Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01077:Trappc8'

53153

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trappc8

Ensembl Gene

ENSMUSG00000033382

Gene Name

trafficking protein particle complex 8

Synonyms

D030074E01Rik, Trs85, 5033403J15Rik

Accession Numbers

Genbank: NM_029491; MGI: 2443008

Is this an essential gene?

Probably essential (E-score: 0.964) question?

Stock #

IGL01077

Quality Score

Status

Chromosome

Chromosomal Location

20817223-20896093 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 20836978 bp

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 985 (T985I)

Ref Sequence

ENSEMBL: ENSMUSP00000153183 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000025177] [ENSMUST00000225661]

Predicted Effect

probably benign
Transcript: ENSMUST00000025177
AA Change: T986I

PolyPhen 2 Score 0.125 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000025177
Gene: ENSMUSG00000033382
AA Change: T986I

Domain	Start	End	E-Value	Type
Pfam:TRAPPC-Trs85	157	604	1e-167	PFAM
low complexity region	769	777	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000225502

Predicted Effect

probably benign
Transcript: ENSMUST00000225661
AA Change: T985I

PolyPhen 2 Score 0.197 (Sensitivity: 0.92; Specificity: 0.87)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

All alleles(11) : Gene trapped(11)

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aox1	A	T	1: 58,057,410		probably benign	Het
Arhgap4	A	G	X: 73,900,093		probably benign	Het
Ascc3	T	G	10: 50,649,317		probably benign	Het
Cacng5	C	T	11: 107,881,705	V106I	probably benign	Het
Car10	T	C	11: 93,597,143	I222T	possibly damaging	Het
Cep250	G	A	2: 155,962,134	V55M	probably damaging	Het
Chst4	T	A	8: 110,029,965	Y422F	probably benign	Het
Dnajc13	T	C	9: 104,231,021	E185G	probably benign	Het
Dtx2	T	A	5: 136,029,203	M454K	possibly damaging	Het
Flg2	T	A	3: 93,220,206	S2142T	unknown	Het
Ganc	C	T	2: 120,446,515	T686M	possibly damaging	Het
Gm53	C	T	11: 96,251,768		noncoding transcript	Het
Gria3	T	C	X: 41,588,492	V254A	possibly damaging	Het
H2-DMb2	G	T	17: 34,148,613	A3S	probably damaging	Het
H2-DMb2	A	G	17: 34,147,720	Y42C	probably damaging	Het
Myzap	T	C	9: 71,546,760	E343G	probably damaging	Het
Nap1l2	T	C	X: 103,185,316	D332G	probably benign	Het
Npr1	T	G	3: 90,458,362	D628A	probably damaging	Het
Raet1e	T	C	10: 22,181,320	L181S	probably damaging	Het
Rnf43	G	T	11: 87,731,892	M606I	probably benign	Het
Serpinb6b	G	A	13: 32,978,066	D283N	possibly damaging	Het
Skiv2l2	A	T	13: 112,914,489	I184K	probably damaging	Het
Slit2	A	G	5: 48,217,443		probably null	Het
Supt5	C	T	7: 28,323,788	W323*	probably null	Het
Svep1	T	A	4: 58,068,760	I3009F	possibly damaging	Het
Tedc1	C	T	12: 113,163,188	R357*	probably null	Het
Tll1	T	C	8: 64,070,232	Y482C	probably benign	Het
Zfp945	T	C	17: 22,852,385	K180R	probably damaging	Het

