Incidental Mutation 'R8787:Zscan10'
ID 670729
Institutional Source Beutler Lab
Gene Symbol Zscan10
Ensembl Gene ENSMUSG00000023902
Gene Name zinc finger and SCAN domain containing 10
Synonyms Zscan10, Zfp206
MMRRC Submission 068633-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.212) question?
Stock # R8787 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 23819830-23829993 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 23829011 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 518 (S518G)
Ref Sequence ENSEMBL: ENSMUSP00000093255 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095595] [ENSMUST00000115509] [ENSMUST00000117606] [ENSMUST00000118369] [ENSMUST00000120967] [ENSMUST00000122285] [ENSMUST00000123866] [ENSMUST00000129227] [ENSMUST00000138487] [ENSMUST00000148062]
AlphaFold Q3URR7
PDB Structure Crystal structure of the SCAN domain from mouse Zfp206 [X-RAY DIFFRACTION]
Predicted Effect probably benign
Transcript: ENSMUST00000095595
AA Change: S518G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000093255
Gene: ENSMUSG00000023902
AA Change: S518G

DomainStartEndE-ValueType
SCAN 39 145 1.28e-34 SMART
low complexity region 173 194 N/A INTRINSIC
ZnF_C2H2 343 366 4.4e-2 SMART
ZnF_C2H2 378 400 5.59e-4 SMART
ZnF_C2H2 406 428 1.25e-1 SMART
ZnF_C2H2 434 456 2.05e-2 SMART
ZnF_C2H2 478 500 2.75e-3 SMART
low complexity region 507 521 N/A INTRINSIC
ZnF_C2H2 524 547 1.82e-3 SMART
ZnF_C2H2 553 575 3.16e-3 SMART
ZnF_C2H2 581 603 1.95e-3 SMART
ZnF_C2H2 609 631 4.17e-3 SMART
ZnF_C2H2 637 659 1.56e-2 SMART
ZnF_C2H2 665 687 2.4e-3 SMART
ZnF_C2H2 693 715 1.98e-4 SMART
ZnF_C2H2 726 748 1.58e-3 SMART
ZnF_C2H2 754 776 6.42e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000115509
AA Change: S408G

PolyPhen 2 Score 0.174 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000111171
Gene: ENSMUSG00000023902
AA Change: S408G

DomainStartEndE-ValueType
SCAN 39 148 3.37e-34 SMART
ZnF_C2H2 233 256 4.4e-2 SMART
ZnF_C2H2 268 290 5.59e-4 SMART
ZnF_C2H2 296 318 1.25e-1 SMART
ZnF_C2H2 324 346 2.05e-2 SMART
ZnF_C2H2 368 390 2.75e-3 SMART
low complexity region 397 411 N/A INTRINSIC
ZnF_C2H2 414 437 1.82e-3 SMART
ZnF_C2H2 443 465 3.16e-3 SMART
ZnF_C2H2 471 493 1.95e-3 SMART
ZnF_C2H2 499 521 4.17e-3 SMART
ZnF_C2H2 527 549 1.56e-2 SMART
ZnF_C2H2 555 577 2.4e-3 SMART
ZnF_C2H2 583 605 1.98e-4 SMART
ZnF_C2H2 616 638 1.58e-3 SMART
ZnF_C2H2 644 666 6.42e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000117606
SMART Domains Protein: ENSMUSP00000112460
Gene: ENSMUSG00000023902

DomainStartEndE-ValueType
SCAN 39 147 1.73e-31 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000118369
SMART Domains Protein: ENSMUSP00000113757
Gene: ENSMUSG00000023902

DomainStartEndE-ValueType
SCAN 39 152 1.59e-30 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000120967
AA Change: S486G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000113386
Gene: ENSMUSG00000023902
AA Change: S486G

DomainStartEndE-ValueType
SCAN 39 145 1.28e-34 SMART
low complexity region 173 194 N/A INTRINSIC
ZnF_C2H2 346 368 5.59e-4 SMART
ZnF_C2H2 374 396 1.25e-1 SMART
ZnF_C2H2 402 424 2.05e-2 SMART
ZnF_C2H2 446 468 2.75e-3 SMART
low complexity region 475 489 N/A INTRINSIC
ZnF_C2H2 492 515 1.82e-3 SMART
ZnF_C2H2 521 543 3.16e-3 SMART
ZnF_C2H2 549 571 1.95e-3 SMART
ZnF_C2H2 577 599 4.17e-3 SMART
ZnF_C2H2 605 627 1.56e-2 SMART
ZnF_C2H2 633 655 2.4e-3 SMART
ZnF_C2H2 661 683 1.98e-4 SMART
ZnF_C2H2 694 716 1.58e-3 SMART
ZnF_C2H2 722 744 6.42e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000122285
SMART Domains Protein: ENSMUSP00000112559
Gene: ENSMUSG00000023902

