Mutagenetix > Incidental Mutation

Incidental Mutation 'R8413:Vmn1r179'

652786

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r179

Ensembl Gene

ENSMUSG00000046924

Gene Name

vomeronasal 1 receptor 179

Synonyms

V1rd17

MMRRC Submission

067767-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

R8413 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

23627811-23628782 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 23628277 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Phenylalanine at position 156 (Y156F)

Ref Sequence

ENSEMBL: ENSMUSP00000055372 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049819]

AlphaFold

Q8R2B4

Predicted Effect

probably benign
Transcript: ENSMUST00000049819
AA Change: Y156F

PolyPhen 2 Score 0.196 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000055372
Gene: ENSMUSG00000046924
AA Change: Y156F

Domain	Start	End	E-Value	Type
Pfam:TAS2R	23	313	3.8e-13	PFAM
Pfam:7tm_1	45	304	2e-8	PFAM
Pfam:V1R	57	312	4.2e-15	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.5%
20x: 98.4%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca16	T	A	7: 120,023,123 (GRCm39)	D86E	probably benign	Het
Adamts5	A	G	16: 85,663,506 (GRCm39)		probably null	Het
Arhgap31	T	C	16: 38,423,283 (GRCm39)	R928G	possibly damaging	Het
Birc6	T	C	17: 74,853,388 (GRCm39)	V164A	possibly damaging	Het
Cdh26	T	A	2: 178,110,022 (GRCm39)	H438Q	probably damaging	Het
Cfap65	T	A	1: 74,956,328 (GRCm39)	K1084*	probably null	Het
Csmd1	T	C	8: 15,950,676 (GRCm39)	H3511R	probably damaging	Het
Ebf1	T	A	11: 44,534,274 (GRCm39)	S178T	possibly damaging	Het
Efcab3	A	C	11: 104,811,135 (GRCm39)	K3192N	unknown	Het
Eln	A	G	5: 134,755,375 (GRCm39)	V226A	unknown	Het
Fat4	A	T	3: 39,063,128 (GRCm39)		probably null	Het
Gcn1	C	T	5: 115,717,698 (GRCm39)	T222I	probably benign	Het
Gm5624	T	G	14: 44,799,347 (GRCm39)	N70T		Het
Gpc6	T	A	14: 118,129,761 (GRCm39)	V387E	possibly damaging	Het
Gyg1	C	T	3: 20,179,619 (GRCm39)	V255M	probably damaging	Het
Henmt1	T	A	3: 108,864,965 (GRCm39)	F146I	probably damaging	Het
Itpr3	T	A	17: 27,330,900 (GRCm39)	L1736Q	probably damaging	Het
Kcnh4	A	G	11: 100,640,619 (GRCm39)	V469A	possibly damaging	Het
Mybpc2	A	G	7: 44,157,729 (GRCm39)	L750P	probably damaging	Het
Naalad2	A	G	9: 18,241,939 (GRCm39)	V655A	probably damaging	Het
Nme8	C	T	13: 19,858,689 (GRCm39)	D289N	probably benign	Het
Or12k5	T	G	2: 36,895,402 (GRCm39)	T75P	probably damaging	Het
Or2t6	A	G	14: 14,175,416 (GRCm38)	V222A	probably benign	Het
Or4c104	T	A	2: 88,587,024 (GRCm39)		probably benign	Het
Or4k15	C	G	14: 50,364,827 (GRCm39)	S264R	probably benign	Het
Or5aq6	T	C	2: 86,923,502 (GRCm39)	K80E	probably benign	Het
Or8g30	T	A	9: 39,230,401 (GRCm39)	K170*	probably null	Het
Phf24	T	A	4: 42,937,906 (GRCm39)	C173*	probably null	Het
Plcb2	A	G	2: 118,549,304 (GRCm39)	F353L	probably damaging	Het
Prss33	C	A	17: 24,052,930 (GRCm39)	W248L	probably damaging	Het
Rgs3	T	G	4: 62,544,254 (GRCm39)	L350R	possibly damaging	Het
Samd11	C	T	4: 156,333,730 (GRCm39)	G200D	probably damaging	Het
Sh3tc2	T	A	18: 62,123,873 (GRCm39)	V878E	probably damaging	Het
Sh3tc2	G	C	18: 62,148,142 (GRCm39)	G1284A	probably benign	Het
Skint5	A	G	4: 113,572,900 (GRCm39)	S780P	unknown	Het
Slc8a3	T	C	12: 81,361,452 (GRCm39)	K456E	probably damaging	Het
Smok2a	T	A	17: 13,444,499 (GRCm39)	H25Q	probably benign	Het
Srrt	A	G	5: 137,298,589 (GRCm39)	L225P	possibly damaging	Het
Stox1	C	T	10: 62,500,754 (GRCm39)	R602Q	probably damaging	Het
Tmem30a	A	T	9: 79,683,507 (GRCm39)	C157S	probably damaging	Het
Tnks1bp1	T	C	2: 84,892,622 (GRCm39)	S850P	probably damaging	Het
Trpm6	A	G	19: 18,809,849 (GRCm39)	I1082V	probably benign	Het
Ttll5	T	A	12: 85,965,895 (GRCm39)	N646K	probably benign	Het
Vmn1r54	T	A	6: 90,246,413 (GRCm39)	L109H	probably damaging	Het
Wdr17	T	C	8: 55,115,953 (GRCm39)	I617V	probably benign	Het
Zeb2	T	A	2: 44,886,183 (GRCm39)	Q958L	probably damaging	Het

