Incidental Mutation 'R8984:Tmem131'
ID 683862
Institutional Source Beutler Lab
Gene Symbol Tmem131
Ensembl Gene ENSMUSG00000026116
Gene Name transmembrane protein 131
Synonyms Rw1, CC28, YR-23, Neg, D1Bwg0491e, 2610524E03Rik
MMRRC Submission 068817-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.885) question?
Stock # R8984 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 36831270-36978714 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 36867228 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 402 (F402L)
Ref Sequence ENSEMBL: ENSMUSP00000027290 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027290] [ENSMUST00000186486] [ENSMUST00000194563]
AlphaFold O70472
Predicted Effect probably benign
Transcript: ENSMUST00000027290
AA Change: F402L

PolyPhen 2 Score 0.053 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000027290
Gene: ENSMUSG00000026116
AA Change: F402L

DomainStartEndE-ValueType
low complexity region 5 44 N/A INTRINSIC
low complexity region 77 89 N/A INTRINSIC
Pfam:TMEM131_like 106 189 1.7e-32 PFAM
transmembrane domain 1081 1103 N/A INTRINSIC
transmembrane domain 1116 1138 N/A INTRINSIC
low complexity region 1232 1258 N/A INTRINSIC
low complexity region 1283 1315 N/A INTRINSIC
low complexity region 1369 1382 N/A INTRINSIC
low complexity region 1384 1433 N/A INTRINSIC
low complexity region 1460 1471 N/A INTRINSIC
low complexity region 1595 1610 N/A INTRINSIC
low complexity region 1613 1626 N/A INTRINSIC
low complexity region 1628 1646 N/A INTRINSIC
low complexity region 1675 1684 N/A INTRINSIC
low complexity region 1693 1701 N/A INTRINSIC
low complexity region 1738 1748 N/A INTRINSIC
low complexity region 1760 1779 N/A INTRINSIC
low complexity region 1799 1810 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000186486
SMART Domains Protein: ENSMUSP00000142080
Gene: ENSMUSG00000026116

DomainStartEndE-ValueType
low complexity region 31 48 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000194563
AA Change: F402L

PolyPhen 2 Score 0.053 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000142307
Gene: ENSMUSG00000026116
AA Change: F402L

DomainStartEndE-ValueType
low complexity region 5 44 N/A INTRINSIC
low complexity region 77 89 N/A INTRINSIC
Pfam:DUF3651 170 243 1.9e-27 PFAM
Pfam:DUF3651 500 580 4.5e-16 PFAM
Pfam:DUF3651 631 706 5.2e-15 PFAM
transmembrane domain 1081 1103 N/A INTRINSIC
transmembrane domain 1116 1138 N/A INTRINSIC
low complexity region 1232 1258 N/A INTRINSIC
low complexity region 1283 1315 N/A INTRINSIC
low complexity region 1369 1382 N/A INTRINSIC
low complexity region 1384 1433 N/A INTRINSIC
low complexity region 1460 1471 N/A INTRINSIC
low complexity region 1595 1610 N/A INTRINSIC
low complexity region 1613 1626 N/A INTRINSIC
low complexity region 1628 1646 N/A INTRINSIC
low complexity region 1675 1684 N/A INTRINSIC
low complexity region 1693 1701 N/A INTRINSIC
low complexity region 1738 1748 N/A INTRINSIC
low complexity region 1760 1779 N/A INTRINSIC
low complexity region 1799 1810 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (68/68)
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd5 T A 9: 122,180,880 (GRCm39) V10E probably benign Het
Adss2 A T 1: 177,601,280 (GRCm39) probably benign Het
AI467606 A T 7: 126,691,673 (GRCm39) I83F probably damaging Het
Atn1 A T 6: 124,723,923 (GRCm39) W437R unknown Het
Atxn7l2 T C 3: 108,116,290 (GRCm39) probably benign Het
