Incidental Mutation 'R4600:Tns2'
| ID |
345572 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tns2
|
| Ensembl Gene |
ENSMUSG00000037003 |
| Gene Name |
tensin 2 |
| Synonyms |
nep, Tenc1, nph |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4600 (G1)
|
| Quality Score |
192 |
|
Status
|
Not validated
|
| Chromosome |
15 |
| Chromosomal Location |
102008848-102024836 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 102017369 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Cysteine
at position 281
(R281C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000155830
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000046144]
[ENSMUST00000169627]
[ENSMUST00000228958]
[ENSMUST00000229592]
[ENSMUST00000230474]
|
| AlphaFold |
Q8CGB6 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000046144
AA Change: R281C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000041087
Gene: ENSMUSG00000037003
AA Change: R281C
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
32 |
79 |
2.78e-9 |
SMART |
|
SCOP:d1d5ra2
|
128 |
295 |
8e-24 |
SMART |
|
PTEN_C2
|
297 |
424 |
6.63e-40 |
SMART |
|
low complexity region
|
494 |
513 |
N/A |
INTRINSIC |
|
SH2
|
1136 |
1236 |
1.69e-16 |
SMART |
|
PTB
|
1269 |
1407 |
6.66e-28 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000169627
AA Change: R281C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000129146
Gene: ENSMUSG00000037003
AA Change: R281C
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
32 |
79 |
2.78e-9 |
SMART |
|
SCOP:d1d5ra2
|
128 |
295 |
8e-24 |
SMART |
|
PTEN_C2
|
297 |
424 |
6.63e-40 |
SMART |
|
low complexity region
|
494 |
513 |
N/A |
INTRINSIC |
|
SH2
|
1129 |
1229 |
1.69e-16 |
SMART |
|
PTB
|
1262 |
1400 |
6.66e-28 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000228958
AA Change: R281C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000229035
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000229592
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000229908
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000230474
AA Change: R273C
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| Meta Mutation Damage Score |
0.2021 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
PHENOTYPE: Affected mice homozygous for a spontaneous deletion show reduced female fertility, increased blood urea nitrogen, low hematocrit, proteinuria, hypoproteinemia, hypercholesterolemia, small kidneys with a yellowish granular surface, glomerular lesions and premature death; some develop systemic edema. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 94 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2700049A03Rik |
T |
C |
12: 71,195,037 (GRCm39) |
F145L |
possibly damaging |
Het |
| Aars2 |
T |
A |
17: 45,827,847 (GRCm39) |
D555E |
probably damaging |
Het |
| Ago1 |
C |
A |
4: 126,354,185 (GRCm39) |
M208I |
probably benign |
Het |
| Ak7 |
G |
A |
12: 105,679,834 (GRCm39) |
V123M |
probably benign |
Het |
| Amfr |
A |
G |
8: 94,700,849 (GRCm39) |
L537P |
probably damaging |
Het |
| Apob |
A |
G |
12: 8,058,568 (GRCm39) |
D2317G |
probably damaging |
Het |
| Asb6 |
T |
A |
2: 30,714,483 (GRCm39) |
D209V |
probably damaging |
Het |
| AY358078 |
T |
A |
14: 52,063,532 (GRCm39) |
C393S |
possibly damaging |
Het |
| Baz2a |
T |
A |
10: 127,957,052 (GRCm39) |
C932S |
probably damaging |
Het |
| Btnl10 |
A |
G |
11: 58,814,426 (GRCm39) |
I369V |
probably benign |
Het |
| Ccdc66 |
T |
C |
14: 27,222,377 (GRCm39) |
N122S |
probably damaging |
Het |
| Cfap96 |
A |
T |
8: 46,423,505 (GRCm39) |
I69N |
probably damaging |
Het |
| Clic4 |
A |
T |
4: 134,966,300 (GRCm39) |
|
probably null |
Het |
| Col6a3 |
A |
G |
1: 90,709,626 (GRCm39) |
S1857P |
unknown |
Het |
| Cracr2a |
A |
C |
6: 127,580,851 (GRCm39) |
D9A |
probably benign |
Het |
| Cspg4b |
A |
G |
13: 113,455,783 (GRCm39) |
R610G |
possibly damaging |
Het |
| Dcst1 |
T |
C |
