Incidental Mutation 'R7739:Prelid2'
ID596460
Institutional Source Beutler Lab
Gene Symbol Prelid2
Ensembl Gene ENSMUSG00000056671
Gene NamePRELI domain containing 2
SynonymsC330008K14Rik, 1700003A01Rik
MMRRC Submission
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R7739 (G1)
Quality Score225.009
Status Not validated
Chromosome18
Chromosomal Location41875696-41951194 bp(-) (GRCm38)
Type of Mutationcritical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to G at 41912368 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000064661 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070949] [ENSMUST00000070949]
Predicted Effect probably null
Transcript: ENSMUST00000070949
SMART Domains Protein: ENSMUSP00000064661
Gene: ENSMUSG00000056671

DomainStartEndE-ValueType
Pfam:PRELI 16 173 2.8e-51 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000070949
SMART Domains Protein: ENSMUSP00000064661
Gene: ENSMUSG00000056671

DomainStartEndE-ValueType
Pfam:PRELI 16 173 2.8e-51 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700016C15Rik T A 1: 177,743,262 I54K probably damaging Het
9130401M01Rik C A 15: 58,022,479 A336S probably benign Het
Abca8b A G 11: 109,974,591 S347P probably benign Het
Acvr1 T C 2: 58,462,971 T326A possibly damaging Het
Atp13a4 A G 16: 29,456,601 I355T Het
Atp2a2 G A 5: 122,469,705 T247I probably damaging Het
Atp2b1 T A 10: 99,001,365 D555E probably benign Het
Aurkb G T 11: 69,048,232 G94* probably null Het
B130006D01Rik A T 11: 95,726,160 H37L unknown Het
Cabin1 A G 10: 75,658,658 L1629P probably damaging Het
Ccdc80 A C 16: 45,095,823 D314A probably benign Het
Cdc42bpg T A 19: 6,310,815 I201N probably damaging Het
Chd9 T C 8: 91,035,025 L2246P probably damaging Het
Cpsf1 T A 15: 76,600,311 M657L probably benign Het
Dmtf1 A G 5: 9,140,453 V87A probably damaging Het
Drd5 G T 5: 38,320,078 W138L probably damaging Het
Dspp G A 5: 104,178,146 D792N unknown Het
Fat2 C A 11: 55,281,131 E2919* probably null Het
Fgf20 A G 8: 40,279,896 V167A probably damaging Het
Gm597 T A 1: 28,777,608 T448S possibly damaging Het
Gm8251 G A 1: 44,056,418 T1840I possibly damaging Het
Grm5 T C 7: 88,130,058 V934A possibly damaging Het
Gtf3c3 G T 1: 54,405,039 A730D possibly damaging Het
H2-T24 A G 17: 36,014,591 V335A probably benign Het
Havcr2 T G 11: 46,456,557 N120K probably damaging Het
Hmcn2 T C 2: 31,458,026 F4895L possibly damaging Het
Igsf3 T C 3: 101,435,531 Y475H probably damaging Het
Lonp1 T C 17: 56,626,620 D85G probably benign Het
Lrrc49 T C 9: 60,593,692 S657G probably benign Het
Lrrk2 T A 15: 91,700,613 Y382N probably damaging Het
Macf1 T C 4: 123,385,598 D3870G probably damaging Het
Mtf1 T A 4: 124,824,288 C260S probably damaging Het
Naa35 A G 13: 59,599,784 D110G probably damaging Het
Npas3 A T 12: 54,068,718 T808S probably damaging Het
Olfr76 A G 19: 12,120,545 W56R probably damaging Het
Pax9 A T 12: 56,700,099 H240L probably benign Het
Pik3c2a T C 7: 116,394,294 T413A probably benign Het
Pik3r1 A G 13: 101,709,697 V127A probably benign Het
Pik3r5 A G 11: 68,490,498 E170G probably damaging Het
Polr1a T C 6: 71,954,835 I966T possibly damaging Het
Rab29 T A 1: 131,872,185 M166K probably damaging Het
Rab2b T C 14: 52,266,260 E135G probably damaging Het
Rnf103 T A 6: 71,509,479 S365T possibly damaging Het
Rnf213 G A 11: 119,410,861 E387K Het
Sh3d19 T C 3: 86,123,731 V734A probably benign Het
Ssbp1 T G 6: 40,477,980 N124K probably damaging Het
Tbc1d31 C T 15: 57,936,098 R227* probably null Het
Tcerg1 A G 18: 42,523,974 T174A unknown Het
Tenm2 T C 11: 36,069,561 S980G possibly damaging Het
Trim30a T C 7: 104,430,179 I156M possibly damaging Het
Trim39 T C 17: 36,260,504 D454G possibly damaging Het
Trpc7 A T 13: 56,773,766 *863K probably null Het
Tubgcp3 A G 8: 12,657,561 Y143H probably benign Het
Vmn1r33 C T 6: 66,612,373 D66N probably benign Het
Vmn2r8 A T 5: 108,802,177 I268N probably damaging Het
Vmn2r91 A C 17: 18,135,818 E582D probably benign Het
Vtcn1 T C 3: 100,883,895 F83S probably damaging Het
Wdr81 G T 11: 75,441,985 D684E Het
Wipi1 A G 11: 109,579,709 S295P probably damaging Het
Zfp27 A T 7: 29,894,274 H755Q possibly damaging Het
Zfp963 A G 8: 69,742,883 F307L possibly damaging Het
Other mutations in Prelid2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00709:Prelid2 APN 18 41912423 missense probably damaging 1.00
IGL01731:Prelid2 APN 18 41937649 missense probably benign 0.03
G1patch:Prelid2 UTSW 18 41912449 missense possibly damaging 0.82
R0217:Prelid2 UTSW 18 41935252 splice site probably benign
R0556:Prelid2 UTSW 18 41951180 start gained probably benign
R0627:Prelid2 UTSW 18 41937652 missense possibly damaging 0.50
R0848:Prelid2 UTSW 18 41935224 missense probably damaging 0.98
R1522:Prelid2 UTSW 18 41881267 missense probably benign
R3919:Prelid2 UTSW 18 41937675 missense possibly damaging 0.79
R4131:Prelid2 UTSW 18 41951159 missense possibly damaging 0.94
R4422:Prelid2 UTSW 18 41912396 missense probably benign 0.01
R4892:Prelid2 UTSW 18 41951144 missense possibly damaging 0.86
R6062:Prelid2 UTSW 18 41912465 missense probably benign 0.00
R6725:Prelid2 UTSW 18 41912449 missense possibly damaging 0.82
R7276:Prelid2 UTSW 18 41912422 missense possibly damaging 0.65
R7941:Prelid2 UTSW 18 41932751 nonsense probably null
R8093:Prelid2 UTSW 18 41932635 missense probably damaging 1.00
R8202:Prelid2 UTSW 18 41932737 missense possibly damaging 0.95
R8393:Prelid2 UTSW 18 41881248 missense probably benign 0.08
Predicted Primers PCR Primer
(F):5'- GAACATGTTCAGACCTTTTCAGC -3'
(R):5'- CTCCTAGGCTCATAGCTTGC -3'

Sequencing Primer
(F):5'- AGACCTTTTCAGCCTGGGC -3'
(R):5'- GAATTTCAATCACGGGGG -3'
Posted On2019-11-26