Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00092:Tarsl2'

306526

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tarsl2

Ensembl Gene

ENSMUSG00000030515

Gene Name

threonyl-tRNA synthetase-like 2

Synonyms

A530046H20Rik

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.115) question?

Stock #

IGL00092

Quality Score

Status

Chromosome

Chromosomal Location

65644898-65692091 bp(+) (GRCm38)

Type of Mutation

critical splice acceptor site

DNA Base Change (assembly)

G to T at 65652259 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000032728 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032728] [ENSMUST00000032728]

Predicted Effect

probably null
Transcript: ENSMUST00000032728

SMART Domains

Protein: ENSMUSP00000032728
Gene: ENSMUSG00000030515

Domain	Start	End	E-Value	Type
low complexity region	2	18	N/A	INTRINSIC
coiled coil region	44	68	N/A	INTRINSIC
Pfam:TGS	151	210	8.8e-14	PFAM
tRNA_SAD	316	365	1.26e-16	SMART
Pfam:tRNA-synt_2b	464	675	2.2e-35	PFAM
Pfam:HGTP_anticodon	687	778	1.1e-20	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000032728

SMART Domains

Protein: ENSMUSP00000032728
Gene: ENSMUSG00000030515

Domain	Start	End	E-Value	Type
low complexity region	2	18	N/A	INTRINSIC
coiled coil region	44	68	N/A	INTRINSIC
Pfam:TGS	151	210	8.8e-14	PFAM
tRNA_SAD	316	365	1.26e-16	SMART
Pfam:tRNA-synt_2b	464	675	2.2e-35	PFAM
Pfam:HGTP_anticodon	687	778	1.1e-20	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000126941

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb5	T	C	12: 118,928,695	D443G	probably benign	Het
Atg16l1	T	C	1: 87,765,397	I28T	possibly damaging	Het
Bpi	T	A	2: 158,274,796	V371E	probably damaging	Het
Cd109	T	G	9: 78,616,969	V55G	probably damaging	Het
Cd300c2	T	C	11: 115,001,549		probably benign	Het
Cic	C	T	7: 25,292,124	R1280C	probably damaging	Het
Cngb1	G	A	8: 95,242,184		probably benign	Het
Cntn4	G	T	6: 106,506,225	C247F	probably damaging	Het
Disp3	C	T	4: 148,241,534	V1256I	probably benign	Het
Farsb	A	T	1: 78,462,993	S338T	probably benign	Het
Fcnb	T	C	2: 28,076,801	N240S	probably benign	Het
Flg2	A	G	3: 93,219,855	S5G	possibly damaging	Het
Git1	T	C	11: 77,505,957	L635P	probably benign	Het
Gm21985	T	G	2: 112,351,334	W685G	probably damaging	Het
Gpt2	T	C	8: 85,512,324	V262A	probably benign	Het
Hecw2	A	G	1: 53,830,737	V1444A	probably damaging	Het
Herc1	T	C	9: 66,483,966	V4017A	probably benign	Het
Klhl17	T	C	4: 156,233,690	T129A	possibly damaging	Het
Krt84	T	G	15: 101,528,735	D331A	probably damaging	Het
Lrrc9	C	T	12: 72,486,243	T963M	possibly damaging	Het
Mtcl1	C	T	17: 66,344,319	V935I	probably benign	Het
Muc4	G	A	16: 32,754,086	G1321R	probably benign	Het
Myocd	T	C	11: 65,180,944		probably null	Het
Nid1	A	G	13: 13,476,392	N505D	probably damaging	Het
Ninj1	A	T	13: 49,193,734		probably null	Het
Olfr1375	C	A	11: 51,048,400	Q98K	probably benign	Het
Olfr1426	A	T	19: 12,087,993	D266E	probably benign	Het
Olfr307	C	T	7: 86,336,061	V112I	probably benign	Het
Plscr2	T	A	9: 92,290,632		probably benign	Het
Ppfia2	A	G	10: 106,819,492	T307A	probably benign	Het
Sart3	T	C	5: 113,746,669	R625G	probably benign	Het
Sohlh2	T	A	3: 55,207,815	L407H	probably damaging	Het
Sorcs1	A	G	19: 50,190,054	S877P	probably damaging	Het
Stat1	T	C	1: 52,122,595	M1T	probably null	Het
Szt2	C	T	4: 118,384,250		probably benign	Het
Terb2	T	A	2: 122,198,386	S141R	probably benign	Het
Tgfbrap1	T	C	1: 43,060,123	Y177C	probably damaging	Het
Trappc9	A	T	15: 73,026,026	I169N	possibly damaging	Het
Trim47	A	G	11: 116,106,194	L578P	probably damaging	Het
Usp34	G	A	11: 23,436,020	R2149H	probably damaging	Het
Vmn2r90	T	C	17: 17,733,496	S641P	probably benign	Het
Vwa5a	T	A	9: 38,737,814		probably null	Het
Zzef1	T	A	11: 72,875,126	I1493N	probably benign	Het

