Incidental Mutation 'R9417:Sst'
ID 712135
Institutional Source Beutler Lab
Gene Symbol Sst
Ensembl Gene ENSMUSG00000004366
Gene Name somatostatin
Synonyms Smst, preprosomatostatin, SRIF, SOM
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9417 (G1)
Quality Score 225.009
Status Not validated
Chromosome 16
Chromosomal Location 23708323-23709708 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 23708487 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 115 (S115P)
Ref Sequence ENSEMBL: ENSMUSP00000004480 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004480]
AlphaFold P60041
Predicted Effect probably damaging
Transcript: ENSMUST00000004480
AA Change: S115P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000004480
Gene: ENSMUSG00000004366
AA Change: S115P

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:Somatostatin 99 116 5.9e-15 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.9%
  • 20x: 99.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele show altered GH secretory dynamics, hypergastremia, and reduced hippocampal bursting and excitatory transmission. Mice homozygous for another null allele show impaired motor learning, higher GH and corticosterone levels,gastric fundus hyperplasia and hyperacidity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930553M12Rik A G 4: 88,786,202 (GRCm39) Y139H unknown Het
Akr1b10 T C 6: 34,371,027 (GRCm39) V259A probably benign Het
Aldh5a1 A T 13: 25,095,673 (GRCm39) N481K probably damaging Het
Ankrd26 A T 6: 118,504,725 (GRCm39) M728K possibly damaging Het
Asic1 A G 15: 99,590,405 (GRCm39) M52V probably benign Het
Bean1 CT C 8: 104,908,664 (GRCm39) probably null Het
Cacna2d2 C A 9: 107,392,689 (GRCm39) Y544* probably null Het
Cdcp3 A G 7: 130,852,218 (GRCm39) D818G possibly damaging Het
Chd4 A G 6: 125,097,688 (GRCm39) N1403S probably damaging Het
Cldn4 G T 5: 134,975,174 (GRCm39) N142K probably benign Het
Cracd GCGCGAGGCCGAGAGGCAGGAGGAGGAAGCAAGACAACGCGAGGCCGAGAGGCAGG GCGCGAGGCCGAGAGGCAGG 5: 77,004,801 (GRCm39) probably benign Het
Dll1 T C 17: 15,593,710 (GRCm39) Y219C probably damaging Het
Dnah2 T A 11: 69,326,990 (GRCm39) I3539F probably damaging Het
Egfr T A 11: 16,825,067 (GRCm39) L469* probably null Het
Elmo1 A G 13: 20,756,573 (GRCm39) N554D possibly damaging Het
Fam234a A C 17: 26,435,225 (GRCm39) F306L probably benign Het
Fbl G A 7: 27,874,052 (GRCm39) G45D unknown Het
Fbxw10 C A 11: 62,753,522 (GRCm39) C505* probably null Het
Ftcd G A 10: 76,417,153 (GRCm39) G221S probably damaging Het
Gad1 A G 2: 70,417,716 (GRCm39) D305G possibly damaging Het
Gdpd4 A G 7: 97,607,074 (GRCm39) D16G probably benign Het
Gsdmc3 T A 15: 63,738,663 (GRCm39) D133V possibly damaging Het
Hpdl T C 4: 116,677,817 (GRCm39) T215A possibly damaging Het
Ift56 T C 6: 38,386,386 (GRCm39) F369S probably damaging Het
Igsf10 A T 3: 59,236,526 (GRCm39) N1218K possibly damaging Het
Isg20 C T 7: 78,569,605 (GRCm39) P192L probably benign Het
Itga7 C T 10: 128,793,543 (GRCm39) T126M unknown Het
Krr1 A G 10: 111,813,026 (GRCm39) I134V probably benign Het
