Incidental Mutation 'R5989:Tmem200c'
ID481906
Institutional Source Beutler Lab
Gene Symbol Tmem200c
Ensembl Gene ENSMUSG00000095407
Gene Nametransmembrane protein 200C
SynonymsGm6338
MMRRC Submission 044169-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.163) question?
Stock #R5989 (G1)
Quality Score207.009
Status Not validated
Chromosome17
Chromosomal Location68837136-68843138 bp(+) (GRCm38)
Type of Mutationstart gained
DNA Base Change (assembly) G to T at 68837436 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000137246 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000178545]
Predicted Effect probably benign
Transcript: ENSMUST00000178545
SMART Domains Protein: ENSMUSP00000137246
Gene: ENSMUSG00000095407

DomainStartEndE-ValueType
Pfam:DUF2371 14 209 4.1e-65 PFAM
SCOP:d1gkub1 227 258 2e-3 SMART
low complexity region 272 291 N/A INTRINSIC
low complexity region 347 377 N/A INTRINSIC
low complexity region 382 398 N/A INTRINSIC
low complexity region 473 486 N/A INTRINSIC
low complexity region 496 509 N/A INTRINSIC
low complexity region 538 550 N/A INTRINSIC
low complexity region 584 599 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.4%
  • 10x: 97.0%
  • 20x: 90.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cartpt T A 13: 99,898,984 I109F probably damaging Het
Csmd3 G A 15: 47,590,764 P3562L possibly damaging Het
Cyp2c40 T C 19: 39,807,580 D118G probably benign Het
Dmrt1 T A 19: 25,545,881 S199T possibly damaging Het
Ebf1 G T 11: 44,996,171 C565F probably damaging Het
Ggnbp1 A G 17: 27,029,747 R97G probably benign Het
Gm10271 A T 10: 116,972,592 F6L probably damaging Het
Gm10767 G A 13: 66,907,986 M14I probably damaging Het
Gm42417 A G 1: 36,532,192 F183L probably damaging Het
Ipcef1 A T 10: 6,979,532 Y69* probably null Het
Lcp1 A T 14: 75,199,387 M58L probably benign Het
Mtif2 A G 11: 29,530,098 T55A probably damaging Het
Nefm A G 14: 68,124,329 V162A probably benign Het
Nmral1 G A 16: 4,719,038 probably benign Het
Olfr191 A T 16: 59,086,334 W50R probably benign Het
Panx2 T C 15: 89,060,252 L60P probably damaging Het
Prkag3 T C 1: 74,741,274 N411D probably benign Het
Prrxl1 A G 14: 32,608,188 N116S probably benign Het
Rnd2 C T 11: 101,468,999 L57F probably damaging Het
Rttn G A 18: 88,973,626 D110N probably damaging Het
Sfta2 G T 17: 35,649,780 probably benign Het
Slc17a3 A G 13: 23,842,428 probably benign Het
Spem1 G A 11: 69,821,125 P238S possibly damaging Het
Trpm2 A G 10: 77,959,900 F131S probably damaging Het
Vps51 A G 19: 6,076,372 S117P probably damaging Het
Zbtb21 G A 16: 97,951,499 P556L probably damaging Het
Other mutations in Tmem200c
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0360:Tmem200c UTSW 17 68840548 missense probably damaging 1.00
R0364:Tmem200c UTSW 17 68840548 missense probably damaging 1.00
R0599:Tmem200c UTSW 17 68840511 missense probably damaging 1.00
R0711:Tmem200c UTSW 17 68842254 missense probably damaging 1.00
R1311:Tmem200c UTSW 17 68840763 missense probably damaging 0.98
R1852:Tmem200c UTSW 17 68840617 missense probably damaging 1.00
R1951:Tmem200c UTSW 17 68840988 missense probably damaging 1.00
R1954:Tmem200c UTSW 17 68840961 missense probably damaging 1.00
R1955:Tmem200c UTSW 17 68840961 missense probably damaging 1.00
R2144:Tmem200c UTSW 17 68842249 missense possibly damaging 0.49
R2189:Tmem200c UTSW 17 68840686 missense probably damaging 0.98
R2397:Tmem200c UTSW 17 68840947 missense probably damaging 1.00
R4546:Tmem200c UTSW 17 68842171 missense probably benign
R4715:Tmem200c UTSW 17 68840470 missense probably damaging 1.00
R4752:Tmem200c UTSW 17 68842240 missense probably benign 0.05
R5214:Tmem200c UTSW 17 68841127 missense probably damaging 1.00
R5751:Tmem200c UTSW 17 68840552 missense probably damaging 1.00
R5827:Tmem200c UTSW 17 68842009 missense probably benign 0.00
R6024:Tmem200c UTSW 17 68841727 missense possibly damaging 0.49
R6634:Tmem200c UTSW 17 68842106 missense probably benign 0.26
R7527:Tmem200c UTSW 17 68841676 missense probably benign 0.04
Predicted Primers
Posted On2017-06-26