Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01077:Trappc8'

53153

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trappc8

Ensembl Gene

ENSMUSG00000033382

Gene Name

trafficking protein particle complex 8

Synonyms

5033403J15Rik, D030074E01Rik, Trs85

Accession Numbers

Essential gene?

Probably essential (E-score: 0.950) question?

Stock #

IGL01077

Quality Score

Status

Chromosome

Chromosomal Location

20950280-21029150 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 20970035 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 985 (T985I)

Ref Sequence

ENSEMBL: ENSMUSP00000153183 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000025177] [ENSMUST00000225661]

AlphaFold

A0A286YCX6

Predicted Effect

probably benign
Transcript: ENSMUST00000025177
AA Change: T986I

PolyPhen 2 Score 0.125 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000025177
Gene: ENSMUSG00000033382
AA Change: T986I

Domain	Start	End	E-Value	Type
Pfam:TRAPPC-Trs85	157	604	1e-167	PFAM
low complexity region	769	777	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000225502

Predicted Effect

probably benign
Transcript: ENSMUST00000225661
AA Change: T985I

PolyPhen 2 Score 0.197 (Sensitivity: 0.92; Specificity: 0.87)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

All alleles(11) : Gene trapped(11)

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aox1	A	T	1: 58,096,569 (GRCm39)		probably benign	Het
Arhgap4	A	G	X: 72,943,699 (GRCm39)		probably benign	Het
Ascc3	T	G	10: 50,525,413 (GRCm39)		probably benign	Het
Cacng5	C	T	11: 107,772,531 (GRCm39)	V106I	probably benign	Het
Car10	T	C	11: 93,487,969 (GRCm39)	I222T	possibly damaging	Het
Cep250	G	A	2: 155,804,054 (GRCm39)	V55M	probably damaging	Het
Chst4	T	A	8: 110,756,597 (GRCm39)	Y422F	probably benign	Het
Dnajc13	T	C	9: 104,108,220 (GRCm39)	E185G	probably benign	Het
Dtx2	T	A	5: 136,058,057 (GRCm39)	M454K	possibly damaging	Het
Flg2	T	A	3: 93,127,513 (GRCm39)	S2142T	unknown	Het
Ganc	C	T	2: 120,276,996 (GRCm39)	T686M	possibly damaging	Het
Gm53	C	T	11: 96,142,594 (GRCm39)		noncoding transcript	Het
Gria3	T	C	X: 40,677,369 (GRCm39)	V254A	possibly damaging	Het
H2-DMb2	G	T	17: 34,367,587 (GRCm39)	A3S	probably damaging	Het
H2-DMb2	A	G	17: 34,366,694 (GRCm39)	Y42C	probably damaging	Het
Mtrex	A	T	13: 113,051,023 (GRCm39)	I184K	probably damaging	Het
Myzap	T	C	9: 71,454,042 (GRCm39)	E343G	probably damaging	Het
Nap1l2	T	C	X: 102,228,922 (GRCm39)	D332G	probably benign	Het
Npr1	T	G	3: 90,365,669 (GRCm39)	D628A	probably damaging	Het
Raet1e	T	C	10: 22,057,219 (GRCm39)	L181S	probably damaging	Het
Rnf43	G	T	11: 87,622,718 (GRCm39)	M606I	probably benign	Het
Serpinb6b	G	A	13: 33,162,049 (GRCm39)	D283N	possibly damaging	Het
Slit2	A	G	5: 48,374,785 (GRCm39)		probably null	Het
Supt5	C	T	7: 28,023,213 (GRCm39)	W323*	probably null	Het
Svep1	T	A	4: 58,068,760 (GRCm39)	I3009F	possibly damaging	Het
Tedc1	C	T	12: 113,126,808 (GRCm39)	R357*	probably null	Het
Tll1	T	C	8: 64,523,266 (GRCm39)	Y482C	probably benign	Het
Zfp945	T	C	17: 23,071,359 (GRCm39)	K180R	probably damaging	Het