3: 89,263,643 (GRCm39) |
E384G |
probably benign |
Het |
| Ddx4 |
T |
C |
13: 112,748,594 (GRCm39) |
K435E |
probably damaging |
Het |
| Deaf1 |
T |
A |
7: 140,890,884 (GRCm39) |
T433S |
possibly damaging |
Het |
| Dnah3 |
T |
A |
7: 119,689,169 (GRCm39) |
M82L |
probably benign |
Het |
| Dnhd1 |
G |
T |
7: 105,352,851 (GRCm39) |
R2668L |
probably damaging |
Het |
| Efcab6 |
C |
T |
15: 83,831,126 (GRCm39) |
G596D |
probably benign |
Het |
| Ercc3 |
G |
A |
18: 32,378,624 (GRCm39) |
A202T |
probably benign |
Het |
| Fam181b |
C |
A |
7: 92,729,992 (GRCm39) |
A255E |
possibly damaging |
Het |
| Fam83e |
T |
A |
7: 45,372,924 (GRCm39) |
D178E |
probably benign |
Het |
| Frem2 |
A |
G |
3: 53,455,228 (GRCm39) |
L2116S |
possibly damaging |
Het |
| Gm16494 |
T |
A |
17: 47,327,723 (GRCm39) |
K54* |
probably null |
Het |
| Golgb1 |
A |
G |
16: 36,738,987 (GRCm39) |
D2442G |
probably damaging |
Het |
| Greb1l |
G |
A |
18: 10,553,705 (GRCm39) |
A1569T |
probably damaging |
Het |
| Grik5 |
C |
G |
7: 24,767,489 (GRCm39) |
E64Q |
probably damaging |
Het |
| Gstm5 |
A |
G |
3: 107,805,302 (GRCm39) |
Y130C |
probably damaging |
Het |
| Gucy2e |
C |
G |
11: 69,126,994 (GRCm39) |
A160P |
possibly damaging |
Het |
| Hydin |
A |
T |
8: 111,293,582 (GRCm39) |
T3510S |
probably benign |
Het |
| Ift70a1 |
T |
C |
2: 75,810,977 (GRCm39) |
T369A |
probably benign |
Het |
| Itgb2 |
A |
G |
10: 77,381,949 (GRCm39) |
I84V |
probably benign |
Het |
| Itsn1 |
A |
G |
16: 91,696,475 (GRCm39) |
Q26R |
probably damaging |
Het |
| Kat6a |
A |
G |
8: 23,429,327 (GRCm39) |
S1561G |
probably benign |
Het |
| Khnyn |
G |
A |
14: 56,124,438 (GRCm39) |
V231I |
probably benign |
Het |
| Kif21b |
A |
G |
1: 136,075,602 (GRCm39) |
D243G |
probably benign |
Het |
| Klk4 |
T |
A |
7: 43,534,762 (GRCm39) |
N240K |
probably damaging |
Het |
| Knl1 |
T |
C |
2: 118,901,025 (GRCm39) |
S909P |
possibly damaging |
Het |
| Lamb1 |
A |
C |
12: 31,373,528 (GRCm39) |
D1419A |
probably benign |
Het |
| Lin9 |
T |
A |
1: 180,508,759 (GRCm39) |
V421D |
probably damaging |
Het |
| Lipt2 |
T |
C |
7: 99,809,519 (GRCm39) |
L202P |
probably benign |
Het |
| Mbd5 |
T |
G |
2: 49,147,209 (GRCm39) |
M473R |
probably benign |
Het |
| Mcc |
A |
T |
18: 44,652,587 (GRCm39) |
I279N |
probably damaging |
Het |
| Mcpt9 |
C |
T |
14: 56,266,049 (GRCm39) |
V60M |
probably damaging |
Het |
| Mrc2 |
G |
A |
11: 105,239,257 (GRCm39) |
|
probably null |
Het |
| Mslnl |
G |
A |
17: 25,961,908 (GRCm39) |
V128M |
probably damaging |
Het |
| Mylk2 |
G |
A |
2: 152,759,476 (GRCm39) |
V389M |
probably damaging |
Het |
| Ndufs7 |
T |
A |
10: 80,092,501 (GRCm39) |
Y203* |
probably null |
Het |
| Nup160 |
T |
A |
2: 90,515,541 (GRCm39) |
|
probably null |
Het |
| Nup88 |
G |
A |
11: 70,860,522 (GRCm39) |
R62* |
probably null |
Het |
| Or2g7 |
T |
C |
17: 38,378,853 (GRCm39) |
S264P |
probably damaging |
Het |
| Or51af1 |
T |
A |
7: 103,141,788 (GRCm39) |
Q99L |
probably damaging |
Het |
| Or6c207 |
G |
A |
10: 129,104,274 (GRCm39) |
A306V |
probably benign |
Het |
| Or8b8 |
T |
A |
9: 37,809,622 (GRCm39) |
S307R |
probably benign |
Het |
| Or8g33 |
A |
G |
9: 39,337,731 (GRCm39) |
M212T |
probably benign |
Het |
| Os9 |
T |
C |
10: 126,934,223 (GRCm39) |
N471S |
probably benign |
Het |
| Otof |
C |
T |
5: 30,529,244 (GRCm39) |
V1757M |
probably damaging |
Het |
| Pakap |
A |
T |
4: 57,709,954 (GRCm39) |
T300S |
probably benign |
Het |
| Pald1 |
T |
C |
10: 61,184,395 (GRCm39) |
T241A |
probably benign |
Het |
| Pappa2 |
G |
A |
1: 158,642,015 (GRCm39) |
S1347L |
probably damaging |
Het |
| Pccb |
T |
C |
9: 100,916,832 (GRCm39) |
T27A |
probably benign |
Het |
| Pde4dip |
A |
T |
3: 97,603,260 (GRCm39) |
V2243D |
probably damaging |
Het |
| Pkd2l2 |
C |
A |
18: 34,571,254 (GRCm39) |
Q590K |
probably benign |
Het |
| Pmepa1 |
G |
A |
2: 173,070,120 (GRCm39) |
P145L |
possibly damaging |
Het |