DomainStartEndE-ValueType
SCAN 39 152 1.59e-30 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000123866
SMART Domains Protein: ENSMUSP00000116748
Gene: ENSMUSG00000023902

DomainStartEndE-ValueType
SCAN 39 148 2.38e-34 SMART
ZnF_C2H2 267 290 4.4e-2 SMART
ZnF_C2H2 302 324 5.59e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000129227
AA Change: S282G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000118987
Gene: ENSMUSG00000023902
AA Change: S282G

DomainStartEndE-ValueType
ZnF_C2H2 142 164 5.59e-4 SMART
ZnF_C2H2 170 192 1.25e-1 SMART
ZnF_C2H2 198 220 2.05e-2 SMART
ZnF_C2H2 242 264 2.75e-3 SMART
low complexity region 271 285 N/A INTRINSIC
ZnF_C2H2 288 311 1.82e-3 SMART
ZnF_C2H2 317 339 3.16e-3 SMART
ZnF_C2H2 345 367 1.95e-3 SMART
ZnF_C2H2 373 395 4.17e-3 SMART
ZnF_C2H2 401 423 1.56e-2 SMART
ZnF_C2H2 429 451 2.4e-3 SMART
ZnF_C2H2 457 479 1.98e-4 SMART
ZnF_C2H2 490 512 1.58e-3 SMART
ZnF_C2H2 518 540 6.42e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000138487
SMART Domains Protein: ENSMUSP00000114341
Gene: ENSMUSG00000023902

DomainStartEndE-ValueType
SCAN 39 148 3.37e-34 SMART
ZnF_C2H2 236 258 5.59e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000148062
AA Change: S441G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000120876
Gene: ENSMUSG00000023902
AA Change: S441G

DomainStartEndE-ValueType
Pfam:SCAN 37 88 7.5e-20 PFAM
low complexity region 128 149 N/A INTRINSIC
ZnF_C2H2 301 323 5.59e-4 SMART
ZnF_C2H2 329 351 1.25e-1 SMART
ZnF_C2H2 357 379 2.05e-2 SMART
ZnF_C2H2 401 423 2.75e-3 SMART
low complexity region 430 444 N/A INTRINSIC
ZnF_C2H2 447 470 1.82e-3 SMART
ZnF_C2H2 476 498 3.16e-3 SMART
ZnF_C2H2 504 526 1.95e-3 SMART
ZnF_C2H2 532 554 4.17e-3 SMART
ZnF_C2H2 560 582 1.56e-2 SMART
ZnF_C2H2 588 610 2.4e-3 SMART
ZnF_C2H2 616 638 1.98e-4 SMART
ZnF_C2H2 649 671 1.58e-3 SMART
ZnF_C2H2 677 699 6.42e-4 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 98% (62/63)
MGI Phenotype PHENOTYPE: Mice homozygous for a gene trap allele exhibit a pleiotropic phenotype including reduced weight, mild hypoplasia in the spleen, heart and long bones, eye malformations including microphthalmia, altered platelet counts, an activated immune status, and behavioral alterations. [provided by MGI curators]
Allele List at MGI

All alleles(357) : Targeted(5) Gene trapped(352)

Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 C T 11: 9,225,053 (GRCm39) H511Y possibly damaging Het
Acp5 G A 9: 22,038,489 (GRCm39) R271* probably null Het
Adamts20 A T 15: 94,184,294 (GRCm39) V1503E possibly damaging Het
Adra2b A T 2: 127,206,417 (GRCm39) E311D probably benign Het
Aldh18a1 T C 19: 40,546,230 (GRCm39) I556V possibly damaging Het
Alox12 C A 11: 70,144,146 (GRCm39) A116S probably benign Het
Alox5 G T 6: 116,390,102 (GRCm39) A552E probably damaging Het
Angpt1 G T 15: 42,375,780 (GRCm39) L159I probably damaging Het
Atp2b4 CTT CTTTTT 1: 133,629,485 (GRCm39) probably benign Het
Bub1b T A 2: 118,462,305 (GRCm39) L726I probably damaging Het
Ccdc78 A T 17: 26,006,807 (GRCm39) T165S probably benign Het
Ccdc88b T C 19: 6,824,791 (GRCm39) D1323G probably damaging Het
Chek1 A T 9: 36,625,033 (GRCm39) C349* probably null Het
Clec1a A T 6: 129,428,617 (GRCm39) L21Q possibly damaging Het
Col1a1 T C 11: 94,833,634 (GRCm39) V445A possibly damaging Het
Efcab7 A G 4: 99,757,791 (GRCm39) T313A probably null Het
Fads1 T A 19: 10,170,325 (GRCm39) Y288* probably null Het
Fgb T A 3: 82,953,969 (GRCm39) T90S probably benign Het
Glg1 C A 8: 111,888,114 (GRCm39) V1026L probably damaging Het
Hadh T A 3: 131,027,825 (GRCm39) Y313F probably damaging Het
Htr4 A G 18: 62,570,853 (GRCm39) I303V possibly damaging Het
Kcnn3 A G 3: 89,552,757 (GRCm39) D487G possibly damaging Het
L1td1 G A 4: 98,625,814 (GRCm39) V604I probably benign Het
Lao1 A G 4: 118,825,565 (GRCm39) T462A probably damaging Het
Lefty1 C A 1: 180,764,118 (GRCm39) A86E probably damaging Het
Lmx1b T C 2: 33,529,522 (GRCm39) Y79C Het
Lrp2 A G 2: 69,382,745 (GRCm39) C47R probably damaging Het
Mrc2 A T 11: 105,238,465 (GRCm39) N1204I probably benign Het
Ncf1 A C 5: 134,254,145 (GRCm39) Y209* probably null Het
Or14j7 T A 17: 38,235,075 (GRCm39) M206K probably benign Het
Or2ad1 A T 13: 21,326,453 (GRCm39) M258K possibly damaging Het
Or8k33 G A 2: 86,384,297 (GRCm39) T57M probably damaging Het
Oxtr T G 6: 112,466,871 (GRCm39) probably benign Het
Pcdhac1 T C 18: 37,224,942 (GRCm39) V585A probably damaging Het
Pdcd11 T G 19: 47,097,019 (GRCm39) L755R probably damaging Het
Pkhd1 A G 1: 20,358,461 (GRCm39) V2705A probably damaging Het
Plch2 C A 4: 155,070,875 (GRCm39) G1168V probably benign Het
Prpf39 T C 12: 65,089,555 (GRCm39) Y98H possibly damaging Het
R3hdm2 T G 10: 127,293,521 (GRCm39) S142A probably damaging Het
Rassf10 T A 7: 112,554,738 (GRCm39) D446E probably benign Het
Rgs13 T C 1: 144,016,482 (GRCm39) Y87C probably damaging Het
Serpinb9h G A 13: 33,588,204 (GRCm39) R263H probably benign Het
Smpd3 G A 8: 106,982,377 (GRCm39) R576C probably damaging Het
Spata31e1 T C 13: 49,938,704 (GRCm39) Y1002C probably damaging Het
Srsf11 A T 3: 157,718,037 (GRCm39) D382E unknown Het
Stpg1 T A 4: 135,261,108 (GRCm39) M306K probably benign Het
Svil C T 18: 5,059,332 (GRCm39) Q696* probably null Het
Syna C T 5: 134,588,723 (GRCm39) M75I probably benign Het
Synj2 T C 17: 6,036,514 (GRCm39) F161S possibly damaging Het
Tek T C 4: 94,738,037 (GRCm39) Y696H probably damaging Het
Tgfbr1 A T 4: 47,405,555 (GRCm39) D386V possibly damaging Het
Tgm4 G T 9: 122,890,910 (GRCm39) G503V probably damaging Het
Tnni3k T C 3: 154,645,691 (GRCm39) E461G probably damaging Het
