Mutagenetix > Incidental Mutation

Incidental Mutation 'R2137:Ncor2'

235877

Institutional Source

Beutler Lab

Gene Symbol

Ncor2

Ensembl Gene

ENSMUSG00000029478

Gene Name

nuclear receptor co-repressor 2

Synonyms

SMRTe, SMRT

MMRRC Submission

040140-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R2137 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

125094217-125256283 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 125107776 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Lysine at position 1607 (I1607K)

Ref Sequence

ENSEMBL: ENSMUSP00000107029 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055256] [ENSMUST00000086083] [ENSMUST00000111393] [ENSMUST00000111394] [ENSMUST00000111398] [ENSMUST00000111402] [ENSMUST00000134404]

AlphaFold

Q9WU42

Predicted Effect

probably damaging
Transcript: ENSMUST00000055256
AA Change: I1608K

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000055954
Gene: ENSMUSG00000029478
AA Change: I1608K

Domain	Start	End	E-Value	Type
low complexity region	147	154	N/A	INTRINSIC
coiled coil region	167	207	N/A	INTRINSIC
SANT	428	476	4.42e-6	SMART
coiled coil region	494	550	N/A	INTRINSIC
SANT	607	655	1.43e-14	SMART
low complexity region	668	686	N/A	INTRINSIC
low complexity region	699	726	N/A	INTRINSIC
low complexity region	768	813	N/A	INTRINSIC
low complexity region	822	828	N/A	INTRINSIC
low complexity region	848	860	N/A	INTRINSIC
low complexity region	867	874	N/A	INTRINSIC
low complexity region	905	919	N/A	INTRINSIC
low complexity region	935	944	N/A	INTRINSIC
low complexity region	989	1000	N/A	INTRINSIC
low complexity region	1011	1025	N/A	INTRINSIC
low complexity region	1027	1043	N/A	INTRINSIC
low complexity region	1086	1096	N/A	INTRINSIC
low complexity region	1100	1116	N/A	INTRINSIC
low complexity region	1366	1380	N/A	INTRINSIC
low complexity region	1481	1497	N/A	INTRINSIC
low complexity region	1616	1622	N/A	INTRINSIC
low complexity region	1709	1726	N/A	INTRINSIC
low complexity region	1737	1754	N/A	INTRINSIC
low complexity region	1764	1776	N/A	INTRINSIC
low complexity region	1800	1807	N/A	INTRINSIC
low complexity region	1921	1939	N/A	INTRINSIC
low complexity region	1959	1975	N/A	INTRINSIC
low complexity region	2062	2076	N/A	INTRINSIC
PDB:2GPV\|I	2293	2314	8e-8	PDB
low complexity region	2324	2336	N/A	INTRINSIC
low complexity region	2433	2453	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000086083
AA Change: I1606K

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000083250
Gene: ENSMUSG00000029478
AA Change: I1606K

Domain	Start	End	E-Value	Type
low complexity region	147	154	N/A	INTRINSIC
coiled coil region	167	207	N/A	INTRINSIC
SANT	428	476	4.42e-6	SMART
coiled coil region	494	550	N/A	INTRINSIC
SANT	607	655	1.43e-14	SMART
low complexity region	668	686	N/A	INTRINSIC
low complexity region	699	726	N/A	INTRINSIC
low complexity region	768	813	N/A	INTRINSIC
low complexity region	822	828	N/A	INTRINSIC
low complexity region	848	860	N/A	INTRINSIC
low complexity region	867	874	N/A	INTRINSIC
low complexity region	905	919	N/A	INTRINSIC
low complexity region	935	944	N/A	INTRINSIC
low complexity region	988	999	N/A	INTRINSIC
low complexity region	1010	1024	N/A	INTRINSIC
low complexity region	1026	1042	N/A	INTRINSIC
low complexity region	1085	1095	N/A	INTRINSIC
low complexity region	1099	1115	N/A	INTRINSIC
low complexity region	1364	1378	N/A	INTRINSIC
low complexity region	1479	1495	N/A	INTRINSIC
low complexity region	1614	1620	N/A	INTRINSIC
low complexity region	1707	1724	N/A	INTRINSIC
low complexity region	1735	1752	N/A	INTRINSIC
low complexity region	1762	1774	N/A	INTRINSIC
low complexity region	1798	1805	N/A	INTRINSIC
low complexity region	1916	1934	N/A	INTRINSIC
low complexity region	1954	1970	N/A	INTRINSIC
low complexity region	2057	2071	N/A	INTRINSIC
PDB:2GPV\|I	2288	2309	8e-8	PDB
low complexity region	2319	2331	N/A	INTRINSIC
low complexity region	2428	2448	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000111393
AA Change: I1467K

