Incidental Mutation 'R7811:Or2r3'
ID 601157
Institutional Source Beutler Lab
Gene Symbol Or2r3
Ensembl Gene ENSMUSG00000091983
Gene Name olfactory receptor family 2 subfamily R member 3
Synonyms GA_x6K02T2P3E9-5088893-5089834, Olfr457, MOR257-1
MMRRC Submission 045866-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.149) question?
Stock # R7811 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 42448169-42449110 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 42448635 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Valine at position 159 (E159V)
Ref Sequence ENSEMBL: ENSMUSP00000144914 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170504] [ENSMUST00000203396] [ENSMUST00000204324]
AlphaFold Q8VGP5
Predicted Effect probably damaging
Transcript: ENSMUST00000170504
AA Change: E159V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000127348
Gene: ENSMUSG00000091983
AA Change: E159V

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 6.4e-53 PFAM
Pfam:7tm_1 41 290 2e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000203396
AA Change: E159V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000145162
Gene: ENSMUSG00000091983
AA Change: E159V

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 6.4e-53 PFAM
Pfam:7tm_1 41 290 2e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000204324
AA Change: E159V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000144914
Gene: ENSMUSG00000091983
AA Change: E159V

DomainStartEndE-ValueType
Pfam:7tm_4 31 125 2.4e-19 PFAM
Pfam:7tm_1 41 125 3.1e-14 PFAM
Meta Mutation Damage Score 0.6329 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (58/58)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T A 11: 9,527,141 (GRCm39) probably null Het
Abca3 A G 17: 24,616,362 (GRCm39) T935A probably benign Het
Anxa7 A T 14: 20,510,254 (GRCm39) Y399N probably benign Het
Arhgef10l G T 4: 140,242,335 (GRCm39) T1030K possibly damaging Het
Ass1 G A 2: 31,404,753 (GRCm39) V345I probably benign Het
Bms1 T C 6: 118,380,099 (GRCm39) D736G probably damaging Het
Bpifb1 T A 2: 154,048,484 (GRCm39) probably null Het
Cbx4 A C 11: 118,972,398 (GRCm39) C326G probably benign Het
Ccdc188 A G 16: 18,036,314 (GRCm39) E94G probably benign Het
Cdh5 A G 8: 104,852,235 (GRCm39) T117A possibly damaging Het
Cdk11b A G 4: 155,724,359 (GRCm39) T326A unknown Het
Clec5a C T 6: 40,558,867 (GRCm39) C73Y probably damaging Het
Cntrl T C 2: 35,052,873 (GRCm39) M1126T probably benign Het
Diaph3 T C 14: 87,219,060 (GRCm39) D455G probably damaging Het
Eml2 T A 7: 18,920,047 (GRCm39) M117K probably benign Het
Ern1 A T 11: 106,325,694 (GRCm39) V112D unknown Het
Eya3 T C 4: 132,439,272 (GRCm39) I466T possibly damaging Het
Fbxl6 T C 15: 76,421,485 (GRCm39) probably null Het
Ffar1 A G 7: 30,560,802 (GRCm39) S32P possibly damaging Het
Fgb T C 3: 82,957,004 (GRCm39) D22G probably benign Het
Fsip2 T C 2: 82,828,797 (GRCm39) Y6865H possibly damaging Het
Gbx1 T C 5: 24,710,035 (GRCm39) E270G probably damaging Het
Golga4 T C 9: 118,361,643 (GRCm39) L207P probably damaging Het
Hnrnpa1 T C 15: 103,149,900 (GRCm39) S54P possibly damaging Het
Htr4 A G 18: 62,545,269 (GRCm39) E18G possibly damaging Het
Ide A C 19: 37,307,910 (GRCm39) L34R Het
Ip6k3 A T 17: 27,376,557 (GRCm39) Y51* probably null Het
Keap1 A G 9: 21,148,956 (GRCm39) L17P possibly damaging Het
Lrrn2 T C 1: 132,866,939 (GRCm39) V668A probably benign Het
Lypd8 A T 11: 58,281,064 (GRCm39) T209S possibly damaging Het
