Incidental Mutation 'R0711:Tmem200c'
ID 62767
Institutional Source Beutler Lab
Gene Symbol Tmem200c
Ensembl Gene ENSMUSG00000095407
Gene Name transmembrane protein 200C
Synonyms Gm6338
MMRRC Submission 038894-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R0711 (G1)
Quality Score 117
Status Validated
Chromosome 17
Chromosomal Location 69144084-69150133 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 69149249 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 611 (T611A)
Ref Sequence ENSEMBL: ENSMUSP00000137246 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000178545]
AlphaFold J3QK46
Predicted Effect probably damaging
Transcript: ENSMUST00000178545
AA Change: T611A

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000137246
Gene: ENSMUSG00000095407
AA Change: T611A

DomainStartEndE-ValueType
Pfam:DUF2371 14 209 4.1e-65 PFAM
SCOP:d1gkub1 227 258 2e-3 SMART
low complexity region 272 291 N/A INTRINSIC
low complexity region 347 377 N/A INTRINSIC
low complexity region 382 398 N/A INTRINSIC
low complexity region 473 486 N/A INTRINSIC
low complexity region 496 509 N/A INTRINSIC
low complexity region 538 550 N/A INTRINSIC
low complexity region 584 599 N/A INTRINSIC
Meta Mutation Damage Score 0.0765 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.4%
  • 20x: 91.4%
Validation Efficiency 100% (91/91)
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik T A 3: 137,773,986 (GRCm39) D1058E probably damaging Het
4933405L10Rik A T 8: 106,435,563 (GRCm39) probably null Het
Adamtsl3 T A 7: 82,114,907 (GRCm39) probably benign Het
Afdn C T 17: 14,072,698 (GRCm39) P874S probably damaging Het
Ankrd6 G A 4: 32,815,326 (GRCm39) A391V probably damaging Het
Arhgef28 T G 13: 98,067,762 (GRCm39) T1388P probably damaging Het
Asxl3 G T 18: 22,657,508 (GRCm39) M1839I probably benign Het
BC005537 T C 13: 24,989,923 (GRCm39) F129L probably damaging Het
Celf2 A G 2: 6,726,226 (GRCm39) probably null Het
Chid1 C T 7: 141,076,590 (GRCm39) V325I probably benign Het
Cnn3 T A 3: 121,243,633 (GRCm39) D31E probably benign Het
Col12a1 G A 9: 79,559,317 (GRCm39) P1857L probably damaging Het
Cpeb1 T A 7: 81,001,618 (GRCm39) R430W probably benign Het
Daw1 T C 1: 83,169,059 (GRCm39) probably benign Het
Dcaf13 A G 15: 39,001,484 (GRCm39) Y264C probably damaging Het
Dnah6 T C 6: 73,064,585 (GRCm39) I2666V probably damaging Het
Dnai2 A C 11: 114,645,158 (GRCm39) D531A probably benign Het
Dock10 A T 1: 80,501,692 (GRCm39) F1833I probably damaging Het
Efhd2 C T 4: 141,587,183 (GRCm39) A200T probably damaging Het
Epb41l5 T A 1: 119,551,641 (GRCm39) probably benign Het
Ermp1 A G 19: 29,608,788 (GRCm39) Y164H possibly damaging Het
Gkn2 T C 6: 87,350,401 (GRCm39) probably benign Het
Golgb1 A T 16: 36,739,152 (GRCm39) Q2497L probably damaging Het
Gzme A T 14: 56,355,196 (GRCm39) M245K probably damaging Het
Iars2 A T 1: 185,054,585 (GRCm39) probably benign Het
Icosl T A 10: 77,909,775 (GRCm39) V240D probably damaging Het
Igsf3 T C 3: 101,334,709 (GRCm39) M262T probably benign Het
Ing3 G T 6: 21,971,236 (GRCm39) E336* probably null Het
Kat2a A T 11: 100,597,297 (GRCm39) V625E probably damaging Het
Ksr1 A G 11: 78,929,073 (GRCm39) probably benign Het
Lypd8 A T 11: 58,277,583 (GRCm39) M122L probably benign Het
Mdfi A T 17: 48,143,855 (GRCm39) probably benign Het
Med13 A G 11: 86,192,179 (GRCm39) probably benign Het
Msh6 C T 17: 88,294,112 (GRCm39) R956C probably damaging Het
Myo15b A G 11: 115,774,664 (GRCm39) E670G probably damaging Het
Myo1d A G 11: 80,375,158 (GRCm39) L972P probably damaging Het
Or4s2b A G 2: 88,509,018 (GRCm39) D266G probably damaging Het
Or51ai2 G A 7: 103,587,024 (GRCm39) A146T probably benign Het
Or7g12 T A 9: 18,899,447 (GRCm39) N54K probably benign Het
Pde8b C G 13: 95,244,325 (GRCm39) S143T possibly damaging Het
Pias4 G T 10: 80,993,364 (GRCm39) probably benign Het
Prkca A G 11: 107,872,480 (GRCm39) Y427H probably benign Het
Psg25 G A 7: 18,263,485 (GRCm39) Q113* probably null Het
Rab3gap2 T A 1: 184,982,123 (GRCm39) S392T probably damaging Het
Scrib A G 15: 75,938,756 (GRCm39) probably benign Het
Sdk2 A G 11: 113,793,970 (GRCm39) probably benign Het