AU040320 T C 4: 126,734,936 (GRCm39) F750S possibly damaging Het
B3gnt6 A G 7: 97,842,821 (GRCm39) S380P probably benign Het
Bod1l T C 5: 41,946,215 (GRCm39) Q3020R probably damaging Het
Borcs6 A T 11: 68,950,828 (GRCm39) I69F probably benign Het
Brd7 T A 8: 89,081,340 (GRCm39) M170L probably benign Het
Ccdc191 T A 16: 43,710,581 (GRCm39) probably benign Het
Cit C T 5: 116,064,534 (GRCm39) T472I possibly damaging Het
Ddx25 G T 9: 35,468,685 (GRCm39) D57E probably benign Het
Dnah7a A T 1: 53,674,436 (GRCm39) L447* probably null Het
Epb41l3 A G 17: 69,554,641 (GRCm39) D247G probably damaging Het
Epha8 G T 4: 136,665,897 (GRCm39) L420M probably damaging Het
Etaa1 A T 11: 17,890,254 (GRCm39) V869E probably damaging Het
Exoc8 T A 8: 125,622,769 (GRCm39) I533F probably benign Het
Fam117a A G 11: 95,254,823 (GRCm39) probably null Het
Fam222a C T 5: 114,749,092 (GRCm39) T96I possibly damaging Het
Farsa C T 8: 85,594,228 (GRCm39) T326I probably damaging Het
Fkbp1b T A 12: 4,891,401 (GRCm39) D12V probably damaging Het
Garin3 C A 11: 46,295,695 (GRCm39) Y22* probably null Het
Gc C T 5: 89,589,421 (GRCm39) probably null Het
Git2 T C 5: 114,868,256 (GRCm39) E705G probably damaging Het
Gm10318 G A 10: 77,689,078 (GRCm39) C128Y unknown Het
H3c3 C A 13: 23,929,393 (GRCm39) A30S probably benign Het
Hcar2 G A 5: 124,002,571 (GRCm39) R311* probably null Het
Hira A G 16: 18,746,261 (GRCm39) Q468R possibly damaging Het
Hspa1l T C 17: 35,197,092 (GRCm39) V377A probably damaging Het
Igkv2-137 T A 6: 67,532,659 (GRCm39) W14R probably damaging Het
Itga3 A T 11: 94,953,391 (GRCm39) L317Q probably damaging Het
Jade2 A C 11: 51,715,906 (GRCm39) L433W probably damaging Het
Kif21a T C 15: 90,840,559 (GRCm39) T1186A probably benign Het
Krtap28-10 C A 1: 83,019,894 (GRCm39) C82F unknown Het
Ksr1 G A 11: 78,931,709 (GRCm39) T333M probably damaging Het
Msi1 T C 5: 115,573,598 (GRCm39) F132S probably damaging Het
Myo7b C A 18: 32,099,402 (GRCm39) K1673N probably null Het
Myom3 T A 4: 135,515,255 (GRCm39) N716K Het
Ndst4 G A 3: 125,515,810 (GRCm39) G312R probably damaging Het
Ndufaf2 A G 13: 108,189,316 (GRCm39) V144A probably benign Het
Omd T C 13: 49,743,576 (GRCm39) S209P possibly damaging Het
Or2n1c A G 17: 38,519,304 (GRCm39) H56R probably damaging Het
Or2t47 G C 11: 58,442,209 (GRCm39) N285K probably damaging Het
Or51b17 G A 7: 103,542,816 (GRCm39) T42I probably benign Het
Or51e1 T A 7: 102,359,219 (GRCm39) I251N possibly damaging Het
Or52a24 T C 7: 103,381,220 (GRCm39) I29T probably damaging Het
Or52e3 T C 7: 102,869,393 (GRCm39) L156P possibly damaging Het
Patl1 T A 19: 11,898,760 (GRCm39) Y152N probably damaging Het
Plaur T A 7: 24,164,577 (GRCm39) M27K probably benign Het
Ppfia2 T A 10: 106,694,439 (GRCm39) probably benign Het
Ppfia3 A G 7: 44,990,100 (GRCm39) V1142A probably damaging Het
Psg28 T A 7: 18,156,981 (GRCm39) N418I probably damaging Het
Ptprd A T 4: 75,863,251 (GRCm39) F1237I probably damaging Het
Ptprj G A 2: 90,270,987 (GRCm39) P1247L probably damaging Het
Rbms3 A T 9: 116,524,886 (GRCm39) probably null Het
Rgs18 A G 1: 144,629,566 (GRCm39) V231A probably benign Het
Rnf112 T C 11: 61,343,277 (GRCm39) R156G possibly damaging Het
Rsad1 A C 11: 94,439,010 (GRCm39) V150G probably damaging Het
Rxrg G A 1: 167,462,005 (GRCm39) V350I possibly damaging Het
Sash1 A G 10: 8,626,808 (GRCm39) I192T possibly damaging Het
Slc25a36 G A 9: 96,961,259 (GRCm39) T259I probably benign Het
Smarcd3 T A 5: 24,798,986 (GRCm39) E324V probably null Het
