Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00336:Flrt1'

5691

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Flrt1

Ensembl Gene

ENSMUSG00000047787

Gene Name

fibronectin leucine rich transmembrane protein 1

Synonyms

D630040I23Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.194) question?

Stock #

IGL00336

Quality Score

Status

Chromosome

Chromosomal Location

7069366-7083094 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 7074277 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Isoleucine at position 90 (N90I)

Ref Sequence

ENSEMBL: ENSMUSP00000109010 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000040261] [ENSMUST00000113383]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000040261

SMART Domains

Protein: ENSMUSP00000039507
Gene: ENSMUSG00000036278

Domain	Start	End	E-Value	Type
low complexity region	9	21	N/A	INTRINSIC
low complexity region	25	41	N/A	INTRINSIC
low complexity region	59	74	N/A	INTRINSIC
A1pp	151	281	7.67e-46	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000113383
AA Change: N90I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000109010
Gene: ENSMUSG00000047787
AA Change: N90I

Domain	Start	End	E-Value	Type
low complexity region	2	28	N/A	INTRINSIC
LRRNT	53	85	4.11e-6	SMART
LRR	127	149	2.61e1	SMART
LRR	150	175	4.71e1	SMART
LRR	177	199	1.76e1	SMART
LRR	200	220	7.36e0	SMART
LRR	221	246	1.49e1	SMART
LRR	247	270	9.77e1	SMART
LRR	271	292	1.53e1	SMART
LRR_TYP	293	316	3.55e-6	SMART
LRRCT	328	379	5.19e-9	SMART
low complexity region	381	392	N/A	INTRINSIC
FN3	434	515	1.49e0	SMART
transmembrane domain	556	578	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain. [provided by RefSeq, Jul 2008]
PHENOTYPE: No notable phenotype was detected in a high-throughput screen of homozygous mice. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A430033K04Rik	A	G	5: 138,645,366 (GRCm39)	Y417C	probably damaging	Het
Adam28	T	A	14: 68,859,569 (GRCm39)	H548L	possibly damaging	Het
Agbl3	A	T	6: 34,823,771 (GRCm39)	D812V	probably damaging	Het
Aopep	A	T	13: 63,163,237 (GRCm39)	D86V	possibly damaging	Het
Aox1	T	A	1: 58,098,203 (GRCm39)	L305Q	probably damaging	Het
Arhgef38	A	G	3: 132,837,812 (GRCm39)	V706A	probably benign	Het
Arl15	A	G	13: 114,291,288 (GRCm39)	I171V	probably benign	Het
Cacna1s	C	A	1: 136,012,011 (GRCm39)	Y237*	probably null	Het
Ccnt1	T	C	15: 98,462,990 (GRCm39)	T61A	possibly damaging	Het
Col25a1	T	A	3: 129,975,433 (GRCm39)		probably benign	Het
Col4a1	T	A	8: 11,290,077 (GRCm39)		probably benign	Het
Dcun1d1	T	C	3: 35,970,455 (GRCm39)	E130G	possibly damaging	Het
Dnah7b	G	A	1: 46,181,309 (GRCm39)	M1065I	probably benign	Het
Ephb2	T	G	4: 136,384,795 (GRCm39)	K872T	probably damaging	Het
Fga	G	A	3: 82,938,981 (GRCm39)	G452D	probably damaging	Het
Fut10	T	A	8: 31,685,319 (GRCm39)		probably null	Het
Gm4553	T	C	7: 141,718,964 (GRCm39)	S155G	unknown	Het
Gpr137b	T	C	13: 13,549,000 (GRCm39)		probably benign	Het
Gprc5d	G	A	6: 135,093,488 (GRCm39)	Q140*	probably null	Het
Ifi27l2b	T	C	12: 103,417,476 (GRCm39)	K237R	unknown	Het
Ipo8	A	T	6: 148,684,284 (GRCm39)	M836K	possibly damaging	Het
Kcnq4	G	A	4: 120,555,213 (GRCm39)	Q657*	probably null	Het
Lama1	A	T	17: 68,120,943 (GRCm39)	H2693L	probably benign	Het
Lrrc23	A	G	6: 124,755,889 (GRCm39)	W40R	probably damaging	Het
Minar1	T	C	9: 89,485,196 (GRCm39)	D67G	probably damaging	Het
Morn2	C	A	17: 80,602,933 (GRCm39)		probably benign	Het
Ms4a6b	T	A	19: 11,506,854 (GRCm39)	N214K	possibly damaging	Het
Nags	A	T	11: 102,039,892 (GRCm39)	S527C	probably damaging	Het
Ndst1	C	T	18: 60,841,028 (GRCm39)	G218D	probably damaging	Het
Or10j5	G	A	1: 172,785,045 (GRCm39)	V228M	probably benign	Het
Or5b94	T	A	19: 12,651,924 (GRCm39)	Y118*	probably null	Het
Or8h7	C	T	2: 86,720,589 (GRCm39)	C310Y	probably benign	Het
Oxa1l	G	T	14: 54,600,802 (GRCm39)	G92*	probably null	Het
Parp16	A	T	9: 65,137,245 (GRCm39)	E157V	probably damaging	Het
Pcdh17	A	T	14: 84,684,984 (GRCm39)	I484F	probably damaging	Het
Pex16	A	G	2: 92,209,580 (GRCm39)	R263G	probably benign	Het
Pkd1l3	G	A	8: 110,356,869 (GRCm39)	E765K	possibly damaging	Het
Plce1	T	C	19: 38,640,350 (GRCm39)	V532A	probably damaging	Het
Polq	A	G	16: 36,885,609 (GRCm39)		probably benign	Het
Pramel5	T	C	4: 143,998,191 (GRCm39)	T351A	probably damaging	Het
Prokr1	A	T	6: 87,565,593 (GRCm39)	I84N	probably damaging	Het
Prss30	A	T	17: 24,192,695 (GRCm39)	S162T	probably benign	Het
Ranbp2	A	G	10: 58,287,806 (GRCm39)	K25E	probably damaging	Het
Rapsn	A	G	2: 90,866,205 (GRCm39)	T22A	probably damaging	Het
Rhoj	G	T	12: 75,355,680 (GRCm39)	G9V	probably damaging	Het
Rnf213	A	G	11: 119,340,169 (GRCm39)	R3467G	probably benign	Het
Rreb1	C	A	13: 38,113,622 (GRCm39)	S327*	probably null	Het
Scn5a	G	A	9: 119,315,290 (GRCm39)	P1806L	probably damaging	Het
Sema6a	C	A	18: 47,423,042 (GRCm39)		probably null	Het
Stag3	G	A	5: 138,295,921 (GRCm39)	E416K	probably benign	Het
Stpg1	T	A	4: 135,256,856 (GRCm39)	S216T	possibly damaging	Het
Tfeb	C	A	17: 48,102,589 (GRCm39)	N426K	probably benign	Het
Trp53bp1	G	T	2: 121,087,060 (GRCm39)	Q199K	possibly damaging	Het
Ubr4	A	G	4: 139,155,877 (GRCm39)	D2234G	probably damaging	Het
Ush1c	T	G	7: 45,846,194 (GRCm39)	Q866P	probably benign	Het
Vdr	T	A	15: 97,782,735 (GRCm39)	D29V	probably damaging	Het
Vps13c	T	C	9: 67,853,224 (GRCm39)	V2439A	probably benign	Het
Xirp2	T	C	2: 67,342,942 (GRCm39)	S1728P	possibly damaging	Het
Zfp9	A	G	6: 118,441,436 (GRCm39)	S409P	probably damaging	Het