Other mutations in Trappc8

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01367:Trappc8	APN	18	20,999,176 (GRCm39)	missense	probably benign	0.01
IGL01537:Trappc8	APN	18	20,968,061 (GRCm39)	missense	probably benign
IGL01563:Trappc8	APN	18	20,970,103 (GRCm39)	missense	probably benign	0.00
IGL01982:Trappc8	APN	18	21,007,769 (GRCm39)	splice site	probably benign
IGL02709:Trappc8	APN	18	20,970,235 (GRCm39)	missense	possibly damaging	0.94
IGL03126:Trappc8	APN	18	20,996,652 (GRCm39)	missense	probably damaging	1.00
IGL03290:Trappc8	APN	18	20,953,992 (GRCm39)	missense	probably damaging	1.00
IGL03348:Trappc8	APN	18	20,985,838 (GRCm39)	missense	probably damaging	1.00
hoppa	UTSW	18	20,969,957 (GRCm39)	missense	probably benign	0.05
Lagomorpha	UTSW	18	20,951,247 (GRCm39)	missense	probably benign	0.11
rabbit	UTSW	18	21,007,737 (GRCm39)	missense	probably damaging	1.00
E7848:Trappc8	UTSW	18	20,983,975 (GRCm39)	missense	probably damaging	0.99
R0483:Trappc8	UTSW	18	20,978,658 (GRCm39)	missense	possibly damaging	0.60
R0492:Trappc8	UTSW	18	20,999,243 (GRCm39)	missense	probably benign	0.07
R0506:Trappc8	UTSW	18	20,977,245 (GRCm39)	missense	possibly damaging	0.49
R0610:Trappc8	UTSW	18	20,970,245 (GRCm39)	missense	probably damaging	1.00
R0892:Trappc8	UTSW	18	20,964,665 (GRCm39)	critical splice donor site	probably null
R1561:Trappc8	UTSW	18	20,974,680 (GRCm39)	nonsense	probably null
R1589:Trappc8	UTSW	18	20,996,608 (GRCm39)	missense	probably damaging	1.00
R1700:Trappc8	UTSW	18	20,966,055 (GRCm39)	missense	probably damaging	1.00
R1785:Trappc8	UTSW	18	20,967,997 (GRCm39)	splice site	probably null
R1786:Trappc8	UTSW	18	20,967,997 (GRCm39)	splice site	probably null
R1989:Trappc8	UTSW	18	20,978,708 (GRCm39)	missense	probably benign	0.04
R2181:Trappc8	UTSW	18	20,952,279 (GRCm39)	critical splice donor site	probably null
R2294:Trappc8	UTSW	18	20,999,211 (GRCm39)	nonsense	probably null
R4551:Trappc8	UTSW	18	21,007,729 (GRCm39)	missense	probably benign	0.10
R4594:Trappc8	UTSW	18	20,970,005 (GRCm39)	missense	probably benign
R4631:Trappc8	UTSW	18	21,000,865 (GRCm39)	missense	probably benign	0.22
R4734:Trappc8	UTSW	18	20,974,629 (GRCm39)	nonsense	probably null
R4834:Trappc8	UTSW	18	20,958,122 (GRCm39)	missense	probably damaging	0.99
R5114:Trappc8	UTSW	18	20,977,237 (GRCm39)	missense	probably benign	0.04
R5262:Trappc8	UTSW	18	20,951,247 (GRCm39)	missense	probably benign	0.11
R5384:Trappc8	UTSW	18	20,966,119 (GRCm39)	splice site	probably null
R5476:Trappc8	UTSW	18	20,998,165 (GRCm39)	missense	probably damaging	1.00
R5503:Trappc8	UTSW	18	20,969,957 (GRCm39)	missense	probably benign	0.05
R5577:Trappc8	UTSW	18	20,969,836 (GRCm39)	nonsense	probably null
R5809:Trappc8	UTSW	18	20,951,139 (GRCm39)	missense	probably benign	0.08
R5825:Trappc8	UTSW	18	21,006,977 (GRCm39)	missense	probably damaging	1.00
R5886:Trappc8	UTSW	18	21,007,737 (GRCm39)	missense	probably damaging	1.00
R5936:Trappc8	UTSW	18	21,007,745 (GRCm39)	missense	probably damaging	1.00
R6024:Trappc8	UTSW	18	20,966,066 (GRCm39)	missense	probably damaging	0.98
R6105:Trappc8	UTSW	18	20,979,504 (GRCm39)	critical splice donor site	probably null
R6229:Trappc8	UTSW	18	21,003,802 (GRCm39)	missense	probably benign	0.00
R6376:Trappc8	UTSW	18	20,970,132 (GRCm39)	missense	probably benign	0.07
R6403:Trappc8	UTSW	18	20,999,128 (GRCm39)	missense	probably benign
R6459:Trappc8	UTSW	18	20,969,925 (GRCm39)	missense	probably benign	0.40
R6673:Trappc8	UTSW	18	21,018,314 (GRCm39)	missense	probably benign	0.01
R7041:Trappc8	UTSW	18	21,007,729 (GRCm39)	missense	probably benign	0.10
R7276:Trappc8	UTSW	18	20,951,148 (GRCm39)	missense	probably damaging	0.99
R7341:Trappc8	UTSW	18	20,985,704 (GRCm39)	missense	probably damaging	1.00
R7684:Trappc8	UTSW	18	20,996,559 (GRCm39)	missense	probably benign	0.01
R7702:Trappc8	UTSW	18	20,958,119 (GRCm39)	missense	probably damaging	0.99
R8210:Trappc8	UTSW	18	21,006,938 (GRCm39)	critical splice donor site	probably null
R8958:Trappc8	UTSW	18	21,003,667 (GRCm39)	missense	probably benign	0.02
R9037:Trappc8	UTSW	18	20,961,539 (GRCm39)	missense	probably benign	0.00
R9217:Trappc8	UTSW	18	21,000,822 (GRCm39)	missense	probably benign	0.01
R9246:Trappc8	UTSW	18	20,993,590 (GRCm39)	missense	possibly damaging	0.64
R9623:Trappc8	UTSW	18	20,983,975 (GRCm39)	missense	possibly damaging	0.91
R9766:Trappc8	UTSW	18	20,979,630 (GRCm39)	missense	possibly damaging	0.68
X0065:Trappc8	UTSW	18	20,993,579 (GRCm39)	missense	probably benign	0.03
Z1177:Trappc8	UTSW	18	20,964,720 (GRCm39)	frame shift	probably null

Posted On

2013-06-21