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000107024
Gene: ENSMUSG00000029478
AA Change: I1467K

Domain	Start	End	E-Value	Type
coiled coil region	1	32	N/A	INTRINSIC
SANT	253	301	4.42e-6	SMART
coiled coil region	319	375	N/A	INTRINSIC
SANT	432	480	1.43e-14	SMART
low complexity region	493	511	N/A	INTRINSIC
low complexity region	524	551	N/A	INTRINSIC
low complexity region	593	638	N/A	INTRINSIC
low complexity region	647	653	N/A	INTRINSIC
low complexity region	673	685	N/A	INTRINSIC
low complexity region	692	699	N/A	INTRINSIC
low complexity region	730	744	N/A	INTRINSIC
low complexity region	760	769	N/A	INTRINSIC
low complexity region	813	824	N/A	INTRINSIC
low complexity region	835	849	N/A	INTRINSIC
low complexity region	851	867	N/A	INTRINSIC
low complexity region	910	920	N/A	INTRINSIC
low complexity region	924	940	N/A	INTRINSIC
low complexity region	1225	1239	N/A	INTRINSIC
low complexity region	1340	1356	N/A	INTRINSIC
low complexity region	1475	1481	N/A	INTRINSIC
low complexity region	1568	1585	N/A	INTRINSIC
low complexity region	1596	1613	N/A	INTRINSIC
low complexity region	1623	1635	N/A	INTRINSIC
low complexity region	1659	1666	N/A	INTRINSIC
low complexity region	1780	1798	N/A	INTRINSIC
low complexity region	1818	1834	N/A	INTRINSIC
low complexity region	1921	1935	N/A	INTRINSIC
PDB:2GPV\|I	2152	2173	7e-8	PDB
low complexity region	2183	2195	N/A	INTRINSIC
low complexity region	2292	2312	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000111394
AA Change: I1388K

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000107025
Gene: ENSMUSG00000029478
AA Change: I1388K

Domain	Start	End	E-Value	Type
SANT	209	257	4.42e-6	SMART
coiled coil region	275	331	N/A	INTRINSIC
SANT	388	436	1.43e-14	SMART
low complexity region	449	467	N/A	INTRINSIC
low complexity region	480	507	N/A	INTRINSIC
low complexity region	549	594	N/A	INTRINSIC
low complexity region	603	609	N/A	INTRINSIC
low complexity region	629	641	N/A	INTRINSIC
low complexity region	648	655	N/A	INTRINSIC
low complexity region	686	700	N/A	INTRINSIC
low complexity region	716	725	N/A	INTRINSIC
low complexity region	769	780	N/A	INTRINSIC
low complexity region	791	805	N/A	INTRINSIC
low complexity region	807	823	N/A	INTRINSIC
low complexity region	866	876	N/A	INTRINSIC
low complexity region	880	896	N/A	INTRINSIC
low complexity region	1146	1160	N/A	INTRINSIC
low complexity region	1261	1277	N/A	INTRINSIC
low complexity region	1396	1402	N/A	INTRINSIC
low complexity region	1489	1506	N/A	INTRINSIC
low complexity region	1517	1534	N/A	INTRINSIC
low complexity region	1544	1556	N/A	INTRINSIC
low complexity region	1580	1587	N/A	INTRINSIC
low complexity region	1701	1719	N/A	INTRINSIC
low complexity region	1739	1755	N/A	INTRINSIC
low complexity region	1842	1856	N/A	INTRINSIC
PDB:2GPV\|I	2073	2094	7e-8	PDB
low complexity region	2104	2116	N/A	INTRINSIC
low complexity region	2213	2233	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000111398
AA Change: I1607K