St3gal4 A G 9: 34,966,944 (GRCm39) V2A possibly damaging Het
Stk17b A C 1: 53,796,784 (GRCm39) S328A probably benign Het
Tbrg1 A G 9: 37,563,949 (GRCm39) Y229H probably damaging Het
Tdg A G 10: 82,484,514 (GRCm39) N409S probably benign Het
Terb1 T C 8: 105,212,036 (GRCm39) E315G possibly damaging Het
Trav4-2 T C 14: 53,656,190 (GRCm39) I64T probably benign Het
Trav4-4-dv10 A G 14: 53,921,574 (GRCm39) T91A probably benign Het
Xdh C T 17: 74,228,346 (GRCm39) G352R probably damaging Het
Zfp551 C A 7: 12,156,559 (GRCm39) probably benign Het
Other mutations in Tmem131
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00561:Tmem131 APN 1 36,850,508 (GRCm39) missense probably damaging 1.00
IGL00945:Tmem131 APN 1 36,866,086 (GRCm39) splice site probably benign
IGL01107:Tmem131 APN 1 36,868,662 (GRCm39) missense probably damaging 1.00
IGL01401:Tmem131 APN 1 36,838,468 (GRCm39) missense probably damaging 1.00
IGL01533:Tmem131 APN 1 36,857,803 (GRCm39) missense probably damaging 1.00
IGL01701:Tmem131 APN 1 36,847,318 (GRCm39) missense probably benign 0.02
IGL01784:Tmem131 APN 1 36,854,564 (GRCm39) missense probably damaging 1.00
IGL01890:Tmem131 APN 1 36,862,237 (GRCm39) splice site probably benign
IGL01969:Tmem131 APN 1 36,864,541 (GRCm39) missense possibly damaging 0.85
IGL02327:Tmem131 APN 1 36,838,103 (GRCm39) missense probably damaging 1.00
IGL02707:Tmem131 APN 1 36,864,560 (GRCm39) missense probably benign 0.03
IGL02743:Tmem131 APN 1 36,832,232 (GRCm39) missense probably benign 0.00
IGL03111:Tmem131 APN 1 36,867,225 (GRCm39) missense probably damaging 1.00
R0063:Tmem131 UTSW 1 36,858,209 (GRCm39) missense probably benign 0.09
R0063:Tmem131 UTSW 1 36,858,209 (GRCm39) missense probably benign 0.09
R0238:Tmem131 UTSW 1 36,867,131 (GRCm39) splice site probably benign
R0239:Tmem131 UTSW 1 36,867,131 (GRCm39) splice site probably benign
R0499:Tmem131 UTSW 1 36,880,754 (GRCm39) missense probably damaging 1.00
R0548:Tmem131 UTSW 1 36,877,119 (GRCm39) missense probably damaging 1.00
R0845:Tmem131 UTSW 1 36,855,303 (GRCm39) missense probably damaging 1.00
R0975:Tmem131 UTSW 1 36,893,966 (GRCm39) missense probably damaging 1.00
R1018:Tmem131 UTSW 1 36,833,900 (GRCm39) missense probably damaging 0.98
R1170:Tmem131 UTSW 1 36,873,979 (GRCm39) nonsense probably null
R1443:Tmem131 UTSW 1 36,864,559 (GRCm39) missense probably damaging 0.98
R1448:Tmem131 UTSW 1 36,866,439 (GRCm39) missense probably benign 0.16
R1472:Tmem131 UTSW 1 36,855,322 (GRCm39) missense possibly damaging 0.68
R1530:Tmem131 UTSW 1 36,866,090 (GRCm39) critical splice donor site probably null
R1672:Tmem131 UTSW 1 36,863,840 (GRCm39) missense probably damaging 1.00
R1872:Tmem131 UTSW 1 36,847,008 (GRCm39) missense probably benign 0.05
R1914:Tmem131 UTSW 1 36,835,347 (GRCm39) missense probably damaging 1.00
R1915:Tmem131 UTSW 1 36,835,347 (GRCm39) missense probably damaging 1.00
R1929:Tmem131 UTSW 1 36,851,352 (GRCm39) missense possibly damaging 0.50
R1971:Tmem131 UTSW 1 36,843,680 (GRCm39) nonsense probably null
R2146:Tmem131 UTSW 1 36,851,690 (GRCm39) missense probably benign 0.13
R2148:Tmem131 UTSW 1 36,851,690 (GRCm39) missense probably benign 0.13
R2149:Tmem131 UTSW 1 36,851,690 (GRCm39) missense probably benign 0.13
R2150:Tmem131 UTSW 1 36,851,690 (GRCm39) missense probably benign 0.13
R2386:Tmem131 UTSW 1 36,868,716 (GRCm39) missense probably benign 0.00
R2879:Tmem131 UTSW 1 36,880,788 (GRCm39) missense possibly damaging 0.76
