8,023,707 (GRCm39) |
missense |
probably damaging |
0.98 |
R2985:Fndc1
|
UTSW |
17 |
7,975,155 (GRCm39) |
missense |
possibly damaging |
0.93 |
R3436:Fndc1
|
UTSW |
17 |
7,969,189 (GRCm39) |
missense |
probably damaging |
0.99 |
R3499:Fndc1
|
UTSW |
17 |
7,972,416 (GRCm39) |
missense |
possibly damaging |
0.70 |
R3508:Fndc1
|
UTSW |
17 |
7,983,940 (GRCm39) |
nonsense |
probably null |
|
R3766:Fndc1
|
UTSW |
17 |
8,003,253 (GRCm39) |
missense |
probably damaging |
1.00 |
R3813:Fndc1
|
UTSW |
17 |
7,992,154 (GRCm39) |
missense |
unknown |
|
R3814:Fndc1
|
UTSW |
17 |
7,992,154 (GRCm39) |
missense |
unknown |
|
R4031:Fndc1
|
UTSW |
17 |
7,988,584 (GRCm39) |
nonsense |
probably null |
|
R4544:Fndc1
|
UTSW |
17 |
7,992,376 (GRCm39) |
missense |
unknown |
|
R4583:Fndc1
|
UTSW |
17 |
7,958,081 (GRCm39) |
missense |
probably damaging |
1.00 |
R4619:Fndc1
|
UTSW |
17 |
7,984,036 (GRCm39) |
missense |
unknown |
|
R4700:Fndc1
|
UTSW |
17 |
7,990,312 (GRCm39) |
missense |
unknown |
|
R4743:Fndc1
|
UTSW |
17 |
7,991,111 (GRCm39) |
nonsense |
probably null |
|
R4803:Fndc1
|
UTSW |
17 |
7,972,538 (GRCm39) |
missense |
probably damaging |
0.98 |
R4862:Fndc1
|
UTSW |
17 |
7,988,567 (GRCm39) |
missense |
unknown |
|
R4876:Fndc1
|
UTSW |
17 |
7,990,471 (GRCm39) |
missense |
unknown |
|
R5057:Fndc1
|
UTSW |
17 |
7,990,802 (GRCm39) |
nonsense |
probably null |
|
R5327:Fndc1
|
UTSW |
17 |
7,991,540 (GRCm39) |
missense |
unknown |
|
R5372:Fndc1
|
UTSW |
17 |
7,984,042 (GRCm39) |
missense |
unknown |
|
R5533:Fndc1
|
UTSW |
17 |
7,991,608 (GRCm39) |
missense |
unknown |
|
R5754:Fndc1
|
UTSW |
17 |
7,988,585 (GRCm39) |
missense |
unknown |
|
R5762:Fndc1
|
UTSW |
17 |
7,990,366 (GRCm39) |
missense |
unknown |
|
R5830:Fndc1
|
UTSW |
17 |
8,007,918 (GRCm39) |
missense |
possibly damaging |
0.87 |
R5924:Fndc1
|
UTSW |
17 |
7,992,442 (GRCm39) |
missense |
unknown |
|
R6147:Fndc1
|
UTSW |
17 |
7,972,594 (GRCm39) |
splice site |
probably null |
|
R6175:Fndc1
|
UTSW |
17 |
7,991,479 (GRCm39) |
missense |
unknown |
|
R6303:Fndc1
|
UTSW |
17 |
7,977,317 (GRCm39) |
missense |
probably damaging |
0.98 |
R6377:Fndc1
|
UTSW |
17 |
7,988,567 (GRCm39) |
missense |
unknown |
|
R6704:Fndc1
|
UTSW |
17 |
7,990,642 (GRCm39) |
missense |
unknown |
|
R6857:Fndc1
|
UTSW |
17 |
7,991,002 (GRCm39) |
missense |
unknown |
|
R6865:Fndc1
|
UTSW |
17 |
7,991,672 (GRCm39) |
missense |
unknown |
|
R7069:Fndc1
|
UTSW |
17 |
7,988,567 (GRCm39) |
missense |
unknown |
|
R7153:Fndc1
|
UTSW |
17 |
8,020,477 (GRCm39) |
missense |
probably damaging |
1.00 |
R7159:Fndc1
|
UTSW |
17 |
8,019,763 (GRCm39) |
missense |
probably damaging |
0.97 |
R7359:Fndc1
|
UTSW |
17 |
8,032,318 (GRCm39) |
splice site |
probably null |
|
R7731:Fndc1
|
UTSW |
17 |
7,992,271 (GRCm39) |
missense |
unknown |
|
R7743:Fndc1
|
UTSW |
17 |
7,983,969 (GRCm39) |
missense |
unknown |
|
R7884:Fndc1
|
UTSW |
17 |
7,992,029 (GRCm39) |
missense |
unknown |
|
R8071:Fndc1
|
UTSW |
17 |
7,991,362 (GRCm39) |
missense |
unknown |
|
R8100:Fndc1
|
UTSW |
17 |
7,990,685 (GRCm39) |
missense |
unknown |
|
R8317:Fndc1
|
UTSW |
17 |
8,019,720 (GRCm39) |
nonsense |
probably null |
|
R8362:Fndc1
|
UTSW |
17 |
8,001,207 (GRCm39) |
missense |
unknown |
|
R8835:Fndc1
|
UTSW |
17 |
7,958,111 (GRCm39) |
missense |
probably damaging |
1.00 |
R8841:Fndc1
|
UTSW |
17 |
7,992,181 (GRCm39) |
missense |
unknown |
|
R8912:Fndc1
|
UTSW |
17 |
8,019,778 (GRCm39) |
missense |
probably null |
0.26 |
R9236:Fndc1
|
UTSW |
17 |
7,992,460 (GRCm39) |
missense |
unknown |
|
R9392:Fndc1
|
UTSW |
17 |
7,991,957 (GRCm39) |
missense |
unknown |
|
R9412:Fndc1
|
UTSW |
17 |
7,991,198 (GRCm39) |
missense |
unknown |
|
R9618:Fndc1
|
UTSW |
17 |
7,990,313 (GRCm39) |
missense |
unknown |
|
R9632:Fndc1
|
UTSW |
17 |
7,991,622 (GRCm39) |
missense |
unknown |
|
R9748:Fndc1
|
UTSW |
17 |
7,991,929 (GRCm39) |
missense |
unknown |
|
Z1088:Fndc1
|
UTSW |
17 |
8,001,311 (GRCm39) |
missense |
probably damaging |
0.96 |
Z1176:Fndc1
|
UTSW |
17 |
8,023,709 (GRCm39) |
missense |
possibly damaging |
0.90 |
Z1176:Fndc1
|
UTSW |
17 |
7,992,425 (GRCm39) |
nonsense |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- TTTCGAGGCTGGTACCAGGTAG -3'
(R):5'- CTCAAACCTCAGCAGATGGG -3'
Sequencing Primer
(F):5'- CCAGGTAGGTGGATGTGAGGC -3'
(R):5'- CCAGTCAGGGAACAGTGGC -3'
|
Posted On |
2014-06-30 |