| Ppp3cb |
T |
C |
14: 20,570,714 (GRCm39) |
N339S |
possibly damaging |
Het |
| Rnf133 |
T |
C |
6: 23,649,041 (GRCm39) |
E296G |
possibly damaging |
Het |
| Secisbp2l |
C |
T |
2: 125,582,657 (GRCm39) |
G933D |
possibly damaging |
Het |
| Serpinb12 |
T |
A |
1: 106,876,883 (GRCm39) |
D66E |
probably benign |
Het |
| Slc35e2 |
T |
C |
4: 155,702,106 (GRCm39) |
F290S |
probably benign |
Het |
| Slc46a2 |
C |
T |
4: 59,911,886 (GRCm39) |
C442Y |
probably damaging |
Het |
| Slc7a1 |
A |
G |
5: 148,278,869 (GRCm39) |
L301P |
probably damaging |
Het |
| Spg21 |
A |
G |
9: 65,383,257 (GRCm39) |
T148A |
probably benign |
Het |
| Stox2 |
A |
G |
8: 47,645,970 (GRCm39) |
S497P |
probably damaging |
Het |
| Sult1c2 |
C |
A |
17: 54,280,983 (GRCm39) |
W40L |
probably benign |
Het |
| Sytl2 |
T |
C |
7: 90,024,977 (GRCm39) |
S322P |
probably benign |
Het |
| Telo2 |
C |
A |
17: 25,324,122 (GRCm39) |
R531L |
possibly damaging |
Het |
| Thbs3 |
T |
C |
3: 89,131,897 (GRCm39) |
V719A |
probably damaging |
Het |
| Tlr9 |
T |
A |
9: 106,101,732 (GRCm39) |
L341Q |
probably damaging |
Het |
| Tmprss5 |
A |
G |
9: 49,024,548 (GRCm39) |
N230D |
possibly damaging |
Het |
| Tpo |
C |
T |
12: 30,148,228 (GRCm39) |
V558M |
probably benign |
Het |
| Trex1 |
T |
G |
9: 108,887,352 (GRCm39) |
Q213P |
possibly damaging |
Het |
| Ttc7b |
G |
A |
12: 100,466,376 (GRCm39) |
R79C |
probably damaging |
Het |
| Ugt1a6a |
A |
G |
1: 88,066,586 (GRCm39) |
K131E |
probably benign |
Het |
| Vipr1 |
T |
A |
9: 121,494,202 (GRCm39) |
|
probably null |
Het |
| Vmn1r22 |
T |
C |
6: 57,877,860 (GRCm39) |
D39G |
probably damaging |
Het |
| Vmn2r58 |
A |
T |
7: 41,522,046 (GRCm39) |
C17S |
probably benign |
Het |
| Vps41 |
T |
C |
13: 18,929,453 (GRCm39) |
Y63H |
probably damaging |
Het |
| Xdh |
G |
T |
17: 74,217,195 (GRCm39) |
T691N |
probably benign |
Het |
| Zfp518b |
T |
C |
5: 38,830,970 (GRCm39) |
N345S |
probably damaging |
Het |
| Zfp536 |
T |
A |
7: 37,267,918 (GRCm39) |
K499N |
probably damaging |
Het |
| Zfp963 |
A |
T |
8: 70,195,510 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Tns2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01575:Tns2
|
APN |
15 |
102,021,626 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01935:Tns2
|
APN |
15 |
102,020,069 (GRCm39) |
splice site |
probably null |
|
|
IGL01994:Tns2
|
APN |
15 |
102,019,814 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02025:Tns2
|
APN |
15 |
102,020,484 (GRCm39) |
nonsense |
probably null |
|
|
IGL02135:Tns2
|
APN |
15 |
102,021,461 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02355:Tns2
|
APN |
15 |
102,020,725 (GRCm39) |
missense |
probably benign |
|
|
IGL02362:Tns2
|
APN |
15 |
102,020,725 (GRCm39) |
missense |
probably benign |
|
|
IGL02439:Tns2
|
APN |
15 |
102,022,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02488:Tns2
|
APN |
15 |
102,021,178 (GRCm39) |
missense |
probably benign |
|
|
IGL02546:Tns2
|
APN |
15 |
102,019,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02616:Tns2
|
APN |
15 |
102,019,850 (GRCm39) |
missense |
probably benign |
|
|
IGL02628:Tns2
|
APN |
15 |
102,020,263 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02658:Tns2
|
APN |
15 |
102,016,231 (GRCm39) |
splice site |
probably benign |
|
|
IGL03267:Tns2
|
APN |
15 |
102,013,813 (GRCm39) |
critical splice donor site |
probably null |
|
|
P0005:Tns2
|
UTSW |
15 |
102,022,491 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0586:Tns2
|
UTSW |
15 |
102,018,020 (GRCm39) |
splice site |
probably benign |
|
|
R0791:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0817:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0818:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0819:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0820:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1451:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1452:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1453:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1454:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1455:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1487:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1510:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1579:Tns2