R2903:Tmem131 UTSW 1 36,864,378 (GRCm39) missense probably damaging 1.00
R3430:Tmem131 UTSW 1 36,847,902 (GRCm39) splice site probably benign
R3821:Tmem131 UTSW 1 36,847,477 (GRCm39) missense probably damaging 0.99
R3961:Tmem131 UTSW 1 36,858,031 (GRCm39) missense probably damaging 1.00
R4153:Tmem131 UTSW 1 36,847,874 (GRCm39) intron probably benign
R4154:Tmem131 UTSW 1 36,847,874 (GRCm39) intron probably benign
R4502:Tmem131 UTSW 1 36,864,560 (GRCm39) missense probably benign 0.03
R4503:Tmem131 UTSW 1 36,864,560 (GRCm39) missense probably benign 0.03
R4795:Tmem131 UTSW 1 36,880,757 (GRCm39) missense probably damaging 1.00
R5030:Tmem131 UTSW 1 36,866,255 (GRCm39) missense possibly damaging 0.78
R5068:Tmem131 UTSW 1 36,893,986 (GRCm39) missense probably damaging 1.00
R5070:Tmem131 UTSW 1 36,893,986 (GRCm39) missense probably damaging 1.00
R5386:Tmem131 UTSW 1 36,911,639 (GRCm39) missense possibly damaging 0.47
R5507:Tmem131 UTSW 1 36,928,361 (GRCm39) missense probably damaging 1.00
R5569:Tmem131 UTSW 1 36,838,419 (GRCm39) missense probably benign 0.02
R5913:Tmem131 UTSW 1 36,858,209 (GRCm39) missense probably benign 0.01
R6044:Tmem131 UTSW 1 36,920,422 (GRCm39) nonsense probably null
R6125:Tmem131 UTSW 1 36,847,387 (GRCm39) missense possibly damaging 0.95
R6259:Tmem131 UTSW 1 36,858,209 (GRCm39) missense probably benign 0.09
R6392:Tmem131 UTSW 1 36,920,423 (GRCm39) missense probably benign 0.10
R6704:Tmem131 UTSW 1 36,835,261 (GRCm39) missense possibly damaging 0.77
R6828:Tmem131 UTSW 1 36,843,724 (GRCm39) missense possibly damaging 0.46
R6964:Tmem131 UTSW 1 36,835,373 (GRCm39) missense probably damaging 0.99
R7034:Tmem131 UTSW 1 36,832,054 (GRCm39) missense possibly damaging 0.80
R7036:Tmem131 UTSW 1 36,832,054 (GRCm39) missense possibly damaging 0.80
R7081:Tmem131 UTSW 1 36,928,376 (GRCm39) missense possibly damaging 0.94
R7278:Tmem131 UTSW 1 36,835,382 (GRCm39) missense probably damaging 0.99
R7282:Tmem131 UTSW 1 36,880,685 (GRCm39) missense probably damaging 1.00
R7294:Tmem131 UTSW 1 36,893,928 (GRCm39) missense possibly damaging 0.88
R7635:Tmem131 UTSW 1 36,911,629 (GRCm39) missense probably damaging 1.00
R7916:Tmem131 UTSW 1 36,862,167 (GRCm39) missense probably benign 0.00
R7948:Tmem131 UTSW 1 36,833,229 (GRCm39) missense probably damaging 1.00
R8012:Tmem131 UTSW 1 36,847,045 (GRCm39) missense probably damaging 1.00
R8244:Tmem131 UTSW 1 36,847,974 (GRCm39) missense probably benign 0.08
R8461:Tmem131 UTSW 1 36,833,902 (GRCm39) missense probably damaging 1.00
R8770:Tmem131 UTSW 1 36,838,186 (GRCm39) splice site probably benign
R8902:Tmem131 UTSW 1 36,848,046 (GRCm39) missense probably damaging 1.00
R8915:Tmem131 UTSW 1 36,868,658 (GRCm39) missense probably damaging 1.00
R8994:Tmem131 UTSW 1 36,854,538 (GRCm39) missense probably benign 0.29
R9105:Tmem131 UTSW 1 36,854,591 (GRCm39) missense probably benign 0.44
R9156:Tmem131 UTSW 1 36,880,767 (GRCm39) missense possibly damaging 0.88
R9328:Tmem131 UTSW 1 36,858,236 (GRCm39) nonsense probably null
R9501:Tmem131 UTSW 1 36,858,265 (GRCm39) missense possibly damaging 0.73
R9633:Tmem131 UTSW 1 36,847,069 (GRCm39) missense probably damaging 0.99
Z1176:Tmem131 UTSW 1 36,835,338 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCCTTTTCACAATAACCCATCAGG -3'
(R):5'- TTGGCCAGTGTAAAAGCTTTC -3'

Sequencing Primer
(F):5'- CCCATCAGGTTAGGTGAACTTTTATC -3'
(R):5'- GCAAGCCTGACAGCATATGTTCTG -3'
Posted On 2021-10-11