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000107029
Gene: ENSMUSG00000029478
AA Change: I1607K

Domain	Start	End	E-Value	Type
low complexity region	147	154	N/A	INTRINSIC
coiled coil region	167	207	N/A	INTRINSIC
SANT	428	476	4.42e-6	SMART
coiled coil region	494	550	N/A	INTRINSIC
SANT	607	655	1.43e-14	SMART
low complexity region	668	686	N/A	INTRINSIC
low complexity region	699	726	N/A	INTRINSIC
low complexity region	768	813	N/A	INTRINSIC
low complexity region	822	828	N/A	INTRINSIC
low complexity region	848	860	N/A	INTRINSIC
low complexity region	867	874	N/A	INTRINSIC
low complexity region	905	919	N/A	INTRINSIC
low complexity region	935	944	N/A	INTRINSIC
low complexity region	988	999	N/A	INTRINSIC
low complexity region	1010	1024	N/A	INTRINSIC
low complexity region	1026	1042	N/A	INTRINSIC
low complexity region	1085	1095	N/A	INTRINSIC
low complexity region	1099	1115	N/A	INTRINSIC
low complexity region	1365	1379	N/A	INTRINSIC
low complexity region	1480	1496	N/A	INTRINSIC
low complexity region	1615	1621	N/A	INTRINSIC
low complexity region	1708	1725	N/A	INTRINSIC
low complexity region	1736	1753	N/A	INTRINSIC
low complexity region	1763	1775	N/A	INTRINSIC
low complexity region	1799	1806	N/A	INTRINSIC
low complexity region	1920	1938	N/A	INTRINSIC
low complexity region	1958	1974	N/A	INTRINSIC
low complexity region	2061	2075	N/A	INTRINSIC
PDB:2GPV\|I	2292	2313	8e-8	PDB
low complexity region	2323	2335	N/A	INTRINSIC
low complexity region	2432	2452	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000111402
AA Change: I1642K

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000107033
Gene: ENSMUSG00000029478
AA Change: I1642K

Domain	Start	End	E-Value	Type
Pfam:GPS2_interact	141	229	4.9e-41	PFAM
SANT	428	476	4.42e-6	SMART
coiled coil region	494	550	N/A	INTRINSIC
SANT	607	655	1.43e-14	SMART
low complexity region	668	686	N/A	INTRINSIC
low complexity region	699	726	N/A	INTRINSIC
low complexity region	768	813	N/A	INTRINSIC
low complexity region	822	828	N/A	INTRINSIC
low complexity region	848	860	N/A	INTRINSIC
low complexity region	867	874	N/A	INTRINSIC
low complexity region	905	919	N/A	INTRINSIC
low complexity region	935	944	N/A	INTRINSIC
low complexity region	988	999	N/A	INTRINSIC
low complexity region	1010	1024	N/A	INTRINSIC
low complexity region	1026	1042	N/A	INTRINSIC
low complexity region	1085	1095	N/A	INTRINSIC
low complexity region	1099	1115	N/A	INTRINSIC
low complexity region	1400	1414	N/A	INTRINSIC
low complexity region	1515	1531	N/A	INTRINSIC
low complexity region	1650	1656	N/A	INTRINSIC
low complexity region	1743	1760	N/A	INTRINSIC
low complexity region	1771	1788	N/A	INTRINSIC
low complexity region	1798	1810	N/A	INTRINSIC
low complexity region	1834	1841	N/A	INTRINSIC
low complexity region	1955	1973	N/A	INTRINSIC
low complexity region	1993	2009	N/A	INTRINSIC
low complexity region	2096	2110	N/A	INTRINSIC
PDB:2GPV\|I	2327	2348	8e-8	PDB
low complexity region	2358	2370	N/A	INTRINSIC
low complexity region	2467	2487	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000125053
AA Change: I689K