Other mutations in Flrt1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01082:Flrt1	APN	19	7,073,339 (GRCm39)	missense	probably benign
IGL02535:Flrt1	APN	19	7,074,098 (GRCm39)	missense	probably benign	0.00
R0240:Flrt1	UTSW	19	7,074,475 (GRCm39)	intron	probably benign
R0240:Flrt1	UTSW	19	7,074,475 (GRCm39)	intron	probably benign
R0403:Flrt1	UTSW	19	7,073,284 (GRCm39)	missense	probably benign	0.01
R0645:Flrt1	UTSW	19	7,074,508 (GRCm39)	intron	probably benign
R0677:Flrt1	UTSW	19	7,073,544 (GRCm39)	nonsense	probably null
R1818:Flrt1	UTSW	19	7,072,711 (GRCm39)	missense	probably damaging	1.00
R2191:Flrt1	UTSW	19	7,073,194 (GRCm39)	missense	probably damaging	0.99
R2228:Flrt1	UTSW	19	7,072,723 (GRCm39)	missense	probably damaging	1.00
R2471:Flrt1	UTSW	19	7,073,856 (GRCm39)	missense	probably damaging	1.00
R4978:Flrt1	UTSW	19	7,074,241 (GRCm39)	missense	probably damaging	1.00
R5460:Flrt1	UTSW	19	7,073,105 (GRCm39)	missense	probably damaging	0.99
R5630:Flrt1	UTSW	19	7,073,830 (GRCm39)	missense	probably damaging	1.00
R6326:Flrt1	UTSW	19	7,073,974 (GRCm39)	missense	probably damaging	1.00
R6734:Flrt1	UTSW	19	7,073,524 (GRCm39)	missense	possibly damaging	0.91
R6905:Flrt1	UTSW	19	7,072,757 (GRCm39)	nonsense	probably null
R7239:Flrt1	UTSW	19	7,073,329 (GRCm39)	missense	probably benign	0.12
R7799:Flrt1	UTSW	19	7,073,229 (GRCm39)	missense	possibly damaging	0.78
R8168:Flrt1	UTSW	19	7,074,002 (GRCm39)	missense	probably damaging	1.00
X0024:Flrt1	UTSW	19	7,073,114 (GRCm39)	missense	probably damaging	1.00
X0062:Flrt1	UTSW	19	7,074,244 (GRCm39)	missense	probably benign	0.00

Posted On

2012-04-20