Mutagenetix > Incidental Mutation

Incidental Mutation 'R0675:Olfr92'

61635

Institutional Source

Beutler Lab

Gene Symbol

Olfr92

Ensembl Gene

ENSMUSG00000096477

Gene Name

olfactory receptor 92

Synonyms

MOR256-29, GA_x6K02T2PSCP-1552066-1551128

MMRRC Submission

038860-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

R0675 (G1)

Quality Score

164

Status

Validated

Chromosome

Chromosomal Location

37110512-37120088 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to C at 37111455 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Valine at position 176 (L176V)

Ref Sequence

ENSEMBL: ENSMUSP00000150988 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168659] [ENSMUST00000214994] [ENSMUST00000216341]

AlphaFold

L7N475

Predicted Effect

probably benign
Transcript: ENSMUST00000168659
AA Change: L176V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000128393
Gene: ENSMUSG00000096477
AA Change: L176V

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srv	23	304	5.1e-7	PFAM
Pfam:7tm_4	29	306	3.4e-50	PFAM
Pfam:7tm_1	39	288	1.1e-26	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000174626

Predicted Effect

probably benign
Transcript: ENSMUST00000214994
AA Change: L176V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

Predicted Effect

probably benign
Transcript: ENSMUST00000216341
AA Change: L176V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.4%
3x: 98.9%
10x: 97.7%
20x: 96.1%

Validation Efficiency

97% (88/91)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 78 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700001C19Rik	T	C	17: 47,413,776	E140G	probably benign	Het
4932431P20Rik	T	C	7: 29,532,517		noncoding transcript	Het
Ablim2	C	T	5: 35,866,780		probably benign	Het
Aire	T	C	10: 78,034,493		probably benign	Het
Akap12	T	C	10: 4,353,315	S42P	probably benign	Het
Amigo1	T	C	3: 108,191,669		probably benign	Het
Angptl3	A	G	4: 99,033,262	T206A	probably benign	Het
Ank1	T	A	8: 23,110,384		probably benign	Het
Ano5	A	T	7: 51,574,810	T472S	probably damaging	Het
Arid3c	T	C	4: 41,725,958	D215G	probably damaging	Het
Cd200	T	C	16: 45,397,110	I73V	probably benign	Het
Cd47	T	C	16: 49,906,799	I318T	possibly damaging	Het
Cep290	A	G	10: 100,568,813		probably null	Het
Cep350	A	G	1: 155,959,753	S66P	possibly damaging	Het
Cfap46	C	T	7: 139,676,034	C300Y	probably damaging	Het
Chd1	T	A	17: 15,758,261		probably benign	Het
Chd5	C	A	4: 152,385,950	T1913K	probably benign	Het
Clec4b1	A	G	6: 123,071,446	Y180C	probably damaging	Het
Cntnap5c	A	T	17: 58,034,995	D227V	probably damaging	Het
Col19a1	C	G	1: 24,575,455		probably benign	Het
Csmd1	A	T	8: 16,158,131	M1270K	probably benign	Het
Cyp2c66	T	A	19: 39,186,616	F487I	possibly damaging	Het
Dpp8	T	C	9: 65,066,502		probably benign	Het
Duoxa1	A	T	2: 122,306,380		probably benign	Het
Edil3	A	G	13: 89,177,280	K263E	probably damaging	Het
Fat2	A	G	11: 55,309,209	L1013P	probably damaging	Het
Fras1	T	C	5: 96,667,387		probably benign	Het
Gab1	A	G	8: 80,769,668	S668P	probably damaging	Het
Galnt14	T	C	17: 73,545,035	T130A	probably damaging	Het
Gm10192	G	A	4: 97,182,872	H99Y	unknown	Het
Gm5592	A	G	7: 41,289,387	T698A	possibly damaging	Het
Gm6605	C	A	7: 38,448,275		noncoding transcript	Het
Gsdma3	A	G	11: 98,631,191	K149R	probably benign	Het
Igkv4-71	A	G	6: 69,243,427	S29P	probably damaging	Het
Igsf10	C	T	3: 59,328,594	V1389I	probably benign	Het
Ik	T	C	18: 36,747,333		probably benign	Het
Ino80	G	A	2: 119,383,481	P1203S	probably damaging	Het
Iqsec2	G	A	X: 152,204,124	E398K	possibly damaging	Het
Jmjd6	A	G	11: 116,840,527	V232A	probably damaging	Het
Klhdc9	G	A	1: 171,360,327	T112M	possibly damaging	Het
Marcks	A	G	10: 37,141,185		probably benign	Het
Mctp2	T	A	7: 72,083,170	T829S	probably damaging	Het
Mroh2a	C	A	1: 88,228,380	A78E	probably damaging	Het
Mroh2a	G	A	1: 88,250,342	D1053N	probably damaging	Het
Mtmr14	A	T	6: 113,270,647	H518L	probably damaging	Het
Mum1	T	A	10: 80,230,080	V56E	probably damaging	Het
Myo5c	T	C	9: 75,278,289	M978T	probably benign	Het
Nlrc3	T	C	16: 3,948,911	I1015V	probably benign	Het
Nlrp5	C	A	7: 23,417,417	Q189K	possibly damaging	Het
Olfr1082	T	C	2: 86,594,079	I250V	probably benign	Het
Olfr385	A	C	11: 73,589,252	L162R	probably damaging	Het
Olfr583	A	G	7: 103,051,702	I135V	probably benign	Het
Otof	T	A	5: 30,382,361	Y1051F	probably benign	Het
Pcdhb14	C	A	18: 37,448,339	T166K	possibly damaging	Het
Pla2g4e	A	G	2: 120,200,198		probably benign	Het
Polr3gl	T	C	3: 96,582,155	E20G	probably damaging	Het
Psmd1	A	G	1: 86,082,039	D295G	probably benign	Het
Ptpn21	C	A	12: 98,688,216	A831S	probably benign	Het
Rd3l	T	C	12: 111,980,162	D60G	probably benign	Het
Rif1	GCCACCA	GCCA	2: 52,110,324		probably benign	Het
Rnf213	A	G	11: 119,441,834	D2624G	probably benign	Het
Sec31a	T	C	5: 100,393,207	D347G	probably damaging	Het
Sema4g	G	A	19: 44,997,587	R289H	probably damaging	Het
Sema5b	C	T	16: 35,660,333	T761I	probably benign	Het
Sept1	A	T	7: 127,216,999	F86L	probably damaging	Het
Shank3	T	C	15: 89,531,388	V627A	possibly damaging	Het
Slc25a46	C	A	18: 31,609,588	G75V	probably benign	Het
Slc45a2	T	A	15: 11,025,778	Y405N	probably damaging	Het
Spidr	T	C	16: 16,037,634	E339G	probably damaging	Het
Sptbn1	A	T	11: 30,117,903	H1770Q	probably damaging	Het
Srgap1	T	C	10: 121,792,235	Y944C	probably damaging	Het
Supt20	C	T	3: 54,706,969	T169I	probably damaging	Het
Tie1	G	A	4: 118,479,769	Q587*	probably null	Het
Tmem214	A	G	5: 30,871,825	T203A	possibly damaging	Het
Tmprss15	C	A	16: 78,985,950	S742I	probably damaging	Het
Zfhx2	A	G	14: 55,063,163	V2377A	probably damaging	Het
Zfp763	G	A	17: 33,019,800	H124Y	possibly damaging	Het
Zfp846	T	C	9: 20,593,557	S238P	probably benign	Het