SMART Domains

Protein: ENSMUSP00000117098
Gene: ENSMUSG00000029478
AA Change: I689K

Domain	Start	End	E-Value	Type
low complexity region	36	47	N/A	INTRINSIC
low complexity region	58	72	N/A	INTRINSIC
low complexity region	74	90	N/A	INTRINSIC
low complexity region	133	143	N/A	INTRINSIC
low complexity region	147	163	N/A	INTRINSIC
low complexity region	448	462	N/A	INTRINSIC
low complexity region	563	579	N/A	INTRINSIC
low complexity region	698	704	N/A	INTRINSIC
low complexity region	791	808	N/A	INTRINSIC
low complexity region	819	836	N/A	INTRINSIC
low complexity region	846	858	N/A	INTRINSIC
low complexity region	882	889	N/A	INTRINSIC
low complexity region	1000	1018	N/A	INTRINSIC
low complexity region	1038	1054	N/A	INTRINSIC
low complexity region	1141	1155	N/A	INTRINSIC
PDB:2GPV\|I	1372	1393	5e-8	PDB
low complexity region	1403	1415	N/A	INTRINSIC
low complexity region	1512	1532	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000130742

Predicted Effect

probably benign
Transcript: ENSMUST00000134404

SMART Domains

Protein: ENSMUSP00000121588
Gene: ENSMUSG00000029478

Domain	Start	End	E-Value	Type
SANT	2	49	1.94e-2	SMART
low complexity region	84	100	N/A	INTRINSIC
low complexity region	113	140	N/A	INTRINSIC
low complexity region	182	227	N/A	INTRINSIC
low complexity region	236	242	N/A	INTRINSIC
low complexity region	262	274	N/A	INTRINSIC
low complexity region	281	288	N/A	INTRINSIC
low complexity region	319	333	N/A	INTRINSIC
low complexity region	349	358	N/A	INTRINSIC
low complexity region	402	413	N/A	INTRINSIC
low complexity region	424	438	N/A	INTRINSIC
low complexity region	440	456	N/A	INTRINSIC
low complexity region	499	509	N/A	INTRINSIC
low complexity region	513	529	N/A	INTRINSIC
low complexity region	813	827	N/A	INTRINSIC
low complexity region	928	944	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000134819

SMART Domains

Protein: ENSMUSP00000115776
Gene: ENSMUSG00000029478

Domain	Start	End	E-Value	Type
low complexity region	4	20	N/A	INTRINSIC
low complexity region	145	159	N/A	INTRINSIC

Meta Mutation Damage Score

0.3872

Coding Region Coverage

1x: 99.2%
3x: 98.7%
10x: 97.4%
20x: 95.4%

Validation Efficiency

97% (60/62)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]
PHENOTYPE: Mice homozygous for a null allele die before E16.5 of heart defects and exhibit neural defects. [provided by MGI curators]

Allele List at MGI

All alleles(145) : Targeted(2) Gene trapped(143)

