Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03393:Vmn2r76'

421134

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r76

Ensembl Gene

ENSMUSG00000091239

Gene Name

vomeronasal 2, receptor 76

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.166) question?

Stock #

IGL03393

Quality Score

Status

Chromosome

Chromosomal Location

85874414-85895409 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 85879034 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Threonine at position 422 (N422T)

Ref Sequence

ENSEMBL: ENSMUSP00000127309 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165771]

AlphaFold

E9Q3F5

Predicted Effect

probably benign
Transcript: ENSMUST00000165771
AA Change: N422T

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000127309
Gene: ENSMUSG00000091239
AA Change: N422T

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	78	470	1.2e-29	PFAM
low complexity region	476	489	N/A	INTRINSIC
Pfam:NCD3G	513	565	3.7e-22	PFAM
Pfam:7tm_3	598	833	1.4e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700113H08Rik	A	G	10: 86,909,902 (GRCm39)		probably benign	Het
Adamts5	G	T	16: 85,665,083 (GRCm39)	S627Y	probably damaging	Het
Allc	G	A	12: 28,610,010 (GRCm39)	R196C	probably damaging	Het
Ccdc65	A	C	15: 98,618,568 (GRCm39)	E241A	probably benign	Het
Dclk3	T	C	9: 111,317,741 (GRCm39)		probably benign	Het
Fzd4	T	C	7: 89,056,505 (GRCm39)	V184A	probably benign	Het
Gfap	T	A	11: 102,784,083 (GRCm39)		probably null	Het
Gpr149	A	G	3: 62,511,366 (GRCm39)	V211A	probably benign	Het
Gprc6a	A	G	10: 51,491,355 (GRCm39)	I623T	probably damaging	Het
Gucy2c	T	C	6: 136,696,665 (GRCm39)	T687A	probably benign	Het
Kcnc4	T	G	3: 107,355,243 (GRCm39)	M402L	possibly damaging	Het
Ktn1	T	C	14: 47,928,391 (GRCm39)	L584S	probably damaging	Het
Mrgprb2	C	T	7: 48,202,650 (GRCm39)	S25N	probably benign	Het
Muc5b	T	A	7: 141,417,875 (GRCm39)	V3607E	probably benign	Het
Or4c58	C	A	2: 89,674,913 (GRCm39)	V135L	probably benign	Het
Or6c3b	T	C	10: 129,527,147 (GRCm39)	I254M	probably damaging	Het
Otx2	A	G	14: 48,898,781 (GRCm39)	I75T	probably damaging	Het
Pabpc4l	T	C	3: 46,400,972 (GRCm39)	D224G	probably damaging	Het
Peg3	A	T	7: 6,710,648 (GRCm39)	C1525S	probably damaging	Het
Polq	A	T	16: 36,865,156 (GRCm39)	L669F	probably damaging	Het
Prss40	A	C	1: 34,597,182 (GRCm39)	V122G	probably damaging	Het
Rims2	A	G	15: 39,326,009 (GRCm39)		probably null	Het
Rrp12	A	T	19: 41,860,232 (GRCm39)	M997K	possibly damaging	Het
Sbno2	G	A	10: 79,902,735 (GRCm39)	R414W	probably damaging	Het
Scn1a	T	C	2: 66,148,362 (GRCm39)	D41G	probably benign	Het
Serpinb1c	A	T	13: 33,066,044 (GRCm39)	D300E	probably damaging	Het
Timeless	G	A	10: 128,087,924 (GRCm39)	D1165N	probably damaging	Het
Tnpo1	T	G	13: 99,024,981 (GRCm39)	K66N	probably damaging	Het
Trappc11	A	T	8: 47,963,912 (GRCm39)	N629K	possibly damaging	Het
Ubr4	T	A	4: 139,179,989 (GRCm39)	L255M	probably damaging	Het
Vmn1r10	T	A	6: 57,091,042 (GRCm39)	Y211*	probably null	Het
Xylt1	C	A	7: 117,192,940 (GRCm39)	N415K	probably damaging	Het
Zfp786	A	T	6: 47,798,458 (GRCm39)	V160E	possibly damaging	Het