Tom1l1 A T 11: 90,561,931 (GRCm39) H232Q probably benign Het
Ubqln5 T C 7: 103,778,329 (GRCm39) N165S probably benign Het
Vmn1r24 G A 6: 57,932,958 (GRCm39) L187F probably benign Het
Vmn2r82 C T 10: 79,213,894 (GRCm39) T160I probably damaging Het
Vmn2r96 G T 17: 18,818,250 (GRCm39) G801V probably damaging Het
Vps39 A G 2: 120,172,506 (GRCm39) S176P probably damaging Het
Vsig10 C A 5: 117,472,981 (GRCm39) H191Q probably benign Het
Wtap G A 17: 13,186,488 (GRCm39) S353L possibly damaging Het
Zmym4 T G 4: 126,816,953 (GRCm39) R248S probably benign Het
Zscan29 A T 2: 120,996,876 (GRCm39) Y282N probably damaging Het
Other mutations in Zscan10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00572:Zscan10 APN 17 23,828,435 (GRCm39) missense probably damaging 0.98
IGL01353:Zscan10 APN 17 23,828,574 (GRCm39) missense probably damaging 1.00
IGL02327:Zscan10 APN 17 23,826,546 (GRCm39) splice site probably benign
IGL02556:Zscan10 APN 17 23,827,119 (GRCm39) missense possibly damaging 0.90
FR4737:Zscan10 UTSW 17 23,828,419 (GRCm39) small deletion probably benign
P0043:Zscan10 UTSW 17 23,828,594 (GRCm39) nonsense probably null
R0345:Zscan10 UTSW 17 23,829,056 (GRCm39) missense probably damaging 1.00
R0401:Zscan10 UTSW 17 23,824,889 (GRCm39) missense probably damaging 1.00
R0699:Zscan10 UTSW 17 23,827,092 (GRCm39) missense probably damaging 1.00
R0838:Zscan10 UTSW 17 23,829,008 (GRCm39) missense possibly damaging 0.83
R0919:Zscan10 UTSW 17 23,828,981 (GRCm39) missense probably damaging 0.99
R1940:Zscan10 UTSW 17 23,828,826 (GRCm39) missense probably damaging 1.00
R4647:Zscan10 UTSW 17 23,829,314 (GRCm39) missense probably benign
R4753:Zscan10 UTSW 17 23,826,208 (GRCm39) missense probably damaging 0.99
R4971:Zscan10 UTSW 17 23,826,147 (GRCm39) missense possibly damaging 0.67
R5110:Zscan10 UTSW 17 23,828,606 (GRCm39) missense probably damaging 1.00
R5410:Zscan10 UTSW 17 23,829,395 (GRCm39) missense probably damaging 1.00
R5516:Zscan10 UTSW 17 23,828,333 (GRCm39) missense possibly damaging 0.66
R5871:Zscan10 UTSW 17 23,826,241 (GRCm39) intron probably benign
R6109:Zscan10 UTSW 17 23,826,103 (GRCm39) missense probably damaging 0.98
R6626:Zscan10 UTSW 17 23,824,831 (GRCm39) missense probably damaging 1.00
R6750:Zscan10 UTSW 17 23,826,164 (GRCm39) missense possibly damaging 0.49
R6846:Zscan10 UTSW 17 23,824,581 (GRCm39) missense probably damaging 0.97
R7184:Zscan10 UTSW 17 23,826,003 (GRCm39) splice site probably null
R7223:Zscan10 UTSW 17 23,828,456 (GRCm39) missense probably benign 0.00
R7436:Zscan10 UTSW 17 23,828,979 (GRCm39) missense possibly damaging 0.52
R8224:Zscan10 UTSW 17 23,828,366 (GRCm39) missense probably benign
R8366:Zscan10 UTSW 17 23,828,952 (GRCm39) missense probably damaging 1.00
R8918:Zscan10 UTSW 17 23,826,116 (GRCm39) missense probably benign 0.24
R8924:Zscan10 UTSW 17 23,824,580 (GRCm39) missense possibly damaging 0.66
R9266:Zscan10 UTSW 17 23,828,385 (GRCm39) missense possibly damaging 0.55
R9454:Zscan10 UTSW 17 23,826,619 (GRCm39) critical splice donor site probably null
R9786:Zscan10 UTSW 17 23,828,330 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CAGGGAAAGAATCTCACGCC -3'
(R):5'- TCGTCTCACAAAGCGTTTGC -3'

Sequencing Primer
(F):5'- GGGAAAGAATCTCACGCCAAATC -3'
(R):5'- GAGGCTTCTCACCCGTATGAATCTG -3'
Posted On 2021-04-30