Other mutations in Trappc8

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01367:Trappc8	APN	18	20866119	missense	probably benign	0.01
IGL01537:Trappc8	APN	18	20835004	missense	probably benign
IGL01563:Trappc8	APN	18	20837046	missense	probably benign	0.00
IGL01982:Trappc8	APN	18	20874712	splice site	probably benign
IGL02709:Trappc8	APN	18	20837178	missense	possibly damaging	0.94
IGL03126:Trappc8	APN	18	20863595	missense	probably damaging	1.00
IGL03290:Trappc8	APN	18	20820935	missense	probably damaging	1.00
IGL03348:Trappc8	APN	18	20852781	missense	probably damaging	1.00
hoppa	UTSW	18	20836900	missense	probably benign	0.05
Lagomorpha	UTSW	18	20818190	missense	probably benign	0.11
rabbit	UTSW	18	20874680	missense	probably damaging	1.00
E7848:Trappc8	UTSW	18	20850918	missense	probably damaging	0.99
R0483:Trappc8	UTSW	18	20845601	missense	possibly damaging	0.60
R0492:Trappc8	UTSW	18	20866186	missense	probably benign	0.07
R0506:Trappc8	UTSW	18	20844188	missense	possibly damaging	0.49
R0610:Trappc8	UTSW	18	20837188	missense	probably damaging	1.00
R0892:Trappc8	UTSW	18	20831608	critical splice donor site	probably null
R1561:Trappc8	UTSW	18	20841623	nonsense	probably null
R1589:Trappc8	UTSW	18	20863551	missense	probably damaging	1.00
R1700:Trappc8	UTSW	18	20832998	missense	probably damaging	1.00
R1785:Trappc8	UTSW	18	20834940	splice site	probably null
R1786:Trappc8	UTSW	18	20834940	splice site	probably null
R1989:Trappc8	UTSW	18	20845651	missense	probably benign	0.04
R2181:Trappc8	UTSW	18	20819222	critical splice donor site	probably null
R2294:Trappc8	UTSW	18	20866154	nonsense	probably null
R4551:Trappc8	UTSW	18	20874672	missense	probably benign	0.10
R4594:Trappc8	UTSW	18	20836948	missense	probably benign
R4631:Trappc8	UTSW	18	20867808	missense	probably benign	0.22
R4734:Trappc8	UTSW	18	20841572	nonsense	probably null
R4834:Trappc8	UTSW	18	20825065	missense	probably damaging	0.99
R5114:Trappc8	UTSW	18	20844180	missense	probably benign	0.04
R5262:Trappc8	UTSW	18	20818190	missense	probably benign	0.11
R5384:Trappc8	UTSW	18	20833062	intron	probably null
R5476:Trappc8	UTSW	18	20865108	missense	probably damaging	1.00
R5503:Trappc8	UTSW	18	20836900	missense	probably benign	0.05
R5577:Trappc8	UTSW	18	20836779	nonsense	probably null
R5809:Trappc8	UTSW	18	20818082	missense	probably benign	0.08
R5825:Trappc8	UTSW	18	20873920	missense	probably damaging	1.00
R5886:Trappc8	UTSW	18	20874680	missense	probably damaging	1.00
R5936:Trappc8	UTSW	18	20874688	missense	probably damaging	1.00
R6024:Trappc8	UTSW	18	20833009	missense	probably damaging	0.98
R6105:Trappc8	UTSW	18	20846447	critical splice donor site	probably null
R6229:Trappc8	UTSW	18	20870745	missense	probably benign	0.00
R6376:Trappc8	UTSW	18	20837075	missense	probably benign	0.07
R6403:Trappc8	UTSW	18	20866071	missense	probably benign
R6459:Trappc8	UTSW	18	20836868	missense	probably benign	0.40
R6673:Trappc8	UTSW	18	20885257	missense	probably benign	0.01
R7041:Trappc8	UTSW	18	20874672	missense	probably benign	0.10
R7276:Trappc8	UTSW	18	20818091	missense	probably damaging	0.99
R7341:Trappc8	UTSW	18	20852647	missense	probably damaging	1.00
R7684:Trappc8	UTSW	18	20863502	missense	probably benign	0.01
R7702:Trappc8	UTSW	18	20825062	missense	probably damaging	0.99
X0065:Trappc8	UTSW	18	20860522	missense	probably benign	0.03

Posted On

2013-06-21