Incidental Mutation 'R5742:Or8g19'
ID 445618
Institutional Source Beutler Lab
Gene Symbol Or8g19
Ensembl Gene ENSMUSG00000049708
Gene Name olfactory receptor family 8 subfamily G member 19
Synonyms MOR171-6, GA_x6K02T2PVTD-32841223-32842158, Olfr27, MTPCR56, Olfr242, GA_x6K02T2KYVW-1037-120
MMRRC Submission 043352-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R5742 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 39039463-39056368 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 39055974 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 193 (F193I)
Ref Sequence ENSEMBL: ENSMUSP00000150009 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000214052] [ENSMUST00000216405]
AlphaFold Q9EQ90
Predicted Effect probably benign
Transcript: ENSMUST00000057811
AA Change: F193I

PolyPhen 2 Score 0.068 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000110642
Gene: ENSMUSG00000049708
AA Change: F193I

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.6e-49 PFAM
Pfam:7tm_1 41 290 2.4e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214052
AA Change: F193I

PolyPhen 2 Score 0.068 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect probably benign
Transcript: ENSMUST00000216405
AA Change: F193I

PolyPhen 2 Score 0.068 (Sensitivity: 0.94; Specificity: 0.84)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933427D14Rik C T 11: 72,056,379 (GRCm39) A794T possibly damaging Het
Abca9 T G 11: 110,051,243 (GRCm39) E151A probably damaging Het
Abcb5 A G 12: 118,881,992 (GRCm39) V579A probably damaging Het
Apob T A 12: 8,057,191 (GRCm39) L1858Q probably damaging Het
Cerk C T 15: 86,025,773 (GRCm39) E223K probably damaging Het
Cntnap2 T A 6: 45,897,860 (GRCm39) Y179* probably null Het
Ddx60 A T 8: 62,401,955 (GRCm39) Y277F probably benign Het
Dlgap1 T G 17: 71,025,194 (GRCm39) V538G probably benign Het
Duox2 A G 2: 122,115,402 (GRCm39) I1050T probably benign Het
Dusp10 A G 1: 183,769,853 (GRCm39) probably null Het
Dync2h1 T A 9: 7,165,762 (GRCm39) I500F possibly damaging Het
Erich3 T A 3: 154,438,960 (GRCm39) C398S probably damaging Het
Fez1 G A 9: 36,761,743 (GRCm39) probably null Het
Fkbp3 A C 12: 65,116,812 (GRCm39) H41Q probably benign Het
Fras1 C G 5: 96,916,240 (GRCm39) Q3425E possibly damaging Het
Fuca1 T C 4: 135,650,286 (GRCm39) V119A probably damaging Het
Grhl2 A G 15: 37,328,616 (GRCm39) K414R probably damaging Het
Heatr5a A T 12: 52,002,335 (GRCm39) C200* probably null Het
Hmgcs2 A G 3: 98,204,832 (GRCm39) N330S probably benign Het
Hspd1 A G 1: 55,123,766 (GRCm39) V118A probably benign Het
Jmjd1c A G 10: 67,056,112 (GRCm39) T511A probably benign Het
Kat6b T C 14: 21,718,503 (GRCm39) S1061P probably damaging Het
Kcnh6 T C 11: 105,899,968 (GRCm39) V79A probably benign Het
Kel C T 6: 41,675,961 (GRCm39) G243E probably damaging Het
Klc4 C T 17: 46,953,197 (GRCm39) R111Q probably damaging Het
Lrp1 T C 10: 127,384,216 (GRCm39) D3641G probably damaging Het
Map2k1 A T 9: 64,101,053 (GRCm39) D208E probably damaging Het
Masp1 T A 16: 23,273,675 (GRCm39) M588L probably benign Het
