Mutagenetix > Incidental Mutation

Incidental Mutation 'R5098:Or5g29'

388114

Institutional Source

Beutler Lab

Gene Symbol

Or5g29

Ensembl Gene

ENSMUSG00000111454

Gene Name

olfactory receptor family 5 subfamily G member 29

Synonyms

Olfr998, GA_x6K02T2Q125-47069356-47070300, MOR175-5

MMRRC Submission

042687-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.232) question?

Stock #

R5098 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

85420854-85421865 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 85420976 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 31 (I31V)

Ref Sequence

ENSEMBL: ENSMUSP00000150713 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000052307] [ENSMUST00000215083]

AlphaFold

Q8VF76

Predicted Effect

probably benign
Transcript: ENSMUST00000052307
AA Change: I31V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000059970
Gene: ENSMUSG00000111454
AA Change: I31V

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	2.6e-54	PFAM
Pfam:7tm_1	41	308	9.5e-18	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000117353

Predicted Effect

probably benign
Transcript: ENSMUST00000215083
AA Change: I31V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.8%
20x: 94.0%

Validation Efficiency

100% (54/54)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca8b	T	C	11: 109,847,944 (GRCm39)	I784V	probably benign	Het
Agxt	A	G	1: 93,065,029 (GRCm39)	H146R	probably benign	Het
Art5	A	G	7: 101,747,177 (GRCm39)	F201L	probably damaging	Het
Bcl2a1b	T	A	9: 89,081,432 (GRCm39)	M7K	probably benign	Het
Card10	G	A	15: 78,660,917 (GRCm39)	A1030V	probably benign	Het
Ccdc66	G	A	14: 27,220,750 (GRCm39)	T58M	probably damaging	Het
Cd72	C	T	4: 43,452,610 (GRCm39)	G74R	probably damaging	Het
Cdc27	T	C	11: 104,398,113 (GRCm39)	K749R	probably damaging	Het
Commd3	A	T	2: 18,678,988 (GRCm39)	T102S	possibly damaging	Het
Cyp2f2	A	G	7: 26,829,304 (GRCm39)	T270A	possibly damaging	Het
Dclre1b	A	G	3: 103,716,452 (GRCm39)		probably benign	Het
Dennd1b	T	A	1: 139,061,459 (GRCm39)	D380E	probably damaging	Het
Dhx58	T	C	11: 100,585,999 (GRCm39)	E674G	probably benign	Het
Dnaaf9	A	G	2: 130,640,101 (GRCm39)	S128P	probably damaging	Het
Ecpas	T	C	4: 58,877,048 (GRCm39)	D129G	probably damaging	Het
Exoc5	T	C	14: 49,286,304 (GRCm39)	T108A	possibly damaging	Het
Fat4	T	C	3: 38,942,438 (GRCm39)	S444P	probably benign	Het
Gm3327	A	T	14: 44,362,292 (GRCm39)	I64F	unknown	Het
Gm4787	G	C	12: 81,424,604 (GRCm39)	T518S	probably benign	Het
Gpr15	T	A	16: 58,538,890 (GRCm39)	R66S	probably damaging	Het
Hmga1b	T	C	11: 120,654,018 (GRCm39)	S102P	probably benign	Het
Kat6b	G	A	14: 21,669,083 (GRCm39)		probably benign	Het
Kdm1b	A	G	13: 47,216,467 (GRCm39)	Y279C	probably damaging	Het
Krtap9-3	C	A	11: 99,488,816 (GRCm39)	C22F	probably benign	Het
Map3k14	T	A	11: 103,115,185 (GRCm39)	D817V	probably damaging	Het
Mybpc1	T	C	10: 88,381,926 (GRCm39)	D588G	probably damaging	Het
Or1e16	AGCGGTCGTAGGC	AGC	11: 73,286,480 (GRCm39)		probably null	Het
Or2t6	A	G	14: 14,175,683 (GRCm38)	V133A	probably benign	Het
Pcdhb20	A	G	18: 37,637,858 (GRCm39)	D128G	probably damaging	Het
Pgap6	A	T	17: 26,337,902 (GRCm39)	N429Y	probably damaging	Het
Ppil6	A	G	10: 41,366,616 (GRCm39)	E47G	probably null	Het
Rad17	A	T	13: 100,754,154 (GRCm39)	*689K	probably null	Het
Scin	A	T	12: 40,127,541 (GRCm39)	Y416*	probably null	Het
Serf1	A	G	13: 100,245,575 (GRCm39)	T18A	probably benign	Het
Sik2	T	C	9: 50,906,891 (GRCm39)		probably benign	Het
Slc39a8	C	A	3: 135,563,918 (GRCm39)	N254K	probably benign	Het
Spint3	A	G	2: 164,411,821 (GRCm39)	F63L	probably damaging	Het
Suox	A	T	10: 128,507,027 (GRCm39)	S334T	probably damaging	Het
Tas2r119	A	G	15: 32,178,228 (GRCm39)	M265V	probably benign	Het
Tmem126b	A	G	7: 90,118,850 (GRCm39)	L146P	probably damaging	Het
Trpc3	G	T	3: 36,717,047 (GRCm39)	D330E	probably benign	Het
Ugt2a2	T	C	5: 87,612,040 (GRCm39)	E290G	possibly damaging	Het
Ugt2b37	T	A	5: 87,390,812 (GRCm39)	T352S	probably damaging	Het
Vmn1r40	T	C	6: 89,691,930 (GRCm39)	V249A	probably damaging	Het
Zc3h18	A	G	8: 123,113,608 (GRCm39)	D200G	probably damaging	Het
Zfp652	T	C	11: 95,643,762 (GRCm39)	V140A	probably damaging	Het