Serpinb1c T A 13: 33,070,266 (GRCm39) probably benign Het
Serpinb9f T A 13: 33,511,904 (GRCm39) W136R probably damaging Het
Skic3 C T 13: 76,331,010 (GRCm39) P1480L probably damaging Het
Skint10 C A 4: 112,573,102 (GRCm39) probably benign Het
Slc25a13 T C 6: 6,117,128 (GRCm39) T196A probably damaging Het
Slc26a5 T C 5: 22,052,230 (GRCm39) H33R probably damaging Het
Slc27a6 T C 18: 58,731,829 (GRCm39) probably benign Het
Slitrk6 A T 14: 110,987,251 (GRCm39) Y819N probably damaging Het
Spata46 C T 1: 170,139,603 (GRCm39) Q201* probably null Het
Sptbn1 A T 11: 30,064,739 (GRCm39) V1920E probably damaging Het
Taf6l A G 19: 8,755,881 (GRCm39) F256L probably benign Het
Tmco3 T A 8: 13,342,039 (GRCm39) N104K probably damaging Het
Tmem202 T G 9: 59,432,655 (GRCm39) Y24S probably damaging Het
Tpp1 A G 7: 105,398,626 (GRCm39) L230P probably damaging Het
Trim56 C T 5: 137,141,846 (GRCm39) E557K probably benign Het
Trrap C T 5: 144,790,309 (GRCm39) L3590F probably damaging Het
Tulp4 A G 17: 6,189,387 (GRCm39) T70A possibly damaging Het
Vcp G C 4: 42,986,201 (GRCm39) A297G probably benign Het
Vwf T A 6: 125,603,234 (GRCm39) H861Q probably benign Het
Wdr64 T C 1: 175,599,751 (GRCm39) I536T probably benign Het
Zfp850 T C 7: 27,689,698 (GRCm39) N170S probably benign Het
Zfp87 G A 13: 74,524,544 (GRCm39) probably benign Het
Other mutations in Tmem200c
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0360:Tmem200c UTSW 17 69,147,543 (GRCm39) missense probably damaging 1.00
R0364:Tmem200c UTSW 17 69,147,543 (GRCm39) missense probably damaging 1.00
R0599:Tmem200c UTSW 17 69,147,506 (GRCm39) missense probably damaging 1.00
R1311:Tmem200c UTSW 17 69,147,758 (GRCm39) missense probably damaging 0.98
R1852:Tmem200c UTSW 17 69,147,612 (GRCm39) missense probably damaging 1.00
R1951:Tmem200c UTSW 17 69,147,983 (GRCm39) missense probably damaging 1.00
R1954:Tmem200c UTSW 17 69,147,956 (GRCm39) missense probably damaging 1.00
R1955:Tmem200c UTSW 17 69,147,956 (GRCm39) missense probably damaging 1.00
R2144:Tmem200c UTSW 17 69,149,244 (GRCm39) missense possibly damaging 0.49
R2189:Tmem200c UTSW 17 69,147,681 (GRCm39) missense probably damaging 0.98
R2397:Tmem200c UTSW 17 69,147,942 (GRCm39) missense probably damaging 1.00
R4546:Tmem200c UTSW 17 69,149,166 (GRCm39) missense probably benign
R4715:Tmem200c UTSW 17 69,147,465 (GRCm39) missense probably damaging 1.00
R4752:Tmem200c UTSW 17 69,149,235 (GRCm39) missense probably benign 0.05
R5214:Tmem200c UTSW 17 69,148,122 (GRCm39) missense probably damaging 1.00
R5751:Tmem200c UTSW 17 69,147,547 (GRCm39) missense probably damaging 1.00
R5827:Tmem200c UTSW 17 69,149,004 (GRCm39) missense probably benign 0.00
R5989:Tmem200c UTSW 17 69,144,431 (GRCm39) start gained probably benign
R6024:Tmem200c UTSW 17 69,148,722 (GRCm39) missense possibly damaging 0.49
R6634:Tmem200c UTSW 17 69,149,101 (GRCm39) missense probably benign 0.26
R7527:Tmem200c UTSW 17 69,148,671 (GRCm39) missense probably benign 0.04
R8046:Tmem200c UTSW 17 69,147,513 (GRCm39) missense probably benign 0.29
R8927:Tmem200c UTSW 17 69,148,733 (GRCm39) missense probably benign 0.00
R8928:Tmem200c UTSW 17 69,148,733 (GRCm39) missense probably benign 0.00
R9185:Tmem200c UTSW 17 69,147,633 (GRCm39) missense probably damaging 1.00
R9241:Tmem200c UTSW 17 69,144,161 (GRCm39) start gained probably benign
R9374:Tmem200c UTSW 17 69,148,682 (GRCm39) missense probably damaging 1.00
R9651:Tmem200c UTSW 17 69,149,181 (GRCm39) missense probably benign 0.02
R9652:Tmem200c UTSW 17 69,149,181 (GRCm39) missense probably benign 0.02
R9653:Tmem200c UTSW 17 69,149,181 (GRCm39) missense probably benign 0.02
R9775:Tmem200c UTSW 17 69,149,118 (GRCm39) missense probably damaging 1.00
Z1176:Tmem200c UTSW 17 69,148,790 (GRCm39) missense probably damaging 0.99
Z1177:Tmem200c UTSW 17 69,148,339 (GRCm39) missense probably benign 0.26
Z1177:Tmem200c UTSW 17 69,148,332 (GRCm39) missense probably benign 0.13
Z1177:Tmem200c UTSW 17 69,148,431 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGATGACCAGTCCAGCAGCAATAAG -3'
(R):5'- ATTGAATGGTTTCCTCGGACCTGTC -3'

Sequencing Primer
(F):5'- TCCAGCAGCAATAAGGGCTAC -3'
(R):5'- ACCTGTCCACAGGGGAATC -3'
Posted On 2013-07-30