Other mutations in Tarsl2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00470:Tarsl2	APN	7	65688908	missense	probably benign	0.03
IGL00594:Tarsl2	APN	7	65676132	critical splice donor site	probably null
IGL01352:Tarsl2	APN	7	65658910	missense	possibly damaging	0.80
IGL01519:Tarsl2	APN	7	65663886	missense	probably damaging	1.00
IGL01726:Tarsl2	APN	7	65682818	missense	possibly damaging	0.46
IGL02370:Tarsl2	APN	7	65661165	missense	probably benign	0.17
IGL02729:Tarsl2	APN	7	65682819	missense	probably damaging	0.97
IGL03234:Tarsl2	APN	7	65652278	missense	probably benign	0.06
gary	UTSW	7	65688952	critical splice donor site	probably null
smart_money	UTSW	7	65678142	missense	probably damaging	1.00
R0127:Tarsl2	UTSW	7	65664969	missense	probably benign	0.19
R0153:Tarsl2	UTSW	7	65684081	missense	probably damaging	1.00
R0605:Tarsl2	UTSW	7	65678071	missense	probably damaging	1.00
R1070:Tarsl2	UTSW	7	65655696	missense	probably damaging	1.00
R1450:Tarsl2	UTSW	7	65647496	missense	probably benign	0.01
R1467:Tarsl2	UTSW	7	65655696	missense	probably damaging	1.00
R1467:Tarsl2	UTSW	7	65655696	missense	probably damaging	1.00
R2142:Tarsl2	UTSW	7	65658897	missense	probably benign
R2143:Tarsl2	UTSW	7	65655791	missense	possibly damaging	0.57
R2144:Tarsl2	UTSW	7	65655791	missense	possibly damaging	0.57
R2145:Tarsl2	UTSW	7	65655791	missense	possibly damaging	0.57
R2208:Tarsl2	UTSW	7	65682848	missense	probably damaging	1.00
R3713:Tarsl2	UTSW	7	65688952	critical splice donor site	probably null
R3715:Tarsl2	UTSW	7	65688952	critical splice donor site	probably null
R3914:Tarsl2	UTSW	7	65683808	missense	probably benign	0.05
R3929:Tarsl2	UTSW	7	65684043	splice site	probably null
R4008:Tarsl2	UTSW	7	65678128	missense	probably damaging	1.00
R4064:Tarsl2	UTSW	7	65652270	missense	possibly damaging	0.90
R4367:Tarsl2	UTSW	7	65682819	missense	probably damaging	0.97
R4652:Tarsl2	UTSW	7	65689969	missense	probably damaging	1.00
R4825:Tarsl2	UTSW	7	65647554	missense	probably benign	0.38
R4901:Tarsl2	UTSW	7	65691294	missense	probably benign	0.05
R4999:Tarsl2	UTSW	7	65658935	missense	probably damaging	0.99
R5423:Tarsl2	UTSW	7	65683819	missense	probably benign	0.00
R5756:Tarsl2	UTSW	7	65675976	missense	probably benign	0.22
R5772:Tarsl2	UTSW	7	65684125	missense	probably damaging	1.00
R6160:Tarsl2	UTSW	7	65682779	missense	probably benign	0.32
R6230:Tarsl2	UTSW	7	65686436	splice site	probably null
R6424:Tarsl2	UTSW	7	65655739	missense	probably damaging	1.00
R6615:Tarsl2	UTSW	7	65678142	missense	probably damaging	1.00
R6792:Tarsl2	UTSW	7	65662303	missense	probably damaging	1.00
R7350:Tarsl2	UTSW	7	65658924	missense	probably damaging	1.00
R7549:Tarsl2	UTSW	7	65647593	missense	probably damaging	0.96
R7592:Tarsl2	UTSW	7	65658871	missense	probably benign	0.01
R7634:Tarsl2	UTSW	7	65676012	missense	probably damaging	0.99
R7710:Tarsl2	UTSW	7	65664969	missense	probably benign	0.19
R7808:Tarsl2	UTSW	7	65652261	missense	probably benign	0.01
R7875:Tarsl2	UTSW	7	65678151	missense	probably benign	0.05
R8254:Tarsl2	UTSW	7	65676061	missense	probably benign
Z1177:Tarsl2	UTSW	7	65652264	nonsense	probably null

Posted On

2015-04-16