Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02155:Zp2'

282184

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zp2

Ensembl Gene

ENSMUSG00000030911

Gene Name

zona pellucida glycoprotein 2

Synonyms

Zp-2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.071) question?

Stock #

IGL02155

Quality Score

Status

Chromosome

Chromosomal Location

119725995-119744514 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 119743340 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 50 (I50F)

Ref Sequence

ENSEMBL: ENSMUSP00000147097 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000033207] [ENSMUST00000207726] [ENSMUST00000208874]

AlphaFold

P20239

Predicted Effect

probably benign
Transcript: ENSMUST00000033207
AA Change: I50F

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000033207
Gene: ENSMUSG00000030911
AA Change: I50F

Domain	Start	End	E-Value	Type
signal peptide	1	34	N/A	INTRINSIC
ZP	364	630	1.06e-86	SMART
low complexity region	655	668	N/A	INTRINSIC
transmembrane domain	684	703	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000207333

Predicted Effect

probably benign
Transcript: ENSMUST00000207726
AA Change: I50F

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000208122

Predicted Effect

probably benign
Transcript: ENSMUST00000208874
AA Change: I50F

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: This gene encodes a member of the zona pellucida family of glycoproteins that play an important role in the survival of growing oocytes, successful fertilization and the passage of early embryos through the oviduct. The encoded preproprotein undergoes proteolytic processing to generate the mature polypeptide that is incorporated into the extracellular matrix surrounding mouse oocytes. Mice lacking the encoded protein develop defective zonae pellucidae that disrupt folliculogenesis, fertility and development. [provided by RefSeq, Sep 2016]
PHENOTYPE: Female homozygous mutants exhibit a thin zona pellucida matrix in early ovarian follicles that becomes disassociated in pre-ovulatory follicles. Few oocytes are produced, and any that are fertilized fail to survive to the two-cell stage. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aacs	A	G	5: 125,583,350 (GRCm39)	H302R	probably null	Het
Abi3bp	A	T	16: 56,408,327 (GRCm39)	H254L	probably damaging	Het
Adcy3	G	A	12: 4,262,142 (GRCm39)	W1064*	probably null	Het
Arvcf	C	T	16: 18,222,650 (GRCm39)	P70S	probably damaging	Het
Ceacam3	A	G	7: 16,896,906 (GRCm39)	D624G	possibly damaging	Het
Cntrl	T	A	2: 35,050,250 (GRCm39)		probably benign	Het
Cyp2a5	T	A	7: 26,542,471 (GRCm39)	F491Y	probably benign	Het
Disp2	C	T	2: 118,622,285 (GRCm39)	R1006C	probably damaging	Het
Dnajc22	T	C	15: 98,998,886 (GRCm39)	Y24H	probably damaging	Het
Fat2	A	G	11: 55,153,245 (GRCm39)	F3656L	probably benign	Het
Fbxo31	A	G	8: 122,285,814 (GRCm39)	F212S	probably damaging	Het
Fsip2	T	C	2: 82,828,696 (GRCm39)	M6831T	probably benign	Het
Gpi1	G	T	7: 33,929,614 (GRCm39)	Q9K	possibly damaging	Het
Hmcn1	T	A	1: 150,439,349 (GRCm39)	S5495C	probably damaging	Het
Ift74	A	G	4: 94,567,488 (GRCm39)	I394V	probably benign	Het
Kcnh5	G	A	12: 75,223,312 (GRCm39)		probably benign	Het
Lars2	A	G	9: 123,284,047 (GRCm39)	D745G	probably damaging	Het
Mitd1	T	A	1: 37,924,356 (GRCm39)	I65F	probably benign	Het
Mlxip	T	C	5: 123,591,455 (GRCm39)	M878T	probably benign	Het
Mrgpra4	T	C	7: 47,631,292 (GRCm39)	Y103C	probably damaging	Het
Notch2	T	C	3: 98,045,806 (GRCm39)	I1657T	probably damaging	Het
Or5m11	T	A	2: 85,782,352 (GRCm39)	M315K	probably benign	Het
Orc1	T	A	4: 108,447,874 (GRCm39)	D40E	probably benign	Het
Rnf40	T	C	7: 127,189,888 (GRCm39)		probably benign	Het
Ro60	C	T	1: 143,637,007 (GRCm39)		probably null	Het
Sema4d	A	G	13: 51,857,303 (GRCm39)	V643A	probably benign	Het
Taf7	A	T	18: 37,776,564 (GRCm39)	M1K	probably null	Het
Tnfsf10	A	T	3: 27,389,380 (GRCm39)	D147V	possibly damaging	Het
Usp45	T	A	4: 21,798,743 (GRCm39)		probably null	Het
Wdr62	T	C	7: 29,962,068 (GRCm39)	D2G	probably damaging	Het