Other mutations in Olfr92

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01527:Olfr92	APN	17	37111809	missense	probably damaging	1.00
IGL02850:Olfr92	APN	17	37111973	missense	probably benign	0.35
IGL03209:Olfr92	APN	17	37111521	missense	probably benign	0.04
R0579:Olfr92	UTSW	17	37111455	missense	probably benign	0.00
R0580:Olfr92	UTSW	17	37111455	missense	probably benign	0.00
R0582:Olfr92	UTSW	17	37111455	missense	probably benign	0.00
R0615:Olfr92	UTSW	17	37111455	missense	probably benign	0.00
R0669:Olfr92	UTSW	17	37111455	missense	probably benign	0.00
R0674:Olfr92	UTSW	17	37111455	missense	probably benign	0.00
R2424:Olfr92	UTSW	17	37111516	missense	probably benign	0.02
R3714:Olfr92	UTSW	17	37111335	missense	probably damaging	1.00
R4393:Olfr92	UTSW	17	37114084	intron	probably benign
R5811:Olfr92	UTSW	17	37111757	missense	probably benign	0.00
R6615:Olfr92	UTSW	17	37111602	missense	probably damaging	1.00
R6853:Olfr92	UTSW	17	37111508	missense	probably benign	0.02
R6876:Olfr92	UTSW	17	37111206	missense	probably damaging	1.00
R7665:Olfr92	UTSW	17	37111391	missense	probably benign	0.20
R8087:Olfr92	UTSW	17	37111548	missense	probably benign
R9224:Olfr92	UTSW	17	37111875	missense	possibly damaging	0.53
R9439:Olfr92	UTSW	17	37111313	missense	probably damaging	1.00
R9541:Olfr92	UTSW	17	37111932	missense	probably benign	0.00
R9559:Olfr92	UTSW	17	37111617	missense	possibly damaging	0.84
Z1177:Olfr92	UTSW	17	37111430	missense	probably benign	0.09

Predicted Primers

PCR Primer
(F):5'- GCAGAGCTTATCTTCAGCACTGCC -3'
(R):5'- GAAACACACTCATCCTCCTGCTGTC -3'

Sequencing Primer
(F):5'- CCTGGCAATGGCACCATAAG -3'
(R):5'- TCATGTCCCTGGGTACAACAG -3'

Posted On

2013-07-30