Incidental Mutation 'IGL03378:Olfr1186'
ID420564
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1186
Ensembl Gene ENSMUSG00000082882
Gene Nameolfactory receptor 1186
SynonymsGA_x6K02T2Q125-50012960-50013871, MOR230-5
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.066) question?
Stock #IGL03378
Quality Score
Status
Chromosome2
Chromosomal Location88518551-88526790 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) T to A at 88526154 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Stop codon at position 190 (Y190*)
Ref Sequence ENSEMBL: ENSMUSP00000151114 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075025] [ENSMUST00000121619] [ENSMUST00000215912] [ENSMUST00000216978]
Predicted Effect probably null
Transcript: ENSMUST00000075025
AA Change: Y190*
SMART Domains Protein: ENSMUSP00000074542
Gene: ENSMUSG00000057735
AA Change: Y190*

DomainStartEndE-ValueType
Pfam:7tm_4 28 302 2.5e-51 PFAM
Pfam:7tm_1 38 284 4.8e-19 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000121619
AA Change: Y190*
Predicted Effect probably null
Transcript: ENSMUST00000215912
AA Change: Y190*
Predicted Effect probably null
Transcript: ENSMUST00000216978
AA Change: Y190*
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9430069I07Rik T A 15: 34,355,632 I261N probably benign Het
Bace1 T A 9: 45,858,901 probably null Het
Caprin2 G T 6: 148,877,854 Q152K probably benign Het
Cdh16 C T 8: 104,619,285 D285N probably benign Het
Cnnm2 G A 19: 46,878,034 A874T possibly damaging Het
Dhx38 A T 8: 109,559,090 probably null Het
Dnhd1 A C 7: 105,713,733 E3834A possibly damaging Het
Erc2 A C 14: 28,011,723 S585R probably damaging Het
Gli3 A G 13: 15,644,420 E269G probably damaging Het
Gpr161 T C 1: 165,310,508 L204P probably damaging Het
Hp A G 8: 109,575,707 V203A probably damaging Het
Krtap6-5 A T 16: 89,047,789 C19S unknown Het
Lce1i A T 3: 92,777,726 S48T unknown Het
Lrp2 A T 2: 69,431,152 S4482T probably damaging Het
Mpdz A T 4: 81,419,048 probably benign Het
Olfr1049 T A 2: 86,255,019 I225L possibly damaging Het
Olfr357 T C 2: 36,996,903 F31S probably damaging Het
Papola G T 12: 105,809,433 probably null Het
Prss23 T C 7: 89,510,144 D239G probably damaging Het
Setd2 A G 9: 110,553,152 T83A unknown Het
Sh3pxd2b T G 11: 32,381,443 L56V probably damaging Het
Ski A G 4: 155,160,872 S300P probably benign Het
Srebf2 T C 15: 82,169,788 S17P probably damaging Het
Svs5 C A 2: 164,333,340 H37Q probably benign Het
Tbx21 A G 11: 97,114,741 S133P probably benign Het
Tgfbr3 G T 5: 107,109,702 S830R probably damaging Het
Thsd1 A T 8: 22,243,778 K280N probably benign Het
Tnfrsf13c T A 15: 82,224,312 M1L probably benign Het
Ttll7 T C 3: 146,909,653 F291L probably benign Het
Ttn A G 2: 76,769,563 V10762A probably damaging Het
Other mutations in Olfr1186
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01311:Olfr1186 APN 2 88525760 missense possibly damaging 0.87
IGL01727:Olfr1186 APN 2 88525927 missense probably benign 0.03
IGL01790:Olfr1186 APN 2 88526423 missense probably damaging 0.99
IGL01868:Olfr1186 APN 2 88525715 missense possibly damaging 0.66
IGL03146:Olfr1186 APN 2 88526144 missense possibly damaging 0.90
R0053:Olfr1186 UTSW 2 88526163 missense probably damaging 1.00
R0829:Olfr1186 UTSW 2 88526228 missense probably damaging 1.00
R1210:Olfr1186 UTSW 2 88526276 missense possibly damaging 0.89
R1754:Olfr1186 UTSW 2 88525815 missense probably damaging 0.99
R2260:Olfr1186 UTSW 2 88526386 missense possibly damaging 0.93
R3426:Olfr1186 UTSW 2 88525864 missense probably damaging 1.00
R3781:Olfr1186 UTSW 2 88526365 missense probably benign 0.23
R4737:Olfr1186 UTSW 2 88526225 missense probably damaging 1.00
R4908:Olfr1186 UTSW 2 88525910 missense probably damaging 1.00
R4932:Olfr1186 UTSW 2 88525735 missense probably benign 0.02
R5071:Olfr1186 UTSW 2 88526041 missense probably damaging 1.00
R5831:Olfr1186 UTSW 2 88526480 nonsense probably null
R6222:Olfr1186 UTSW 2 88499270 missense probably benign 0.34
R6370:Olfr1186 UTSW 2 88499368 nonsense probably null
R6802:Olfr1186 UTSW 2 88525597 missense probably benign 0.02
R6931:Olfr1186 UTSW 2 88526194 missense possibly damaging 0.50
R7044:Olfr1186 UTSW 2 88526486 missense probably benign
R7121:Olfr1186 UTSW 2 88525826 missense probably damaging 1.00
R7166:Olfr1186 UTSW 2 88525646 missense possibly damaging 0.89
R7387:Olfr1186 UTSW 2 88526400 nonsense probably null
R7891:Olfr1186 UTSW 2 88525945 missense probably benign 0.04
R7951:Olfr1186 UTSW 2 88525804 missense probably damaging 0.98
R7978:Olfr1186 UTSW 2 88525670 nonsense probably null
R8016:Olfr1186 UTSW 2 88526173 missense probably damaging 0.99
R8039:Olfr1186 UTSW 2 88525871 missense probably benign 0.07
R8389:Olfr1186 UTSW 2 88525587 start codon destroyed probably null
Posted On2016-08-02