Other mutations in Vmn2r76

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00969:Vmn2r76	APN	7	85,877,925 (GRCm39)	missense	probably benign
IGL01374:Vmn2r76	APN	7	85,874,857 (GRCm39)	missense	probably benign	0.02
IGL01419:Vmn2r76	APN	7	85,874,910 (GRCm39)	missense	probably benign	0.32
IGL01627:Vmn2r76	APN	7	85,874,871 (GRCm39)	missense	probably damaging	1.00
IGL01730:Vmn2r76	APN	7	85,879,406 (GRCm39)	missense	probably benign	0.02
IGL01957:Vmn2r76	APN	7	85,877,925 (GRCm39)	missense	probably benign
IGL02214:Vmn2r76	APN	7	85,879,138 (GRCm39)	missense	probably benign	0.07
IGL02489:Vmn2r76	APN	7	85,878,071 (GRCm39)	missense	probably benign	0.41
IGL02543:Vmn2r76	APN	7	85,879,356 (GRCm39)	missense	probably benign	0.06
IGL02579:Vmn2r76	APN	7	85,877,961 (GRCm39)	nonsense	probably null
IGL02598:Vmn2r76	APN	7	85,877,879 (GRCm39)	missense	probably benign	0.05
IGL02720:Vmn2r76	APN	7	85,874,914 (GRCm39)	missense	probably benign	0.35
IGL02745:Vmn2r76	APN	7	85,879,495 (GRCm39)	missense	probably benign	0.06
R0483:Vmn2r76	UTSW	7	85,874,959 (GRCm39)	missense	probably damaging	1.00
R0513:Vmn2r76	UTSW	7	85,877,987 (GRCm39)	missense	probably benign	0.01
R0528:Vmn2r76	UTSW	7	85,879,506 (GRCm39)	missense	possibly damaging	0.80
R0601:Vmn2r76	UTSW	7	85,875,323 (GRCm39)	critical splice acceptor site	probably null
R0662:Vmn2r76	UTSW	7	85,879,578 (GRCm39)	missense	probably benign	0.39
R0883:Vmn2r76	UTSW	7	85,877,904 (GRCm39)	missense	probably benign	0.00
R1532:Vmn2r76	UTSW	7	85,879,454 (GRCm39)	missense	probably benign	0.02
R1694:Vmn2r76	UTSW	7	85,879,356 (GRCm39)	missense	probably benign	0.06
R1696:Vmn2r76	UTSW	7	85,880,464 (GRCm39)	missense	possibly damaging	0.56
R2135:Vmn2r76	UTSW	7	85,880,219 (GRCm39)	missense	probably benign	0.02
R2151:Vmn2r76	UTSW	7	85,879,692 (GRCm39)	missense	probably benign
R2181:Vmn2r76	UTSW	7	85,874,743 (GRCm39)	missense	probably benign	0.00
R2268:Vmn2r76	UTSW	7	85,879,707 (GRCm39)	missense	probably benign	0.03
R2877:Vmn2r76	UTSW	7	85,875,201 (GRCm39)	missense	probably benign	0.00
R3155:Vmn2r76	UTSW	7	85,874,959 (GRCm39)	missense	probably damaging	1.00
R3746:Vmn2r76	UTSW	7	85,874,763 (GRCm39)	missense	probably benign	0.11
R3799:Vmn2r76	UTSW	7	85,875,244 (GRCm39)	missense	probably benign	0.00
R3825:Vmn2r76	UTSW	7	85,880,415 (GRCm39)	missense	probably benign	0.10
R4058:Vmn2r76	UTSW	7	85,879,508 (GRCm39)	missense	probably benign	0.00
R4237:Vmn2r76	UTSW	7	85,879,740 (GRCm39)	missense	probably benign	0.00
R4404:Vmn2r76	UTSW	7	85,877,511 (GRCm39)	missense	probably benign	0.16
R4796:Vmn2r76	UTSW	7	85,879,652 (GRCm39)	missense	possibly damaging	0.95
R4838:Vmn2r76	UTSW	7	85,874,733 (GRCm39)	missense	probably damaging	1.00
R5175:Vmn2r76	UTSW	7	85,877,915 (GRCm39)	missense	probably benign	0.00
R5268:Vmn2r76	UTSW	7	85,875,267 (GRCm39)	missense	probably damaging	1.00
R5381:Vmn2r76	UTSW	7	85,874,496 (GRCm39)	missense	probably damaging	1.00
R5531:Vmn2r76	UTSW	7	85,874,657 (GRCm39)	missense	probably damaging	1.00
R5566:Vmn2r76	UTSW	7	85,875,286 (GRCm39)	missense	probably damaging	1.00
R5646:Vmn2r76	UTSW	7	85,875,261 (GRCm39)	missense	probably damaging	0.98
R5664:Vmn2r76	UTSW	7	85,895,202 (GRCm39)	critical splice donor site	probably null
R5818:Vmn2r76	UTSW	7	85,879,142 (GRCm39)	missense	probably benign	0.00
R6093:Vmn2r76	UTSW	7	85,877,469 (GRCm39)	nonsense	probably null
R6651:Vmn2r76	UTSW	7	85,878,059 (GRCm39)	missense	possibly damaging	0.64
R6741:Vmn2r76	UTSW	7	85,879,560 (GRCm39)	missense	probably benign
R6750:Vmn2r76	UTSW	7	85,875,114 (GRCm39)	missense	probably damaging	1.00
R7082:Vmn2r76	UTSW	7	85,874,440 (GRCm39)	missense	probably benign	0.01
R7136:Vmn2r76	UTSW	7	85,877,975 (GRCm39)	missense	probably benign	0.06
R7524:Vmn2r76	UTSW	7	85,879,374 (GRCm39)	missense	probably benign	0.00
R7524:Vmn2r76	UTSW	7	85,874,577 (GRCm39)	missense	probably benign	0.22
R7611:Vmn2r76	UTSW	7	85,879,388 (GRCm39)	missense	probably benign	0.04
R7833:Vmn2r76	UTSW	7	85,877,892 (GRCm39)	missense	probably benign
R8002:Vmn2r76	UTSW	7	85,879,271 (GRCm39)	missense	probably benign	0.05
R8021:Vmn2r76	UTSW	7	85,874,958 (GRCm39)	missense	probably damaging	1.00
R8023:Vmn2r76	UTSW	7	85,879,028 (GRCm39)	missense	probably benign	0.00
R8250:Vmn2r76	UTSW	7	85,875,231 (GRCm39)	missense	possibly damaging	0.82
R8428:Vmn2r76	UTSW	7	85,874,479 (GRCm39)	missense	possibly damaging	0.63
R8874:Vmn2r76	UTSW	7	85,877,999 (GRCm39)	missense	probably damaging	1.00
R9139:Vmn2r76	UTSW	7	85,879,170 (GRCm39)	missense	probably benign	0.02
R9357:Vmn2r76	UTSW	7	85,880,428 (GRCm39)	missense	probably benign	0.43
Z1176:Vmn2r76	UTSW	7	85,895,271 (GRCm39)	missense	probably benign	0.39

Posted On

2016-08-02