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankrd24	C	T	10: 81,482,143 (GRCm39)	T88I	probably damaging	Het
Atm	A	T	9: 53,364,675 (GRCm39)	V49D	probably damaging	Het
Bub1b	G	T	2: 118,467,199 (GRCm39)	E841*	probably null	Het
Cdh20	A	T	1: 110,027,836 (GRCm39)	N527I	probably damaging	Het
Cdh22	G	A	2: 164,958,314 (GRCm39)		probably benign	Het
Cog1	T	C	11: 113,550,127 (GRCm39)	L262P	probably damaging	Het
Col22a1	T	C	15: 71,878,797 (GRCm39)	H120R	possibly damaging	Het
Col4a2	T	C	8: 11,483,749 (GRCm39)	S890P	probably benign	Het
Cubn	T	C	2: 13,340,978 (GRCm39)	I2248V	probably benign	Het
Evpl	T	C	11: 116,112,665 (GRCm39)	E1675G	probably damaging	Het
Faiml	G	A	9: 99,114,545 (GRCm39)	P115S	probably benign	Het
Fgg	A	T	3: 82,915,745 (GRCm39)	D62V	possibly damaging	Het
Gak	C	T	5: 108,754,743 (GRCm39)		probably null	Het
Galntl6	C	T	8: 58,988,939 (GRCm39)		probably null	Het
Glyr1	T	C	16: 4,836,346 (GRCm39)	Y501C	probably benign	Het
Gm9847	G	T	12: 14,545,082 (GRCm39)		noncoding transcript	Het
Gria4	T	G	9: 4,427,026 (GRCm39)		probably benign	Het
Il36b	A	G	2: 24,044,672 (GRCm39)	N24S	probably benign	Het
Il6st	C	A	13: 112,639,392 (GRCm39)	H606N	possibly damaging	Het
Itprid1	A	G	6: 55,866,174 (GRCm39)	Q189R	probably damaging	Het
Kctd10	A	G	5: 114,505,389 (GRCm39)	F202L	probably damaging	Het
Kif17	T	A	4: 137,989,978 (GRCm39)	D55E	probably damaging	Het
Klf1	C	T	8: 85,629,775 (GRCm39)	A200V	possibly damaging	Het
Klhl32	A	T	4: 24,629,275 (GRCm39)	Y497*	probably null	Het
Kng2	G	T	16: 22,816,076 (GRCm39)		probably benign	Het
Lats1	T	C	10: 7,577,611 (GRCm39)	V245A	possibly damaging	Het
Mbd3l2	A	T	9: 18,356,254 (GRCm39)	D193V	probably damaging	Het
Ms4a18	A	T	19: 10,974,695 (GRCm39)	V332D	possibly damaging	Het
Mss51	T	C	14: 20,537,591 (GRCm39)	I47V	probably benign	Het
Myoz2	G	A	3: 122,827,861 (GRCm39)	T19M	probably benign	Het
Nampt	T	A	12: 32,880,309 (GRCm39)	N67K	probably benign	Het
Nudt4	T	C	10: 95,399,600 (GRCm39)	Q7R	probably damaging	Het
Or5b119	A	G	19: 13,457,173 (GRCm39)	Y130H	probably damaging	Het
Or5b121	T	A	19: 13,507,802 (GRCm39)	I255N	probably damaging	Het
Or8b12i	T	A	9: 20,082,463 (GRCm39)	I135F	probably damaging	Het
Pgm2	A	T	5: 64,273,709 (GRCm39)	M565L	probably benign	Het
Phactr1	T	G	13: 43,288,651 (GRCm39)	F639V	possibly damaging	Het
Plod3	C	A	5: 137,017,571 (GRCm39)	R165S	probably damaging	Het
Polr2b	T	A	5: 77,468,193 (GRCm39)	N164K	probably benign	Het
Rcbtb2	G	A	14: 73,399,491 (GRCm39)	G52S	probably damaging	Het
Rfc1	A	G	5: 65,468,382 (GRCm39)		probably null	Het
Rheb	A	G	5: 25,012,601 (GRCm39)		probably null	Het
Rin2	C	T	2: 145,702,366 (GRCm39)	T354I	probably benign	Het
Ripor2	G	A	13: 24,905,817 (GRCm39)		probably null	Het
Rsf1	ATGGCG	ATGGCGACGGTGGCG	7: 97,229,111 (GRCm39)		probably benign	Het
Scg3	A	T	9: 75,584,092 (GRCm39)	D136E	probably damaging	Het
Slc10a4	C	T	5: 73,164,923 (GRCm39)	L172F	probably damaging	Het
Slc35c2	A	G	2: 165,123,299 (GRCm39)	Y113H	probably damaging	Het
Slc47a1	T	A	11: 61,235,318 (GRCm39)	D505V	probably benign	Het
Snap29	C	A	16: 17,246,113 (GRCm39)	D244E	possibly damaging	Het
Taar1	T	C	10: 23,797,168 (GRCm39)	F289L	probably benign	Het
Thbs2	T	A	17: 14,893,568 (GRCm39)	N871Y	probably damaging	Het
Tmem108	T	A	9: 103,377,162 (GRCm39)	T96S	possibly damaging	Het
Tnk2	G	T	16: 32,489,620 (GRCm39)		probably null	Het
Trak1	T	A	9: 121,302,028 (GRCm39)	M928K	possibly damaging	Het
Tuba3b	A	G	6: 145,564,559 (GRCm39)	I110V	probably benign	Het
Tyk2	A	G	9: 21,022,281 (GRCm39)		probably benign	Het
Ugt1a9	T	A	1: 87,998,759 (GRCm39)	C70S	probably benign	Het
Vmn2r10	A	T	5: 109,151,410 (GRCm39)	I68K	possibly damaging	Het
Wfs1	T	C	5: 37,124,845 (GRCm39)	E682G	probably damaging	Het
Zfp213	T	C	17: 23,778,481 (GRCm39)		probably null	Het
Zfp809	T	C	9: 22,146,434 (GRCm39)	V41A	probably benign	Het
Zfp831	A	G	2: 174,547,539 (GRCm39)	K1574R	possibly damaging	Het