|
UTSW |
15 |
102,019,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1698:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1772:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1779:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1843:Tns2
|
UTSW |
15 |
102,021,568 (GRCm39) |
splice site |
probably null |
|
|
R1923:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1924:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1927:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1980:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2051:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2087:Tns2
|
UTSW |
15 |
102,015,554 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R2100:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2103:Tns2
|
UTSW |
15 |
102,021,100 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R2105:Tns2
|
UTSW |
15 |
102,015,941 (GRCm39) |
missense |
probably benign |
0.27 |
|
R2224:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2225:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2227:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2252:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2253:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2290:Tns2
|
UTSW |
15 |
102,020,458 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2304:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2318:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2446:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2447:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2448:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2566:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2567:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2897:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2898:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3159:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3160:Tns2
|
UTSW |
15 |
102,021,771 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R3162:Tns2
|
UTSW |
15 |
102,021,771 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R3162:Tns2
|
UTSW |
15 |
102,021,771 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R3196:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3237:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3426:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3427:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3428:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3695:Tns2
|
UTSW |
15 |
102,021,184 (GRCm39) |
missense |
probably null |
|
|
R3767:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3911:Tns2
|
UTSW |
15 |
102,022,272 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4113:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4157:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4394:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4395:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4396:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4439:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4441:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4537:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4538:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4541:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4599:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4602:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4773:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4774:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4775:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4776:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4880:Tns2