Other mutations in Zp2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00402:Zp2	APN	7	119,732,623 (GRCm39)	missense	probably benign	0.00
IGL00707:Zp2	APN	7	119,732,636 (GRCm39)	missense	probably benign	0.03
IGL00916:Zp2	APN	7	119,737,397 (GRCm39)	missense	probably damaging	1.00
IGL01554:Zp2	APN	7	119,737,548 (GRCm39)	missense	possibly damaging	0.78
IGL01845:Zp2	APN	7	119,737,414 (GRCm39)	missense	probably damaging	1.00
IGL02111:Zp2	APN	7	119,731,641 (GRCm39)	missense	possibly damaging	0.75
IGL02145:Zp2	APN	7	119,739,074 (GRCm39)	critical splice acceptor site	probably null
IGL02178:Zp2	APN	7	119,732,973 (GRCm39)	missense	possibly damaging	0.85
IGL02646:Zp2	APN	7	119,734,564 (GRCm39)	missense	possibly damaging	0.92
IGL03220:Zp2	APN	7	119,736,450 (GRCm39)	missense	possibly damaging	0.90
PIT4687001:Zp2	UTSW	7	119,741,102 (GRCm39)	missense	probably benign	0.00
R0138:Zp2	UTSW	7	119,736,423 (GRCm39)	missense	probably damaging	0.96
R0197:Zp2	UTSW	7	119,742,799 (GRCm39)	splice site	probably benign
R0519:Zp2	UTSW	7	119,737,372 (GRCm39)	missense	probably damaging	1.00
R0573:Zp2	UTSW	7	119,734,693 (GRCm39)	splice site	probably benign
R0879:Zp2	UTSW	7	119,734,757 (GRCm39)	missense	probably damaging	1.00
R0883:Zp2	UTSW	7	119,742,799 (GRCm39)	splice site	probably benign
R1160:Zp2	UTSW	7	119,735,268 (GRCm39)	missense	probably damaging	1.00
R1235:Zp2	UTSW	7	119,737,566 (GRCm39)	missense	possibly damaging	0.57
R1753:Zp2	UTSW	7	119,737,328 (GRCm39)	missense	probably benign
R1883:Zp2	UTSW	7	119,732,624 (GRCm39)	missense	probably benign	0.02
R1995:Zp2	UTSW	7	119,734,388 (GRCm39)	missense	probably damaging	0.97
R2196:Zp2	UTSW	7	119,737,529 (GRCm39)	missense	probably benign
R2850:Zp2	UTSW	7	119,737,529 (GRCm39)	missense	probably benign
R3715:Zp2	UTSW	7	119,741,057 (GRCm39)	missense	possibly damaging	0.95
R3931:Zp2	UTSW	7	119,731,580 (GRCm39)	intron	probably benign
R4082:Zp2	UTSW	7	119,734,475 (GRCm39)	missense	probably benign	0.01
R4731:Zp2	UTSW	7	119,737,343 (GRCm39)	missense	probably damaging	0.96
R4732:Zp2	UTSW	7	119,737,343 (GRCm39)	missense	probably damaging	0.96
R4733:Zp2	UTSW	7	119,737,343 (GRCm39)	missense	probably damaging	0.96
R4754:Zp2	UTSW	7	119,737,541 (GRCm39)	missense	probably benign	0.01
R4863:Zp2	UTSW	7	119,734,995 (GRCm39)	missense	probably damaging	1.00
R5274:Zp2	UTSW	7	119,737,315 (GRCm39)	missense	possibly damaging	0.92
R5392:Zp2	UTSW	7	119,734,987 (GRCm39)	nonsense	probably null
R5877:Zp2	UTSW	7	119,732,562 (GRCm39)	missense	probably null	0.94
R6390:Zp2	UTSW	7	119,740,453 (GRCm39)	missense	probably benign	0.23
R6404:Zp2	UTSW	7	119,734,765 (GRCm39)	missense	possibly damaging	0.73
R6546:Zp2	UTSW	7	119,731,748 (GRCm39)	missense	probably benign	0.00
R6622:Zp2	UTSW	7	119,741,136 (GRCm39)	missense	probably benign
R6622:Zp2	UTSW	7	119,731,748 (GRCm39)	missense	probably benign	0.00
R6707:Zp2	UTSW	7	119,733,145 (GRCm39)	missense	possibly damaging	0.85
R7274:Zp2	UTSW	7	119,731,614 (GRCm39)	makesense	probably null
R7275:Zp2	UTSW	7	119,734,576 (GRCm39)	splice site	probably null
R7541:Zp2	UTSW	7	119,735,279 (GRCm39)	missense	probably damaging	1.00
R7585:Zp2	UTSW	7	119,733,167 (GRCm39)	missense	probably damaging	1.00
R7709:Zp2	UTSW	7	119,734,998 (GRCm39)	missense	probably damaging	1.00
R7742:Zp2	UTSW	7	119,731,731 (GRCm39)	missense	unknown
R7767:Zp2	UTSW	7	119,736,392 (GRCm39)	missense	probably benign	0.01
R7771:Zp2	UTSW	7	119,742,865 (GRCm39)	missense	probably damaging	0.96
R8391:Zp2	UTSW	7	119,726,179 (GRCm39)	missense	probably benign	0.00
R8872:Zp2	UTSW	7	119,733,025 (GRCm39)	missense	probably benign	0.14
R8880:Zp2	UTSW	7	119,742,835 (GRCm39)	missense	possibly damaging	0.80
R9673:Zp2	UTSW	7	119,733,238 (GRCm39)	missense	probably damaging	1.00
X0017:Zp2	UTSW	7	119,732,608 (GRCm39)	missense	probably damaging	1.00
X0023:Zp2	UTSW	7	119,732,590 (GRCm39)	missense	probably damaging	1.00
Z1176:Zp2	UTSW	7	119,734,402 (GRCm39)	missense	not run
Z1177:Zp2	UTSW	7	119,734,432 (GRCm39)	missense	probably damaging	1.00
Z1177:Zp2	UTSW	7	119,734,402 (GRCm39)	missense	not run

Posted On

2015-04-16