Other mutations in Ncor2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00330:Ncor2	APN	5	125,119,807 (GRCm39)	critical splice donor site	probably null
IGL00519:Ncor2	APN	5	125,161,988 (GRCm39)	missense	unknown
IGL00900:Ncor2	APN	5	125,102,848 (GRCm39)	missense	probably damaging	1.00
IGL00950:Ncor2	APN	5	125,163,954 (GRCm39)	missense	unknown
IGL01320:Ncor2	APN	5	125,186,991 (GRCm39)	missense	probably benign	0.00
IGL01382:Ncor2	APN	5	125,132,837 (GRCm39)	missense	probably damaging	0.96
IGL01573:Ncor2	APN	5	125,162,090 (GRCm39)	missense	unknown
IGL01721:Ncor2	APN	5	125,128,001 (GRCm39)	missense	probably damaging	1.00
IGL01875:Ncor2	APN	5	125,142,934 (GRCm39)	missense	unknown
IGL02090:Ncor2	APN	5	125,111,467 (GRCm39)	missense	probably damaging	0.99
IGL02192:Ncor2	APN	5	125,101,301 (GRCm39)	missense	probably damaging	1.00
IGL02396:Ncor2	APN	5	125,114,978 (GRCm39)	missense	probably damaging	1.00
IGL02934:Ncor2	APN	5	125,102,621 (GRCm39)	missense	probably benign	0.33
IGL02997:Ncor2	APN	5	125,196,634 (GRCm39)	intron	probably benign
R0019:Ncor2	UTSW	5	125,196,545 (GRCm39)	critical splice donor site	probably null
R0331:Ncor2	UTSW	5	125,161,981 (GRCm39)	missense	unknown
R0333:Ncor2	UTSW	5	125,111,408 (GRCm39)	splice site	probably benign
R0403:Ncor2	UTSW	5	125,110,401 (GRCm39)	missense	possibly damaging	0.73
R0557:Ncor2	UTSW	5	125,183,369 (GRCm39)	nonsense	probably null
R0562:Ncor2	UTSW	5	125,162,093 (GRCm39)	missense	unknown
R0671:Ncor2	UTSW	5	125,126,451 (GRCm39)	missense	probably benign	0.13
R0699:Ncor2	UTSW	5	125,106,176 (GRCm39)	unclassified	probably benign
R0865:Ncor2	UTSW	5	125,116,046 (GRCm39)	missense	probably benign	0.17
R1183:Ncor2	UTSW	5	125,100,585 (GRCm39)	missense	possibly damaging	0.65
R1325:Ncor2	UTSW	5	125,195,844 (GRCm39)	intron	probably benign
R1344:Ncor2	UTSW	5	125,102,510 (GRCm39)	missense	probably damaging	1.00
R1433:Ncor2	UTSW	5	125,187,039 (GRCm39)	intron	probably benign
R1481:Ncor2	UTSW	5	125,104,202 (GRCm39)	nonsense	probably null
R1539:Ncor2	UTSW	5	125,187,003 (GRCm39)	missense	probably benign	0.07
R1558:Ncor2	UTSW	5	125,110,610 (GRCm39)	missense	probably damaging	1.00
R1585:Ncor2	UTSW	5	125,162,062 (GRCm39)	missense	unknown
R1611:Ncor2	UTSW	5	125,187,084 (GRCm39)	intron	probably benign
R1764:Ncor2	UTSW	5	125,105,679 (GRCm39)	missense	possibly damaging	0.91
R1789:Ncor2	UTSW	5	125,096,954 (GRCm39)	missense	probably damaging	1.00
R1809:Ncor2	UTSW	5	125,195,857 (GRCm39)	intron	probably benign