Other mutations in Vmn1r179

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02211:Vmn1r179	APN	7	23,628,630 (GRCm39)	missense	probably benign	0.00
R0029:Vmn1r179	UTSW	7	23,628,630 (GRCm39)	missense	probably benign	0.00
R0029:Vmn1r179	UTSW	7	23,628,630 (GRCm39)	missense	probably benign	0.00
R0058:Vmn1r179	UTSW	7	23,628,592 (GRCm39)	missense	possibly damaging	0.88
R0470:Vmn1r179	UTSW	7	23,627,818 (GRCm39)	missense	probably benign	0.00
R1451:Vmn1r179	UTSW	7	23,628,275 (GRCm39)	nonsense	probably null
R4923:Vmn1r179	UTSW	7	23,628,491 (GRCm39)	missense	possibly damaging	0.79
R4953:Vmn1r179	UTSW	7	23,628,515 (GRCm39)	missense	probably damaging	0.99
R5248:Vmn1r179	UTSW	7	23,628,478 (GRCm39)	missense	probably damaging	0.99
R5304:Vmn1r179	UTSW	7	23,628,100 (GRCm39)	missense	probably benign	0.02
R5434:Vmn1r179	UTSW	7	23,628,387 (GRCm39)	missense	probably benign	0.21
R6341:Vmn1r179	UTSW	7	23,628,491 (GRCm39)	missense	possibly damaging	0.79
R6451:Vmn1r179	UTSW	7	23,628,076 (GRCm39)	missense	possibly damaging	0.94
R6501:Vmn1r179	UTSW	7	23,628,342 (GRCm39)	missense	probably benign	0.25
R7107:Vmn1r179	UTSW	7	23,627,819 (GRCm39)	nonsense	probably null
R7480:Vmn1r179	UTSW	7	23,628,558 (GRCm39)	nonsense	probably null
R8185:Vmn1r179	UTSW	7	23,628,163 (GRCm39)	missense	possibly damaging	0.89
R8245:Vmn1r179	UTSW	7	23,628,396 (GRCm39)	missense	possibly damaging	0.54
R8255:Vmn1r179	UTSW	7	23,628,436 (GRCm39)	missense	probably benign	0.21
R9031:Vmn1r179	UTSW	7	23,628,234 (GRCm39)	missense	probably benign	0.01
R9522:Vmn1r179	UTSW	7	23,628,202 (GRCm39)	missense	probably damaging	0.97
X0061:Vmn1r179	UTSW	7	23,627,819 (GRCm39)	nonsense	probably null
Z1088:Vmn1r179	UTSW	7	23,627,907 (GRCm39)	missense	probably benign	0.10

Predicted Primers

PCR Primer
(F):5'- GCTGTGGCCAATATCTTGATTC -3'
(R):5'- TCATGAATGTGGCATCATAGGC -3'

Sequencing Primer
(F):5'- CCAATGTGATGACTTTTGCTCCAAG -3'
(R):5'- TGTGGCATCATAGGCAATCC -3'

Posted On

2020-10-20