Mutagenetix > Incidental Mutation

Incidental Mutation 'R8837:Or1o3'

674248

Institutional Source

Beutler Lab

Gene Symbol

Or1o3

Ensembl Gene

ENSMUSG00000063660

Gene Name

olfactory receptor family 1 subfamily O member 3

Synonyms

Olfr98, GA_x6K02T2PSCP-1703582-1702653, MOR156-4

MMRRC Submission

068665-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

R8837 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

37573624-37574553 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to T at 37573807 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 249 (Y249*)

Ref Sequence

ENSEMBL: ENSMUSP00000094936 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080759]

AlphaFold

Q8VFD9

Predicted Effect

probably null
Transcript: ENSMUST00000080759
AA Change: Y249*

SMART Domains

Protein: ENSMUSP00000094936
Gene: ENSMUSG00000063660
AA Change: Y249*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	28	305	9.2e-53	PFAM
Pfam:7TM_GPCR_Srsx	32	302	1.9e-5	PFAM
Pfam:7tm_1	38	287	2.4e-20	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.9%

Validation Efficiency

100% (59/59)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb4	T	G	5: 8,986,873 (GRCm39)	F764C	probably damaging	Het
Aff1	A	G	5: 103,982,078 (GRCm39)	D739G	possibly damaging	Het
Atosb	A	G	4: 43,034,531 (GRCm39)	S355P	probably damaging	Het
Atp1a3	T	C	7: 24,677,980 (GRCm39)	Y1012C	probably damaging	Het
Btbd10	T	C	7: 112,929,133 (GRCm39)	T206A	probably benign	Het
Capn8	G	T	1: 182,456,199 (GRCm39)	A650S	possibly damaging	Het
Catsper1	A	C	19: 5,386,070 (GRCm39)	N101T	probably damaging	Het
Cdh23	A	C	10: 60,160,755 (GRCm39)	S2070R	probably benign	Het
Cep350	A	G	1: 155,737,518 (GRCm39)	V2775A	probably benign	Het
Clybl	G	A	14: 122,419,194 (GRCm39)		probably null	Het
Cog4	T	A	8: 111,579,004 (GRCm39)	N148K	probably benign	Het
Dbnl	G	A	11: 5,741,839 (GRCm39)	G44D	possibly damaging	Het
Dgcr2	A	T	16: 17,667,630 (GRCm39)	N276K	possibly damaging	Het
Dnah9	T	A	11: 65,746,060 (GRCm39)	T4018S	possibly damaging	Het
Dock3	A	G	9: 106,774,539 (GRCm39)	L72P	probably benign	Het
Dync2i2	T	C	2: 29,928,374 (GRCm39)	D84G	probably benign	Het
Fabp4	T	C	3: 10,271,105 (GRCm39)	T51A	probably benign	Het
Fars2	T	A	13: 36,430,409 (GRCm39)	I279N	probably damaging	Het
Fas	A	T	19: 34,296,049 (GRCm39)	Q164L	probably benign	Het
Focad	A	G	4: 88,072,905 (GRCm39)	K107E	probably damaging	Het
Gga3	G	A	11: 115,479,305 (GRCm39)	S338L	probably benign	Het
Grip1	A	G	10: 119,765,940 (GRCm39)	R91G	probably damaging	Het
Igkv3-7	A	G	6: 70,584,942 (GRCm39)	D94G	possibly damaging	Het
Kank3	G	C	17: 34,036,627 (GRCm39)	R165P	probably damaging	Het
Kmt2d	A	T	15: 98,762,048 (GRCm39)	L434Q	unknown	Het
Krt18	A	G	15: 101,938,265 (GRCm39)	T163A	possibly damaging	Het
Lcn10	T	A	2: 25,575,298 (GRCm39)		probably benign	Het
Lrrc37a	G	T	11: 103,394,795 (GRCm39)	P210Q	probably benign	Het
Lyst	T	A	13: 13,852,548 (GRCm39)	S2183T	probably benign	Het
Mga	G	A	2: 119,769,272 (GRCm39)		probably benign	Het
Myh9	G	A	15: 77,661,137 (GRCm39)	A818V	possibly damaging	Het
Or1j15	T	C	2: 36,458,703 (GRCm39)	I31T	probably benign	Het
Or8b1	A	T	9: 38,399,597 (GRCm39)	I91F	probably benign	Het
Pde7b	A	G	10: 20,314,469 (GRCm39)		probably null	Het
Pik3cb	A	T	9: 98,936,117 (GRCm39)	Y772N	possibly damaging	Het
Ppl	C	G	16: 4,906,854 (GRCm39)	R1147P	probably damaging	Het
Prl3d2	A	T	13: 27,307,926 (GRCm39)	D69V	probably benign	Het
Psd3	A	G	8: 68,172,596 (GRCm39)	F871L	probably damaging	Het
Rlf	G	A	4: 121,045,432 (GRCm39)	P152S	probably benign	Het
Rpa1	T	C	11: 75,204,167 (GRCm39)	E270G	possibly damaging	Het
Scfd2	T	C	5: 74,691,656 (GRCm39)	T209A	probably benign	Het
Scn11a	A	G	9: 119,621,410 (GRCm39)	L669P	probably damaging	Het
Sec31b	A	T	19: 44,506,106 (GRCm39)	C933*	probably null	Het
Serpina3k	G	T	12: 104,309,292 (GRCm39)	M245I	probably benign	Het
Slc9a3	T	A	13: 74,305,823 (GRCm39)	I280N	probably damaging	Het
Soat1	A	G	1: 156,261,772 (GRCm39)	V412A	probably damaging	Het
Spata31d1a	A	T	13: 59,850,596 (GRCm39)	S511T	possibly damaging	Het
Sphkap	A	T	1: 83,253,384 (GRCm39)	V1455E	possibly damaging	Het
Spns1	G	A	7: 125,971,593 (GRCm39)	S319F	possibly damaging	Het
Tbxas1	G	T	6: 39,048,364 (GRCm39)	M403I		Het
Tln2	A	T	9: 67,157,866 (GRCm39)	C1158S	probably damaging	Het
Tnrc18	T	C	5: 142,778,811 (GRCm39)	T98A	possibly damaging	Het
Ttc23	T	C	7: 67,319,494 (GRCm39)	L118P	probably damaging	Het
Tyr	T	A	7: 87,087,223 (GRCm39)	I430L	probably damaging	Het
Uck2	A	G	1: 167,070,715 (GRCm39)	F5L	probably benign	Het
Ush2a	G	A	1: 188,485,847 (GRCm39)	V2986I	probably benign	Het
Vmn2r96	A	G	17: 18,802,888 (GRCm39)	D266G	probably benign	Het
Yrdc	A	G	4: 124,747,677 (GRCm39)	D213G	probably benign	Het
Zfp612	C	A	8: 110,815,603 (GRCm39)	T270K	probably damaging	Het