|
UTSW |
15 |
102,020,474 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4989:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5014:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5058:Tns2
|
UTSW |
15 |
102,016,295 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R5253:Tns2
|
UTSW |
15 |
102,019,888 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5336:Tns2
|
UTSW |
15 |
102,019,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5351:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5452:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5453:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5629:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5630:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5631:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5685:Tns2
|
UTSW |
15 |
102,015,538 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5844:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6048:Tns2
|
UTSW |
15 |
102,019,846 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6067:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6079:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6130:Tns2
|
UTSW |
15 |
102,019,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6136:Tns2
|
UTSW |
15 |
102,015,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6138:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6199:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6210:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6426:Tns2
|
UTSW |
15 |
102,015,472 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R6544:Tns2
|
UTSW |
15 |
102,022,269 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6594:Tns2
|
UTSW |
15 |
102,018,994 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6596:Tns2
|
UTSW |
15 |
102,018,994 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6734:Tns2
|
UTSW |
15 |
102,011,551 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7061:Tns2
|
UTSW |
15 |
102,012,914 (GRCm39) |
start codon destroyed |
probably null |
|
|
R7070:Tns2
|
UTSW |
15 |
102,012,968 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R7110:Tns2
|
UTSW |
15 |
102,013,801 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7410:Tns2
|
UTSW |
15 |
102,018,961 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7447:Tns2
|
UTSW |
15 |
102,019,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7751:Tns2
|
UTSW |
15 |
102,018,163 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8052:Tns2
|
UTSW |
15 |
102,021,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8114:Tns2
|
UTSW |
15 |
102,019,825 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8906:Tns2
|
UTSW |
15 |
102,020,039 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8964:Tns2
|
UTSW |
15 |
102,011,553 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9192:Tns2
|
UTSW |
15 |
102,021,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9273:Tns2
|
UTSW |
15 |
102,021,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9307:Tns2
|
UTSW |
15 |
102,018,996 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9402:Tns2
|
UTSW |
15 |
102,021,623 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9612:Tns2
|
UTSW |
15 |
102,015,577 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9655:Tns2
|
UTSW |
15 |
102,012,933 (GRCm39) |
missense |
probably benign |
0.03 |
|
U15987:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0009:Tns2
|
UTSW |
15 |
102,020,900 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
X0026:Tns2
|
UTSW |
15 |
102,018,937 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTACAGAGGATCTCATGATTCCTCC -3'
(R):5'- CCTGTGGAGTCTTTCTTACAAGC -3'
Sequencing Primer
(F):5'- CCTTCCCTGGGGTTTAGGTATAGAAG -3'
(R):5'- GCCAGAACGATCTAGTCTGTTTACG -3'
|
| Posted On |
2015-09-25 |
Incidental Mutation