Krt71 T A 15: 101,646,731 (GRCm39) T326S probably benign Het
Lamb1 T A 12: 31,337,983 (GRCm39) V480E probably damaging Het
Mmp19 T A 10: 128,630,523 (GRCm39) L102Q possibly damaging Het
Mtor T A 4: 148,622,776 (GRCm39) L1952* probably null Het
Myo15a T A 11: 60,378,243 (GRCm39) V215E Het
Nfs1 T A 2: 155,965,851 (GRCm39) K77* probably null Het
Or52s1 A T 7: 102,861,156 (GRCm39) I30F possibly damaging Het
Or9a4 T A 6: 40,549,096 (GRCm39) Y259N Het
Pcdhga4 T C 18: 37,820,560 (GRCm39) F703S probably damaging Het
Pdzd7 A G 19: 45,034,022 (GRCm39) S21P probably damaging Het
Pitrm1 A T 13: 6,617,394 (GRCm39) I583F possibly damaging Het
Ppox A G 1: 171,107,855 (GRCm39) L77P unknown Het
Ppp1r37 G T 7: 19,269,658 (GRCm39) R114S probably damaging Het
Ppp4r3b T C 11: 29,144,598 (GRCm39) V316A probably benign Het
Ptprd A G 4: 75,865,335 (GRCm39) I1214T probably damaging Het
Rasal3 A G 17: 32,615,441 (GRCm39) F466L probably benign Het
Ric8b A T 10: 84,761,447 (GRCm39) D41V probably benign Het
Rin2 T C 2: 145,686,713 (GRCm39) S81P probably benign Het
Sft2d1 T A 17: 8,542,139 (GRCm39) C128S probably damaging Het
Skint1 T C 4: 111,878,509 (GRCm39) V147A probably benign Het
Slc9c1 T C 16: 45,413,848 (GRCm39) V992A probably benign Het
Sv2b G T 7: 74,769,772 (GRCm39) S590Y probably damaging Het
Syne1 C T 10: 5,082,021 (GRCm39) V868I probably benign Het
Tex35 T C 1: 156,934,789 (GRCm39) I42V possibly damaging Het
Tlr2 T C 3: 83,744,892 (GRCm39) N397S probably damaging Het
Tmem202 A G 9: 59,431,999 (GRCm39) probably null Het
Usp20 A G 2: 30,873,030 (GRCm39) probably null Het
Usp32 C T 11: 84,885,369 (GRCm39) R1226Q probably damaging Het
Usp47 C T 7: 111,688,801 (GRCm39) A736V possibly damaging Het
Vmn2r-ps117 T A 17: 19,044,037 (GRCm39) L371* probably null Het
Wwp1 T A 4: 19,662,215 (GRCm39) N127Y possibly damaging Het
Yae1d1 A T 13: 18,167,770 (GRCm39) V41D probably damaging Het
Zbtb8b T C 4: 129,326,517 (GRCm39) D216G probably benign Het
Zfp462 T C 4: 55,016,988 (GRCm39) S903P probably benign Het
Zranb1 G A 7: 132,585,466 (GRCm39) G638D probably damaging Het
Other mutations in Sst
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1472:Sst UTSW 16 23,709,448 (GRCm39) missense probably benign
R1853:Sst UTSW 16 23,709,403 (GRCm39) missense probably damaging 1.00
R2209:Sst UTSW 16 23,708,558 (GRCm39) missense probably benign 0.05
R3919:Sst UTSW 16 23,708,591 (GRCm39) missense possibly damaging 0.59
R4350:Sst UTSW 16 23,708,565 (GRCm39) missense probably damaging 0.99
R4351:Sst UTSW 16 23,708,565 (GRCm39) missense probably damaging 0.99
R4352:Sst UTSW 16 23,708,565 (GRCm39) missense probably damaging 0.99
R5586:Sst UTSW 16 23,708,487 (GRCm39) missense probably damaging 1.00
R6844:Sst UTSW 16 23,708,592 (GRCm39) missense probably benign 0.00
R7492:Sst UTSW 16 23,708,576 (GRCm39) missense probably damaging 1.00
R8903:Sst UTSW 16 23,708,499 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AGAAGTCAAACGCTTGCTCTTC -3'
(R):5'- TCTCACTGCCCTATCCAGGAAC -3'

Sequencing Primer
(F):5'- AGTCAAACGCTTGCTCTTCATAATC -3'
(R):5'- AGGAACTGGCCAAGTACTTCTTG -3'
Posted On 2022-05-16