Mutagenetix > Incidental Mutation

Incidental Mutation 'R7434:Tas2r113'

576626

Institutional Source

Beutler Lab

Gene Symbol

Tas2r113

Ensembl Gene

ENSMUSG00000056926

Gene Name

taste receptor, type 2, member 113

Synonyms

T2R13, mGR13, Tas2r13, mt2r58

MMRRC Submission

045511-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.051) question?

Stock #

R7434 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

132869974-132870903 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 132870272 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 100 (T100I)

Ref Sequence

ENSEMBL: ENSMUSP00000078044 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079035]

AlphaFold

Q7M711

Predicted Effect

probably benign
Transcript: ENSMUST00000079035
AA Change: T100I

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000078044
Gene: ENSMUSG00000056926
AA Change: T100I

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	301	9.4e-78	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.0%

Validation Efficiency

100% (43/43)

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamtsl1	T	C	4: 86,344,115 (GRCm39)	V1731A	probably damaging	Het
Bcat2	A	G	7: 45,225,429 (GRCm39)		probably null	Het
Bcl6	T	G	16: 23,788,798 (GRCm39)	E523D	possibly damaging	Het
Cdcp3	C	T	7: 130,881,212 (GRCm39)	S1828F	unknown	Het
Col4a2	T	A	8: 11,471,250 (GRCm39)	N503K	probably damaging	Het
Cyb5r1	G	A	1: 134,335,576 (GRCm39)	C166Y	probably benign	Het
Cyp2w1	T	C	5: 139,342,775 (GRCm39)	V490A	possibly damaging	Het
Erich6b	A	G	14: 75,901,024 (GRCm39)	I113V	probably benign	Het
Fabp12	C	T	3: 10,312,738 (GRCm39)	V95I	probably benign	Het
Gask1b	T	A	3: 79,848,669 (GRCm39)	F472I	probably damaging	Het
Gpr3	T	C	4: 132,938,448 (GRCm39)	M75V	probably benign	Het
Grm5	T	G	7: 87,779,682 (GRCm39)	S1073A	probably benign	Het
Hoxc9	A	G	15: 102,892,414 (GRCm39)	K209R	probably damaging	Het
Irgm2	T	G	11: 58,110,291 (GRCm39)	V6G	probably benign	Het
Jakmip2	A	G	18: 43,690,444 (GRCm39)	V627A	possibly damaging	Het
Kansl1l	C	G	1: 66,801,262 (GRCm39)	S568T	probably damaging	Het
Lims1	A	G	10: 58,230,301 (GRCm39)	T21A	probably benign	Het
Lpar2	G	T	8: 70,279,165 (GRCm39)	A320S	probably benign	Het
Lpcat4	A	G	2: 112,073,400 (GRCm39)	N235S	probably damaging	Het
Ly6g2	T	C	15: 75,088,567 (GRCm39)	F12L	probably benign	Het
Meis1	A	T	11: 18,835,542 (GRCm39)	S359T	unknown	Het
Mtor	C	T	4: 148,549,416 (GRCm39)	T600I	probably benign	Het
Ncbp1	T	C	4: 46,149,910 (GRCm39)	S144P	probably damaging	Het
Ncor1	T	C	11: 62,274,025 (GRCm39)	E205G	probably damaging	Het
Nid1	T	C	13: 13,643,049 (GRCm39)	I329T	probably benign	Het
Nos3	T	C	5: 24,587,633 (GRCm39)	I1031T	probably damaging	Het
Nyap1	A	G	5: 137,734,530 (GRCm39)	S168P	probably damaging	Het
Or56a4	A	G	7: 104,806,106 (GRCm39)	V261A	probably damaging	Het
Pam	T	A	1: 97,903,515 (GRCm39)	K73*	probably null	Het
Pcdhga11	T	C	18: 37,891,005 (GRCm39)	V671A	probably benign	Het
Ptpn18	G	A	1: 34,512,445 (GRCm39)	D417N	possibly damaging	Het
Ric1	A	G	19: 29,552,180 (GRCm39)	D317G	probably damaging	Het
Scn1a	T	C	2: 66,103,389 (GRCm39)	E1957G	probably benign	Het
Srcap	T	C	7: 127,159,414 (GRCm39)	S3097P	unknown	Het
Tnni1	A	G	1: 135,735,260 (GRCm39)	D57G		Het
Trim29	G	A	9: 43,246,428 (GRCm39)	V575I	probably damaging	Het
Trpv3	G	A	11: 73,179,087 (GRCm39)	V499M	probably damaging	Het
Ubr1	C	T	2: 120,693,161 (GRCm39)	M1748I	probably benign	Het
Upk1a	A	T	7: 30,306,617 (GRCm39)	M99K	probably damaging	Het
Usp16	T	A	16: 87,276,207 (GRCm39)	L515*	probably null	Het
Vmn1r103	T	C	7: 20,244,435 (GRCm39)	K9E	probably damaging	Het
Vwde	A	G	6: 13,187,639 (GRCm39)	V616A	probably benign	Het
Zfp101	A	T	17: 33,600,564 (GRCm39)	S397R	possibly damaging	Het

