Incidental Mutation 'R7455:Or8c8'
ID 578080
Institutional Source Beutler Lab
Gene Symbol Or8c8
Ensembl Gene ENSMUSG00000094778
Gene Name olfactory receptor family 8 subfamily C member 8
Synonyms MOR170-6, Olfr143, GA_x6K02T2PVTD-31941084-31942025, K18
MMRRC Submission 045529-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R7455 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 38164715-38165656 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 38165550 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 276 (V276A)
Ref Sequence ENSEMBL: ENSMUSP00000149842 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093865] [ENSMUST00000213129]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000093865
AA Change: V279A

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000091388
Gene: ENSMUSG00000094778
AA Change: V279A

DomainStartEndE-ValueType
Pfam:7tm_4 34 310 1e-49 PFAM
Pfam:7tm_1 44 293 1.1e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213129
AA Change: V276A

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 98% (62/63)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agbl1 C T 7: 76,074,503 (GRCm39) H646Y unknown Het
Ak5 C T 3: 152,187,209 (GRCm39) R426H probably damaging Het
Akap9 T C 5: 4,022,792 (GRCm39) V1207A probably benign Het
Asph A T 4: 9,531,732 (GRCm39) probably null Het
Avpr1a T G 10: 122,285,169 (GRCm39) C154G probably damaging Het
Boll T C 1: 55,339,262 (GRCm39) Q283R probably benign Het
Cad C T 5: 31,231,506 (GRCm39) P1743S probably damaging Het
Ccdc137 T G 11: 120,350,985 (GRCm39) M129R probably damaging Het
Cdh23 A G 10: 60,142,003 (GRCm39) I3028T possibly damaging Het
Cep68 T A 11: 20,180,571 (GRCm39) I687F probably damaging Het
Ces2a T A 8: 105,464,154 (GRCm39) I262N probably damaging Het
Cfap44 A G 16: 44,225,147 (GRCm39) probably benign Het
Cfap69 T G 5: 5,675,873 (GRCm39) H247P possibly damaging Het
Cideb T C 14: 55,992,292 (GRCm39) T134A probably damaging Het
Cilp2 A T 8: 70,333,721 (GRCm39) D1092E probably damaging Het
Cptp G A 4: 155,950,957 (GRCm39) R170C probably damaging Het
Cysrt1 A G 2: 25,129,422 (GRCm39) L30S probably benign Het
Dcc A G 18: 71,553,394 (GRCm39) V754A probably benign Het
Entrep2 A G 7: 64,409,161 (GRCm39) V411A probably benign Het
Fer1l5 A T 1: 36,428,064 (GRCm39) T453S probably benign Het
Fnbp4 ACCACCTCCACCTCCACCTCC ACCACCTCCACCTCCACCTCCACCTCC 2: 90,608,159 (GRCm39) probably benign Het
Frem2 C T 3: 53,479,701 (GRCm39) probably null Het
Gm13941 A G 2: 110,925,085 (GRCm39) F173L unknown Het
Greb1l G A 18: 10,554,915 (GRCm39) A1654T probably damaging Het
Inpp4b T A 8: 82,798,332 (GRCm39) I840N probably damaging Het
Kdm4b T A 17: 56,703,657 (GRCm39) I746N probably damaging Het
Lins1 C A 7: 66,361,692 (GRCm39) H448N probably benign Het
Ly9 A T 1: 171,421,507 (GRCm39) Y581* probably null Het
Mark1 T A 1: 184,651,947 (GRCm39) E186V probably damaging Het
Mcph1 T A 8: 18,681,775 (GRCm39) V304E probably benign Het
Mical3 T C 6: 120,935,705 (GRCm39) D1607G probably damaging Het