Mgl2 T A 11: 70,027,510 (GRCm39) N239K probably benign Het
Mki67 G A 7: 135,306,102 (GRCm39) T625M probably benign Het
Ndufb5 T C 3: 32,801,930 (GRCm39) Y112H probably damaging Het
Npr3 A G 15: 11,883,494 (GRCm39) S312P probably damaging Het
Nuf2 A T 1: 169,344,191 (GRCm39) I125N probably damaging Het
Obox1 G A 7: 15,289,430 (GRCm39) G73D possibly damaging Het
Odad4 G A 11: 100,436,699 (GRCm39) G25R possibly damaging Het
Or51a43 G T 7: 103,717,412 (GRCm39) H275Q probably damaging Het
Pcdhb15 T C 18: 37,607,820 (GRCm39) S351P probably damaging Het
Phc2 G T 4: 128,639,661 (GRCm39) R121L probably damaging Het
Pla2g2a A G 4: 138,560,653 (GRCm39) K87E probably benign Het
Plekhh2 T A 17: 84,905,408 (GRCm39) S1101T probably damaging Het
Ppp4r1 T C 17: 66,144,741 (GRCm39) I786T probably damaging Het
Prxl2a T C 14: 40,724,460 (GRCm39) E57G possibly damaging Het
Ros1 A T 10: 52,018,234 (GRCm39) probably null Het
Styxl2 A T 1: 165,927,023 (GRCm39) V863E probably benign Het
Trnt1 T A 6: 106,755,878 (GRCm39) L311* probably null Het
Vmn1r47 T A 6: 89,999,500 (GRCm39) L211M probably damaging Het
Zfp12 A G 5: 143,230,945 (GRCm39) E424G probably damaging Het
Zranb2 T A 3: 157,246,340 (GRCm39) Y17* probably null Het
Other mutations in Or8g19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00226:Or8g19 APN 9 39,056,053 (GRCm39) missense possibly damaging 0.94
IGL00905:Or8g19 APN 9 39,056,326 (GRCm39) missense probably damaging 1.00
IGL02346:Or8g19 APN 9 39,055,939 (GRCm39) missense probably damaging 1.00
R0117:Or8g19 UTSW 9 39,056,146 (GRCm39) missense probably damaging 1.00
R0118:Or8g19 UTSW 9 39,055,399 (GRCm39) start codon destroyed probably null 0.97
R0590:Or8g19 UTSW 9 39,056,017 (GRCm39) missense probably benign 0.01
R2915:Or8g19 UTSW 9 39,055,762 (GRCm39) missense possibly damaging 0.94
R4299:Or8g19 UTSW 9 39,056,295 (GRCm39) missense probably benign 0.11
R4367:Or8g19 UTSW 9 39,055,725 (GRCm39) missense probably damaging 0.98
R4663:Or8g19 UTSW 9 39,056,145 (GRCm39) missense probably damaging 0.97
R5276:Or8g19 UTSW 9 39,055,611 (GRCm39) missense probably damaging 1.00
R5503:Or8g19 UTSW 9 39,055,780 (GRCm39) missense probably benign 0.02
R5986:Or8g19 UTSW 9 39,056,278 (GRCm39) missense probably null 1.00
R6801:Or8g19 UTSW 9 39,055,506 (GRCm39) missense probably benign 0.01
R7247:Or8g19 UTSW 9 39,056,153 (GRCm39) nonsense probably null
R7520:Or8g19 UTSW 9 39,055,414 (GRCm39) missense probably benign
R7787:Or8g19 UTSW 9 39,055,548 (GRCm39) missense probably benign 0.22
R8360:Or8g19 UTSW 9 39,055,761 (GRCm39) nonsense probably null
R8721:Or8g19 UTSW 9 39,055,386 (GRCm39) start gained probably benign
R8880:Or8g19 UTSW 9 39,055,899 (GRCm39) missense probably damaging 1.00
R8883:Or8g19 UTSW 9 39,056,083 (GRCm39) missense probably benign 0.00
R9143:Or8g19 UTSW 9 39,055,722 (GRCm39) missense possibly damaging 0.94
R9445:Or8g19 UTSW 9 39,055,766 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AACCCCTTGCTTTACAATGTAACC -3'
(R):5'- GTAAGTACGTGAATGCACCAG -3'

Sequencing Primer
(F):5'- TGCTTTACAATGTAACCATGTCC -3'
(R):5'- GTGAATGCACCAGAACCATAAAAG -3'
Posted On 2016-11-21