R1901:Ncor2	UTSW	5	125,102,489 (GRCm39)	missense	probably benign	0.39
R1946:Ncor2	UTSW	5	125,111,476 (GRCm39)	missense	probably damaging	1.00
R1970:Ncor2	UTSW	5	125,115,982 (GRCm39)	missense	probably damaging	0.99
R2048:Ncor2	UTSW	5	125,161,996 (GRCm39)	missense	unknown
R2270:Ncor2	UTSW	5	125,115,019 (GRCm39)	missense	probably benign	0.33
R2380:Ncor2	UTSW	5	125,113,144 (GRCm39)	missense	possibly damaging	0.89
R2570:Ncor2	UTSW	5	125,105,864 (GRCm39)	critical splice acceptor site	probably null
R2918:Ncor2	UTSW	5	125,102,824 (GRCm39)	missense	probably damaging	0.99
R2921:Ncor2	UTSW	5	125,132,855 (GRCm39)	missense	probably damaging	1.00
R2922:Ncor2	UTSW	5	125,132,855 (GRCm39)	missense	probably damaging	1.00
R2923:Ncor2	UTSW	5	125,132,855 (GRCm39)	missense	probably damaging	1.00
R3116:Ncor2	UTSW	5	125,101,230 (GRCm39)	missense	probably damaging	1.00
R3768:Ncor2	UTSW	5	125,105,751 (GRCm39)	missense	probably damaging	1.00
R3826:Ncor2	UTSW	5	125,195,756 (GRCm39)	intron	probably benign
R3829:Ncor2	UTSW	5	125,195,756 (GRCm39)	intron	probably benign
R3830:Ncor2	UTSW	5	125,195,756 (GRCm39)	intron	probably benign
R3951:Ncor2	UTSW	5	125,109,320 (GRCm39)	missense	possibly damaging	0.94
R4175:Ncor2	UTSW	5	125,128,020 (GRCm39)	missense	probably damaging	0.99
R4360:Ncor2	UTSW	5	125,106,036 (GRCm39)	missense	probably damaging	1.00
R4470:Ncor2	UTSW	5	125,179,705 (GRCm39)	critical splice donor site	probably null
R4490:Ncor2	UTSW	5	125,113,879 (GRCm39)	splice site	probably null
R4573:Ncor2	UTSW	5	125,132,889 (GRCm39)	missense	probably damaging	0.99
R4611:Ncor2	UTSW	5	125,107,923 (GRCm39)	missense	probably damaging	1.00
R4799:Ncor2	UTSW	5	125,114,124 (GRCm39)	critical splice donor site	probably null
R4851:Ncor2	UTSW	5	125,110,431 (GRCm39)	missense	possibly damaging	0.93
R4853:Ncor2	UTSW	5	125,158,247 (GRCm39)	missense	unknown
R4853:Ncor2	UTSW	5	125,102,169 (GRCm39)	missense	probably damaging	0.99
R4896:Ncor2	UTSW	5	125,126,404 (GRCm39)	critical splice donor site	probably null
R4997:Ncor2	UTSW	5	125,111,074 (GRCm39)	missense	probably damaging	0.99
R5057:Ncor2	UTSW	5	125,125,130 (GRCm39)	missense	possibly damaging	0.86
R5253:Ncor2	UTSW	5	125,103,994 (GRCm39)	missense	probably benign	0.44
R5461:Ncor2	UTSW	5	125,104,177 (GRCm39)	missense	probably damaging	1.00
R5585:Ncor2	UTSW	5	125,144,975 (GRCm39)	nonsense	probably null
R5638:Ncor2	UTSW	5	125,125,364 (GRCm39)	missense	probably benign	0.33
R5879:Ncor2	UTSW	5	125,103,839 (GRCm39)	unclassified	probably benign