Other mutations in Tas2r113

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00858:Tas2r113	APN	6	132,870,115 (GRCm39)	missense	probably benign	0.01
IGL01118:Tas2r113	APN	6	132,870,278 (GRCm39)	missense	probably benign	0.00
IGL01366:Tas2r113	APN	6	132,870,760 (GRCm39)	missense	probably benign	0.06
IGL01955:Tas2r113	APN	6	132,870,817 (GRCm39)	missense	probably benign
IGL02629:Tas2r113	APN	6	132,870,299 (GRCm39)	missense	probably damaging	1.00
IGL02681:Tas2r113	APN	6	132,870,330 (GRCm39)	missense	probably damaging	1.00
IGL02883:Tas2r113	APN	6	132,870,382 (GRCm39)	missense	probably damaging	1.00
R0002:Tas2r113	UTSW	6	132,870,742 (GRCm39)	missense	probably benign	0.21
R0309:Tas2r113	UTSW	6	132,870,341 (GRCm39)	missense	probably damaging	1.00
R1700:Tas2r113	UTSW	6	132,870,755 (GRCm39)	missense	possibly damaging	0.92
R1748:Tas2r113	UTSW	6	132,870,695 (GRCm39)	missense	probably damaging	0.98
R1854:Tas2r113	UTSW	6	132,870,292 (GRCm39)	missense	probably damaging	1.00
R1974:Tas2r113	UTSW	6	132,870,796 (GRCm39)	missense	probably benign	0.00
R4697:Tas2r113	UTSW	6	132,870,479 (GRCm39)	missense	probably benign	0.04
R4798:Tas2r113	UTSW	6	132,870,670 (GRCm39)	missense	possibly damaging	0.69
R4816:Tas2r113	UTSW	6	132,870,745 (GRCm39)	missense	probably benign	0.09
R4906:Tas2r113	UTSW	6	132,870,521 (GRCm39)	missense	possibly damaging	0.69
R6005:Tas2r113	UTSW	6	132,870,659 (GRCm39)	missense	probably benign	0.02
R6012:Tas2r113	UTSW	6	132,870,644 (GRCm39)	missense	probably damaging	1.00
R6107:Tas2r113	UTSW	6	132,869,977 (GRCm39)	missense	probably damaging	1.00
R6603:Tas2r113	UTSW	6	132,870,421 (GRCm39)	missense	probably benign	0.01
R7263:Tas2r113	UTSW	6	132,870,539 (GRCm39)	missense	possibly damaging	0.90
R7759:Tas2r113	UTSW	6	132,870,890 (GRCm39)	missense	possibly damaging	0.85
R8803:Tas2r113	UTSW	6	132,870,104 (GRCm39)	missense	possibly damaging	0.79
R9104:Tas2r113	UTSW	6	132,870,116 (GRCm39)	missense	probably benign	0.08
X0022:Tas2r113	UTSW	6	132,870,259 (GRCm39)	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- TCTGCATAGACTGGGTCCAAAG -3'
(R):5'- TACCGTGGACATAACAAAAGGTATG -3'

Sequencing Primer
(F):5'- CTGGGTCCAAAGAAGAAAAATCTC -3'
(R):5'- TGAGACACATTTCTTTGAACACTATC -3'

Posted On

2019-10-07