Other mutations in Or5g29

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01763:Or5g29	APN	2	85,421,691 (GRCm39)	missense	probably benign	0.00
R0091:Or5g29	UTSW	2	85,421,696 (GRCm39)	missense	probably benign	0.38
R0241:Or5g29	UTSW	2	85,421,154 (GRCm39)	missense	probably benign	0.20
R0241:Or5g29	UTSW	2	85,421,154 (GRCm39)	missense	probably benign	0.20
R0268:Or5g29	UTSW	2	85,421,645 (GRCm39)	missense	possibly damaging	0.78
R0481:Or5g29	UTSW	2	85,421,448 (GRCm39)	missense	possibly damaging	0.94
R1816:Or5g29	UTSW	2	85,421,269 (GRCm39)	missense	probably benign	0.00
R1988:Or5g29	UTSW	2	85,420,985 (GRCm39)	missense	probably benign	0.00
R2008:Or5g29	UTSW	2	85,421,766 (GRCm39)	missense	probably damaging	1.00
R2060:Or5g29	UTSW	2	85,421,627 (GRCm39)	missense	possibly damaging	0.78
R2273:Or5g29	UTSW	2	85,420,932 (GRCm39)	missense	probably damaging	1.00
R4409:Or5g29	UTSW	2	85,421,274 (GRCm39)	missense	probably damaging	1.00
R4783:Or5g29	UTSW	2	85,421,282 (GRCm39)	missense	probably benign	0.03
R4785:Or5g29	UTSW	2	85,421,282 (GRCm39)	missense	probably benign	0.03
R5176:Or5g29	UTSW	2	85,421,779 (GRCm39)	missense	possibly damaging	0.88
R5462:Or5g29	UTSW	2	85,421,640 (GRCm39)	missense	probably damaging	1.00
R6092:Or5g29	UTSW	2	85,420,950 (GRCm39)	missense	probably benign	0.14
R6278:Or5g29	UTSW	2	85,421,342 (GRCm39)	missense	probably benign	0.00
R7022:Or5g29	UTSW	2	85,420,942 (GRCm39)	missense	probably benign	0.01
R7673:Or5g29	UTSW	2	85,421,406 (GRCm39)	missense	possibly damaging	0.75
R8054:Or5g29	UTSW	2	85,421,184 (GRCm39)	missense	probably damaging	1.00
R8118:Or5g29	UTSW	2	85,421,332 (GRCm39)	nonsense	probably null
R8940:Or5g29	UTSW	2	85,421,528 (GRCm39)	missense	probably benign
R9617:Or5g29	UTSW	2	85,421,279 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCTTTGTGGGGAGAGTCACC -3'
(R):5'- TCCTCTGCAAAGATATCACAGAGC -3'

Sequencing Primer
(F):5'- GACCCTGTACCCAAGATTATACATG -3'
(R):5'- TCACAGAGCATCTTAGGAGCTATG -3'

Posted On

2016-06-06