Incidental Mutation 'R9585:Or5l14'
ID 722734
Institutional Source Beutler Lab
Gene Symbol Or5l14
Ensembl Gene ENSMUSG00000075143
Gene Name olfactory receptor family 5 subfamily L member 14
Synonyms MOR174-1, GA_x6K02T2Q125-49446395-49445457, Olfr1157
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.169) question?
Stock # R9585 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 87792296-87798601 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 87792919 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 106 (T106S)
Ref Sequence ENSEMBL: ENSMUSP00000097429 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099841]
AlphaFold A2AVC4
Predicted Effect probably benign
Transcript: ENSMUST00000099841
AA Change: T106S

PolyPhen 2 Score 0.125 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000097429
Gene: ENSMUSG00000075143
AA Change: T106S

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 9.7e-48 PFAM
Pfam:7tm_1 41 290 2.6e-20 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700006A11Rik T A 3: 124,199,993 (GRCm39) D533V possibly damaging Het
4933411K16Rik A G 19: 42,041,352 (GRCm39) E161G probably benign Het
Abca12 A G 1: 71,342,745 (GRCm39) S912P probably damaging Het
Abca3 G A 17: 24,619,486 (GRCm39) M1196I probably benign Het
Adprs A T 4: 126,211,786 (GRCm39) D175E probably benign Het
Asrgl1 A G 19: 9,090,398 (GRCm39) L316P probably benign Het
Avl9 T A 6: 56,734,299 (GRCm39) M626K probably damaging Het
Birc6 A G 17: 74,916,265 (GRCm39) N1727S probably damaging Het
Casp14 G A 10: 78,549,194 (GRCm39) R251W probably damaging Het
Cfap69 A G 5: 5,631,269 (GRCm39) I919T possibly damaging Het
Cibar2 T C 8: 120,901,450 (GRCm39) E85G probably null Het
Cps1 T A 1: 67,195,341 (GRCm39) M254K probably damaging Het
Ctc1 A G 11: 68,925,490 (GRCm39) E1009G probably damaging Het
Ddx25 A T 9: 35,455,009 (GRCm39) Y426* probably null Het
Dok3 A G 13: 55,672,057 (GRCm39) F207S probably damaging Het
Epha8 G T 4: 136,665,897 (GRCm39) L420M probably damaging Het
Fcrla A T 1: 170,749,868 (GRCm39) M1K probably null Het
Heatr4 A T 12: 84,014,472 (GRCm39) S588R probably damaging Het
Iglv3 A G 16: 19,059,960 (GRCm39) *123Q probably null Het
Igsf9b T C 9: 27,233,532 (GRCm39) I344T probably damaging Het
Il18 T C 9: 50,490,661 (GRCm39) S99P probably damaging Het
Krt36 G A 11: 99,994,892 (GRCm39) L227F probably damaging Het
Lrriq1 A G 10: 103,051,250 (GRCm39) S501P probably benign Het
Lvrn T C 18: 47,011,411 (GRCm39) probably null Het
Myo18a T A 11: 77,709,495 (GRCm39) M535K probably benign Het
Myocd T A 11: 65,095,192 (GRCm39) S158C probably damaging Het
Naip6 A T 13: 100,436,577 (GRCm39) C649S probably damaging Het
Oasl2 T C 5: 115,035,901 (GRCm39) V59A probably damaging Het
Obscn C A 11: 58,965,831 (GRCm39) V2942F probably benign Het
Or10a49 T A 7: 108,467,552 (GRCm39) T270S probably benign Het
Osbpl6 A G 2: 76,354,438 (GRCm39) T18A probably benign Het
Pcf11 A T 7: 92,311,006 (GRCm39) D327E probably benign Het
Per3 G T 4: 151,097,138 (GRCm39) Q796K probably benign Het
Pex5l T C 3: 33,060,091 (GRCm39) T227A probably benign Het
Phf11b G T 14: 59,568,704 (GRCm39) P70T probably benign Het
Pkd1l1 T G 11: 8,804,390 (GRCm39) I2184L Het
Polr3a A T 14: 24,502,289 (GRCm39) M1288K probably damaging Het
Pth1r T A 9: 110,573,847 (GRCm39) R3S probably benign Het
Ptprk C A 10: 28,369,147 (GRCm39) Y706* probably null Het
Rmi2 C T 16: 10,703,983 (GRCm39) T108I probably benign Het
Rrbp1 T C 2: 143,799,479 (GRCm39) N1076S probably benign Het
Setd3 A C 12: 108,074,814 (GRCm39) probably null Het
Slc4a1 A G 11: 102,247,915 (GRCm39) Y360H probably benign Het
Sox21 A G 14: 118,472,993 (GRCm39) S19P possibly damaging Het
Speer4a2 T C 5: 26,291,542 (GRCm39) H88R possibly damaging Het
Stx18 T A 5: 38,249,916 (GRCm39) N76K possibly damaging Het
Sv2c T C 13: 96,122,466 (GRCm39) T437A probably benign Het
Trrap G A 5: 144,777,330 (GRCm39) V3043M probably damaging Het
Vps50 T A 6: 3,600,348 (GRCm39) S936T probably benign Het
Other mutations in Or5l14
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4453001:Or5l14 UTSW 2 87,792,802 (GRCm39) missense possibly damaging 0.90
R1502:Or5l14 UTSW 2 87,792,379 (GRCm39) missense probably damaging 1.00
R2127:Or5l14 UTSW 2 87,793,176 (GRCm39) missense probably benign 0.01
R2284:Or5l14 UTSW 2 87,793,137 (GRCm39) missense probably damaging 0.99
R2443:Or5l14 UTSW 2 87,793,209 (GRCm39) missense possibly damaging 0.47
R4021:Or5l14 UTSW 2 87,793,066 (GRCm39) missense possibly damaging 0.77
R4693:Or5l14 UTSW 2 87,793,053 (GRCm39) missense probably benign 0.39
R4752:Or5l14 UTSW 2 87,792,693 (GRCm39) missense probably damaging 1.00
R4879:Or5l14 UTSW 2 87,793,040 (GRCm39) missense possibly damaging 0.91
R4983:Or5l14 UTSW 2 87,793,042 (GRCm39) missense probably benign 0.26
R5592:Or5l14 UTSW 2 87,792,684 (GRCm39) missense probably damaging 1.00
R5945:Or5l14 UTSW 2 87,792,946 (GRCm39) missense probably damaging 1.00
R6412:Or5l14 UTSW 2 87,792,693 (GRCm39) missense probably damaging 1.00
R7470:Or5l14 UTSW 2 87,792,793 (GRCm39) missense possibly damaging 0.74
Predicted Primers PCR Primer
(F):5'- GATCTCAAGGGCTAAGCACAAATG -3'
(R):5'- CATTTATGGAGTCACCGCCC -3'

Sequencing Primer
(F):5'- TGAATCAGAGAACACATTGATGCAC -3'
(R):5'- ACCTGGGAATGACTGCACTGATTC -3'
Posted On 2022-08-09