Myo10 T C 15: 25,804,610 (GRCm39) I1635T probably damaging Het
Myo1e T A 9: 70,234,544 (GRCm39) V299E probably damaging Het
Nadk A T 4: 155,661,332 (GRCm39) probably benign Het
Nalcn A T 14: 123,536,357 (GRCm39) W1231R probably damaging Het
Odf2l A G 3: 144,859,148 (GRCm39) T602A probably benign Het
Or13g1 T A 7: 85,955,554 (GRCm39) T256S probably damaging Het
Pde6c T C 19: 38,128,507 (GRCm39) V190A possibly damaging Het
Ppp4r3a C A 12: 101,019,821 (GRCm39) R378L probably damaging Het
Pus7l A C 15: 94,438,707 (GRCm39) V46G probably damaging Het
Satb2 G A 1: 56,884,880 (GRCm39) S466L probably benign Het
Serpina6 A G 12: 103,620,395 (GRCm39) M118T probably damaging Het
Slc29a1 T C 17: 45,897,189 (GRCm39) R366G probably damaging Het
Slc6a1 T C 6: 114,279,515 (GRCm39) F98S probably damaging Het
Spg7 T C 8: 123,824,164 (GRCm39) I738T possibly damaging Het
Srcap T C 7: 127,141,221 (GRCm39) V1667A probably damaging Het
Stxbp5 T C 10: 9,684,248 (GRCm39) N574S probably benign Het
Syne2 A G 12: 76,030,501 (GRCm39) probably null Het
Tbc1d10a T C 11: 4,136,948 (GRCm39) S54P possibly damaging Het
Trim12c T C 7: 103,990,469 (GRCm39) N336S unknown Het
Ubap2 T C 4: 41,211,710 (GRCm39) S351G probably benign Het
Unc13c G T 9: 73,600,553 (GRCm39) A1397E possibly damaging Het
Ush1c G A 7: 45,854,710 (GRCm39) R681* probably null Het
Vmn2r57 A T 7: 41,074,439 (GRCm39) C541* probably null Het
Vmn2r73 T C 7: 85,524,956 (GRCm39) D64G possibly damaging Het
Vmn2r88 A T 14: 51,656,160 (GRCm39) T790S Het
Zfp568 A G 7: 29,697,295 (GRCm39) T72A possibly damaging Het
Zfp950 A T 19: 61,108,353 (GRCm39) Y243* probably null Het
Zmym5 A G 14: 57,036,434 (GRCm39) S238P probably damaging Het
Zswim5 A G 4: 116,734,673 (GRCm39) E6G unknown Het
Other mutations in Or2r3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01417:Or2r3 APN 6 42,449,046 (GRCm39) missense probably benign 0.00
IGL01915:Or2r3 APN 6 42,448,223 (GRCm39) missense probably benign 0.01
IGL02006:Or2r3 APN 6 42,449,025 (GRCm39) missense probably benign 0.37
IGL02440:Or2r3 APN 6 42,449,100 (GRCm39) missense probably benign
R0024:Or2r3 UTSW 6 42,448,194 (GRCm39) missense probably benign
R0662:Or2r3 UTSW 6 42,448,708 (GRCm39) missense possibly damaging 0.75
R1599:Or2r3 UTSW 6 42,448,176 (GRCm39) missense probably damaging 1.00
R2087:Or2r3 UTSW 6 42,448,985 (GRCm39) missense probably damaging 1.00
R5002:Or2r3 UTSW 6 42,448,906 (GRCm39) missense probably benign 0.18
R5022:Or2r3 UTSW 6 42,448,221 (GRCm39) missense possibly damaging 0.92
R5288:Or2r3 UTSW 6 42,448,186 (GRCm39) missense probably benign
R5342:Or2r3 UTSW 6 42,448,836 (GRCm39) missense probably damaging 1.00
R5823:Or2r3 UTSW 6 42,448,906 (GRCm39) missense probably benign 0.18
R5824:Or2r3 UTSW 6 42,448,906 (GRCm39) missense probably benign 0.18
R6378:Or2r3 UTSW 6 42,448,687 (GRCm39) missense probably benign 0.01
R7384:Or2r3 UTSW 6 42,448,257 (GRCm39) missense possibly damaging 0.89
R7442:Or2r3 UTSW 6 42,448,434 (GRCm39) missense probably benign 0.02
R7631:Or2r3 UTSW 6 42,448,870 (GRCm39) missense probably benign 0.01
R7896:Or2r3 UTSW 6 42,449,100 (GRCm39) missense probably benign 0.22
R9244:Or2r3 UTSW 6 42,448,537 (GRCm39) missense possibly damaging 0.88
R9579:Or2r3 UTSW 6 42,448,574 (GRCm39) nonsense probably null
X0017:Or2r3 UTSW 6 42,448,752 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATGATGGCAGCCACAATGTG -3'
(R):5'- AAAGACCATCTCTTTTGCCCTG -3'

Sequencing Primer
(F):5'- CACAATGTGGGCATAGGACAG -3'
(R):5'- TGTGTGGGACCCAGCTC -3'
Posted On 2019-11-26