Mup18 A G 4: 61,592,171 (GRCm39) V31A probably benign Het
Nectin3 A T 16: 46,317,105 (GRCm39) C11* probably null Het
Nedd1 A T 10: 92,536,787 (GRCm39) L172M probably benign Het
Nim1k G A 13: 120,173,995 (GRCm39) R300W probably damaging Het
Oprm1 T C 10: 6,780,204 (GRCm39) F289L probably damaging Het
Or4c115 G T 2: 88,927,434 (GRCm39) P279Q probably damaging Het
Or7g12 A G 9: 18,900,150 (GRCm39) I289V possibly damaging Het
Parg T C 14: 31,931,432 (GRCm39) Y351H probably benign Het
Phf3 A C 1: 30,876,239 (GRCm39) V118G probably damaging Het
Pik3c2g T C 6: 139,913,643 (GRCm39) Y1014H unknown Het
Pmp22 A G 11: 63,025,339 (GRCm39) probably null Het
Ppfibp1 T A 6: 146,917,848 (GRCm39) F501L probably damaging Het
Rgl2 G A 17: 34,151,657 (GRCm39) A234T probably benign Het
Rhpn2 G A 7: 35,070,669 (GRCm39) probably null Het
Ryr3 T C 2: 112,559,211 (GRCm39) K3058E probably damaging Het
Sbsn A T 7: 30,452,602 (GRCm39) Q539L possibly damaging Het
Scgn G A 13: 24,150,848 (GRCm39) R168C probably benign Het
Serpinb10 A G 1: 107,463,832 (GRCm39) Y38C probably damaging Het
Sfmbt2 G A 2: 10,582,766 (GRCm39) V709I probably benign Het
Slc1a2 A T 2: 102,566,299 (GRCm39) M10L probably benign Het
Sox6 T G 7: 115,088,904 (GRCm39) I653L probably benign Het
Tespa1 A G 10: 130,196,559 (GRCm39) I166V probably benign Het
Tex15 T C 8: 34,067,025 (GRCm39) Y2152H possibly damaging Het
Tlr9 A G 9: 106,101,729 (GRCm39) N340S probably benign Het
Tmem198 G A 1: 75,456,430 (GRCm39) R28Q unknown Het
Tut7 T C 13: 59,969,871 (GRCm39) Y8C probably benign Het
Vmn2r7 T C 3: 64,624,014 (GRCm39) D102G probably benign Het
Wdr93 A G 7: 79,425,267 (GRCm39) M529V probably benign Het
Zfp110 A G 7: 12,581,984 (GRCm39) H310R probably benign Het
Zfp36l2 A G 17: 84,494,575 (GRCm39) S21P probably damaging Het
Zfp534 G A 4: 147,759,212 (GRCm39) H486Y probably damaging Het
Zfp638 G A 6: 83,907,127 (GRCm39) V431I probably damaging Het
Other mutations in Or8c8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02269:Or8c8 APN 9 38,165,232 (GRCm39) missense possibly damaging 0.82
R0417:Or8c8 UTSW 9 38,165,160 (GRCm39) missense probably benign 0.03
R1191:Or8c8 UTSW 9 38,165,501 (GRCm39) missense probably damaging 0.99
R1863:Or8c8 UTSW 9 38,165,016 (GRCm39) missense probably damaging 0.99
R1868:Or8c8 UTSW 9 38,164,986 (GRCm39) missense probably damaging 1.00
R2252:Or8c8 UTSW 9 38,165,126 (GRCm39) missense probably benign
R5128:Or8c8 UTSW 9 38,164,866 (GRCm39) missense probably damaging 1.00
R7254:Or8c8 UTSW 9 38,164,719 (GRCm39) missense probably benign 0.04
R7504:Or8c8 UTSW 9 38,165,539 (GRCm39) missense possibly damaging 0.60
R7881:Or8c8 UTSW 9 38,165,406 (GRCm39) missense probably benign 0.31
R9324:Or8c8 UTSW 9 38,164,962 (GRCm39) missense probably benign 0.44
Z1176:Or8c8 UTSW 9 38,165,148 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AGGTTCAGCTATCATTTTATGCTGC -3'
(R):5'- ACTCACAGAGTTACATTGCATGG -3'

Sequencing Primer
(F):5'- ACATGTGGGTCTCACATC -3'
(R):5'- TTGCATGGTTTAAAGAGAAGACATG -3'
Posted On 2019-10-07