Other mutations in Or1o3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02402:Or1o3	APN	17	37,574,111 (GRCm39)	missense	possibly damaging	0.46
PIT4495001:Or1o3	UTSW	17	37,573,721 (GRCm39)	missense	possibly damaging	0.88
R0574:Or1o3	UTSW	17	37,573,772 (GRCm39)	missense	probably damaging	1.00
R1490:Or1o3	UTSW	17	37,573,733 (GRCm39)	missense	probably benign	0.00
R1633:Or1o3	UTSW	17	37,574,553 (GRCm39)	start codon destroyed	probably benign	0.02
R2105:Or1o3	UTSW	17	37,573,964 (GRCm39)	missense	probably benign	0.26
R4996:Or1o3	UTSW	17	37,573,758 (GRCm39)	missense	probably benign	0.02
R5114:Or1o3	UTSW	17	37,573,730 (GRCm39)	missense	probably damaging	1.00
R5225:Or1o3	UTSW	17	37,573,919 (GRCm39)	missense	probably benign	0.30
R5338:Or1o3	UTSW	17	37,574,532 (GRCm39)	missense	probably benign	0.00
R5995:Or1o3	UTSW	17	37,574,539 (GRCm39)	missense	probably benign	0.01
R6190:Or1o3	UTSW	17	37,573,635 (GRCm39)	missense	probably benign	0.00
R7006:Or1o3	UTSW	17	37,573,625 (GRCm39)	makesense	probably null
R7246:Or1o3	UTSW	17	37,573,905 (GRCm39)	missense	probably benign	0.00
R7261:Or1o3	UTSW	17	37,574,076 (GRCm39)	missense	probably benign
R7611:Or1o3	UTSW	17	37,573,745 (GRCm39)	missense	probably benign	0.02
R7642:Or1o3	UTSW	17	37,573,964 (GRCm39)	missense	probably benign	0.26
R9528:Or1o3	UTSW	17	37,574,087 (GRCm39)	missense	probably benign	0.16

Predicted Primers

PCR Primer
(F):5'- CTGACTCACTTTGCATGTGTG -3'
(R):5'- TCAATGAGAGTCTGATGATGGC -3'

Sequencing Primer
(F):5'- GCAGGGCATGATCCTTCCTTAG -3'
(R):5'- CTTTGAGTGGACTTTTAGCAATCAG -3'

Posted On

2021-07-15