R5967:Ncor2	UTSW	5	125,146,048 (GRCm39)	missense	unknown
R5999:Ncor2	UTSW	5	125,110,505 (GRCm39)	missense	probably damaging	1.00
R6020:Ncor2	UTSW	5	125,097,075 (GRCm39)	missense	probably benign	0.14
R6109:Ncor2	UTSW	5	125,132,910 (GRCm39)	missense	probably damaging	1.00
R6423:Ncor2	UTSW	5	125,164,966 (GRCm39)	missense	unknown
R6462:Ncor2	UTSW	5	125,101,236 (GRCm39)	missense	probably damaging	1.00
R6478:Ncor2	UTSW	5	125,187,069 (GRCm39)	intron	probably benign
R7074:Ncor2	UTSW	5	125,126,430 (GRCm39)	nonsense	probably null
R7179:Ncor2	UTSW	5	125,132,847 (GRCm39)	missense	unknown
R7261:Ncor2	UTSW	5	125,187,143 (GRCm39)	splice site	probably null
R7263:Ncor2	UTSW	5	125,109,196 (GRCm39)	missense
R7273:Ncor2	UTSW	5	125,100,687 (GRCm39)	missense
R7282:Ncor2	UTSW	5	125,097,104 (GRCm39)	missense
R7570:Ncor2	UTSW	5	125,107,153 (GRCm39)	missense
R7725:Ncor2	UTSW	5	125,100,630 (GRCm39)	missense
R7747:Ncor2	UTSW	5	125,104,102 (GRCm39)	missense
R7748:Ncor2	UTSW	5	125,187,031 (GRCm39)	missense	unknown
R7825:Ncor2	UTSW	5	125,114,141 (GRCm39)	missense	possibly damaging	0.53
R8008:Ncor2	UTSW	5	125,144,983 (GRCm39)	missense	unknown
R8126:Ncor2	UTSW	5	125,183,268 (GRCm39)	missense	unknown
R8137:Ncor2	UTSW	5	125,114,957 (GRCm39)	missense
R8706:Ncor2	UTSW	5	125,145,010 (GRCm39)	missense	unknown
R8751:Ncor2	UTSW	5	125,115,964 (GRCm39)	missense
R8819:Ncor2	UTSW	5	125,106,291 (GRCm39)	missense
R8820:Ncor2	UTSW	5	125,106,291 (GRCm39)	missense
R8824:Ncor2	UTSW	5	125,195,821 (GRCm39)	missense
R8867:Ncor2	UTSW	5	125,179,739 (GRCm39)	missense	unknown
R8919:Ncor2	UTSW	5	125,106,253 (GRCm39)	missense
R8922:Ncor2	UTSW	5	125,163,939 (GRCm39)	missense	unknown
R9076:Ncor2	UTSW	5	125,111,086 (GRCm39)	missense
R9249:Ncor2	UTSW	5	125,186,988 (GRCm39)	missense	unknown
R9276:Ncor2	UTSW	5	125,113,150 (GRCm39)	missense
R9362:Ncor2	UTSW	5	125,095,265 (GRCm39)	missense
R9667:Ncor2	UTSW	5	125,125,545 (GRCm39)	missense	unknown
R9684:Ncor2	UTSW	5	125,102,139 (GRCm39)	missense
Z1088:Ncor2	UTSW	5	125,163,904 (GRCm39)	critical splice donor site	probably null
Z1088:Ncor2	UTSW	5	125,144,852 (GRCm39)	missense	unknown
Z1177:Ncor2	UTSW	5	125,113,913 (GRCm39)	missense
Z1177:Ncor2	UTSW	5	125,125,058 (GRCm39)	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- CCTCACTTACTGCAAGGTACAG -3'
(R):5'- AGGACCGGAAGCTGACATCTAC -3'

Sequencing Primer
(F):5'- TGCAAGGTACAGATGAATCCTC -3'
(R):5'- ATCTACACCCCGGGAGATCG -3'

Posted On

2014-10-01