Incidental Mutation 'R3720:Or10al7'
ID 258879
Institutional Source Beutler Lab
Gene Symbol Or10al7
Ensembl Gene ENSMUSG00000081724
Gene Name olfactory receptor family 10 subfamily AL member 7
Synonyms MOR263-9, GA_x6K02T2PSCP-2503741-2502776, Olfr129
MMRRC Submission 040711-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.123) question?
Stock # R3720 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 38365490-38370675 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 38366259 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 66 (Y66C)
Ref Sequence ENSEMBL: ENSMUSP00000149327 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000122318] [ENSMUST00000174675] [ENSMUST00000216476]
AlphaFold Q8VEY1
Predicted Effect probably damaging
Transcript: ENSMUST00000122318
AA Change: Y75C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000113564
Gene: ENSMUSG00000081724
AA Change: Y75C

DomainStartEndE-ValueType
Pfam:7tm_4 46 323 4.6e-56 PFAM
Pfam:7TM_GPCR_Srsx 50 319 1.1e-5 PFAM
Pfam:7tm_1 56 305 3.2e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000174675
AA Change: Y66C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000133865
Gene: ENSMUSG00000060017
AA Change: Y66C

DomainStartEndE-ValueType
transmembrane domain 33 55 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000216476
AA Change: Y66C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.4601 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 97.0%
  • 20x: 94.0%
Validation Efficiency 93% (40/43)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Appl1 G A 14: 26,649,801 (GRCm39) T575M probably damaging Het
Atp2c1 A T 9: 105,300,175 (GRCm39) M708K probably damaging Het
C9 A G 15: 6,512,600 (GRCm39) T241A possibly damaging Het
Ccrl2 T C 9: 110,885,432 (GRCm39) D22G probably benign Het
Cd47 A G 16: 49,688,205 (GRCm39) I42V probably benign Het
Cntnap5c T C 17: 58,637,197 (GRCm39) S1025P probably benign Het
Col8a1 T C 16: 57,447,279 (GRCm39) M744V unknown Het
Cstf3 A G 2: 104,483,431 (GRCm39) probably benign Het
Dnah8 G A 17: 31,073,872 (GRCm39) R4514H probably damaging Het
Dnai1 G A 4: 41,602,615 (GRCm39) R113H probably damaging Het
Fry T C 5: 150,378,037 (GRCm39) S410P probably damaging Het
Glt6d1 ACCC ACCCC 2: 25,685,179 (GRCm39) probably null Het
Gm10717 A G 9: 3,025,532 (GRCm39) Y39C probably benign Het
Hivep1 C T 13: 42,312,077 (GRCm39) T1439I probably benign Het
Iqgap2 T C 13: 95,805,036 (GRCm39) probably null Het
Kbtbd11 T A 8: 15,079,118 (GRCm39) C572* probably null Het
Kif1c T C 11: 70,594,597 (GRCm39) F86L possibly damaging Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Ldb1 C T 19: 46,033,331 (GRCm39) probably benign Het
Lrmda T A 14: 22,077,399 (GRCm39) probably benign Het
Med23 T C 10: 24,767,018 (GRCm39) L369S probably damaging Het
Mei1 A G 15: 81,987,405 (GRCm39) H399R possibly damaging Het
Myo1b G T 1: 51,815,505 (GRCm39) H614N possibly damaging Het
Neurl1b C T 17: 26,633,949 (GRCm39) T4M probably damaging Het
Or5t15 T C 2: 86,681,935 (GRCm39) T36A probably benign Het
Polg G A 7: 79,106,539 (GRCm39) Q163* probably null Het
Pramel12 A G 4: 143,145,949 (GRCm39) T473A probably benign Het
Sdk2 G A 11: 113,691,070 (GRCm39) P1835L probably damaging Het
Slc35a5 A T 16: 44,967,685 (GRCm39) I138N probably damaging Het
Snx31 T C 15: 36,523,704 (GRCm39) probably null Het
Speg A T 1: 75,403,426 (GRCm39) H2590L probably damaging Het
Spink4 T A 4: 40,929,136 (GRCm39) C54S probably damaging Het
Swap70 A G 7: 109,869,254 (GRCm39) E349G probably damaging Het
Sybu A G 15: 44,536,028 (GRCm39) V766A possibly damaging Het
Tns3 G A 11: 8,442,999 (GRCm39) R455W probably damaging Het
Tnxb T A 17: 34,931,938 (GRCm39) V2157E possibly damaging Het
Trak2 A T 1: 58,985,404 (GRCm39) probably null Het
Trav18 C T 14: 54,069,074 (GRCm39) R39C possibly damaging Het
Uroc1 G A 6: 90,323,337 (GRCm39) V352M probably damaging Het
Zfp106 A C 2: 120,365,080 (GRCm39) I442M probably benign Het
Zfp935 G A 13: 62,602,846 (GRCm39) Q98* probably null Het
Other mutations in Or10al7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02140:Or10al7 APN 17 38,366,481 (GRCm39) start codon destroyed probably null 0.15
IGL02163:Or10al7 APN 17 38,365,641 (GRCm39) missense probably benign 0.06
IGL02374:Or10al7 APN 17 38,366,412 (GRCm39) missense probably damaging 1.00
R0840:Or10al7 UTSW 17 38,366,463 (GRCm39) missense probably benign 0.00
R1774:Or10al7 UTSW 17 38,366,328 (GRCm39) missense probably benign 0.00
R3794:Or10al7 UTSW 17 38,365,786 (GRCm39) missense probably damaging 1.00
R3840:Or10al7 UTSW 17 38,366,239 (GRCm39) missense probably damaging 1.00
R4002:Or10al7 UTSW 17 38,365,879 (GRCm39) missense probably damaging 1.00
R4273:Or10al7 UTSW 17 38,366,163 (GRCm39) missense probably damaging 1.00
R4872:Or10al7 UTSW 17 38,366,467 (GRCm39) missense probably benign
R5606:Or10al7 UTSW 17 38,365,693 (GRCm39) missense probably damaging 0.98
R6309:Or10al7 UTSW 17 38,366,043 (GRCm39) missense probably damaging 1.00
R7269:Or10al7 UTSW 17 38,366,442 (GRCm39) missense probably damaging 1.00
R7450:Or10al7 UTSW 17 38,366,000 (GRCm39) missense probably benign 0.00
R7829:Or10al7 UTSW 17 38,366,220 (GRCm39) missense possibly damaging 0.64
R8103:Or10al7 UTSW 17 38,365,903 (GRCm39) missense probably damaging 1.00
R8994:Or10al7 UTSW 17 38,366,220 (GRCm39) missense possibly damaging 0.64
R9388:Or10al7 UTSW 17 38,366,148 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAATGCAACCTGTTCCCCATG -3'
(R):5'- TGGCAGGAGAACAGCTTGTC -3'

Sequencing Primer
(F):5'- CCATGAAACTATTGCCAAATGGG -3'
(R):5'- CAGCTTGTCTGTCAAACGC -3'
Posted On 2015-01-23